Invention Publication
- Patent Title: FOLD PROMOTERS AND THEIR USE FOR THE PRODUCTION AND STABILIZATION OF POLYPEPTIDES
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Application No.: US18262981Application Date: 2022-01-28
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Publication No.: US20240173398A1Publication Date: 2024-05-30
- Inventor: Dirk GÖRLICH , Metin AKSU , Thomas GÜTTLER , Oleh RYMARENKO , Renate REES , Kathrin GREGOR , Waltraud TAXER
- Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- Applicant Address: DE München
- Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- Current Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- Current Assignee Address: DE München
- Priority: EP 154077.8 2021.01.28
- International Application: PCT/EP2022/052087 2022.01.28
- Date entered country: 2023-07-26
- Main IPC: A61K39/215
- IPC: A61K39/215 ; A61K39/00 ; C07K14/005 ; C07K16/10 ; C12N7/00
Abstract:
The present invention relates to the recombinant production of a protein of interest in a prokaryotic host cell or eukaryotic host cell wherein the protein of interest is obtained in a correctly folded and stable form. The protein of interest may be a difficult-to-make polypeptide for use as a vaccine or a pharmaceutical. The protein of interest is co-expressed with or fused to a ‘fold promoter’, which may be a VHH antibody recognizing the said protein.
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