公开(公告)号：US20160024249A1

公开(公告)日：2016-01-28

申请号：US14806642

申请日：2015-07-22

申请人： Vanderbilt University

发明人： Hak-Joon Sung ,  Xintong Wang ,  Mukesh K. Gupta ,  Timothy C. Boire

IPC分类号： C08G63/91 ,  A61K38/10 ,  A61K47/48 ,  A61K9/00 ,  A61K38/07

CPC分类号： A61K38/10 ,  A61K9/0024 ,  A61K35/28 ,  A61K38/1709 ,  A61L27/18 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/80 ,  C08G63/664 ,  A61K2300/00 ,  C08L71/02 ,  C08L67/04

摘要： Embodiments of the invention include polymeric compounds that comprise a co-polymer microgel at least one bioactive agent, pharmaceutical compounds comprising compounds of the present invention, and methods for treating damaged tissue to a patient in need thereof by administering by injection an effect amount of the composition.

摘要翻译： 本发明的实施方案包括包含共聚物微凝胶至少一种生物活性剂的聚合物化合物，包含本发明化合物的药物化合物和通过注射施用有效量的治疗有需要的患者的受损组织的方法 组成。

公开(公告)号：US10046086B2

公开(公告)日：2018-08-14

申请号：US15290875

申请日：2016-10-11

申请人： Vanderbilt University

发明人： Scott A. Guelcher ,  Madison McGough ,  Mukesh K. Gupta ,  Craig L. Duvall ,  John Martin ,  Jon Page

IPC分类号： A61L27/18 ,  A61L27/58 ,  A61L27/54 ,  C07C323/12 ,  C08G18/77 ,  C08G18/38 ,  C08G18/10 ,  C08G18/20 ,  A61L27/42

摘要： A biodegradable scaffold, a low-molecular weight thioketal, and a method of forming a biodegradable scaffold are provided. The biodegradable scaffold includes a thioketal and an isocyanate, where the thioketal is linked to the isocyanate to form the scaffold. The low-molecular weight thioketal includes 2,2-dimethoxypropane and thioglycolic acid, wherein the thioketal includes at least two hydroxyl terminal groups. The method of forming the biodegradable scaffold includes blending a thioketal with an excess isocyanate, forming a quasi-prepolymer, mixing the thioketal, the quasi-prepolymer, and a ceramic, and then adding a catalyst to form the biodegradable scaffold. The thioketal is a low-molecular weight thioketal having at least two hydroxyl terminal groups.

公开(公告)号：US20170119924A1

公开(公告)日：2017-05-04

申请号：US15290875

申请日：2016-10-11

申请人： Vanderbilt University

发明人： Scott A. Guelcher ,  Madison A.P. McEnery ,  Mukesh K. Gupta ,  Craig L. Duvall ,  John Martin ,  Jon Page

IPC分类号： A61L27/18 ,  A61L27/12 ,  A61L27/54 ,  C08G18/20 ,  C08G18/77 ,  C08G18/38 ,  C08G18/10 ,  A61L27/58 ,  C07C323/12

CPC分类号： A61L27/18 ,  A61L27/425 ,  A61L27/54 ,  A61L27/58 ,  A61L2400/06 ,  A61L2430/02 ,  C07C323/12 ,  C08G18/10 ,  C08G18/2063 ,  C08G18/3868 ,  C08G18/771 ,  C08G2230/00 ,  C08L75/04

摘要： A biodegradable scaffold, a low-molecular weight thioketal, and a method of forming a biodegradable scaffold are provided. The biodegradable scaffold includes a thioketal and an isocyanate, where the thioketal is linked to the isocyanate to form the scaffold. The low-molecular weight thioketal includes 2,2-dimethoxypropane and thioglycolic acid, wherein the thioketal includes at least two hydroxyl terminal groups. The method of forming the biodegradable scaffold includes blending a thioketal with an excess isocyanate, forming a quasi-prepolymer, mixing the thioketal, the quasi-prepolymer, and a ceramic, and then adding a catalyst to form the biodegradable scaffold. The thioketal is a low-molecular weight thioketal having at least two hydroxyl terminal groups.

公开(公告)号：US10532125B1

公开(公告)日：2020-01-14

申请号：US14318179

申请日：2014-06-27

申请人： Vanderbilt University

发明人： Hak-Joon Sung ,  Timothy C. Boire ,  Mukesh K. Gupta ,  Angela L. Zachman ,  Sue Hyun-Lee ,  Colleen M. Brophy

IPC分类号： A61F2/82 ,  A61L27/18 ,  C08G63/08 ,  A61L27/54 ,  A61L27/26 ,  A61L27/50 ,  A61L27/58 ,  A61L31/06 ,  A61L31/14 ,  A61L31/16

摘要： The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photocrosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.

公开(公告)号：US10172956B2

公开(公告)日：2019-01-08

申请号：US14438596

申请日：2013-10-28

申请人： Vanderbilt University

发明人： Craig L. Duvall ,  Christopher E. Nelson ,  James Kintzing ,  Joshua M. Shannon ,  Mukesh K. Gupta ,  Scott A. Guelcher ,  Elizabeth J. Adolph ,  Jeffrey M. Davidson

IPC分类号： C07H21/04 ,  A61K47/48 ,  C12N15/88 ,  A61K48/00 ,  C08F283/06 ,  C12N15/113 ,  C08J3/12 ,  A61K9/51

摘要： The presently-disclosed subject matter includes nanoparticles that comprise a plurality of assembled polymers. In some embodiments the polymers comprise a first block that includes hydrophilic monomers, the first block substantially forming an outer shell of the nanoparticle, and a second block that includes cationic monomers and hydrophobic monomers, the second block substantially forming a core of the nanoparticle. In some embodiments a polynucleotide is provided that is bound to the cationic monomers of the nanoparticle. The presently-disclosed subject matter also comprises methods for using the present nanoparticles to include RNAi in a cell as well as methods for making the present nanoparticles.

公开(公告)号：US20160303241A1

公开(公告)日：2016-10-20

申请号：US15132076

申请日：2016-04-18

申请人： VANDERBILT UNIVERSITY

发明人： Craig L. Duvall ,  Mukesh K. Gupta ,  John R. Martin ,  Bryan R. Dollinger

IPC分类号： A61K47/32 ,  A61K41/00 ,  C08G75/08 ,  A61K9/00 ,  C08F287/00 ,  C08F283/00 ,  A61K9/06 ,  A61K9/107

CPC分类号： A61K47/32 ,  A61K9/0019 ,  A61K9/06 ,  A61K41/0028 ,  C08F283/00 ,  C08F287/00 ,  C08F293/005 ,  C08G75/08

摘要： The presently-disclosed subject matter includes a polymer (i.e., copolymer) comprising a thermally responsive block and a hydrophobic block. In some embodiments the copolymer is a terpolymer. Specific embodiments include a thermo-responsive, ROS degradable ABC triblock terpolymer comprising poly(propylenesulfide)-block-poly(N,N-dimethylacrylamide)-block-poly(N-isopropylacrylamide) (PPS-b-PDMA-b-PNIPAAM).

摘要翻译： 目前公开的主题包括包含热响应性嵌段和疏水嵌段的聚合物（即共聚物）。 在一些实施方案中，共聚物是三元共聚物。 具体实施方案包括包含聚（丙烯基硫醚） - 嵌段 - 聚（N，N-二甲基丙烯酰胺） - 嵌段 - 聚（N-异丙基丙烯酰胺）（PPS-b-PDMA-b-PNIPAAM）的热响应性ROS可降解ABC三嵌段三元共聚物。

公开(公告)号：US20150283254A1

公开(公告)日：2015-10-08

申请号：US14438596

申请日：2013-10-28

申请人： VANDERBILT UNIVERSITY

发明人： Craig L. Duvall ,  Christopher E. Nelson ,  James Kintzing ,  Joshua M. Shannon ,  Mukesh K. Gupta ,  Scott A. Guelcher ,  Elizabeth J. Adolph ,  Jeffrey M. Davidson

IPC分类号： A61K47/48 ,  C12N15/113 ,  A61K48/00 ,  C08F283/06

CPC分类号： A61K47/489 ,  A61K9/5138 ,  A61K47/58 ,  A61K47/60 ,  A61K47/6925 ,  A61K47/6933 ,  A61K48/00 ,  A61K48/0041 ,  C08F283/06 ,  C08F2438/03 ,  C08J3/126 ,  C08J2353/00 ,  C12N15/113 ,  C12N15/1137 ,  C12N15/88 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/30 ,  C12Y502/01008 ,  C08F220/34 ,  C08F2220/1825

摘要： The presently-disclosed subject matter includes nanoparticles that comprise a plurality of assembled polymers. In some embodiments the polymers comprise a first block that includes hydrophilic monomers, the first block substantially forming an outer shell of the nanoparticle, and a second block that includes cationic monomers and hydrophobic monomers, the second block substantially forming a core of the nanoparticle. In some embodiments a polynucleotide is provided that is bound to the cationic monomers of the nanoparticle. The presently-disclosed subject matter also comprises methods for using the present nanoparticles to include RNAi in a cell as well as methods for making the present nanoparticles.

摘要翻译： 目前公开的主题包括包含多个组装的聚合物的纳米颗粒。 在一些实施方案中，聚合物包含第一嵌段，其包括亲水性单体，第一嵌段基本上形成纳米颗粒的外壳，第二嵌段包括阳离子单体和疏水性单体，第二嵌段基本上形成纳米颗粒的芯。 在一些实施方案中，提供了与纳米颗粒的阳离子单体结合的多核苷酸。 目前公开的主题还包括使用本发明的纳米颗粒将RNAi包括在细胞中的方法以及制备本发明的纳米颗粒的方法。

公开(公告)号：US20200323785A1

公开(公告)日：2020-10-15

申请号：US16844870

申请日：2020-04-09

申请人： Vanderbilt University

发明人： Craig L Duvall ,  Joseph Paul Vanderburgh ,  Mukesh K. Gupta ,  Scott A. Guelcher ,  Julie A. Rhoades

IPC分类号： A61K9/50 ,  C08G81/02 ,  A61K31/444

摘要： A polymeric nanocarrier and method of treating a bone disease are provided. The polymeric nanocarrier includes an amphiphilic copolymer including a hydrophobic block and a hydrophilic block, where the hydrophilic block comprises a random copolymer. The method of treating a bone disease includes administering the polymeric nanocarrier to a subject in need thereof.

公开(公告)号：US20180280568A1

公开(公告)日：2018-10-04

申请号：US15768818

申请日：2016-10-14

申请人： Vanderbilt University

发明人： Scott A. Guelcher ,  Madison A.P. McEnery ,  Mukesh K. Gupta ,  Craig L. Duvall

IPC分类号： A61L27/18 ,  A61L27/46 ,  C08L75/04

摘要： A biodegradable scaffold, a low-molecular weight thioketal, and a method of forming a biodegradable scaffold are provided. The biodegradable scaffold includes a thioketal and an isocyanate, where the thioketal is linked to the isocyanate to form the scaffold. The low-molecular weight thioketal includes 2,2-dimethoxypropane and thioglycolic acid, wherein the thioketal includes at least two hydroxyl terminal groups. The method of forming the biodegradable scaffold includes blending a thioketal with an excess isocyanate, forming a quasi-prepolymer, mixing the thioketal, the quasi-prepolymer, and a ceramic, and then adding a catalyst to form the biodegradable scaffold. The thioketal is a low-molecular weight thioketal having at least two hydroxyl terminal groups.