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公开(公告)号：US10078264B2
公开(公告)日：2018-09-18
申请号：US15331056
申请日：2016-10-21
发明人： Jun Hatakeyama , Takeshi Sasami , Masaki Ohashi
IPC分类号： G03F7/004 , G03F7/40 , C07C69/74 , C07C69/753 , C07C69/757 , C07C69/78 , C07C69/95 , C07C205/06 , C07C205/11 , C07C303/32 , C08F228/02 , G03F7/039 , C07C309/12 , C07J31/00 , C07D307/00 , G03F7/20 , C07C309/04 , C07C309/24 , C07C309/06 , C07C309/20 , C07C309/73 , C07J43/00
CPC分类号： G03F7/0397 , C07C69/74 , C07C69/753 , C07C69/757 , C07C69/78 , C07C69/95 , C07C205/06 , C07C205/11 , C07C303/32 , C07C309/04 , C07C309/06 , C07C309/12 , C07C309/20 , C07C309/24 , C07C309/73 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2601/20 , C07C2602/08 , C07C2602/10 , C07C2602/24 , C07C2602/28 , C07C2602/42 , C07C2603/16 , C07C2603/18 , C07C2603/24 , C07C2603/50 , C07C2603/68 , C07C2603/74 , C07C2603/86 , C07D307/00 , C07J31/006 , C07J43/003 , C08F228/02 , G03F7/0045 , G03F7/0046 , G03F7/2037 , G03F7/2059
摘要： A resist composition comprising a base resin comprising acid labile group-containing recurring units and preferably acid generator-containing recurring units, and a sodium, magnesium, potassium, calcium, rubidium, strontium, yttrium, cesium, barium or cerium salt of α-fluorinated sulfonic acid bonded to an alkyl, alkenyl, alkynyl or aryl group exhibits a high resolution and sensitivity and forms a pattern of satisfactory profile with minimal LWR after exposure and development.
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公开(公告)号：US09802880B2
公开(公告)日：2017-10-31
申请号：US15122160
申请日：2015-02-12
IPC分类号： C07C50/28 , A61K31/122 , A61K31/13 , A61K31/215 , C07C69/757 , C07C225/28
CPC分类号： C07C50/28 , A61K31/122 , A61K31/13 , A61K31/215 , C07C69/757 , C07C69/95 , C07C225/28 , C07C2601/14 , C07C2601/16
摘要： The present invention relates to novel cannabigerol quinone derivatives of formula (I) wherein R is the carbon atom of a linear or branched group, represented by: aryl, alkenyl, alkynyl or alcoxycarbonil groups; or wherein R is the nitrogen atom of a linear or branched group, represented by: alkylamino, arylamino, alkenylamino or alkynylamino groups; or, alternatively, R represents a bond between 2 molecules of formula (I) forming a dimer. The invention also relates to the use of any of the compounds of formula (I) as medicaments in therapy, particularly for treating PPARg-related diseases due to their high PPARg agonistic effect lacking electrophilic (Nrf2 activation) and cytotoxic activities. This invention also provides pharmaceutical compositions comprising said compounds and method of treating diseases with said compounds.
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3.发明授权Skin treatments containing carboxylic acid-substituted idebenone derivatives and methods of preparation and use thereof 有权含有羧酸取代的艾地苯醌衍生物的皮肤处理及其制备方法及用途公开(公告)号：US08354550B2
公开(公告)日：2013-01-15
申请号：US13349651
申请日：2012-01-13
申请人： Falko Diedrich , Birgit Neudecker , Eberhard Wieland , Joseph A. Lewis, II , Joseph C. Dinardo , Andrew S. Thompson , James Alan Kerschen , Peter C. Wade
发明人： Falko Diedrich , Birgit Neudecker , Eberhard Wieland , Joseph A. Lewis, II , Joseph C. Dinardo , Andrew S. Thompson , James Alan Kerschen , Peter C. Wade
IPC分类号： C07C59/31 , A61K31/225 , A61K8/00
CPC分类号： A61K8/37 , A61K8/375 , A61K8/67 , A61K8/671 , A61K8/673 , A61K8/676 , A61K8/678 , A61K8/97 , A61Q17/04 , A61Q19/004 , A61Q19/007 , A61Q19/02 , A61Q19/06 , A61Q19/08 , A61Q19/10 , A61Q90/00 , C07C67/08 , C07C67/14 , C07C67/28 , C07C67/31 , C07C69/67 , C07C69/95 , C07C2601/16 , C07C69/28 , C07C69/675
摘要： The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted idebenone derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.
摘要翻译： 本发明涉及新的羧酸取代的艾地苯醌衍生物，含有这些羧酸取代的艾地苯醌衍生物的皮肤处理组合物，通过局部施用这些羧酸取代的艾地苯醌衍生物来治疗皮肤变化的方法及其合成方法。 本发明的羧酸取代的艾地苯醌衍生物在治疗皮肤方面是意想不到的，特别是在皮肤耐受性方面。 当包含在局部组合物中时，本发明的羧酸取代的艾地苯醌衍生物具有可用于治疗皮肤变化的抗氧化作用。
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4.发明申请Skin Treatments Containing Carboxylic Acid-Substituted Idebenone Derivatives and Methods of Preparation and Use Thereof 有权包含羧酸取代的艾地苯醌衍生物的皮肤处理及其制备和使用方法公开(公告)号：US20120130098A1
公开(公告)日：2012-05-24
申请号：US13349651
申请日：2012-01-13
IPC分类号： C07C69/95
CPC分类号： A61K8/37 , A61K8/375 , A61K8/67 , A61K8/671 , A61K8/673 , A61K8/676 , A61K8/678 , A61K8/97 , A61Q17/04 , A61Q19/004 , A61Q19/007 , A61Q19/02 , A61Q19/06 , A61Q19/08 , A61Q19/10 , A61Q90/00 , C07C67/08 , C07C67/14 , C07C67/28 , C07C67/31 , C07C69/67 , C07C69/95 , C07C2601/16 , C07C69/28 , C07C69/675
摘要： The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted idebenone derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.
摘要翻译： 本发明涉及新的羧酸取代的艾地苯醌衍生物，含有这些羧酸取代的艾地苯醌衍生物的皮肤处理组合物，通过局部施用这些羧酸取代的艾地苯醌衍生物来治疗皮肤变化的方法及其合成方法。 本发明的羧酸取代的艾地苯醌衍生物在治疗皮肤方面是意想不到的，特别是在皮肤耐受性方面。 当包含在局部组合物中时，本发明的羧酸取代的艾地苯醌衍生物具有可用于治疗皮肤变化的抗氧化作用。
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5.发明申请ESTERS OF 4,5-DISUBSTITUTED-OXY-2-METHYL-3,6-DIOXO-CYCLOHEXA-1,4-DIENYL ALKYL ACIDS AND PREPARATION THEREOF 失效4,5-二氧杂-2-甲基-3,6-二氧代环己基-1,4-二烯基酸的酯及其制备公开(公告)号：US20100076077A1
公开(公告)日：2010-03-25
申请号：US12236171
申请日：2008-09-23
IPC分类号： A61K31/215 , C07C69/608 , C12P7/62 , A61P17/00
CPC分类号： A61K31/22 , A61K31/23 , C07C67/08 , C07C69/95 , C07C2601/16
摘要： Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.
摘要翻译： 化学和/或酶促制备4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯。 取决于酯，实现了改善的黑素细胞细胞毒性。 改进的细胞毒性特征与酯类似物与其相应的酸相比更具生理学相容性并且对皮肤刺激性较低。
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公开(公告)号：US5864048A
公开(公告)日：1999-01-26
申请号：US903660
申请日：1997-07-31
申请人： Guido Di Napoli
发明人： Guido Di Napoli
IPC分类号： A61K20060101 , A61K31/165 , A61K31/22 , A61K31/235 , C07C20060101 , C07C50/26 , C07C65/40 , C07C67/31 , C07C67/313 , C07C69/017 , C07C69/90 , C07C69/95 , C07C205/25 , C07C205/42 , C07C229/52 , C07C229/66 , C07C229/74 , C07C233/54 , C07C235/84 , C07C245/20
CPC分类号： C07C69/95 , A61K8/355 , A61Q19/00 , C07C229/66 , C07C229/74 , C07C233/33 , C07C235/84 , C07C69/18 , C07C2103/24
摘要： The present description relates to new anthraquinone-derivatives endowed with inhibitory activity of the serine proteinase enzymes, useful for the treatment of rheumatoid arthritis, acute respiratory syndrome of adult, and pulmonary emphysema, and to new processes for the preparation of rhein derivatives.
摘要翻译： 本说明书涉及可用于治疗类风湿性关节炎，成人急性呼吸综合征和肺气肿的丝氨酸蛋白酶抑制活性的新型蒽醌衍生物以及制备大黄酸衍生物的新方法。
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公开(公告)号：US2993069A
公开(公告)日：1961-07-18
申请号：US58134756
申请日：1956-04-30
申请人： ROHM & HAAS
IPC分类号： C07C69/95
CPC分类号： C07C69/95
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公开(公告)号：US20150344404A1
公开(公告)日：2015-12-03
申请号：US14655631
申请日：2013-12-26
发明人： Satoshi OMURA , Hirofumi NAKANO , Kenzaburo YAMAJI , Tsuyoshi YAMAMOTO , Hiroshi KIDO , Kazuhiko YAMANE , Toshiaki SUNAZUKA , Tomoyasu HIROSE
IPC分类号： C07C69/95 , C07C66/00 , A61K8/368 , C07C50/38 , C07D493/20 , C07C251/32 , A61K8/40 , C07C235/84 , A61K8/42 , A61Q19/00 , A61K8/37 , A61K8/35
CPC分类号： C07C69/95 , A61K8/355 , A61K8/368 , A61K8/37 , A61K8/40 , A61K8/42 , A61K31/122 , A61K31/136 , A61K31/166 , A61K31/192 , A61K31/198 , A61K31/216 , A61K31/235 , A61K31/37 , A61K31/47 , A61K2800/782 , A61Q19/00 , A61Q19/08 , C07C50/38 , C07C66/00 , C07C235/66 , C07C235/84 , C07C251/32 , C07C251/40 , C07D493/20
摘要： The present invention to provide a novel pyruvate dehydrogenase kinase inhibitors. A pyruvate dehydrogenase kinase inhibitor comprising a compound represented by the general formula (I) as an active ingredient (wherein, ring A represents a 6-membered aromatic hydrocarbon ring optionally substituted with 2-4 substituents, R1 and R4, which are the same or different, represent a hydrogen atom, a hydroxyl group, an optionally substituted C1-6 alkyl group, R2 and R3, which are the same or different, represent a hydrogen atom, a carboxyl group, an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group, or a group represented by —C (═R9)—R10), a pharmaceutical composition for treatment or prophylaxis of diseases or disorders that pyruvate dehydrogenase kinase relates to its development or aggravation, and a cosmetic composition, and the like.
摘要翻译： 本发明提供了一种新的丙酮酸脱氢酶激酶抑制剂。 丙酮酸脱氢酶激酶抑制剂，其包含由通式（I）表示的化合物作为活性成分（其中环A表示任选被2-4个取代基取代的6元芳族烃环，R 1和R 4相同或不同） 不同的，表示氢原子，羟基，任选取代的C 1-6烷基，R 2和R 3相同或不同，表示氢原子，羧基，任选取代的C 1-6烷基， 任选取代的C 6-10芳基或由-C（= R 9）-R 10表示的基团），用于治疗或预防丙酮酸脱氢酶激酶涉及其发展或加重的疾病或病症的药物组合物，以及化妆品组合物， 等等。
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公开(公告)号：US20090156836A1
公开(公告)日：2009-06-18
申请号：US12250705
申请日：2008-10-14
IPC分类号： C07D313/20 , C07C69/76
CPC分类号： C07C67/343 , C07C67/307 , C07C67/31 , C07C67/313 , C07C69/95 , C07C2603/24 , C07D313/20
摘要： The present invention relates to a process for preparing mumbaistatin derivatives (I), where the anthraquinone skeleton is constructed via a Diels-Alder reaction and the central methylene bridge via a transition metal-catalyzed reaction, and to the intermediates used in this process.
摘要翻译： 本发明涉及一种通过狄尔斯 - 阿尔德反应构建蒽醌骨架和通过过渡金属催化反应构建中间亚甲基桥的制备孟巴斯丁衍生物（I）的方法，以及该方法中使用的中间体。
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10.发明申请Naphthoquinone derivative and electrophotographic photoreceptor containing the same 失效萘醌衍生物和含有它的电子照相感光体公开(公告)号：US20040156651A1
公开(公告)日：2004-08-12
申请号：US10670264
申请日：2003-09-26
发明人： Beom-jun Kim , Saburo Yokota , Kyung-yol Yon , Hwan-Koo Lee
IPC分类号： G03G005/06 , C07C050/12 , C07C050/38
CPC分类号： C07C69/95 , C07C50/38 , G03G5/0605 , G03G5/0607 , G03G5/0609
摘要： A naphthoquinone derivative is utilized in an electrophotographic photoreceptor as an electron-transporting material. The electrophotographic photoreceptor is improved in terms of solubility in an organic solvent, compatibility with a binder resin, and electron transport capability.
摘要翻译： 电子照相感光体中使用萘醌衍生物作为电子传输材料。 电子照相感光体在有机溶剂中的溶解性，与粘合剂树脂的相容性和电子传输能力方面得到改善。
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