- 专利标题： THERAPEUTIC AND DIAGNOSTIC VHH ANTIBODIES AGAINST SARS-COV-2 AND METHODS FOR THEIR ENHANCEMENT
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申请号： US18007236申请日： 2021-07-29
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公开(公告)号： US20230287087A1公开(公告)日： 2023-09-14
- 发明人: Dirk GÖRLICH , Volker CORDES , Thomas GÜTTLER , Philip GUNKEL , Renate REES , Jens KRULL , Kathrin GREGOR , Waltraud TAXER , Leonie NEUMANN , Tino PLEINER , Bianka MUSSIL , Ulrike TEICHMANN , Aksu METIN , Oleh RYMARENKO , Jürgen SCHÜNEMANN , Matthias DOBBELSTEIN , Kim Maren STEGMANN , Antje DICKMANNS
- 申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- 申请人地址： DE München
- 专利权人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- 当前专利权人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- 当前专利权人地址： DE München
- 优先权： EP 188451.7 2020.07.29 EP 151145.6 2021.01.12 EP 151159.7 2021.01.12 EP 183420.5 2021.07.02
- 国际申请： PCT/EP2021/071310 2021.07.29
- 进入国家日期： 2023-01-27
- 主分类号： C07K16/10
- IPC分类号： C07K16/10 ; A61P31/14
摘要：
The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2, a strategy for an enhanced block of the homotrimeric viral spike proteins by symmetry-matching VHH-fusions, implementations of this strategy, as well as VHH antibodies for sensitive detection of SARS-CoV2-infections.
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