发明公开
- 专利标题： METHOD AND DEVICE FOR ULTRA-RAPID CRYO-FIXATION OF A SAMPLE FOR MICROSCOPIC STUDIES
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申请号： US18286563申请日： 2022-04-27
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公开(公告)号： US20240201056A1公开(公告)日： 2024-06-20
- 发明人: Philippe I.H. Bastiaens , Jan Hubinger , Hernán Edgardo Grecco
- 申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , University of Buenos Aires , National Scientific & Technical Research Council
- 申请人地址： DE Munich
- 专利权人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.,University of Buenos Aires,National Scientific & Technical Research Council
- 当前专利权人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.,University of Buenos Aires,National Scientific & Technical Research Council
- 当前专利权人地址： DE Munich
- 优先权： EP 21170604.9 2021.04.27 EP 21212333.5 2021.12.03
- 国际申请： PCT/EP2022/061123 2022.04.27
- 进入国家日期： 2023-10-12
- 主分类号： G01N1/42
- IPC分类号： G01N1/42 ; G01N1/28 ; G01N21/64
摘要：
The present invention relates to method for decreasing temperature of a sample, in particular a method for ultra-rapid cryofixation of a sample for time and spatially resolved microscopic measurements as well as a device for ultra-rapid cryofixation of a sample at any particular time point of interest on a microscope. Said method and device are particularly useful for studying native molecular organization as well as (bio)chemical reactions within living cells with spatial and spectroscopic resolution beyond the fundamental limits caused by molecular motion at positive Celsius temperatures.
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