Invention Publication
- Patent Title: METHOD AND DEVICE FOR ULTRA-RAPID CRYO-FIXATION OF A SAMPLE FOR MICROSCOPIC STUDIES
-
Application No.: US18286563Application Date: 2022-04-27
-
Publication No.: US20240201056A1Publication Date: 2024-06-20
- Inventor: Philippe I.H. Bastiaens , Jan Hubinger , Hernán Edgardo Grecco
- Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , University of Buenos Aires , National Scientific & Technical Research Council
- Applicant Address: DE Munich
- Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.,University of Buenos Aires,National Scientific & Technical Research Council
- Current Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.,University of Buenos Aires,National Scientific & Technical Research Council
- Current Assignee Address: DE Munich
- Priority: EP 21170604.9 2021.04.27 EP 21212333.5 2021.12.03
- International Application: PCT/EP2022/061123 2022.04.27
- Date entered country: 2023-10-12
- Main IPC: G01N1/42
- IPC: G01N1/42 ; G01N1/28 ; G01N21/64
Abstract:
The present invention relates to method for decreasing temperature of a sample, in particular a method for ultra-rapid cryofixation of a sample for time and spatially resolved microscopic measurements as well as a device for ultra-rapid cryofixation of a sample at any particular time point of interest on a microscope. Said method and device are particularly useful for studying native molecular organization as well as (bio)chemical reactions within living cells with spatial and spectroscopic resolution beyond the fundamental limits caused by molecular motion at positive Celsius temperatures.
Information query
