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公开(公告)号：US20120035354A1
公开(公告)日：2012-02-09
申请号：US13044037
申请日：2011-03-09
IPC分类号： C07H21/04
CPC分类号： C12N9/0004 , C12N9/0008 , C12N9/001 , C12N9/0059 , C12N9/0061 , C12N9/0065 , C12N9/0071 , C12N9/0083 , C12N9/1007 , C12N9/1011 , C12N9/1051 , C12N9/2422 , C12N9/2445 , C12N9/86 , C12N9/93 , C12N15/8255 , C12Y110/03001 , C12Y110/03002 , C12Y114/13011 , C12Y201/01006 , C12Y302/01001 , C12Y302/01021
摘要： Novel isolated polynucleotides and polypeptides associated with the lignin biosynthetic pathway are provided, together with genetic constructs including such sequences. Methods for the modulation of lignin content, lignin structure and lignin composition in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides of the present invention into the genome of a target organism.
摘要翻译： 提供了与木质素生物合成途径相关的新型分离的多核苷酸和多肽，以及包括这些序列的遗传构建体。 还公开了调节靶生物体中木质素含量，木质素结构和木质素组成的方法，所述方法包括将一种或多种本发明的多核苷酸掺入目标生物体的基因组中。
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2.发明申请Metabolically Engineered Cells for the Production of Resveratrol or an Oligomeric or Glycosidically-Bound Derivative Thereof 有权用于生产白藜芦醇或其低聚糖或糖苷结合衍生物的代谢工程细胞公开(公告)号：US20080286844A1
公开(公告)日：2008-11-20
申请号：US11816847
申请日：2006-02-21
CPC分类号： C12P7/22 , A23C3/08 , A61K31/05 , C12N9/0042 , C12N9/0073 , C12N9/1029 , C12N9/1037 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/42 , C12P23/00 , C12Y106/02004 , C12Y114/13011 , C12Y203/01074 , C12Y403/01005 , C12Y602/01012 , C12Y604/01002 , Y02A50/473 , Y02P20/52
摘要： A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA, or in which L-phenylalanine- or tyrosine-ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.
摘要翻译： 通过苯丙氨酸氨裂解酶（PAL）从苯丙氨酸产生反式肉桂酸，肉桂酸4-羟化酶（C4H）的途径产生白藜芦醇的重组微生物从所述反式肉桂酸，4-香豆酸 - 辅酶A产生4-香豆酸 连接酶（4CL）从所述4-香豆酸生成4-香豆酰CoA，白藜芦醇合酶（VST）从所述4-香豆酰CoA或其中L-苯丙氨酸或酪氨酸 - 氨裂解酶（PAL / TAL）产生白藜芦醇 4-香豆酸，4-香豆酸-CaA连接酶（4CL）从所述4-香豆酸生成4-香豆酰CoA，白藜芦醇合酶（VST）从所述4-香豆酰CoA产生所述白藜芦醇。 微生物可以是酵母，真菌或细菌，包括酿酒酵母，大肠杆菌，乳酸乳球菌，黑曲霉或米曲霉。
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公开(公告)号：US09404129B2
公开(公告)日：2016-08-02
申请号：US14514718
申请日：2014-10-15
申请人： Evolva SA
IPC分类号： C12N1/20 , C12N1/00 , C12P7/22 , C07H21/04 , C12P23/00 , C12N9/10 , C12N9/02 , C12N9/88 , C12N9/00 , C12N15/52 , C12P7/42 , A23C3/08 , A61K31/05
CPC分类号： C12P7/22 , A23C3/08 , A61K31/05 , C12N9/0042 , C12N9/0073 , C12N9/1029 , C12N9/1037 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/42 , C12P23/00 , C12Y106/02004 , C12Y114/13011 , C12Y203/01074 , C12Y403/01005 , C12Y602/01012 , C12Y604/01002 , Y02A50/473 , Y02P20/52
摘要： A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA, or in which L-phenylalanine- or tyrosine-ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.
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4.发明授权Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof 有权用于生产白藜芦醇或其寡聚或糖苷结合衍生物的代谢工程细胞公开(公告)号：US08895287B2
公开(公告)日：2014-11-25
申请号：US11816847
申请日：2006-02-21
IPC分类号： C12N1/20 , C12N1/00 , C12P7/22 , C07H21/04 , C12P7/42 , C12N9/02 , C12N9/10 , C12N9/88 , C12N9/00 , C12N15/52
CPC分类号： C12P7/22 , A23C3/08 , A61K31/05 , C12N9/0042 , C12N9/0073 , C12N9/1029 , C12N9/1037 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/42 , C12P23/00 , C12Y106/02004 , C12Y114/13011 , C12Y203/01074 , C12Y403/01005 , C12Y602/01012 , C12Y604/01002 , Y02A50/473 , Y02P20/52
摘要： A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA, or in which L-phenylalanine- or tyrosine-ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.
摘要翻译： 通过苯丙氨酸氨裂解酶（PAL）从苯丙氨酸产生反式肉桂酸，肉桂酸4-羟化酶（C4H）的途径产生白藜芦醇的重组微生物从所述反式肉桂酸，4-香豆酸 - 辅酶A产生4-香豆酸 连接酶（4CL）从所述4-香豆酸生成4-香豆酰CoA，白藜芦醇合酶（VST）从所述4-香豆酰CoA或其中L-苯丙氨酸或酪氨酸 - 氨裂解酶（PAL / TAL）产生白藜芦醇 4-香豆酸，4-香豆酸-CaA连接酶（4CL）从所述4-香豆酸生成4-香豆酰CoA，白藜芦醇合酶（VST）从所述4-香豆酰CoA产生所述白藜芦醇。 微生物可以是酵母，真菌或细菌，包括酿酒酵母，大肠杆菌，乳酸乳球菌，黑曲霉或米曲霉。
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公开(公告)号：US20030131373A1
公开(公告)日：2003-07-10
申请号：US10174693
申请日：2002-06-18
IPC分类号： A01H005/00 , C12Q001/68 , C07H021/04 , C12N009/00 , C12P021/02 , C12N005/04
CPC分类号： C12Y110/03001 , C12N9/0004 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0059 , C12N9/0061 , C12N9/0065 , C12N9/0071 , C12N9/0083 , C12N9/1007 , C12N9/1011 , C12N9/1051 , C12N9/2422 , C12N9/2445 , C12N9/86 , C12N9/88 , C12N9/93 , C12N15/8255 , C12Y110/03002 , C12Y114/13011 , C12Y201/01006 , C12Y302/01001 , C12Y302/01021
摘要： Novel isolated polynucleotides and polypeptides associated with the lignin biosynthetic pathway are provided, together with genetic constructs including such sequences. Methods for the modulation of lignin content, lignin structure and lignin composition in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides of the present invention into the genome of a target organism.
摘要翻译： 提供了与木质素生物合成途径相关的新型分离的多核苷酸和多肽，以及包括这些序列的遗传构建体。 还公开了调节靶生物体中木质素含量，木质素结构和木质素组成的方法，所述方法包括将一种或多种本发明的多核苷酸掺入目标生物体的基因组中。
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公开(公告)号：US09040269B2
公开(公告)日：2015-05-26
申请号：US12081571
申请日：2008-04-17
IPC分类号： C12P7/22 , C12N1/00 , C07H21/04 , C12P7/42 , C12P23/00 , C12N9/10 , C12N9/02 , C12N9/88 , C12N9/00 , C12N15/52
CPC分类号： C12P7/22 , A23C3/08 , A61K31/05 , C12N9/0042 , C12N9/0073 , C12N9/1029 , C12N9/1037 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/42 , C12P23/00 , C12Y106/02004 , C12Y114/13011 , C12Y203/01074 , C12Y403/01005 , C12Y602/01012 , C12Y604/01002 , Y02A50/473 , Y02P20/52
摘要： A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA, or in which L-phenylalanine- or tyrosine-ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.
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公开(公告)号：US07910326B2
公开(公告)日：2011-03-22
申请号：US11397533
申请日：2006-04-03
IPC分类号： C12P21/02
CPC分类号： C12N9/0004 , C12N9/0008 , C12N9/001 , C12N9/0059 , C12N9/0061 , C12N9/0065 , C12N9/0071 , C12N9/0083 , C12N9/1007 , C12N9/1011 , C12N9/1051 , C12N9/2422 , C12N9/2445 , C12N9/86 , C12N9/93 , C12N15/8255 , C12Y110/03001 , C12Y110/03002 , C12Y114/13011 , C12Y201/01006 , C12Y302/01001 , C12Y302/01021
摘要： Novel isolated polynucleotides and polypeptides associated with the lignin biosynthetic pathway are provided, together with genetic constructs including such sequences. Methods for the modulation of lignin content, lignin structure and lignin composition in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides of the present invention into the genome of a target organism.
摘要翻译： 提供了与木质素生物合成途径相关的新型分离的多核苷酸和多肽，以及包括这些序列的遗传构建体。 还公开了调节靶生物体中木质素含量，木质素结构和木质素组成的方法，所述方法包括将一种或多种本发明的多核苷酸掺入目标生物体的基因组中。
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8.发明申请Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof 有权用于生产白藜芦醇或其寡聚或糖苷结合衍生物的代谢工程细胞公开(公告)号：US20090035839A1
公开(公告)日：2009-02-05
申请号：US12081571
申请日：2008-04-17
IPC分类号： C12N1/00
CPC分类号： C12P7/22 , A23C3/08 , A61K31/05 , C12N9/0042 , C12N9/0073 , C12N9/1029 , C12N9/1037 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/42 , C12P23/00 , C12Y106/02004 , C12Y114/13011 , C12Y203/01074 , C12Y403/01005 , C12Y602/01012 , C12Y604/01002 , Y02A50/473 , Y02P20/52
摘要： A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA, or in which L-phenylalanine- or tyrosine-ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.
摘要翻译： 通过苯丙氨酸氨裂解酶（PAL）从苯丙氨酸产生反式肉桂酸，肉桂酸4-羟化酶（C4H）的途径产生白藜芦醇的重组微生物从所述反式肉桂酸，4-香豆酸 - 辅酶A产生4-香豆酸 连接酶（4CL）从所述4-香豆酸生成4-香豆酰CoA，白藜芦醇合酶（VST）从所述4-香豆酰CoA或其中L-苯丙氨酸或酪氨酸 - 氨裂解酶（PAL / TAL）产生白藜芦醇 4-香豆酸，4-香豆酸-CaA连接酶（4CL）从所述4-香豆酸生成4-香豆酰CoA，白藜芦醇合酶（VST）从所述4-香豆酰CoA产生所述白藜芦醇。 微生物可以是酵母，真菌或细菌，包括酿酒酵母，大肠杆菌，乳酸乳球菌，黑曲霉或米曲霉。
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公开(公告)号：US11987829B2
公开(公告)日：2024-05-21
申请号：US17429459
申请日：2020-02-11
CPC分类号： C12P19/60 , C12N9/0042 , C12N9/0071 , C12N9/0073 , C12N9/1007 , C12N9/1051 , C12N9/1085 , C12N9/88 , C12N9/90 , C12N9/93 , C12Y106/02004 , C12Y114/11022 , C12Y114/13011 , C12Y114/14 , C12Y204/01 , C12Y204/01185 , C12Y205/01006 , C12Y402/01076 , C12Y403/01023 , C12Y403/01024 , C12Y505/01006 , C12Y602/01012
摘要： The present invention relates to a recombinant microorganism which is modified to be capable of producing diosmin and hesperidin and to the use thereof for producing diosmin and/or hesperidin.
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公开(公告)号：US09834793B2
公开(公告)日：2017-12-05
申请号：US14690542
申请日：2015-04-20
申请人： Evolva SA
IPC分类号： C12P7/22 , C12N1/00 , C07H21/04 , C12P23/00 , C12N9/10 , C12N9/02 , C12N9/88 , C12N9/00 , C12N15/52 , C12P7/42 , A23C3/08 , A61K31/05
CPC分类号： C12P7/22 , A23C3/08 , A61K31/05 , C12N9/0042 , C12N9/0073 , C12N9/1029 , C12N9/1037 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/42 , C12P23/00 , C12Y106/02004 , C12Y114/13011 , C12Y203/01074 , C12Y403/01005 , C12Y602/01012 , C12Y604/01002 , Y02A50/473 , Y02P20/52
摘要： A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA, or in which L-phenylalanine- or tyrosine-ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.
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