公开(公告)号：US20180025801A1

公开(公告)日：2018-01-25

申请号：US15521207

申请日：2015-10-22

Applicant: The University of Hull

Inventor： Stephen James Archibald ,  Ping He ,  Stephen John Haswell ,  Nicole Pamme ,  Nathan Joel Brown ,  Mark Duncan Tarn ,  Richard Alexander

IPC: G21G1/00 ,  A61K51/04 ,  B01D57/02

CPC classification number: G21G1/001 ,  A61K51/0491 ,  B01D57/02 ,  G21G2001/0015

Abstract: The present invention relates to a method and an apparatus for separating and recovering a radioisotope from a solution. More particularly, certain embodiments of the invention relate to a method for recovering a radioisotope from a solution by electro-trapping and release using a microfluidic cell (10). The radioisotope may subsequently be used in the preparation of radiopharmaceuticals.

公开(公告)号：US11369955B2

公开(公告)日：2022-06-28

申请号：US15521204

申请日：2015-10-22

Applicant: The University of Hull

Inventor： Stephen James Archibald ,  Ping He ,  Stephen John Haswell ,  Nicole Pamme ,  Nathan Joel Brown ,  Mark Duncan Tarn ,  Richard Alexander ,  Mohammad Mehdi Nasr Esfahani

IPC: G01N33/15 ,  B01L3/00 ,  A61K51/04 ,  G01N31/22 ,  G01N33/94 ,  G01N21/65 ,  G01N33/00

Abstract: Embodiments of the present invention relate to microfluidic devices and systems comprising such devices for use in the determination of sample characteristics. Certain embodiments relate to methods for determining one or more characteristics of a sample comprising a compound for in vivo use. Aptly, certain embodiments of the present invention relate to devices and methods for assessing radiopharmaceuticals and their suitability for administration to a patient in need thereof.

公开(公告)号：US20180033510A1

公开(公告)日：2018-02-01

申请号：US15521205

申请日：2015-10-22

Applicant: The University of Hull

Inventor： Stephen James Archibald ,  Ping He ,  Nathan Joel Brown ,  Mark Duncan Tarn ,  Stephen John Haswell ,  Mohammad Mehdi Nasr Esfahani ,  Nicole Pamme ,  Richard Alexander

IPC: G21G1/00 ,  G01N33/60 ,  B01J39/26 ,  G01N30/74 ,  B01J19/00 ,  B01J20/283 ,  C07B59/00 ,  A61K51/04

CPC classification number: G21G1/0005 ,  A61K51/0491 ,  B01J19/0093 ,  B01J20/283 ,  B01J39/26 ,  C07B59/00 ,  G01N30/74 ,  G01N33/60 ,  G01N2030/77

Abstract: Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.

公开(公告)号：US11559785B2

公开(公告)日：2023-01-24

申请号：US15521198

申请日：2015-10-22

Applicant: The University of Hull

Inventor： Stephen James Archibald ,  Ping He ,  Stephen John Haswell ,  Nicole Pamme ,  Nathan Joel Brown ,  Mark Duncan Tarn ,  Richard Alexander ,  Mohammad Mehdi Nasr Esfahani

IPC: G01N33/15 ,  G01N30/02 ,  B01J20/28 ,  B01J39/26 ,  B01J41/20 ,  B01J20/283 ,  B01J19/00 ,  G21G1/00 ,  B01J20/291 ,  B01L3/00 ,  B01D15/32 ,  B01D15/36 ,  B01J20/02 ,  B01J20/10 ,  B01J20/22 ,  B01J20/282 ,  B01J20/30 ,  B29C45/14 ,  B29C71/02 ,  G01N30/96 ,  G01N33/00 ,  B29K105/00 ,  B29K709/00

Abstract: The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.

公开(公告)号：US11075019B2

公开(公告)日：2021-07-27

申请号：US15521205

申请日：2015-10-22

Applicant: The University of Hull

Inventor： Stephen James Archibald ,  Ping He ,  Nathan Joel Brown ,  Mark Duncan Tarn ,  Stephen John Haswell ,  Mohammad Mehdi Nasr Esfahani ,  Nicole Pamme ,  Richard Alexander

IPC: B01J19/00 ,  C07B59/00 ,  G21G1/00 ,  A61K51/04 ,  B01J20/283 ,  B01J39/26 ,  G01N30/74 ,  G01N33/60 ,  G01N30/00

Abstract: Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.

公开(公告)号：US20180169654A1

公开(公告)日：2018-06-21

申请号：US15521204

申请日：2015-10-22

Applicant: The University of Hull

Inventor： Stephen James Archibald ,  Ping He ,  Stephen John Haswell ,  Nicole Pamme ,  Nathan Joel Brown ,  Mark Duncan Tarn ,  Richard Alexander ,  Mohammad Mehdi Nasr Esfahani

IPC: B01L3/00 ,  G01N31/22 ,  G01N33/15 ,  G01N33/94 ,  A61K51/04

CPC classification number: B01L3/502715 ,  A61K51/0491 ,  B01L3/502738 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2200/143 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/18 ,  B01L2400/0622 ,  G01N21/65 ,  G01N31/221 ,  G01N33/15 ,  G01N33/94 ,  G01N2033/0093

Abstract: Embodiments of the present invention relate to microfluidic devices and systems comprising such devices for use in the determination of sample characteristics. Certain embodiments relate to methods for determining one or more characteristics of a sample comprising a compound for in vivo use. Aptly, certain embodiments of the present invention relate to devices and methods for assessing radiopharmaceuticals and their suitability for administration to a patient in need thereof.

公开(公告)号：US20170368534A1

公开(公告)日：2017-12-28

申请号：US15521198

申请日：2015-10-22

Applicant: The University of Hull

Inventor： Stephen James Archibald ,  Ping He ,  Stephen John Haswell ,  Nicole Pamme ,  Nathan Joel Brown ,  Mark Duncan Tarn ,  Richard Alexander ,  Mohammad Mehdi Nasr Esfahani

IPC: B01J20/28 ,  B01D15/32 ,  G01N30/96 ,  B01D15/36 ,  B01J20/02 ,  B29C71/02 ,  B29C45/14 ,  B01J41/20 ,  B01J39/26 ,  B01J20/30 ,  B01J20/283 ,  B01J20/282 ,  B01J20/22 ,  B01J20/10 ,  G01N33/15 ,  B29K105/00 ,  B29K709/00

CPC classification number: B01J20/28042 ,  B01D15/322 ,  B01D15/362 ,  B01D15/363 ,  B01J19/0093 ,  B01J20/02 ,  B01J20/103 ,  B01J20/22 ,  B01J20/28061 ,  B01J20/28092 ,  B01J20/282 ,  B01J20/283 ,  B01J20/291 ,  B01J20/3007 ,  B01J20/3078 ,  B01J39/26 ,  B01J41/20 ,  B01J2219/0079 ,  B01J2219/00792 ,  B01J2219/00813 ,  B01J2219/00824 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00916 ,  B01J2220/82 ,  B29C45/14 ,  B29C71/02 ,  B29C2071/022 ,  B29K2105/0058 ,  B29K2709/00 ,  G01N30/96 ,  G01N33/15 ,  G21G1/001

Abstract: The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.