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公开(公告)号：US08703117B2
公开(公告)日：2014-04-22
申请号：US13555656
申请日：2012-07-23
Applicant: Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
Inventor： Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
CPC classification number: A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
Abstract translation: 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地，可交联蛋白质包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地，无毒材料包含转谷氨酰胺酶（TG），其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶，其可以例如任选地是微生物转谷氨酰胺酶（mTG）。
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公开(公告)号：US20110110882A1
公开(公告)日：2011-05-12
申请号：US13000021
申请日：2009-06-18
Applicant: Orahn Preiss-Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
Inventor： Orahn Preiss-Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
IPC: A61K31/785 , A61K38/45 , A61P3/00
CPC classification number: A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
Abstract translation: 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地，可交联蛋白包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地，无毒材料包含转谷氨酰胺酶（TG），其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶，其可以例如任选地是微生物转谷氨酰胺酶（mTG）。
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公开(公告)号：US20120329132A1
公开(公告)日：2012-12-27
申请号：US13555656
申请日：2012-07-23
Applicant: Orahn Preiss BLOOM , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
Inventor： Orahn Preiss BLOOM , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
IPC: C12N9/10
CPC classification number: A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
Abstract translation: 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地，可交联蛋白质包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地，无毒材料包含转谷氨酰胺酶（TG），其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶，其可以例如任选地是微生物转谷氨酰胺酶（mTG）。
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Patent Agency Ranking
公开(公告)号：US08722039B2
公开(公告)日：2014-05-13
申请号：US13341946
申请日：2011-12-31
Applicant: Orahn Preiss-Bloom , Ishay Attar , Natalie Iram
Inventor： Orahn Preiss-Bloom , Ishay Attar , Natalie Iram
CPC classification number: A61L15/38 , A61L15/32 , A61L15/325 , A61L15/42 , A61L15/585 , A61L24/043 , A61L24/104 , A61L26/0038 , A61L26/0047 , A61L26/0052 , A61L26/0061 , A61L2400/04
Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.
Abstract translation: 一种用于医疗用途的粘合剂材料，包括明胶和无毒交联材料如转谷氨酰胺酶。 本发明的任选实施方案包括敷料，其中转谷氨酰胺酶层夹在第一和第二层明胶之间。 止血产品可用于治疗伤口组织。
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公开(公告)号：US08367388B2
公开(公告)日：2013-02-05
申请号：US13000021
申请日：2009-06-18
Applicant: Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
Inventor： Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
CPC classification number: A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
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公开(公告)号：US09017664B2
公开(公告)日：2015-04-28
申请号：US12519167
申请日：2007-12-17
Applicant: Orahn Preiss-Bloom , Ishay Attar , Natalie Iram
Inventor： Orahn Preiss-Bloom , Ishay Attar , Natalie Iram
CPC classification number: A61L15/38 , A61L15/32 , A61L15/325 , A61L15/42 , A61L15/585 , A61L24/043 , A61L24/104 , A61L26/0038 , A61L26/0047 , A61L26/0052 , A61L26/0061 , A61L2400/04
Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.
Abstract translation: 一种用于医疗用途的粘合剂材料，包括明胶和无毒交联材料如转谷氨酰胺酶。 本发明的任选实施方案包括敷料，其中转谷氨酰胺酶层夹在第一和第二层明胶之间。 止血产品可用于治疗伤口组织。
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公开(公告)号：US20120226211A1
公开(公告)日：2012-09-06
申请号：US13341946
申请日：2011-12-31
Applicant: Orahn PREISS-BLOOM , Ishay Attar , Natalie Iram
Inventor： Orahn PREISS-BLOOM , Ishay Attar , Natalie Iram
IPC: A61F13/02
CPC classification number: A61L15/38 , A61L15/32 , A61L15/325 , A61L15/42 , A61L15/585 , A61L24/043 , A61L24/104 , A61L26/0038 , A61L26/0047 , A61L26/0052 , A61L26/0061 , A61L2400/04
Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.
Abstract translation: 一种用于医疗用途的粘合剂材料，包括明胶和无毒交联材料如转谷氨酰胺酶。 本发明的任选实施方案包括敷料，其中转谷氨酰胺酶层夹在第一和第二层明胶之间。 止血产品可用于治疗伤口组织。
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公开(公告)号：US20100063459A1
公开(公告)日：2010-03-11
申请号：US12519167
申请日：2007-12-17
Applicant: Orahn Preiss-Bloom , Ishay Attar , Natalie Iram
Inventor： Orahn Preiss-Bloom , Ishay Attar , Natalie Iram
CPC classification number: A61L15/38 , A61L15/32 , A61L15/325 , A61L15/42 , A61L15/585 , A61L24/043 , A61L24/104 , A61L26/0038 , A61L26/0047 , A61L26/0052 , A61L26/0061 , A61L2400/04
Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.
Abstract translation: 一种用于医疗用途的粘合剂材料，包括明胶和无毒交联材料如转谷氨酰胺酶。 本发明的任选实施方案包括敷料，其中转谷氨酰胺酶层夹在第一和第二层明胶之间。 止血产品可用于治疗伤口组织。
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