公开(公告)号：US20190125936A1

公开(公告)日：2019-05-02

申请号：US16099834

申请日：2017-05-09

Applicant: LIFEBOND, LTD.

Inventor： Orahn PREISS-BLOOM ,  Guy TOMER ,  Amir HADID ,  Alon POLAKEWICZ ,  Ariel MAIZLER ,  Denis KRAMARENKO ,  Daniella GODER ,  Danny YOSUFOV

IPC: A61L31/10 ,  A61L31/12 ,  A61L31/14 ,  C08L89/00

Abstract: A mesh-based composition comprising a cross-linkable protein or polypeptide and one or more cross-linking materials according to at least some embodiments.

公开(公告)号：US20140193386A1

公开(公告)日：2014-07-10

申请号：US14181841

申请日：2014-02-17

Applicant: LifeBond Ltd.

Inventor： Orahn PREISS-BLOOM ,  Guy TOMER ,  Nadav BRAMSON

IPC: C12N9/10

CPC classification number: C12N9/1044

Abstract: A method for cross-linking albumin for use as a sealant or glue for a biological system, for example to induce hemostasis and/or prevent leakage of any other fluid from a biological tube or tissue, such as lymph for example. The cross-linked albumin may optionally and preferably be applied as part of a bandage for example. In other embodiments, the present invention provides a method of enzymatically cross-linking globular proteins, by altering the structure of the protein to improve the accessibility of the protein to the cross-linking enzyme.

Abstract translation: 用于交联白蛋白以用作生物系统的密封剂或胶水的方法，例如诱导止血和/或防止任何其它流体从生物管或组织例如淋巴液泄漏。 交联的白蛋白可以任选并优选作为绷带的一部分施用。 在其它实施方案中，本发明提供了通过改变蛋白质的结构来改善蛋白质对交联酶的可及性的酶促交联球形蛋白质的方法。

公开(公告)号：US20200155721A1

公开(公告)日：2020-05-21

申请号：US16508356

申请日：2019-07-11

Applicant: LIFEBOND LTD.

Inventor： Gideon STURLESI ,  Guy TOMER ,  Aurelie BENADDI ,  Mary HAINRICHSON ,  Amir HADID ,  Ofer YATZIV

IPC: A61L24/04 ,  A61L24/00

Abstract: A biocompatible material for securing such implantable medical devices, for example by using an adhesive path.

公开(公告)号：US09655988B2

公开(公告)日：2017-05-23

申请号：US14693854

申请日：2015-04-22

Applicant: LifeBond Ltd.

Inventor： Natalie Iram ,  Orahn Preiss-Bloom ,  Ishay Attar

IPC: A61L15/32 ,  A61L15/38 ,  A61L15/42 ,  A61L15/58 ,  A61L24/04 ,  A61L24/10 ,  A61L26/00

CPC classification number: A61L15/38 ,  A61L15/32 ,  A61L15/325 ,  A61L15/42 ,  A61L15/585 ,  A61L24/043 ,  A61L24/104 ,  A61L26/0038 ,  A61L26/0047 ,  A61L26/0052 ,  A61L26/0061 ,  A61L2400/04

Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.

公开(公告)号：US09636433B2

公开(公告)日：2017-05-02

申请号：US14624316

申请日：2015-02-17

Applicant: LifeBond Ltd.

Inventor： Natalie Iram ,  Orahn Preiss-Bloom ,  Ishay Attar

IPC: A61L15/32 ,  A61L15/38 ,  A61L15/42 ,  A61L15/58 ,  A61L24/04 ,  A61L24/10 ,  A61L26/00

CPC classification number: A61L15/38 ,  A61L15/32 ,  A61L15/325 ,  A61L15/42 ,  A61L15/585 ,  A61L24/043 ,  A61L24/104 ,  A61L26/0038 ,  A61L26/0047 ,  A61L26/0052 ,  A61L26/0061 ,  A61L2400/04

Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.

公开(公告)号：US20150273103A1

公开(公告)日：2015-10-01

申请号：US14693854

申请日：2015-04-22

Applicant: LifeBond Ltd.

Inventor： Natalie IRAM ,  Orahn PREISS-BLOOM ,  Ishay ATTAR

IPC: A61L15/38 ,  A61L24/04 ,  A61L15/58 ,  A61L15/32 ,  A61L26/00

CPC classification number: A61L15/38 ,  A61L15/32 ,  A61L15/325 ,  A61L15/42 ,  A61L15/585 ,  A61L24/043 ,  A61L24/104 ,  A61L26/0038 ,  A61L26/0047 ,  A61L26/0052 ,  A61L26/0061 ,  A61L2400/04

Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.

公开(公告)号：US20200016295A1

公开(公告)日：2020-01-16

申请号：US16508343

申请日：2019-07-11

Applicant: LIFEBOND, LTD.

Inventor： Guy TOMER ,  Aurelie BENADDI ,  Mary HAINRICHSON ,  Moriah ANOUCHI ,  Amir HADID ,  Ofer YATZIV

IPC: A61L27/22 ,  A61L27/18 ,  A61L27/26 ,  A61L27/54 ,  A61L27/24 ,  A61L27/20 ,  A61L27/56 ,  A61L27/58

Abstract: An injectable scaffold made from biocompatible materials. The biocompatible materials comprise a biopolymer, a porogen and a cross-linking agent. The biopolymer may optionally comprise a polypeptide or a polysaccharide.

公开(公告)号：US10202585B2

公开(公告)日：2019-02-12

申请号：US14696390

申请日：2015-04-25

Applicant: LIFEBOND, LTD.

Inventor： Guy Tomer ,  Orahn Preiss-Bloom

IPC: C12N9/10 ,  A61L17/08 ,  A61L24/10 ,  A61K38/45 ,  A61L24/08 ,  A61L27/20 ,  A61L27/22 ,  C07K14/78

Abstract: Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided.

公开(公告)号：US20150196683A1

公开(公告)日：2015-07-16

申请号：US14624316

申请日：2015-02-17

Applicant: LIFEBOND LTD.

Inventor： Natalie IRAM ,  Orahn PREISS-BLOOM ,  Ishay ATTAR

IPC: A61L26/00

CPC classification number: A61L15/38 ,  A61L15/32 ,  A61L15/325 ,  A61L15/42 ,  A61L15/585 ,  A61L24/043 ,  A61L24/104 ,  A61L26/0038 ,  A61L26/0047 ,  A61L26/0052 ,  A61L26/0061 ,  A61L2400/04

Abstract: An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer of a transglutaminase is sandwiched between a first and second layer of gelatin. The hemostatic products are useful for the treatment of wounded tissue.

Abstract translation: 一种用于医疗用途的粘合剂材料，包括明胶和无毒交联材料如转谷氨酰胺酶。 本发明的任选实施方案包括敷料，其中转谷氨酰胺酶层夹在第一和第二层明胶之间。 止血产品可用于治疗伤口组织。

公开(公告)号：US09044456B2

公开(公告)日：2015-06-02

申请号：US14188711

申请日：2014-02-25

Applicant: Lifebond Ltd.

Inventor： Orahn Preiss-Bloom

IPC: A61K38/39 ,  A61K8/04 ,  A61K8/20 ,  A61K8/36 ,  A61K8/365 ,  A61K8/60 ,  A61K8/65 ,  A61K8/66 ,  A61K9/00 ,  A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/46 ,  A61L15/24 ,  A61L15/26 ,  A61L15/32 ,  A61L26/00 ,  A61Q19/00 ,  C08H1/06 ,  C08L89/06

CPC classification number: A61K38/39 ,  A61K8/042 ,  A61K8/20 ,  A61K8/36 ,  A61K8/365 ,  A61K8/60 ,  A61K8/65 ,  A61K8/66 ,  A61K9/0014 ,  A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/183 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/46 ,  A61L15/24 ,  A61L15/26 ,  A61L15/32 ,  A61L26/0014 ,  A61L26/0019 ,  A61L26/0038 ,  A61Q19/00 ,  C08H1/06 ,  C08L89/06 ,  C08L29/04 ,  C08L71/02

Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).

Abstract translation: 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地，可交联蛋白质包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地，无毒材料包含转谷氨酰胺酶（TG），其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶，其可以例如任选地是微生物转谷氨酰胺酶（mTG）。