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公开(公告)号：US10077455B2
公开(公告)日：2018-09-18
申请号：US14896905
申请日：2014-06-12
CPC分类号： C12P7/42 , C12N9/0006 , C12P7/52 , C12Y101/01284
摘要： Cells and cell cultures are provided that have improved tolerance to 3-hydroxypropionic acid (3HP). Genetic modifications to provide a mutated or overexpressed SFA1 gene or other enhancement of 3HP detoxification via a glutathione-dependent dehydrogenase reaction, including medium supplementation with glutathione, may be combined with a 3HP producing metabolic pathway.
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2.发明授权Reducing agent from microorganism belonging to genus Bacillus and application for same 有权来自属于芽孢杆菌属的微生物的还原剂及其应用公开(公告)号：US09241507B2
公开(公告)日：2016-01-26
申请号：US14048538
申请日：2013-10-08
申请人： Amano Enzyme Inc.
发明人： Keita Okuda , Shotaro Yamaguchi
IPC分类号： A23L1/31 , C12N9/02 , C12P21/06 , C07H21/04 , C07K1/00 , A23L1/272 , A23L1/314 , A61K35/74 , A23L1/30 , A23L1/27 , C12N9/04 , A61K35/00
CPC分类号： A23L1/272 , A23L5/40 , A23L5/41 , A23L13/48 , A23L33/10 , A23L33/105 , A61K35/74 , A61K2035/11 , C12N9/0004 , C12N9/0006 , C12N9/0051 , C12Y101/01284 , C12Y108/01004
摘要： The present invention is intended to provide a reducing agent effective for color development of meat and uses therefor. The present invention provides a reducing agent containing a heme reductase derived from a microorganism belonging to the genus Bacillus. Preferably, crushed bacterial cells of Bacillus subtilis, Bacillus amyloliquefaciens, Bacillus natto, Bacillus thuringiensis, or Bacillus mycoides are used.
摘要翻译： 本发明旨在提供一种有效用于肉类发色的还原剂及其用途。 本发明提供含有源自属于芽孢杆菌属的微生物的血红素还原酶的还原剂。 优选使用枯草芽孢杆菌，解淀粉芽孢杆菌，纳豆芽孢杆菌，苏云金芽孢杆菌或芽孢杆菌的破碎的细菌细胞。
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公开(公告)号：US08771679B2
公开(公告)日：2014-07-08
申请号：US13059014
申请日：2009-08-13
IPC分类号： A61K38/43
CPC分类号： C12N5/0693 , A61K38/00 , C07K14/47 , C07K2319/33 , C12N9/0036 , C12N9/0077 , C12N9/1211 , C12N9/2445 , C12N9/48 , C12N9/78 , C12N9/86 , C12Y101/01284 , C12Y207/01021 , C12Y302/01021 , C12Y305/02006 , C12Y305/04001 , Y02A50/473
摘要： The present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a prodrug activating enzyme and a protein that binds a cancer specific marker, polynucleotides encoding the polypeptides, and molecular switches for converting a prodrug into a toxin, comprising the polypeptides. The invention also features methods for converting a prodrug into a toxin, methods for treating cancer, and methods for making the molecular switches, as well as kits.
摘要翻译： 本发明的特征在于将两种独立蛋白质的结构域结合到分子开关中的新型蛋白质工程策略。 本发明的特征在于包含前体药物活化酶和结合癌症特异性标志物的蛋白质，编码多肽的多核苷酸以及用于将前药转化成毒素的分子开关的多肽，其包含多肽。 本发明还涉及将前药转化为毒素的方法，用于治疗癌症的方法，以及制备分子开关的方法以及试剂盒。
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4.发明申请REDUCING AGENT FROM MICROORGANISM BELONGING TO GENUS BACILLUS AND APPLICATION FOR SAME 审中-公开从微生物降低代谢物到基因杆菌并应用于其中公开(公告)号：US20130058911A1
公开(公告)日：2013-03-07
申请号：US13696446
申请日：2011-05-09
申请人： Keita Okuda , Shotaro Yamaguchi
发明人： Keita Okuda , Shotaro Yamaguchi
CPC分类号： A23L5/41 , A23L5/40 , A23L13/48 , A23L33/10 , A23L33/105 , A61K35/74 , A61K2035/11 , C12N9/0004 , C12N9/0006 , C12N9/0051 , C12Y101/01284 , C12Y108/01004
摘要： The present invention is intended to provide a reducing agent effective for color development of meat and uses therefor. The present invention provides a reducing agent containing a heme reductase derived from a microorganism belonging to the genus Bacillus. Preferably, crushed bacterial cells of Bacillus subtilis, Bacillus amyloliquefaciens, Bacillus natto, Bacillus thuringiensis, or Bacillus mycoides are used.
摘要翻译： 本发明旨在提供一种有效用于肉类发色的还原剂及其用途。 本发明提供含有源自属于芽孢杆菌属的微生物的血红素还原酶的还原剂。 优选使用枯草芽孢杆菌，解淀粉芽孢杆菌，纳豆芽孢杆菌，苏云金芽孢杆菌或芽孢杆菌的破碎的细菌细胞。
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公开(公告)号：US20160130613A1
公开(公告)日：2016-05-12
申请号：US14896905
申请日：2014-06-12
CPC分类号： C12P7/42 , C12N9/0006 , C12P7/52 , C12Y101/01284
摘要： Cells and cell cultures are provided that have improved tolerance to 3-hydroxypropionic acid (3HP). Genetic modifications to provide a mutated or overexpressed SFA1 gene or other enhancement of 3HP detoxification via a glutathione-dependent dehydrogenase reaction, including medium supplementation with glutathione, may be combined with a 3HP producing metabolic pathway.
摘要翻译： 提供具有改善的对3-羟基丙酸（3HP）的耐受性的细胞和细胞培养物。 提供突变或过表达的SFA1基因或通过谷胱甘肽依赖性脱氢酶反应（包括补充谷胱甘肽的3HP）解毒的其他增强的遗传修饰可与产生3HP的代谢途径组合。
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公开(公告)号：US09249132B2
公开(公告)日：2016-02-02
申请号：US13991973
申请日：2011-12-16
申请人： Xicheng Sun , Jian Qiu , Adam Stout
发明人： Xicheng Sun , Jian Qiu , Adam Stout
IPC分类号： C07D417/10 , C07D215/20 , C07D217/16 , C07D239/34 , C07D241/42 , C07D253/10 , C07D401/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/10 , C07C65/105 , C07C65/24 , C07D213/79 , C07D239/28 , C07D241/24 , C07D295/155 , C07D215/06 , C07D239/74 , C07D409/14 , C07D215/60 , C07D239/26 , C07D401/10 , C07D217/04
CPC分类号： A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/498 , A61K31/517 , A61K31/53 , C07C65/105 , C07C65/17 , C07C65/24 , C07D213/79 , C07D215/06 , C07D215/20 , C07D215/60 , C07D217/04 , C07D217/16 , C07D237/24 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/74 , C07D241/24 , C07D241/42 , C07D249/18 , C07D253/10 , C07D257/04 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10 , C12N9/0006 , C12N9/0065 , C12N9/99 , C12Y101/01284
摘要： The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
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7.发明申请公开(公告)号：US20130261123A1
公开(公告)日：2013-10-03
申请号：US13991972
申请日：2011-12-16
申请人： Xicheng Sun , Jian Qiu , Adam Stout
发明人： Xicheng Sun , Jian Qiu , Adam Stout
IPC分类号： C07D417/10 , C07D401/10 , C07D413/10 , C07D241/42 , C07D409/14 , C07D239/74 , C07D403/10 , C07D253/10 , C07D215/06 , C07D409/04
CPC分类号： A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/498 , A61K31/517 , A61K31/53 , C07C65/105 , C07C65/17 , C07C65/24 , C07D213/79 , C07D215/06 , C07D215/20 , C07D215/60 , C07D217/04 , C07D217/16 , C07D237/24 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/74 , C07D241/24 , C07D241/42 , C07D249/18 , C07D253/10 , C07D257/04 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10 , C12N9/0006 , C12N9/0065 , C12N9/99 , C12Y101/01284
摘要： The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
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8.发明申请公开(公告)号：US20130261122A1
公开(公告)日：2013-10-03
申请号：US13991973
申请日：2011-12-16
申请人： Xicheng Sun , Jian Qiu , Adam Stout
发明人： Xicheng Sun , Jian Qiu , Adam Stout
IPC分类号： C07C65/105 , C07D295/155 , C07D241/24 , C07D239/28 , C07C65/24 , C07D213/79
CPC分类号： A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/498 , A61K31/517 , A61K31/53 , C07C65/105 , C07C65/17 , C07C65/24 , C07D213/79 , C07D215/06 , C07D215/20 , C07D215/60 , C07D217/04 , C07D217/16 , C07D237/24 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/74 , C07D241/24 , C07D241/42 , C07D249/18 , C07D253/10 , C07D257/04 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10 , C12N9/0006 , C12N9/0065 , C12N9/99 , C12Y101/01284
摘要： The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
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9.发明授权Bacterial nitroreductase for the reduction of CB1954 and analogues thereof to a cytotoxic form 失效用于将CB1954及其类似物还原成细胞毒性形式的细菌硝基还原酶
公开(公告)号：US5977065A
公开(公告)日：1999-11-02
申请号：US87855
申请日：1998-06-01
申请人： Gillian Anlezark , Roger Melton , Roger Sherwood , Thomas Connors , Frank Friedlos , Michael Jarman , Richard Knox , Anthony Mauger , Caroline Joy Springer
发明人： Gillian Anlezark , Roger Melton , Roger Sherwood , Thomas Connors , Frank Friedlos , Michael Jarman , Richard Knox , Anthony Mauger , Caroline Joy Springer
IPC分类号： C12N9/12 , A61K38/00 , C07C219/34 , C07C271/18 , C07D203/14 , C07D487/14 , C07H15/252 , C07H19/048 , C07K7/06 , C12N9/02 , C12N15/00 , C12N15/09 , C12N15/53 , C12P17/10 , C12P21/08 , C12R1/01 , C12R1/07 , C12R1/19 , G01N33/53 , G01N33/573 , A61K38/12 , C07K5/00 , C07K7/00
CPC分类号： C07D203/14 , C07C219/34 , C07C271/18 , C07D487/14 , C07H15/252 , C07H19/048 , C07K7/06 , C12N9/0036 , C12P17/10 , C12Y101/01284 , A61K38/00 , Y02E50/16
摘要： A prodrug of the formula (I): ##STR1## where R.sup.1 is a group such that the compound R.sup.1 NH.sub.2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): ##STR2## a prodrug of the formula (II): ##STR3## where R.sup.2 is a group such that the compound R.sup.2 OH is a phenolic nitrogen mustard; and processes whereby the prodrugs shown above are made in which a prodrug precursor compound is reacted with 4-nitrobenzyl chloroformate under anhydrous conditions.
摘要翻译： 式（I）的前药：其中R1是使化合物R1NH2表示放线菌素D，多柔比星，丝裂霉素C或式（IV）的氮芥的基团：式（II）的前药：其中R 2 是化合物R 2 OH是酚氮芥的基团; 以及其中制备前述前药的方法，其中前药前体化合物与无水条件下的氯甲酸4-硝基苄酯反应。
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10.发明申请公开(公告)号：US20160067254A1
公开(公告)日：2016-03-10
申请号：US14944468
申请日：2015-11-18
发明人： Xicheng Sun , Jian Qiu , Adam Stout
IPC分类号： A61K31/53 , A61K31/4709 , C12N9/04 , A61K31/498 , A61K31/472 , A61K31/47 , A61K31/517
CPC分类号： A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/498 , A61K31/517 , A61K31/53 , C07C65/105 , C07C65/17 , C07C65/24 , C07D213/79 , C07D215/06 , C07D215/20 , C07D215/60 , C07D217/04 , C07D217/16 , C07D237/24 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/74 , C07D241/24 , C07D241/42 , C07D249/18 , C07D253/10 , C07D257/04 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10 , C12N9/0006 , C12N9/0065 , C12N9/99 , C12Y101/01284
摘要： The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
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