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公开(公告)号：US20250037787A1
公开(公告)日：2025-01-30
申请号：US16967961
申请日：2019-02-12
Inventor： Anika Küken , Georg Basler , Jeanne Marie Onana Eloundou Mbebi , Zoran Nikoloski
Abstract: The present invention relates to a computer-implemented method of calculating the ranges of concentrations, of fluxes, or of reaction rate constants in a network of chemical reactions.
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公开(公告)号：US20240415023A1
公开(公告)日：2024-12-12
申请号：US18262761
申请日：2022-01-19
Inventor： Yury KHAYDUKOV , Thomas KELLER , Bernhard KEIMER , Roman MORARI , Anatolie SIDORENKO
Abstract: A method for fabricating a magnetic device comprises providing a layer stack, the layer stack comprising a substrate, a first ferromagnetic layer disposed above the substrate, the first ferromagnetic layer comprising a uniaxial magnetic anisotropy including an easy axis, a non-magnetic layer disposed on the first ferromagnetic layer, a second ferromagnetic layer disposed on the non-magnetic layer, the second ferromagnetic layer comprising a unidirectional anisotropy, and an antiferromagnetic layer disposed on the second ferromagnetic layer, the antiferromagnetic layer comprising a Néel temperature TN; heating the layer stack above the Néel temperature TN of the antiferromagnetic layer; applying a magnetic field HCL to the layer stack, the magnetic field HCL comprising a magnetic field direction having an arbitrary angle with respect to the easy axis; cooling the layer stack below the Néel temperature TN of the antiferromagnetic layer with the magnetic field HCL applied; and removing the magnetic field HCL.
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公开(公告)号：US20240252454A1
公开(公告)日：2024-08-01
申请号：US18289283
申请日：2022-05-02
Applicant: LEAD DISCOVERY CENTER GMBH , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
Inventor： Tim BERGBREDE , Raffaella DI LUCREZIA , Anke UNGER , Axel CHOIDAS , Bert KLEBL , Peter NUSSBAUMER , Sascha MENNINGER , Peter HABENBERGER , Gunther ZISCHINSKY , Uwe KOCH , Peter SCHRÖDER , Pavla JESTRABOVÁ , Lenka PALOVÁ-JELÍNKOVÁ , Klára DÁNOVÁ , Maria FALKENBERG-GUSTAFSSON , Laleh ARABANIAN , Claes GUSTAFSSON , Nils-Göran LARSSON , Lars PALMQVIST
IPC: A61K31/166 , A61K31/4184 , A61K31/453 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K31/711 , A61P35/00
CPC classification number: A61K31/166 , A61K31/4184 , A61K31/453 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K31/711 , A61P35/00
Abstract: The present invention relates to a composition comprising at least one inhibitor of mitochondrial transcription (IMT) and at least one anti-cancer drug. Furthermore, the present invention is directed to compositions for use as a medicament and to compositions for use in the treatment and/or prevention of cancer.
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公开(公告)号：US20240241032A1
公开(公告)日：2024-07-18
申请号：US18574585
申请日：2021-07-30
Inventor： Iliya Stoev , Nicola Maghelli , Moritz Kreysing
IPC: G01N15/1434 , G01N15/1404 , G01N15/1429
CPC classification number: G01N15/1434 , G01N15/1404 , G01N15/1429 , G01N2015/1413 , G01N2015/1415 , G01N2015/1445
Abstract: The invention concerns a method for measuring a force on at least one particle in a fluid wherein an inhomogeneous field of hydrodynamic flows is generated in a fluid by specific dynamic localized heating events, the particle is spatially manipulated by the hydrodynamic flows, a spatial configuration of the particle(s) within the fluid is captured and at least one force acting on the particle(s) is determined by evaluating the captured spatial configuration of the particle(s). The invention concerns furthermore an apparatus for measuring a force on at least one particle in a fluid, a computer program product, and a computer-readable storage medium.
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公开(公告)号：US20240223054A1
公开(公告)日：2024-07-04
申请号：US18557558
申请日：2022-03-17
Inventor： Vu NGUYEN , Bernard JAVOT , Katherine J. KUCHENBECKER
IPC: H02K21/24 , H02K1/14 , H02K1/2795
CPC classification number: H02K21/24 , H02K1/146 , H02K1/2795
Abstract: An electric machine, in particular a motor or a generator, comprising a rotor and a stator, wherein the rotor comprises a planar, ring-shaped rotor base element and the stator comprises a planar ring-shaped stator base element, wherein the rotor base element and the stator base element are aligned along an axial axis (Z) of the electric machine, wherein a plurality of magnet elements are arranged around the circumference of the ring-shaped rotor base element forming a Halbach magnet-ring assembly, wherein the Halbach magnet-ring assembly generates a magnetic field (BR) with axial and azimuthal components, wherein a plurality of coils are arranged around the circumference (C) of the ring-shaped stator base element.
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Patent Agency Ranking
公开(公告)号：US20240222641A1
公开(公告)日：2024-07-04
申请号：US18289132
申请日：2021-05-19
Inventor： Timotheus JAHNKE , Yuanzhen WANG , Erik FARLEY , Joachim SPATZ
CPC classification number: H01M4/663 , G06F30/27 , H01M4/505 , H01M4/525 , H01M4/623 , H01M4/625 , H01M10/0525 , H01M2004/021
Abstract: The present invention relates to a method for optimizing material properties of components of a battery comprising the following steps: Inputting material parameter data, with said material parameter data relating to properties of constituents of the components of the battery; simulating one or more components and/or constituents of components of the battery using a simulation model which takes the material parameter data as input to generate simulation result data as output, with the simulation result data comprising at least one of the following data: data on microscopic geometric features of the component, data on a conductivity of the component, data on a current collector, data on a binder phase, data on a diffusivity of the electrolyte and data on a charging and discharging potential of the component; training an AI model with the material parameter data as input and the simulation result data as output; evaluating a final accuracy of the AI model with respect to the simulation model using extended material parameter data; using the AI model to output material properties of the constituents of the components of the battery. The invention further relates to a method for manufacturing a fiber network, to an electrode and to a battery.
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公开(公告)号：US20240201056A1
公开(公告)日：2024-06-20
申请号：US18286563
申请日：2022-04-27
Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , University of Buenos Aires , National Scientific & Technical Research Council
Inventor： Philippe I.H. Bastiaens , Jan Hubinger , Hernán Edgardo Grecco
CPC classification number: G01N1/42 , G01N1/2813 , G01N21/6428 , G01N21/6456
Abstract: The present invention relates to method for decreasing temperature of a sample, in particular a method for ultra-rapid cryofixation of a sample for time and spatially resolved microscopic measurements as well as a device for ultra-rapid cryofixation of a sample at any particular time point of interest on a microscope. Said method and device are particularly useful for studying native molecular organization as well as (bio)chemical reactions within living cells with spatial and spectroscopic resolution beyond the fundamental limits caused by molecular motion at positive Celsius temperatures.
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公开(公告)号：US20240173398A1
公开(公告)日：2024-05-30
申请号：US18262981
申请日：2022-01-28
Inventor： Dirk GÖRLICH , Metin AKSU , Thomas GÜTTLER , Oleh RYMARENKO , Renate REES , Kathrin GREGOR , Waltraud TAXER
IPC: A61K39/215 , A61K39/00 , C07K14/005 , C07K16/10 , C12N7/00
CPC classification number: A61K39/215 , C07K14/005 , C07K16/1003 , C12N7/00 , A61K2039/6031 , C07K2317/569 , C12N2770/20022 , C12N2770/20034 , C12N2770/20052
Abstract: The present invention relates to the recombinant production of a protein of interest in a prokaryotic host cell or eukaryotic host cell wherein the protein of interest is obtained in a correctly folded and stable form. The protein of interest may be a difficult-to-make polypeptide for use as a vaccine or a pharmaceutical. The protein of interest is co-expressed with or fused to a ‘fold promoter’, which may be a VHH antibody recognizing the said protein.
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公开(公告)号：US11980932B2
公开(公告)日：2024-05-14
申请号：US17609997
申请日：2020-05-11
Inventor： Joachim P. Spatz
CPC classification number: B22D13/101 , B22D13/105 , B22D39/00 , B22F1/062 , B22F3/002 , B22F9/10 , B22F2009/088 , B22F2998/10 , D01D5/08
Abstract: The invention relates to a method of producing elongate metal strands or fibres with a crucible, the method comprising the steps of; directing molten metal through a nozzle having a nozzle direction in a deposition direction at a regulated pressure difference between the inside and the outside of the crucible; depositing said molten metal from said nozzle on a rotating planar surface having an axis of rotation; entraining said molten metal in one plane via said rotating planar surface to form elongate metal strands, wherein said rotating surface is aligned at an alignment angle, to the deposition direction during the entraining of the molten metal; cooling said elongate metal strands to form solidified metal strands; and guiding said metal strands to collecting means to collect the solidified metal strands formed on the rotating planar surface.
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10.发明公开公开(公告)号：US20240142761A1
公开(公告)日：2024-05-02
申请号：US18497032
申请日：2023-10-30
Inventor： Moritz Kreysing , Anatol Fritsch , Matthaeus Mittasch
CPC classification number: G02B21/36 , B01L3/50273 , G02B21/0032 , G02B21/02 , G02B21/08 , G02B21/28 , G02B21/30 , B01L2400/0463 , G01N21/6458
Abstract: The present invention relates to an apparatus for simultaneous imaging and execution of contact-free directed hydrodynamic flow in a specimen with at least one light source, in particular a laser, adapted to dynamically heat the interior and/or a surface of the specimen, a microscope with an objective adapted to image at least a part of the specimen and to guide, in particular focus, a light beam of the light source, in particular a laser beam, into and/or onto the specimen to heat at least one specified location of the specimen, means for manipulating the specified location, and a sample chamber for the specimen that is accessible for imaging radiation and the light beam to allow simultaneous imaging and manipulation of the sample via the objective. Furthermore the present invention is directed to a method for simultaneous imaging and executing contact-free directed hydrodynamic flow in a specimen wherein, at least one light source, in particular a laser, dynamically heats the interior and/or a surface of the specimen via a light beam, in particular via a laser beam, the beam of the at least one light source is directed to the specimen through an objective of a microscope, the light beam is variably guided, in particular focused, to specified locations of the specimen inducing a hydrodynamic flow in the specimen, and imaging the specimen via the same objective as used for introduction of the light beam.
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