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1.发明申请公开(公告)号：US20190099522A1
公开(公告)日：2019-04-04
申请号：US16081605
申请日：2017-03-07
Applicant: Orahn PREISS-BLOOM , OSSIO LTD
Inventor： Orahn PREISS-BLOOM , Taly Pnina LINDNER
Abstract: Reinforced biocomposite materials having a unique treated surface, in which the surface may comprise a plurality of layers. According to at least some embodiments, medical implants are provided that incorporate novel structures, alignments, orientations and forms comprised of such reinforced bioabsorbable materials, as well as methods of treatment thereof.
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公开(公告)号：US20170246356A1
公开(公告)日：2017-08-31
申请号：US15523389
申请日：2015-12-28
Applicant: Orahn PREISS-BLOOM , Ossio Ltd
Inventor： Orahn PREISS-BLOOM , Taly Pnina LINDNER , Eyal EPSTEIN , Danielle POREH
CPC classification number: A61L31/128 , A61B17/864 , A61B17/866 , A61F2/4455 , A61F2/447 , A61F2002/30062 , A61F2002/4475 , A61F2002/4495 , A61L27/446 , A61L27/58 , A61L31/06 , A61L31/08 , A61L31/148 , C08L67/04
Abstract: A medical implant comprising a plurality of layers, each layer comprising a polymer and a plurality of uni-directionally aligned continuous reinforcement fibers.
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公开(公告)号：US20110110882A1
公开(公告)日：2011-05-12
申请号：US13000021
申请日：2009-06-18
Applicant: Orahn Preiss-Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
Inventor： Orahn Preiss-Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
IPC: A61K31/785 , A61K38/45 , A61P3/00
CPC classification number: A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
Abstract translation: 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地，可交联蛋白包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地，无毒材料包含转谷氨酰胺酶（TG），其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶，其可以例如任选地是微生物转谷氨酰胺酶（mTG）。
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4.发明授权Dry composition wound dressings and adhesives comprising gelatin and transglutaminase in a cross-linked matrix 有权干组合伤口敷料和包含明胶和转谷氨酰胺酶在交联基质中的粘合剂
公开(公告)号：US08961544B2
公开(公告)日：2015-02-24
申请号：US13813814
申请日：2011-08-05
Applicant: Chagai Komlos , Guy Tomer , Maria Ziv , Orahn Preiss-Bloom , Thomas Bayer
Inventor： Chagai Komlos , Guy Tomer , Maria Ziv , Orahn Preiss-Bloom , Thomas Bayer
IPC: A61B17/08
CPC classification number: A61F2/0063 , A61L15/325 , A61L15/38 , A61L15/425 , A61L31/045 , A61L31/047 , A61L31/14
Abstract: Patches comprising dry gelatin compositions.
Abstract translation: 贴剂包括干明胶组合物。
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公开(公告)号：US20120329132A1
公开(公告)日：2012-12-27
申请号：US13555656
申请日：2012-07-23
Applicant: Orahn Preiss BLOOM , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
Inventor： Orahn Preiss BLOOM , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
IPC: C12N9/10
CPC classification number: A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
Abstract translation: 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地，可交联蛋白质包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地，无毒材料包含转谷氨酰胺酶（TG），其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶，其可以例如任选地是微生物转谷氨酰胺酶（mTG）。
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6.发明授权Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices 有权酶交联剂的改性，用于控制交联基质的性质
公开(公告)号：US09066991B2
公开(公告)日：2015-06-30
申请号：US13517906
申请日：2010-12-22
Applicant: Orahn Preiss-Bloom , Guy Tomer
Inventor： Orahn Preiss-Bloom , Guy Tomer
CPC classification number: C12N9/1029 , A61K38/45 , A61L17/08 , A61L24/08 , A61L24/10 , A61L27/20 , A61L27/22 , A61L2400/04 , C07K14/78 , C12N9/1044 , C12Y203/02013
Abstract: Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided.
Abstract translation: 通过聚合物的酶交联形成的改进的基质或水凝胶，其中交联酶分子已经被改性以改善基质的交联密度，机械性能或其它性质，和/或提供对速率和 /或交联程度，其中酶分子被修饰以改变所形成的交联基质中酶分子的感知体积。 还提供了生产和使用方法。
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公开(公告)号：US08722039B2
公开(公告)日：2014-05-13
申请号：US13341946
申请日：2011-12-31
Applicant: Orahn Preiss-Bloom , Ishay Attar , Natalie Iram
Inventor： Orahn Preiss-Bloom , Ishay Attar , Natalie Iram
CPC classification number: A61L15/38 , A61L15/32 , A61L15/325 , A61L15/42 , A61L15/585 , A61L24/043 , A61L24/104 , A61L26/0038 , A61L26/0047 , A61L26/0052 , A61L26/0061 , A61L2400/04
Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.
Abstract translation: 一种用于医疗用途的粘合剂材料，包括明胶和无毒交联材料如转谷氨酰胺酶。 本发明的任选实施方案包括敷料，其中转谷氨酰胺酶层夹在第一和第二层明胶之间。 止血产品可用于治疗伤口组织。
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公开(公告)号：US20130131701A1
公开(公告)日：2013-05-23
申请号：US13813814
申请日：2011-08-05
Applicant: Chagai Komlos , Guy Tomer , Maria Ziv , Orahn Preiss-Bloom , Thomas Bayer
Inventor： Chagai Komlos , Guy Tomer , Maria Ziv , Orahn Preiss-Bloom , Thomas Bayer
IPC: A61F2/00
CPC classification number: A61F2/0063 , A61L15/325 , A61L15/38 , A61L15/425 , A61L31/045 , A61L31/047 , A61L31/14
Abstract: Patches comprising dry gelatin compositions and methods of use and manufacture thereof.
Abstract translation: 包含干明胶组合物的胶料及其使用和制造方法。
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公开(公告)号：US08367388B2
公开(公告)日：2013-02-05
申请号：US13000021
申请日：2009-06-18
Applicant: Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
Inventor： Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
CPC classification number: A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
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公开(公告)号：US20080213243A1
公开(公告)日：2008-09-04
申请号：US11978713
申请日：2007-10-30
Applicant: Orahn Preiss-Bloom , Ishay Attar
Inventor： Orahn Preiss-Bloom , Ishay Attar
CPC classification number: A61K38/39 , A61K38/45 , A61L15/325 , A61L15/42 , A61L24/104 , A61L26/0038 , A61L2400/04 , A61K2300/00
Abstract: An adhesive material comprising gelatin and a non-toxic cross-linking material such as transglutaminase. The adhesive material is useful for medical purposes as hemostatic products. The hemostatic products are useful for the treatment of wounded tissue.
Abstract translation: 包含明胶和无毒交联材料如谷氨酰胺转移酶的粘合剂材料。 粘合剂材料用于医疗用途作为止血产品。 止血产品可用于治疗伤口组织。
