公开(公告)号：US20240173398A1

公开(公告)日：2024-05-30

申请号：US18262981

申请日：2022-01-28

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： Dirk GÖRLICH ,  Metin AKSU ,  Thomas GÜTTLER ,  Oleh RYMARENKO ,  Renate REES ,  Kathrin GREGOR ,  Waltraud TAXER

IPC分类号： A61K39/215 ,  A61K39/00 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00

CPC分类号： A61K39/215 ,  C07K14/005 ,  C07K16/1003 ,  C12N7/00 ,  A61K2039/6031 ,  C07K2317/569 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20052

摘要： The present invention relates to the recombinant production of a protein of interest in a prokaryotic host cell or eukaryotic host cell wherein the protein of interest is obtained in a correctly folded and stable form. The protein of interest may be a difficult-to-make polypeptide for use as a vaccine or a pharmaceutical. The protein of interest is co-expressed with or fused to a ‘fold promoter’, which may be a VHH antibody recognizing the said protein.

公开(公告)号：US20230303664A1

公开(公告)日：2023-09-28

申请号：US18007224

申请日：2021-07-29

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： Dirk GÖRLICH ,  Volker CORDES ,  Thomas GÜTTLER ,  Philip GUNKEL ,  Renate REES ,  Jens KRULL ,  Kathrin GREGOR ,  Waltraud TAXER ,  Leonie NEUMANN ,  Tino PLEINER ,  Bianka MUSSIL ,  Ulrike TEICHMANN ,  Aksu METIN ,  Oleh RYMARENKO ,  Jürgen SCHÜNEMANN ,  Matthias DOBBELSTEIN ,  Kim Maren STEGMANN ,  Antje DICKMANNS

IPC分类号： C07K16/10 ,  G01N33/569 ,  A61P31/14

CPC分类号： C07K16/10 ,  G01N33/56983 ,  A61P31/14 ,  C07K2317/565 ,  C07K2317/94

摘要： The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2, a strategy for an enhanced block of the homotrimeric viral spike proteins by symmetry-matching VHH-fusions, implementations of this strategy, as well as VHH antibodies for sensitive detection of SARS-CoV2-infections.

公开(公告)号：US20230287087A1

公开(公告)日：2023-09-14

申请号：US18007236

申请日：2021-07-29

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： Dirk GÖRLICH ,  Volker CORDES ,  Thomas GÜTTLER ,  Philip GUNKEL ,  Renate REES ,  Jens KRULL ,  Kathrin GREGOR ,  Waltraud TAXER ,  Leonie NEUMANN ,  Tino PLEINER ,  Bianka MUSSIL ,  Ulrike TEICHMANN ,  Aksu METIN ,  Oleh RYMARENKO ,  Jürgen SCHÜNEMANN ,  Matthias DOBBELSTEIN ,  Kim Maren STEGMANN ,  Antje DICKMANNS

IPC分类号： C07K16/10 ,  A61P31/14

CPC分类号： C07K16/10 ,  A61P31/14 ,  C07K2317/569 ,  C07K2317/565 ,  C07K2317/14 ,  C07K2317/94

摘要： The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2, a strategy for an enhanced block of the homotrimeric viral spike proteins by symmetry-matching VHH-fusions, implementations of this strategy, as well as VHH antibodies for sensitive detection of SARS-CoV2-infections.