公开(公告)号：US20170247308A1

公开(公告)日：2017-08-31

申请号：US15122160

申请日：2015-02-12

Applicant: VIVACELL BIOTECHNOLOGY ESPAÑA, S.L

Inventor： Giovanni APPENDINO ,  María Luz BELLIDO CABELLO DE ALBA ,  Eduardo MUÑOZ BLANCO

IPC: C07C50/28 ,  A61K31/122 ,  C07C225/28 ,  A61K31/13 ,  C07C69/757 ,  A61K31/215

CPC classification number: C07C50/28 ,  A61K31/122 ,  A61K31/13 ,  A61K31/215 ,  C07C69/757 ,  C07C69/95 ,  C07C225/28 ,  C07C2601/14 ,  C07C2601/16

Abstract: The present invention relates to novel cannabigerol quinone derivatives of formula (I) wherein R is the carbon atom of a linear or branched group, represented by: aryl, alkenyl, alkynyl or alcoxycarbonil groups; or wherein R is the nitrogen atom of a linear or branched group, represented by: alkylamino, arylamino, alkenylamino or alkynylamino groups; or, alternatively, R represents a bond between 2 molecules of formula (I) forming a dimer. The invention also relates to the use of any of the compounds of formula (I) as medicaments in therapy, particularly for treating PPARg-related diseases due to their high PPARg agonistic effect lacking electrophilic (Nrf2 activation) and cytotoxic activities. This invention also provides pharmaceutical compositions comprising said compounds and method of treating diseases with said compounds.

公开(公告)号：US3114755A

公开(公告)日：1963-12-17

申请号：US9469461

申请日：1961-03-10

Applicant: US RUBBER CO

Inventor： COVEY RUPERT A

CPC classification number: C07C221/00 ,  C07C225/28 ,  C07C225/30

公开(公告)号：US09701618B2

公开(公告)日：2017-07-11

申请号：US15304810

申请日：2014-04-16

Applicant: VIVACELL BIOTECHNOLOGY ESPAÑA S.L.

Inventor： Giovanni Appendino ,  María Luz Bellido Cabello De Alba ,  Eduardo Muñoz Blanco

IPC: C07C225/28 ,  C07C69/95

CPC classification number: C07C225/28 ,  C07B2200/07 ,  C07C69/95 ,  C07C2601/16 ,  C07C2602/42

Abstract: The present invention relates to novel cannabidiol quinone derivatives of formula (I) (I) wherein R is the carbon atom of a, linear or branched group, represented by: alkyl, aryl, alkenyl, alkynyl, acyl or alkoxycarbonyl groups; or wherein R is the nitrogen atom of a, linear or branched group represented by: alkylamine, arylamine, alkenylamine or alkynylamine groups. The invention also relates to the use of any of the compounds of formula (I) as medicaments in therapy, particularly for treating diseases and conditions responsive to PPARg modulation due to their high PPARg agonistic effect lacking electrophilic (Nrf2 activation) and cytotoxic activities. This invention also provides pharmaceutical compositions comprising said compounds and method of treating diseases with said compounds.

公开(公告)号：US20170044092A1

公开(公告)日：2017-02-16

申请号：US15304810

申请日：2014-04-16

Applicant: VIVACELL BIOTECHNOLOGY ESPAÑA S.L.

Inventor： Giovanni APPENDINO ,  María Luz BELLIDO CABELLO DE ALBA ,  Eduardo MUÑOZ BLANCO

IPC: C07C225/28 ,  C07C69/95

CPC classification number: C07C225/28 ,  C07B2200/07 ,  C07C69/95 ,  C07C2601/16 ,  C07C2602/42

Abstract: The present invention relates to novel cannabidiol quinone derivatives of formula (I) (I) wherein R is the carbon atom of a, linear or branched group, represented by: alkyl, aryl, alkenyl, alkynyl, acyl or alkoxycarbonyl groups; or wherein R is the nitrogen atom of a, linear or branched group represented by: alkylamine, arylamine, alkenylamine or alkynylamine groups. The invention also relates to the use of any of the compounds of formula (I) as medicamentsin therapy, particularly for treating diseases and conditions responsive to PPARg modulation due to their high PPARg agonistic effect lacking electrophilic (Nrf2 activation) and cytotoxic activities. This invention also provides pharmaceutical compositions comprising said compounds and method of treating diseases with said compounds.

Abstract translation: 本发明涉及式（I）（I）的新型大二酚醌衍生物，其中R是直链或支链基团的碳原子，由烷基，芳基，烯基，炔基，酰基或烷氧基羰基表示; 或其中R为由烷基胺，芳基胺，链烯基胺或炔基胺基团表示的直链或支链基团的氮原子。 本发明还涉及任何式（I）化合物作为治疗药物的用途，特别是用于治疗由于其不具有亲电子（Nrf2活化）和细胞毒活性的高PPARg激动作用而对PPARg调节有反应的疾病和病症。 本发明还提供包含所述化合物的药物组合物和用所述化合物治疗疾病的方法。

公开(公告)号：US09233057B2

公开(公告)日：2016-01-12

申请号：US14365224

申请日：2012-12-13

Applicant: L'OREAL

Inventor： Stephane Sabelle

IPC: A61Q5/10 ,  A61K8/35 ,  A61K8/41 ,  C07C215/82 ,  C07C225/28 ,  C07C251/82 ,  A61Q5/06 ,  C09B23/01

CPC classification number: A61K8/355 ,  A61K8/41 ,  A61K8/411 ,  A61K8/415 ,  A61K2800/10 ,  A61Q5/065 ,  A61Q5/10 ,  C07C215/82 ,  C07C225/28 ,  C07C251/82 ,  C09B23/0066

Abstract: The present invention relates to quinone direct dyes of formula (I) below, organic or mineral acid or base salts thereof, tautomeric forms, optical isomers or geometrical isomers thereof and/or solvates thereof: and also to the use thereof for dyeing keratin fibers, in particular human keratin fibers such as the hair. The invention also relates to a composition for dyeing keratin fibers, comprising such direct dyes in a suitable dyeing medium. Similarly, a subject of the present invention is a process for dyeing keratin fibers, using the said dye composition.

Abstract translation: 本发明涉及以下式（I）的醌直接染料，其有机或无机酸或其盐，互变异构形式，光学异构体或其几何异构体和/或溶剂合物：以及其用于染色角蛋白纤维的用途， 特别是人角蛋白纤维如头发。 本发明还涉及用于染色角蛋白纤维的组合物，其在合适的染色介质中包含这种直接染料。 类似地，本发明的主题是使用所述染料组合物染色角蛋白纤维的方法。

公开(公告)号：US20090093521A1

公开(公告)日：2009-04-09

申请号：US11917560

申请日：2005-06-13

Applicant: Maria Laura Bolognesi ,  Rita Banzi ,  Anna Minarini ,  Carlo Melchiorre

Inventor： Maria Laura Bolognesi ,  Rita Banzi ,  Anna Minarini ,  Carlo Melchiorre

IPC: A61K31/135 ,  C07C211/33 ,  C07D409/12 ,  C07D401/12 ,  A61P25/28 ,  A61K31/444 ,  A61K31/381

CPC classification number: C07C225/28 ,  C07D213/38 ,  C07D333/20

Abstract: Synthesis of 2,5-bis-diamine-[1,4]benzoquinonic derivatives having the general formula (I), products and intermediates of said synthesis; the synthesis involves the use of p-benzoquinones having the general formula (IX) and diamines having the general formula (XI).

Abstract translation: 具有通式（I）的2,5-双 - 二胺 - [1,4]苯醌衍生物的合成，所述合成的产物和中间体; 合成涉及使用具有通式（Ⅸ）的对苯醌和具有通式（Ⅺ）的二胺。

公开(公告)号：US20170334871A1

公开(公告)日：2017-11-23

申请号：US15502944

申请日：2014-08-09

Applicant: United Arab Emirates University

Inventor： Alaa Eldin Salem ,  Ismail El Haty ,  Ibrahim Abdou ,  Abdu Adem ,  Samir Attoub

IPC: C07D295/13 ,  C07C225/28 ,  C07C221/00

CPC classification number: C07D295/13 ,  A61K31/122 ,  A61K31/5375 ,  A61K45/06 ,  A61P35/00 ,  C07C221/00 ,  C07C225/28 ,  A61K2300/00

Abstract: The present invention describes thymoquinone compounds formula (I): (i) These compounds have been identified as being useful in the treatment of cancer.

公开(公告)号：US20160308213A1

公开(公告)日：2016-10-20

申请号：US15195742

申请日：2016-06-28

Applicant: Huawei Technologies Co., Ltd.

Inventor： Pinghua Wang

IPC: H01M4/60 ,  H01M4/133 ,  H01M4/1393 ,  H01M4/587 ,  C07C225/28 ,  H01M4/66 ,  H01M4/04 ,  H01M2/16 ,  H01M10/0585 ,  C01B31/04 ,  H01M10/0525 ,  H01M4/62

CPC classification number: H01M4/60 ,  C01B32/194 ,  C07C225/28 ,  H01M2/162 ,  H01M2/1653 ,  H01M2/1686 ,  H01M4/0404 ,  H01M4/0433 ,  H01M4/0471 ,  H01M4/133 ,  H01M4/137 ,  H01M4/1393 ,  H01M4/1399 ,  H01M4/587 ,  H01M4/623 ,  H01M4/625 ,  H01M4/661 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0585 ,  H01M2004/027 ,  H01M2004/028 ,  H01M2220/30

Abstract: A quinone compound-graphene composite material, including quinone compound and graphene, where the quinone compound is chemically bonded on the surface of the graphene, and the quinone compound is quinone compound monomer or quinone polymer. The quinone compound-graphene composite material has high energy density, high flexibility, high conductivity, and high stability, and can be used as cathode material for preparing flexible electrode. Additionally, a preparation method of quinone compound-graphene composite material, and flexible lithium secondary battery uses the quinone compound-graphene composite material as cathode active material.

Abstract translation: 醌化合物和石墨烯的醌化合物 - 石墨烯复合材料，其中醌化合物化学键合在石墨烯的表面上，醌化合物为醌化合物单体或醌类聚合物。 醌化合物 - 石墨烯复合材料具有高能量密度，高柔韧性，高导电性和高稳定性，可用作准备柔性电极的阴极材料。 此外，醌化合物 - 石墨烯复合材料和柔性锂二次电池的制备方法使用醌化合物 - 石墨烯复合材料作为阴极活性材料。

公开(公告)号：US5104874A

公开(公告)日：1992-04-14

申请号：US627149

申请日：1990-12-13

Applicant: Takafumi Ikeda ,  Hiroaki Wakabayashi ,  Masami Nakane

Inventor： Takafumi Ikeda ,  Hiroaki Wakabayashi ,  Masami Nakane

IPC: A61K31/135 ,  A61K31/16 ,  A61K31/18 ,  A61K31/19 ,  A61K31/215 ,  A61K31/33 ,  A61K31/495 ,  A61K31/496 ,  A61P29/00 ,  A61P43/00 ,  C07C225/28 ,  C07C229/14 ,  C07C229/18 ,  C07C229/32 ,  C07C229/42 ,  C07C229/48 ,  C07C229/56 ,  C07C231/12 ,  C07C235/80 ,  C07C237/20 ,  C07C237/30 ,  C07C311/39 ,  C07D213/74 ,  C07D263/56 ,  C07D295/10 ,  C07D307/14 ,  C07D307/52

CPC classification number: C07D213/74 ,  C07C225/28 ,  C07C229/14 ,  C07C229/42 ,  C07C229/48 ,  C07C229/56 ,  C07C235/80 ,  C07C237/20 ,  C07C311/39 ,  C07D307/14 ,  C07D307/52 ,  C07C2101/14 ,  C07C2101/16

Abstract: A series of 2-amino-5,6-dimethyl-1,4-benzoquinone derivatives, inhibitors of cyclooxygenase and lipoxygenase and useful as antiallergic and antiinflammatory agents.

公开(公告)号：US2267741A

公开(公告)日：1941-12-30

申请号：US2267741D

CPC classification number: C07D209/88 ,  C07C225/28