公开(公告)号：US20240325066A1

公开(公告)日：2024-10-03

申请号：US18622232

申请日：2024-03-29

申请人： CARDIOFOCUS, INC.

发明人： Judy Syrkin-Nikolau ,  Jacob I. Laughner ,  David W. Hunter

IPC分类号： A61B18/00

CPC分类号： A61B18/00 ,  A61B2018/00267 ,  A61B2018/00297 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00678 ,  A61B2018/00732 ,  A61B2018/00761 ,  A61B2018/00767 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00898

摘要： A treatment catheter is part of a system that includes a local impedance indicator that is displayed on a display. The local impedance indicator displays relative changes in impedance to the user in order to quickly communicate information that helps the user better understand where in the heart chamber the catheter is located.

公开(公告)号：US12048594B2

公开(公告)日：2024-07-30

申请号：US17180947

申请日：2021-02-22

申请人： Navix International Limited

发明人： Yitzhack Schwartz ,  Eli Dichterman ,  Adi Rabinovich

IPC分类号： A61B18/14 ,  A61B5/00 ,  A61B5/0538 ,  A61B5/06 ,  A61B34/10 ,  A61B34/20 ,  A61B90/00 ,  G06F30/00 ,  G06F30/20 ,  G16H10/60 ,  G16H30/20 ,  G16H50/50 ,  A61B17/00 ,  A61B18/00 ,  A61M25/01 ,  G01H17/00 ,  G06F17/18 ,  H02K7/18

CPC分类号： A61B90/06 ,  A61B5/0538 ,  A61B5/063 ,  A61B5/6833 ,  A61B18/1492 ,  A61B34/10 ,  A61B34/20 ,  A61B90/37 ,  G06F30/00 ,  G06F30/20 ,  G16H10/60 ,  G16H30/20 ,  G16H50/50 ,  A61B2017/00026 ,  A61B2018/00357 ,  A61B2018/00494 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00654 ,  A61B2018/00702 ,  A61B2018/00732 ,  A61B2018/00738 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00904 ,  A61B2034/104 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/2046 ,  A61B2034/2053 ,  A61B2090/065 ,  A61B2090/365 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B90/39 ,  A61B2090/3983 ,  A61M2025/0166 ,  G01H17/00 ,  G06F17/18 ,  H02J2203/20 ,  H02K7/1823

摘要： Devices and methods for assessing tissue contact based on dielectric properties and/or impedance sensing are disclosed. In some embodiments, one or more probing frequencies are delivered via electrodes including an electrode in proximity to a tissue (for example, myocardial tissue). In some embodiments, dielectric parameter values, optionally together with other known and/or estimated tissue characteristics, are measured to determine a contact quality with the tissue. In some embodiments, dielectric contact quality is used, for example, in guiding the formation of a lesion (for example, RF ablation of heart tissue to alter electrical transmission characteristics).

公开(公告)号：US20240225723A1

公开(公告)日：2024-07-11

申请号：US18612572

申请日：2024-03-21

申请人： May Health US Inc.

发明人： Denise ZARINS ,  Neil BARMAN ,  Garrett SCHWAB ,  Roger OSBORNE ,  Douglas SUTTON

IPC分类号： A61B18/14 ,  A61B8/00 ,  A61B8/08 ,  A61B8/12 ,  A61B17/00 ,  A61B17/22 ,  A61B17/34 ,  A61B17/42 ,  A61B18/00 ,  A61B18/02 ,  A61B18/04 ,  A61B18/06 ,  A61B18/12 ,  A61B18/16 ,  A61B18/22 ,  A61B90/00 ,  A61F6/20 ,  A61N7/00 ,  A61N7/02

CPC分类号： A61B18/1485 ,  A61B8/0841 ,  A61B8/085 ,  A61B8/12 ,  A61B18/1482 ,  A61F6/20 ,  A61B8/4427 ,  A61B8/4433 ,  A61B2017/00278 ,  A61B2017/003 ,  A61B2017/00455 ,  A61B17/22004 ,  A61B2017/3405 ,  A61B2017/3413 ,  A61B17/42 ,  A61B2017/4233 ,  A61B2018/00196 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00595 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/0072 ,  A61B2018/00726 ,  A61B2018/00732 ,  A61B2018/00744 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00982 ,  A61B2018/0293 ,  A61B2018/048 ,  A61B18/06 ,  A61B18/1206 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1475 ,  A61B18/16 ,  A61B18/22 ,  A61B2090/378 ,  A61B2090/3925 ,  A61B2090/3966 ,  A61N2007/0043 ,  A61N7/02 ,  A61N7/022

摘要： Described here are methods and systems for the manipulation of ovarian tissues. The methods and systems may be used in the treatment of polycystic ovary syndrome (PCOS). The systems and methods may be useful in the treatment of infertility associated with PCOS.

公开(公告)号：US20240206937A1

公开(公告)日：2024-06-27

申请号：US18288335

申请日：2022-05-10

申请人： SNIPE MEDICAL LTD

发明人： Yuval TAFF ,  Ben OMRI

IPC分类号： A61B18/00

CPC分类号： A61B18/00 ,  A61B2018/00083 ,  A61B2018/0016 ,  A61B2018/00184 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/0072 ,  A61B2018/00732 ,  A61B2018/00767 ,  A61B2018/00839

摘要： An apparatus for use with a tumor comprises a tumor-ablating device that has a distal region that comprises (i) an inner shaft, comprising: (a) a first bioimpedance-sensing electrode, and (b) a first electroporation electrode, mounted at a fixed position proximally from the first bioimpedance-sensing electrode, and (ii) an outer shaft within which the inner shaft is coaxially disposed, the outer shaft comprising: (a) a second bioimpedance-sensing electrode, and (b) a second electroporation electrode, mounted at a fixed position distally from the second bioimpedance-sensing electrode. The inner shaft and the outer shaft are telescopically slidable with respect to each other in a manner that changes a first axial distance between the first electroporation electrode and the second electroporation electrode. Other embodiments are also described.

公开(公告)号：US11969208B2

公开(公告)日：2024-04-30

申请号：US16662889

申请日：2018-06-01

申请人： CREO MEDICAL LIMITED

发明人： Christopher Paul Hancock ,  John Bishop

IPC分类号： A61B18/18 ,  A61B18/00 ,  A61B18/14

CPC分类号： A61B18/1815 ,  A61B18/1492 ,  A61B2018/00077 ,  A61B2018/0016 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00708 ,  A61B2018/00732 ,  A61B2018/00982 ,  A61B2018/00994 ,  A61B2018/1823 ,  A61B2018/1853 ,  A61B2018/1861

摘要： An electrosurgical instrument capable of performing both thermal ablation and electroporation in a minimally invasive manner. The instrument is dimensioned to fit within an instrument channel of an endoscope to enable non-percutaneous insertion. The instrument comprises a radiating tip mounted at a distal end of a coaxial transmission line to receive microwave EM energy from the coaxial transmission line and emit it as a field around the radiating tip. The instrument further comprises an auxiliary transmission line arranged to convey electromagnetic energy having an electroporation waveform to a microelectrode array mounted on the radiating tip. The electroporation waveform may be a radiofrequency or low frequency electromagnetic (EM) signal. The microelectrode array may comprise a plurality of nanoscale conductive electrode elements.

公开(公告)号：US11963717B2

公开(公告)日：2024-04-23

申请号：US17057399

申请日：2019-06-07

申请人： Nova-Tech Engineering, LLC

发明人： Marc S. Gorans ,  James J. Kleven ,  Wade D. Werder ,  Jacob R. French ,  Derek Worcester

IPC分类号： A61N5/04 ,  A61B18/00 ,  A61B18/18 ,  A61D1/00

CPC分类号： A61B18/1815 ,  A61D1/005 ,  A61N5/04 ,  A61B2018/00642 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00732 ,  A61B2018/00755 ,  A61B2018/00785 ,  A61B2018/00904 ,  A61B2018/1823 ,  A61B2018/1876

摘要： An energy delivery system includes an RF synthesizer circuit configured to generate an RF electric signal and a preamplification stage operably coupled to the RF synthesizer circuit. The preamplification stage has at least one attenuator. A board controller is operably coupled to the attenuator of the preamplification stage that is configured to modify a gain setting of the attenuator. An output connection is configured to provide a low-power signal or a high-power signal based on at least the RF electric signal and the gain setting. The low-power signal or high-power signal is provided to an RF applicator configured to couple an alternating RF electric field to animal tissue.

公开(公告)号：US11896279B2

公开(公告)日：2024-02-13

申请号：US16562185

申请日：2019-09-05

申请人： Cilag GmbH International

发明人： Ryan M. Asher ,  Eitan T. Wiener ,  John B. Schulte

IPC分类号： A61B34/00 ,  A61B18/00 ,  A61B34/35 ,  A61B34/20 ,  A61B90/00 ,  A61B17/32 ,  A61B18/12 ,  G16H20/40 ,  A61B18/14 ,  H04L49/25 ,  H04L9/40 ,  H04L67/10 ,  H04L67/12 ,  A61B18/16 ,  H04B5/00 ,  H01R43/26 ,  A61B90/90 ,  H05K5/00 ,  H04M1/72406 ,  G06F8/65 ,  A61B17/072 ,  A61B17/00 ,  A61B90/30 ,  A61B34/30 ,  H04L27/04 ,  A61B34/37 ,  H05K7/02

CPC分类号： A61B18/00 ,  A61B17/072 ,  A61B17/320068 ,  A61B17/320092 ,  A61B18/1206 ,  A61B18/1233 ,  A61B18/1445 ,  A61B18/16 ,  A61B34/20 ,  A61B34/25 ,  A61B34/35 ,  A61B34/74 ,  A61B90/361 ,  A61B90/90 ,  G06F8/65 ,  G16H20/40 ,  H01R43/26 ,  H04B5/0031 ,  H04L49/25 ,  H04L63/0245 ,  H04L67/10 ,  H04L67/12 ,  H04M1/72406 ,  H05K5/0021 ,  A61B34/37 ,  A61B90/30 ,  A61B90/37 ,  A61B2017/00026 ,  A61B2017/00199 ,  A61B2017/00221 ,  A61B2017/00225 ,  A61B2017/00398 ,  A61B2017/00477 ,  A61B2017/00526 ,  A61B2017/00973 ,  A61B2017/07257 ,  A61B2017/07271 ,  A61B2017/07285 ,  A61B2017/320074 ,  A61B2018/0063 ,  A61B2018/0072 ,  A61B2018/0094 ,  A61B2018/00178 ,  A61B2018/00208 ,  A61B2018/00601 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00732 ,  A61B2018/00767 ,  A61B2018/00845 ,  A61B2018/00875 ,  A61B2018/00916 ,  A61B2018/00958 ,  A61B2018/00994 ,  A61B2018/126 ,  A61B2018/128 ,  A61B2018/1253 ,  A61B2018/1273 ,  A61B2018/1286 ,  A61B2018/165 ,  A61B2034/2048 ,  A61B2034/2055 ,  A61B2034/305 ,  A61B2090/371 ,  A61B2090/378 ,  A61B2218/002 ,  A61B2218/007 ,  A61B2218/008 ,  A61B2560/0443 ,  A61B2560/0456 ,  H01R2201/12 ,  H04L27/04 ,  H05K5/0026 ,  H05K5/0065 ,  H05K7/023

摘要： A modular surgical system for use in a surgical procedure to treat tissue is disclosed. The modular surgical system includes a footer module including a power supply, a first surgical module configured to be stacked on top of the footer module, and a second surgical module configured to be stacked on top of the first surgical module. The first surgical module is detachably couplable to the footer module to receive power from the power supply of the footer module to generate a first therapeutic energy for delivery to the tissue. The second surgical module is detachably couplable to the first surgical module to receive power from the power supply of the footer module to generate a second therapeutic energy for delivery to the tissue.

公开(公告)号：US11857245B2

公开(公告)日：2024-01-02

申请号：US17472481

申请日：2021-09-10

申请人： Biosense Webster (Israel) Ltd.

发明人： Michael Levin ,  Boris Ashkinezer ,  Eyal Rotman ,  Shlomo Fried Zichron

IPC分类号： A61B18/12 ,  A61B18/14 ,  A61B18/00

CPC分类号： A61B18/1206 ,  A61B18/1492 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00732 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00827 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/128 ,  A61B2018/1273

摘要： A plurality of control-signal generators are configured to generate respective control signals having respective control-signal amplitudes and different respective control-signal frequencies, and a plurality of signal adders are configured to produce respective composite signals for application to a subject, by adding the control signals to respective ablation signals having respective ablation-signal amplitudes. The control-signal generators are configured to generate the control signals such that respective ratios between the control-signal amplitudes and the ablation-signal amplitudes are constant during the application of the composite signals to the subject. A plurality of controlled voltage dividers are configured to adjust respective amplitudes of the composite signals during the application of the composite signals to the subject, and one or more controllers are configured to control the adjusting of the amplitudes by the controlled voltage dividers, in response to respective currents of, and respective voltages of, the control signals, and based on the constant ratios.

公开(公告)号：US11833082B2

公开(公告)日：2023-12-05

申请号：US17154399

申请日：2021-01-21

申请人： Light Matter Interaction Inc.

发明人： Darren Kraemer

IPC分类号： A61F9/008 ,  A61F9/009 ,  A61B17/00 ,  A61B18/00 ,  A61B18/20 ,  A61B18/22

CPC分类号： A61F9/00834 ,  A61F9/009 ,  A61F9/00821 ,  A61F9/00825 ,  A61B17/00234 ,  A61B18/22 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00732 ,  A61B2018/00863 ,  A61B2018/2005 ,  A61B2218/002 ,  A61B2218/007 ,  A61F2009/0087 ,  A61F2009/00872 ,  A61F2009/00887 ,  A61F2009/00897

摘要： An apparatus for disruption of tissue. The apparatus includes a housing; a source of pulsed laser radiation; and an optical waveguide. The optical waveguide is configured to transmit the pulsed laser radiation from the source of pulsed laser radiation, and is coupleable to the source of pulsed laser radiation at a proximal end of the optical waveguide to receive the pulsed laser radiation from the source of pulsed laser radiation. The apparatus also includes a driving mechanism coupled to the optical waveguide for controllably changing the position of the optical waveguide relative to a distal end of the housing.

公开(公告)号：US11737807B2

公开(公告)日：2023-08-29

申请号：US16774421

申请日：2020-01-28

申请人： Jerome Canady Research Institute for Advanced Biological and Technological Sciences

发明人： Jerome Canady

IPC分类号： A61B18/00 ,  A61B18/04

CPC分类号： A61B18/042 ,  A61B2018/00601 ,  A61B2018/00702 ,  A61B2018/00732 ,  A61B2018/00744 ,  A61B2018/00988

摘要： To determine appropriate treatment doses of cold atmospheric plasma (CAP), the Canady Helios Cold Plasma Scalpel was tested across numerous cancer cell types including renal adenocarcinoma, colorectal carcinoma, pancreatic adenocarcinoma, ovarian adenocarcinoma, and esophageal adenocarcinoma. Various CAP doses were tested consisting of both high (3 L/min) and low (1 L/min) helium flow rates, several power settings, and a range of treatment times up to 5 minutes. The impact of cold plasma on the reduction of viability was consistently dose dependent, however the anti-cancer capability varied significantly between cell lines. While the lowest effective dose varied from cell line to cell line, in each case an 80-99% reduction in viability was achievable 48 hours after CAP treatment. Therefore, it is critical to select the appropriate CAP dose necessary for treating a specific cancer cell type.