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发明申请
US20090035839A1 Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof 有权
用于生产白藜芦醇或其寡聚或糖苷结合衍生物的代谢工程细胞

Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof
摘要：
A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA, or in which L-phenylalanine- or tyrosine-ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.
摘要（中）：

通过苯丙氨酸氨裂解酶（PAL）从苯丙氨酸产生反式肉桂酸，肉桂酸4-羟化酶（C4H）的途径产生白藜芦醇的重组微生物从所述反式肉桂酸，4-香豆酸 - 辅酶A产生4-香豆酸 连接酶（4CL）从所述4-香豆酸生成4-香豆酰CoA，白藜芦醇合酶（VST）从所述4-香豆酰CoA或其中L-苯丙氨酸或酪氨酸 - 氨裂解酶（PAL / TAL）产生白藜芦醇 4-香豆酸，4-香豆酸-CaA连接酶（4CL）从所述4-香豆酸生成4-香豆酰CoA，白藜芦醇合酶（VST）从所述4-香豆酰CoA产生所述白藜芦醇。 微生物可以是酵母，真菌或细菌，包括酿酒酵母，大肠杆菌，乳酸乳球菌，黑曲霉或米曲霉。

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