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公开(公告)号：US20210382061A1
公开(公告)日：2021-12-09
申请号：US17287349
申请日：2019-10-22
Applicant: THE GENERAL HOSPITAL CORPORATION
Inventor： Seok-Hyun Yun , Paul Dannenberg
IPC: G01N33/58 , C12Q1/6869
Abstract: An apparatus for capturing biological material. The apparatus includes: an optically readable capture particle (ORCP) including: one or more optically readable particles (ORPs) each including an optical barcode to identify the ORCP; and a plurality of biological capture sites associated with the one or more ORPs, each of the plurality of biological capture sites including a cellular barcode to identify the ORCP.
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公开(公告)号：US10952608B2
公开(公告)日：2021-03-23
申请号：US15548264
申请日：2016-09-02
Applicant: The General Hospital Corporation , Intelon Optics, Inc.
Inventor： Jang Lawrence Hyun Yoo , Dominik Jean Michel Beck , Giuliano Scarcelli , Niaz Karim , Seok-Hyun Yun
Abstract: A procedure is performed on at least one section of an ocular component. At least one first electro-magnetic radiation is provided to the section so as to interact with at least one acoustic wave in the ocular component. At least one second electro-magnetic radiation is produced based on the interaction. Multiple portions of the second electromagnetic radiation are received. Each portion was emitted from a different corresponding segment of the section. A visco-elastic modulus of the section is monitored based on the multiple portions during the procedure. Feedback is applied to the procedure based at least in part on the monitored visco-elastic modulus, including at least one of: (1) guiding a trajectory of an incision based on different respective monitored values of visco-elastic modulus for the segments, or (2) determining a number of incisions to be made based on different respective monitored values of visco-elastic modulus for the segments.
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公开(公告)号：US09951269B2
公开(公告)日：2018-04-24
申请号：US14683985
申请日：2015-04-10
Applicant: The General Hospital Corporation
Inventor： Seok-Hyun Yun , Malte C. Gather
IPC: H01S3/16 , C09K11/06 , G01N21/64 , G02B6/138 , H01S3/213 , H01S3/20 , G01N21/77 , G02B6/293 , H01S3/08 , H01S3/094 , H01S3/083
CPC classification number: C09K11/06 , C09K2211/10 , C09K2211/14 , G01N21/645 , G01N21/7746 , G02B6/138 , G02B6/29341 , H01S3/08022 , H01S3/08059 , H01S3/083 , H01S3/094034 , H01S3/094076 , H01S3/168 , H01S3/20 , H01S3/213
Abstract: In one exemplary embodiment, an apparatus can be provided which includes at least one biological medium that causes gain. According to another exemplary embodiment, an arrangement can be provided which is configured to be provided in an anatomical structure. This exemplary arrangement can include at least one emitter having a cross-sectional area of at most 10 microns within the anatomical structure, and which is configured to generate at least one laser radiation. In a further exemplary embodiment, an apparatus can be provided which can include at least one medium which is configured to cause gain; and at least one optical biological resonator which is configured to provide an optical feedback to the medium. In still another exemplary embodiment, a process can be whereas, a solution of an optical medium can be applied to a substrate. Further, it is possible to generate a wave guide having a shape that is defined by (i) at least one property of the solution of the optical medium, or (ii) drying properties thereof.
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4.发明申请公开(公告)号：US20180002398A1
公开(公告)日：2018-01-04
申请号：US15690403
申请日：2017-08-30
Applicant: The General Hospital Corporation
Inventor： Seok-Hyun Yun
IPC: C07K14/705 , G01N21/47 , A61B5/00 , G01J3/44 , G01N21/63
CPC classification number: C07K14/70503 , A61B3/102 , A61B3/117 , A61B5/0059 , A61B5/0066 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0095 , A61B5/0097 , A61B5/4088 , A61B5/412 , A61B5/413 , C07K2319/30 , C07K2319/32 , C07K2319/70 , G01B9/02091 , G01J3/4412 , G01N21/1717 , G01N21/4795 , G01N21/636 , G01N2021/1725 , G01N2021/638 , G01N2201/06 , G01N2201/0612 , G01N2800/042 , G01N2800/387 , G01N2800/7023 , G01N2800/7028 , G02B21/0052
Abstract: Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced based on the acoustic wave. At least one portion of at least one second electro-magnetic radiation can be provided so as to determine information associated with at least one portion of the anatomical sample. In addition, the information based on data associated with the second electro-magnetic radiation can be analyzed. The first electro-magnetic radiation may include at least one first magnitude and at least one first frequency. The second electro-magnetic radiation can include at least one second magnitude and at least one second frequency. The data may relate to a first difference between the first and second magnitudes and/or a second difference between the first and second frequencies. The second difference may be approximately between −100 GHz and 100 GHz, excluding zero.
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5.发明申请公开(公告)号：US20130128274A1
公开(公告)日：2013-05-23
申请号：US13720507
申请日：2012-12-19
Applicant: THE GENERAL HOSPITAL CORPORATION
IPC: G01B9/02
CPC classification number: H01S5/5045 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02002 , G01B9/02004 , G01B9/02043 , G01B9/02075 , G01B9/02081 , G01B9/02083 , G01B9/02084 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0218 , G01J3/0264 , G01J3/453 , G01J9/0215 , G01N21/4795 , G02B6/3604 , G02B26/12 , G02B27/48 , G02F1/093 , G02F1/11 , H01S3/0071 , H01S3/0078 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S3/1068 , H01S5/0071 , H01S5/0078 , H01S5/1025 , H01S5/14 , H01S5/141 , H01S5/146
Abstract: An apparatus and method are provided. In particular, at least one first electro-magnetic radiation may be provided to a sample and at least one second electro-magnetic radiation can be provided to a non-reflective reference. A frequency of the first and/or second radiations varies over time. An interference is detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. Alternatively, the first electro-magnetic radiation and/or second electro-magnetic radiation have a spectrum which changes over time. The spectrum may contain multiple frequencies at a particular time. In addition, it is possible to detect the interference signal between the third radiation and the fourth radiation in a first polarization state. Further, it may be preferable to detect a further interference signal between the third and fourth radiations in a second polarization state which is different from the first polarization state. The first and/or second electro-magnetic radiations may have a spectrum whose mean frequency changes substantially continuously over time at a tuning speed that is greater than 100 Tera Hertz per millisecond.
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Patent Agency Ranking
公开(公告)号：US10800831B2
公开(公告)日：2020-10-13
申请号：US15599662
申请日：2017-05-19
Applicant: The General Hospital Corporation
Inventor： Seok-Hyun Yun
IPC: A61B5/00 , C07K14/705 , G01J3/44 , G01N21/17 , G01N21/63 , G01N21/47 , A61B3/10 , A61B3/117 , G01B9/02 , G02B21/00
Abstract: This disclosure provides systems and methods for mapping and/or measuring a mechanical property of a medium. The mechanical property can be measured by Brillouin spectroscopy. The systems and methods can include a three-dimensional imaging modality that is co-registered with a Brillouin probe beam of a Brillouin spectrometer. The three-dimensional imaging modality can be optical coherence tomography or Scheimpflug camera imaging.
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7.发明授权公开(公告)号：US09812846B2
公开(公告)日：2017-11-07
申请号：US15140125
申请日：2016-04-27
Applicant: The General Hospital Corporation
IPC: H01S3/08 , H01S5/50 , H01S5/00 , H01S5/14 , H01S5/10 , A61B5/00 , G01J3/02 , G01J3/453 , G01N21/47 , G02B27/48 , G01B9/02 , G02B6/36 , G02B26/12 , G02F1/09 , G02F1/11 , H01S3/00 , H01S3/106 , G01J9/02 , H01S3/105
CPC classification number: H01S5/5045 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02002 , G01B9/02004 , G01B9/02043 , G01B9/02075 , G01B9/02081 , G01B9/02083 , G01B9/02084 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0218 , G01J3/0264 , G01J3/453 , G01J9/0215 , G01N21/4795 , G02B6/3604 , G02B26/12 , G02B27/48 , G02F1/093 , G02F1/11 , H01S3/0071 , H01S3/0078 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S3/1068 , H01S5/0071 , H01S5/0078 , H01S5/1025 , H01S5/14 , H01S5/141 , H01S5/146
Abstract: Exemplary apparatus and method are provided. In particular, an electromagnetic radiation can be emitted with, e.g. a light source arrangement. For example, the light source arrangement can include a cavity and a filter, and a spectrum of the electromagnetic radiation can be controlled, e.g., with such cavity and filter, to have a mean frequency that changes (i) at an absolute rate that is greater than about 100 terahertz per millisecond, and (ii) over a range that is greater than about 10 terahertz. Additionally or alternatively, the light source arrangement can include a frequency shifting device which can shift the mean frequency of the electromagnetic radiation.
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公开(公告)号：US20160223842A1
公开(公告)日：2016-08-04
申请号：US14917324
申请日：2014-09-09
Applicant: THE GENERAL HOSPITAL CORPORATION DBA MASSACHUSETTS GENERAL HOSPITAL , POHANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventor： Seok-Hyun Yun , Ehsan Kamrani , Sei Kwang Hahn , Hyemin Kim , Dohee Keum , Keon Jae Lee , Choun-Ki Joo
CPC classification number: G02C11/10 , A61F2/16 , A61F2/1624 , A61F9/0017 , A61F2250/0001 , G02C7/04
Abstract: One aspect of the present disclosure relates to a remotely controllable lens device. The lens device can include a lens material and a circuit physically coupled to the lens material. The circuit can be configured to be powered based on an energy signal from a power source to perform a function (e.g., release of drug, generation of electromagnetic radiation, detection of electromagnetic radiation, and/or control of an optical refractive property). For example, the power source can be an external power source and/or an auto-powered source. The external power source can be, for example, a power source that utilizes synchronized magnetic flux phase coupling (e.g., WiTricity). The auto-powered source can be provided on-site (e.g., on-chip) using a harvesting system (e.g., solar-cell, photo-cell, piezoelectric, etc.)
Abstract translation: 本公开的一个方面涉及一种可远程控制的透镜装置。 透镜装置可以包括透镜材料和物理耦合到透镜材料的电路。 电路可以被配置为基于来自电源的能量信号来供电以执行功能（例如，释放药物，产生电磁辐射，检测电磁辐射和/或控制光学折射特性）。 例如，电源可以是外部电源和/或自动供电源。 外部电源可以是例如利用同步磁通相位耦合（例如，WiTricity）的电源。 可以使用采集系统（例如，太阳能电池，光电池，压电等）在现场（例如，芯片上）提供自动供电的源，
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公开(公告)号：US20240222935A1
公开(公告)日：2024-07-04
申请号：US17905806
申请日：2021-03-12
Inventor： Seok-Hyun Yun , Paul Dannenberg
IPC: H01S5/10
CPC classification number: H01S5/1075 , H01S5/1042 , H01S2301/18
Abstract: A laser microparticle for generating laser light with high omnidirectionality, including: an optical cavity including an active gain material capable of supporting one or more lasing cavity modes: and an optical scattering element which is incorporated into the optical cavity and configured to change a radiation pattern of the one or more lasing cavity modes to increase omnidirectionality of the radiation pattern, the size of the microparticle being less than 10 pm in each dimension.
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公开(公告)号：US20220326080A1
公开(公告)日：2022-10-13
申请号：US17615991
申请日：2020-06-03
Applicant: THE GENERAL HOSPITAL CORPORATION
Inventor： Seok-Hyun Yun , Amira Eltony , Desmond Chow Ming Chia
Abstract: Systems and methods are provided for analyzing a biomechanical property of a medium using stimulated Brillouin scattering microscopy. The method can include a first step of applying a probe beam and pulsed pump beam to a target section of the medium, wherein the pump beam interacts with the probe beam to generate at least one acoustic wave in the medium and at least one Brillouin signal is produced as a result of the generated acoustic wave. The method can also include a second step of receiving the produced Brillouin signal and a third step of determining, using a processor and the
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