-
公开(公告)号：US09932588B2
公开(公告)日：2018-04-03
申请号：US14542501
申请日：2014-11-14
发明人： Rishi Arora
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C12N15/11 , C12N15/113 , A61B5/046 , A61B5/00 , A61B5/04
CPC分类号： C12N15/1137 , A61B5/04012 , A61B5/046 , A61B5/4848 , C12N2310/14 , C12N2310/531 , C12Y106/03
摘要： Disclosed herein are pharmaceutical compositions and methods for inhibiting oxidative stress in a subject having atrial or ventricular arrhythmias, ventricular failure or heart failure. The methods include administering an effective amount of a NOX2 inhibitor agent to the subject, wherein said administering is under conditions such that a level of oxidative stress in myocardial tissue is reduced or eliminated. The pharmaceutical compositions include a NOX2 inhibitor agent.
-
公开(公告)号：US20150203852A1
公开(公告)日：2015-07-23
申请号：US14542501
申请日：2014-11-14
发明人： Rishi Arora
IPC分类号： C12N15/113 , A61B5/00 , A61B5/04 , A61B5/046
CPC分类号： C12N15/1137 , A61B5/04012 , A61B5/046 , A61B5/4848 , C12N2310/14 , C12N2310/531 , C12Y106/03
摘要： Disclosed herein are pharmaceutical compositions and methods for inhibiting oxidative stress in a subject having atrial or ventricular arrhythmias, ventricular failure or heart failure. The methods include administering an effective amount of a NOX2 inhibitor agent to the subject, wherein said administering is under conditions such that a level of oxidative stress in myocardial tissue is reduced or eliminated. The pharmaceutical compositions include a NOX2 inhibitor agent.
摘要翻译： 本文公开了用于抑制患有心房或室性心律失常，心室衰竭或心力衰竭的受试者的氧化应激的药物组合物和方法。 所述方法包括向受试者施用有效量的NOX 2抑制剂，其中所述施用在使得心肌组织中的氧化应激水平降低或消除的条件下。 药物组合物包括NOX2抑制剂。
-
3.发明申请Compositions and Methods for Detecting, Treating and Preventing Diseases and Disorders 审中-公开检测，治疗和预防疾病和疾病的组合和方法公开(公告)号：US20150210774A1
公开(公告)日：2015-07-30
申请号：US14414734
申请日：2013-07-16
申请人： YALE UNIVERSITY
发明人： Gary Desir
IPC分类号： C07K16/40 , C12Q1/68 , A61K38/44 , G01N33/573
CPC分类号： C07K16/40 , A61K38/44 , C07K2317/24 , C07K2317/622 , C07K2317/75 , C12Q1/26 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Y106/03 , G01N33/573 , G01N33/6893 , G01N2333/90209 , G01N2333/90633 , G01N2800/321 , G01N2800/325 , G01N2800/347
摘要： The invention described herein relates to the discovery that renalase, and fragments thereof, are useful for the treatment or prevention of cardiac and renal diseases or disorders. Thus, the invention relates to compositions comprising renalase, or fragments thereof, and methods for treating and preventing cardiac and renal disease or disorders.
摘要翻译： 本文描述的发明涉及肾酶及其片段可用于治疗或预防心脏和肾脏疾病或病症的发现。 因此，本发明涉及包含肾酶或其片段的组合物，以及用于治疗和预防心脏和肾脏疾病或病症的方法。
-
4.发明申请INHIBITORS OF NOX4 EXPRESSION AND /OR NOX4 FUNCTION AND THEIR USE IN THE PREVENTION AND TREATMENT OF NERVE INJURY AND/OR NEUROPATHIC PAIN 审中-公开NOX4表达和/或NOX4功能的抑制剂及其在预防和治疗神经损伤和/或神经性疼痛中的应用公开(公告)号：US20150051264A1
公开(公告)日：2015-02-19
申请号：US14345241
申请日：2012-09-14
申请人： Achim Schmidtko , Wiebke Kallenborn-Gerhardt , Gerd Geisslinger , Ralf Brandes , Katrin Schroeder
发明人： Achim Schmidtko , Wiebke Kallenborn-Gerhardt , Gerd Geisslinger , Ralf Brandes , Katrin Schroeder
IPC分类号： C12N15/113 , C12Q1/68 , C12Q1/26
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/7088 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/321 , C12N2310/3231 , C12N2310/3233 , C12Q1/26 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12Y106/03 , G01N2333/90209 , G01N2500/04
摘要： The present invention relates to modulators, in particular inhibitors, of the expression and/or the function of NADPH Oxidase 4 (Nox4) for use in the prevention and/or treatment of nerve injury, in particular pain, more particularly neuropathic pain. Further disclosed is a method for the identification of Nox4 modulators, a pharmaceutical composition comprising a Nox4 inhibitor and a method for preventing and treating pain, in particular neuropathic pain, in a subject in need of such a treatment. Also, the invention relates to modulators, in particular inhibitors, of the expression and/or the function of NADPH Oxidase 4 (Nox4) for use in the prevention and/or treatment of nerve injury associated with dysmyelination and methods for preventing and treating dysmyelination and diseases associated with dysmyelination.
摘要翻译： 本发明涉及用于预防和/或治疗神经损伤，特别是疼痛，特别是神经性疼痛的NADPH氧化酶4（Nox4）的表达和/或功能的调节剂，特别是抑制剂。 还公开了用于鉴定在需要这种治疗的受试者中的Nox4调节剂，包含Nox4抑制剂的药物组合物和预防和治疗疼痛，特别是神经性疼痛的方法。 此外，本发明涉及调节剂，特别是抑制剂，用于预防和/或治疗与脱髓鞘病相关的神经损伤的NADPH氧化酶4（Nox4）的表达和/或功能以及用于预防和治疗异常髓鞘的方法，以及 与失语症有关的疾病
-
公开(公告)号：US20130030164A1
公开(公告)日：2013-01-31
申请号：US13574458
申请日：2011-01-19
申请人： Shinichi Yoshida , Akira Iwasaki , Motohisa Washida , Tozo Nishiyama , Daisuke Moriyama , Naoaki Taoka
发明人： Shinichi Yoshida , Akira Iwasaki , Motohisa Washida , Tozo Nishiyama , Daisuke Moriyama , Naoaki Taoka
CPC分类号： C12N9/0036 , C12N9/0065 , C12P7/02 , C12P7/18 , C12P7/42 , C12P13/04 , C12P19/36 , C12Y106/03 , C12Y106/03001 , C12Y111/01001
摘要： Water-forming NADH oxidase derived from Streptococcus mutans should be further improved in terms of stability for practical use in industrial production. An object of the present invention is to provide an enzyme that is obtained through modification of a water-forming NADH oxidase, which is useful as an NAD+ regeneration system for stereoselective oxidation catalyzed by an oxidoreductase, by protein engineering techniques so that the enzyme can withstand long-term use without exhibiting a reduction of its activity for the regeneration of NAD+, that is, an enzyme having improved stability, and to provide a method for efficiently producing a useful substance such as an optically active alcohol or amino acid. The present invention relates to an enzyme modification method that can improve the stability of water-forming NADH oxidase derived from Streptococcus mutans by appropriately introducing mutation.
摘要翻译： 来自变形链球菌的成水NADH氧化酶在工业生产实际使用的稳定性方面应进一步提高。 本发明的目的是提供通过蛋白质工程技术，通过改性水合NADH氧化酶获得的酶，其可用作由氧化还原酶催化的用于立体选择性氧化的NAD +再生系统，使得酶能够承受 长期使用而不显示其NAD +再生活性的活性降低，即稳定性提高的酶，以及提供有效生产光学活性醇或氨基酸等有用物质的方法。 本发明涉及通过适当地引入突变来提高来自变形链球菌的水形成NADH氧化酶的稳定性的酶修饰方法。
-
公开(公告)号：US20180282827A1
公开(公告)日：2018-10-04
申请号：US15766461
申请日：2016-10-07
CPC分类号： C12R1/225 , A23L27/25 , C12P7/26 , C12Y101/01004 , C12Y101/01027 , C12Y101/01028 , C12Y101/01303 , C12Y106/03 , C12Y207/01069 , C12Y207/01144 , C12Y302/01085 , C12Y401/0204 , C12Y503/01026
摘要： The present invention provides a genetically modified lactic acid bacterium capable of producing diacetyl under aerobic conditions. Additionally the invention provides a method for producing diacetyl using the genetically modified lactic acid bacterium under aerobic conditions in the presence of a source of iron-containing porphyrin and a metal ion selected from Fe3+, Fe2+ and Cu2+. The lactic acid bacterium is genetically modified by deletion of those genes in its genome that encode polypeptides having lactate dehydrogenase (E.C 1.1.1.27/E.C.1.1.1.28); α-acetolactate decarboxylase (E.C 4.1.1.5); water-forming NADH oxidase (E.C. 1.6.3.4); phosphotransacetylase (E.C.2.3.1.8) activity; and optionally devoid of or deleted for genes encoding polypeptides having diacetyl reductase ((R)-acetoin forming; EC: 1.1.1.303); D-acetoin reductase; butanediol dehydrogenase ((R,R)-butane-2,3-diol forming; E.C. 1.1.1.4/1.1.1.-) and alcohol dehydrogenase (E.C. 1.2.1.10) activity. The invention provides for use of the genetically modified lactic acid bacterium for the production of diacetyl and a food product.
-
7.发明申请公开(公告)号：US20170226228A1
公开(公告)日：2017-08-10
申请号：US15321015
申请日：2015-06-26
申请人： Yale University
发明人： Gary Desir , Abigail Hunt , Jessica O-Rear , Peter Flynn
IPC分类号： C07K16/40 , A61K39/395
CPC分类号： C07K16/40 , A61K39/39558 , A61K2039/505 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12Y106/03 , G01N33/573 , G01N2333/90209
摘要： The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules act as therapeutics.
-
公开(公告)号：US20160145585A1
公开(公告)日：2016-05-26
申请号：US15011989
申请日：2016-02-01
申请人： Kaneka Corporation
发明人： Shinichi Yoshida , Akira Iwasaki , Motohisa Washida , Tozo Nishiyama , Daisuke Moriyama , Naoaki Taoka
IPC分类号： C12N9/02
CPC分类号： C12N9/0036 , C12N9/0065 , C12P7/02 , C12P7/18 , C12P7/42 , C12P13/04 , C12P19/36 , C12Y106/03 , C12Y106/03001 , C12Y111/01001
摘要： Water-forming NADH oxidase derived from Streptococcus mutans should be further improved in terms of stability for practical use in industrial production. An object of the present invention is to provide an enzyme that is obtained through modification of a water-forming NADH oxidase, which is useful as an NAD+ regeneration system for stereoselective oxidation catalyzed by an oxidoreductase, by protein engineering techniques so that the enzyme can withstand long-term use without exhibiting a reduction of its activity for the regeneration of NAD+, that is, an enzyme having improved stability, and to provide a method for efficiently producing a useful substance such as an optically active alcohol or amino acid. The present invention relates to an enzyme modification method that can improve the stability of water-forming NADH oxidase derived from Streptococcus mutans by appropriately introducing mutation.
摘要翻译： 来自变形链球菌的成水NADH氧化酶在工业生产实际使用的稳定性方面应进一步提高。 本发明的目的是提供通过蛋白质工程技术，通过改性水合NADH氧化酶获得的酶，其可用作由氧化还原酶催化的用于立体选择性氧化的NAD +再生系统，使得酶能够承受 长期使用而不显示其NAD +再生活性的活性降低，即稳定性提高的酶，以及提供有效生产光学活性醇或氨基酸等有用物质的方法。 本发明涉及通过适当地引入突变来提高来自变形链球菌的水形成NADH氧化酶的稳定性的酶修饰方法。
-
公开(公告)号：US20170166935A1
公开(公告)日：2017-06-15
申请号：US15327181
申请日：2015-07-23
申请人： ALDERYS
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0036 , C12N9/1022 , C12N9/88 , C12N15/52 , C12Y101/01004 , C12Y106/03 , C12Y202/01006 , C12Y401/01001 , C12Y401/01005
摘要： A recombinant yeast having a reduced pyruvate decarboxylase activity, in the génome of which has been inserted: —one or more nucleic acids encoding an acetolactate synthase or ALS, —one or more nucleic acids encoding an acetolactate decarboxylase or ALD, —one or more nucleic acids encoding a butancdiol dehydrogenase or BDH, and —one or more copies of a nucleic acids encoding a NADH oxidase or NOXE.
-
公开(公告)号：US09376667B2
公开(公告)日：2016-06-28
申请号：US15011989
申请日：2016-02-01
申请人： Kaneka Corporation
发明人： Shinichi Yoshida , Akira Iwasaki , Motohisa Washida , Tozo Nishiyama , Daisuke Moriyama , Naoaki Taoka
IPC分类号： C12N9/02
CPC分类号： C12N9/0036 , C12N9/0065 , C12P7/02 , C12P7/18 , C12P7/42 , C12P13/04 , C12P19/36 , C12Y106/03 , C12Y106/03001 , C12Y111/01001
摘要： Water-forming NADH oxidase derived from Streptococcus mutans should be further improved in terms of stability for practical use in industrial production. An object of the present invention is to provide an enzyme that is obtained through modification of a water-forming NADH oxidase, which is useful as an NAD+ regeneration system for stereoselective oxidation catalyzed by an oxidoreductase, by protein engineering techniques so that the enzyme can withstand long-term use without exhibiting a reduction of its activity for the regeneration of NAD+, that is, an enzyme having improved stability, and to provide a method for efficiently producing a useful substance such as an optically active alcohol or amino acid. The present invention relates to an enzyme modification method that can improve the stability of water-forming NADH oxidase derived from Streptococcus mutans by appropriately introducing mutation.
摘要翻译： 来自变形链球菌的成水NADH氧化酶在工业生产实际使用的稳定性方面应进一步提高。 本发明的目的是提供通过蛋白质工程技术，通过改性水合NADH氧化酶获得的酶，其可用作由氧化还原酶催化的用于立体选择性氧化的NAD +再生系统，使得酶能够承受 长期使用而不显示其NAD +再生活性的活性降低，即稳定性提高的酶，以及提供有效生产光学活性醇或氨基酸等有用物质的方法。 本发明涉及通过适当地引入突变来提高来自变形链球菌的水形成NADH氧化酶的稳定性的酶修饰方法。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.018 秒)
