公开(公告)号：US20240201056A1

公开(公告)日：2024-06-20

申请号：US18286563

申请日：2022-04-27

Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. ,  University of Buenos Aires ,  National Scientific & Technical Research Council

Inventor： Philippe I.H. Bastiaens ,  Jan Hubinger ,  Hernán Edgardo Grecco

IPC: G01N1/42 ,  G01N1/28 ,  G01N21/64

CPC classification number: G01N1/42 ,  G01N1/2813 ,  G01N21/6428 ,  G01N21/6456

Abstract: The present invention relates to method for decreasing temperature of a sample, in particular a method for ultra-rapid cryofixation of a sample for time and spatially resolved microscopic measurements as well as a device for ultra-rapid cryofixation of a sample at any particular time point of interest on a microscope. Said method and device are particularly useful for studying native molecular organization as well as (bio)chemical reactions within living cells with spatial and spectroscopic resolution beyond the fundamental limits caused by molecular motion at positive Celsius temperatures.