公开(公告)号：US08961544B2

公开(公告)日：2015-02-24

申请号：US13813814

申请日：2011-08-05

Applicant: Chagai Komlos ,  Guy Tomer ,  Maria Ziv ,  Orahn Preiss-Bloom ,  Thomas Bayer

Inventor： Chagai Komlos ,  Guy Tomer ,  Maria Ziv ,  Orahn Preiss-Bloom ,  Thomas Bayer

IPC: A61B17/08

CPC classification number: A61F2/0063 ,  A61L15/325 ,  A61L15/38 ,  A61L15/425 ,  A61L31/045 ,  A61L31/047 ,  A61L31/14

Abstract: Patches comprising dry gelatin compositions.

Abstract translation: 贴剂包括干明胶组合物。

公开(公告)号：US20140193386A1

公开(公告)日：2014-07-10

申请号：US14181841

申请日：2014-02-17

Applicant: LifeBond Ltd.

Inventor： Orahn PREISS-BLOOM ,  Guy TOMER ,  Nadav BRAMSON

IPC: C12N9/10

CPC classification number: C12N9/1044

Abstract: A method for cross-linking albumin for use as a sealant or glue for a biological system, for example to induce hemostasis and/or prevent leakage of any other fluid from a biological tube or tissue, such as lymph for example. The cross-linked albumin may optionally and preferably be applied as part of a bandage for example. In other embodiments, the present invention provides a method of enzymatically cross-linking globular proteins, by altering the structure of the protein to improve the accessibility of the protein to the cross-linking enzyme.

Abstract translation: 用于交联白蛋白以用作生物系统的密封剂或胶水的方法，例如诱导止血和/或防止任何其它流体从生物管或组织例如淋巴液泄漏。 交联的白蛋白可以任选并优选作为绷带的一部分施用。 在其它实施方案中，本发明提供了通过改变蛋白质的结构来改善蛋白质对交联酶的可及性的酶促交联球形蛋白质的方法。

公开(公告)号：US20150291939A1

公开(公告)日：2015-10-15

申请号：US14696390

申请日：2015-04-25

Applicant: Guy TOMER ,  Orahn PREISS-BLOOM

Inventor： Guy TOMER ,  Orahn PREISS-BLOOM

IPC: C12N9/10 ,  C07K14/78

CPC classification number: C12N9/1029 ,  A61K38/45 ,  A61L17/08 ,  A61L24/08 ,  A61L24/10 ,  A61L27/20 ,  A61L27/22 ,  A61L2400/04 ,  C07K14/78 ,  C12N9/1044 ,  C12Y203/02013

Abstract: Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided.

Abstract translation: 通过聚合物的酶交联形成的改进的基质或水凝胶，其中交联酶分子已经被改性以改善基质的交联密度，机械性能或其它性质，和/或提供对速率和 /或交联程度，其中酶分子被修饰以改变所形成的交联基质中酶分子的感知体积。 还提供了生产和使用方法。

公开(公告)号：US08703117B2

公开(公告)日：2014-04-22

申请号：US13555656

申请日：2012-07-23

Applicant: Orahn Preiss Bloom ,  Ishay Attar ,  Natalie Iram ,  Chagai Komlos ,  Meir Haber

Inventor： Orahn Preiss Bloom ,  Ishay Attar ,  Natalie Iram ,  Chagai Komlos ,  Meir Haber

IPC: A61K31/74 ,  C12N9/10 ,  A61K38/17

CPC classification number: A61K38/39 ,  A61K8/042 ,  A61K8/20 ,  A61K8/36 ,  A61K8/365 ,  A61K8/60 ,  A61K8/65 ,  A61K8/66 ,  A61K9/0014 ,  A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/183 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/46 ,  A61L15/24 ,  A61L15/26 ,  A61L15/32 ,  A61L26/0014 ,  A61L26/0019 ,  A61L26/0038 ,  A61Q19/00 ,  C08H1/06 ,  C08L89/06 ,  C08L29/04 ,  C08L71/02

Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).

Abstract translation: 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地，可交联蛋白质包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地，无毒材料包含转谷氨酰胺酶（TG），其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶，其可以例如任选地是微生物转谷氨酰胺酶（mTG）。

公开(公告)号：US20130039899A1

公开(公告)日：2013-02-14

申请号：US13642145

申请日：2011-04-20

Applicant: Orahn Preiss-Bloom ,  Ishay Attar ,  Omer Shezifi ,  Yuval Shezifi ,  Golan Salman

Inventor： Orahn Preiss-Bloom ,  Ishay Attar ,  Omer Shezifi ,  Yuval Shezifi ,  Golan Salman

IPC: A61K38/45

CPC classification number: A61B17/00491 ,  A61B17/07292 ,  A61B17/1155 ,  A61B2017/00495 ,  A61B2017/00858

Abstract: Methods of application and devices thereof for tissue adhesives. The adhesives comprise a plurality of components which are provided separately but which are mixed together to form the adhesive. At least one component is a crosslinkable protein solution and at least one other component is a crosslinking material solution. The devices preferably include a mixing unit, which may include dynamic mixing elements, static mixing elements, or a combination of the two.

Abstract translation: 用于组织粘合剂的应用方法及其装置。 粘合剂包括分开设置但被混合在一起以形成粘合剂的多个组分。 至少一种组分是可交联的蛋白质溶液，并且至少一种其它组分是交联材料溶液。 这些装置优选地包括混合单元，其可以包括动态混合元件，静态混合元件或两者的组合。

公开(公告)号：US10202585B2

公开(公告)日：2019-02-12

申请号：US14696390

申请日：2015-04-25

Applicant: LIFEBOND, LTD.

Inventor： Guy Tomer ,  Orahn Preiss-Bloom

IPC: C12N9/10 ,  A61L17/08 ,  A61L24/10 ,  A61K38/45 ,  A61L24/08 ,  A61L27/20 ,  A61L27/22 ,  C07K14/78

Abstract: Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided.

公开(公告)号：US09044456B2

公开(公告)日：2015-06-02

申请号：US14188711

申请日：2014-02-25

Applicant: Lifebond Ltd.

Inventor： Orahn Preiss-Bloom

IPC: A61K38/39 ,  A61K8/04 ,  A61K8/20 ,  A61K8/36 ,  A61K8/365 ,  A61K8/60 ,  A61K8/65 ,  A61K8/66 ,  A61K9/00 ,  A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/46 ,  A61L15/24 ,  A61L15/26 ,  A61L15/32 ,  A61L26/00 ,  A61Q19/00 ,  C08H1/06 ,  C08L89/06

CPC classification number: A61K38/39 ,  A61K8/042 ,  A61K8/20 ,  A61K8/36 ,  A61K8/365 ,  A61K8/60 ,  A61K8/65 ,  A61K8/66 ,  A61K9/0014 ,  A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/183 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/46 ,  A61L15/24 ,  A61L15/26 ,  A61L15/32 ,  A61L26/0014 ,  A61L26/0019 ,  A61L26/0038 ,  A61Q19/00 ,  C08H1/06 ,  C08L89/06 ,  C08L29/04 ,  C08L71/02

Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).

Abstract translation: 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地，可交联蛋白质包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地，无毒材料包含转谷氨酰胺酶（TG），其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶，其可以例如任选地是微生物转谷氨酰胺酶（mTG）。

公开(公告)号：US20140314732A1

公开(公告)日：2014-10-23

申请号：US14188711

申请日：2014-02-25

Applicant: Lifebond Ltd.

Inventor： Orahn PREISS-BLOOM

IPC: A61K38/39 ,  A61K47/42

CPC classification number: A61K38/39 ,  A61K8/042 ,  A61K8/20 ,  A61K8/36 ,  A61K8/365 ,  A61K8/60 ,  A61K8/65 ,  A61K8/66 ,  A61K9/0014 ,  A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/183 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/46 ,  A61L15/24 ,  A61L15/26 ,  A61L15/32 ,  A61L26/0014 ,  A61L26/0019 ,  A61L26/0038 ,  A61Q19/00 ,  C08H1/06 ,  C08L89/06 ,  C08L29/04 ,  C08L71/02

Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).

Abstract translation: 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地，可交联蛋白质包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地，无毒材料包含转谷氨酰胺酶（TG），其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶，其可以例如任选地是微生物转谷氨酰胺酶（mTG）。

公开(公告)号：US09655988B2

公开(公告)日：2017-05-23

申请号：US14693854

申请日：2015-04-22

Applicant: LifeBond Ltd.

Inventor： Natalie Iram ,  Orahn Preiss-Bloom ,  Ishay Attar

IPC: A61L15/32 ,  A61L15/38 ,  A61L15/42 ,  A61L15/58 ,  A61L24/04 ,  A61L24/10 ,  A61L26/00

CPC classification number: A61L15/38 ,  A61L15/32 ,  A61L15/325 ,  A61L15/42 ,  A61L15/585 ,  A61L24/043 ,  A61L24/104 ,  A61L26/0038 ,  A61L26/0047 ,  A61L26/0052 ,  A61L26/0061 ,  A61L2400/04

Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.

公开(公告)号：US09636433B2

公开(公告)日：2017-05-02

申请号：US14624316

申请日：2015-02-17

Applicant: LifeBond Ltd.

Inventor： Natalie Iram ,  Orahn Preiss-Bloom ,  Ishay Attar

IPC: A61L15/32 ,  A61L15/38 ,  A61L15/42 ,  A61L15/58 ,  A61L24/04 ,  A61L24/10 ,  A61L26/00

CPC classification number: A61L15/38 ,  A61L15/32 ,  A61L15/325 ,  A61L15/42 ,  A61L15/585 ,  A61L24/043 ,  A61L24/104 ,  A61L26/0038 ,  A61L26/0047 ,  A61L26/0052 ,  A61L26/0061 ,  A61L2400/04

Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.