-
1.发明公开公开(公告)号：US20240052528A1
公开(公告)日：2024-02-15
申请号：US18491647
申请日：2023-10-20
申请人： Tepha, Inc.
发明人： Amit Ganatra , Fabio Felix , Bhavin Shah , Matthew Bernasconi , Said Rizk , David P. Martin , Simon F. Williams
CPC分类号： D01F6/625 , A61L17/105 , A61L31/06 , A61L31/148 , B29C55/005 , D01F8/14 , D01D5/08 , D02G3/04 , B29K2073/00
摘要： Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawirg the multifilament, yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.
-
公开(公告)号：US20220096716A1
公开(公告)日：2022-03-31
申请号：US17482063
申请日：2021-09-22
申请人： Tepha, Inc.
发明人： Said Rizk , David P. Martin , Fabio Felix , Matthew Bernasconi , Bhavin Shah , Simon F. Williams
摘要： Methods to produce laminates including layers of constructs made from P4HB and copolymers thereof have been developed. These laminates may be used as medical implants, or further processed to make medical implants. The laminates are produced at a temperature equal to or greater than the softening points of the P4HB or copolymers thereof. The layers may include oriented forms of the constructs. Orientation can be preserved during lamination so that the laminate is also oriented, when the laminates are formed at temperatures less than the de-orientation temperatures of the layers. The laminate layers may include, for example, films, textiles, including woven, knitted, braided and non-woven textiles, foams, thermoforms, and fibers. The laminates preferably include one or more oriented P4HB films.
-
公开(公告)号：US10179189B2
公开(公告)日：2019-01-15
申请号：US15599975
申请日：2017-05-19
申请人： Tepha, Inc.
IPC分类号： A61L27/00 , A61L31/00 , A61L27/18 , B29C51/00 , B29C51/42 , A61L31/06 , A61L27/48 , A61L27/50 , A61L27/54 , A61L31/12 , A61L31/14 , A61L31/16 , B29K67/00 , B29L31/00
摘要： Methods to produce thermoforms from P4HB homopolymer and blends thereof have been developed. These thermoforms are produced from films and sheets including P4HB, wherein the intrinsic viscosity of the P4HB is less than 3.5 dl/g, but greater than 0.35 dl/g, and the thermoforms are produced at a temperature equal to or greater than the softening point of P4HB, and more preferably at a temperature higher than the melting point of P4HB. A preferred embodiment includes a P4HB thermoform wherein a film or sheet including a P4HB polymer is thermoformed at a temperature between its melting point and 150° C. In a particularly preferred embodiment the thermoform is a laminate made from a P4HB film and a P4HB mesh.
-
4.发明申请公开(公告)号：US20170081784A1
公开(公告)日：2017-03-23
申请号：US15368922
申请日：2016-12-05
申请人： Tepha, Inc.
发明人： Amit Ganatra , Fabio Felix , Bhavin Shah , Matthew Bernasconi , Said Rizk , David P. Martin , Simon F. Williams
CPC分类号： D01F6/625 , A61L17/105 , A61L31/06 , A61L31/148 , B29C55/005 , B29K2073/00 , B29K2673/00 , B29L2031/731 , D01D5/08 , D01F8/14 , D02G3/04 , D10B2331/04 , D10B2331/041 , D10B2401/063 , D10B2509/04 , D10B2509/08
摘要： Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.
-
5.发明申请公开(公告)号：US20200240044A1
公开(公告)日：2020-07-30
申请号：US16813430
申请日：2020-03-09
申请人： Tepha, Inc.
发明人： Amit Ganatra , Fabio Felix , Bhavin Shah , Matthew Bernasconi , Said Rizk , David P. Martin , Simon F. Williams
IPC分类号： D01F6/62 , A61L17/10 , A61L31/14 , D01D5/08 , B29C55/00 , A61L31/06 , D02G3/04 , D01F8/14 , B29K73/00 , B29K673/00 , B29L31/00
摘要： Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.
-
6.发明申请公开(公告)号：US20180209073A1
公开(公告)日：2018-07-26
申请号：US15924693
申请日：2018-03-19
申请人： Tepha, Inc.
发明人： Amit Ganatra , Fabio Felix , Bhavin Shah , Matthew Bernasconi , Said Rizk , David P. Martin , Simon F. Williams
IPC分类号： D01F6/62 , D01D5/08 , A61L31/06 , A61L31/14 , B29C55/00 , A61L17/10 , D01F8/14 , D02G3/04 , B29K73/00 , B29K673/00 , B29L31/00
CPC分类号： D01F6/625 , A61L17/105 , A61L31/06 , A61L31/148 , B29C55/005 , B29K2073/00 , B29K2673/00 , B29L2031/731 , D01D5/08 , D01F8/14 , D02G3/04 , D10B2331/04 , D10B2331/041 , D10B2401/063 , D10B2509/04 , D10B2509/08
摘要： Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.
-
公开(公告)号：US09655609B2
公开(公告)日：2017-05-23
申请号：US14328210
申请日：2014-07-10
申请人： Tepha, Inc.
CPC分类号： A61B17/0401 , A61B2017/044 , A61B2017/0445 , A61B2017/0464 , A61L31/127 , A61L31/128 , B29C47/0038 , C08L67/04 , C08L23/06
摘要： Compositions and materials for making soft suture anchors comprising materials that improve osteointegration have been developed. These compositions and materials comprise bioceramics, resorbable materials, and combinations thereof. A preferred embodiment comprises a soft suture anchor comprising a resorbable ceramic and a resorbable suture.
-
公开(公告)号：US09149561B2
公开(公告)日：2015-10-06
申请号：US13800853
申请日：2013-03-13
申请人： Tepha, Inc.
发明人： Said Rizk , Dennis W. Connelly , Matthew Bernasconi , Andrew J. Carter , David P. Martin , Simon F. Williams
IPC分类号： A61K47/30 , A61L27/18 , C08G63/06 , B29C45/00 , A61L31/12 , A61L27/44 , A61L27/46 , A61L27/58 , A61L31/14
CPC分类号： A61L27/18 , A61L27/446 , A61L27/46 , A61L27/58 , A61L31/127 , A61L31/128 , A61L31/148 , B29C45/0055 , C08G63/06
摘要： Compositions of P4HB and processes to injection mold these compositions have been developed. These compositions are prepared from P4HB polymers and blends having intrinsic viscosities less than 3.2 dl/g but greater than 0.8 dl/g, moisture contents of less than 0.5% by weight, and more preferably less than 0.05% by weight, and using a polymer melt temperature during molding of at least 150° C. A preferred embodiment comprises a P4HB molding with an intrinsic viscosity of less than 3.2 dl/g that degrades rapidly in vivo.
摘要翻译： 已经开发了P4HB的组合物和注射成型方法。 这些组合物由P4HB聚合物和特性粘度小于3.2dl / g但大于0.8dl / g，水分含量小于0.5wt％，更优选小于0.05wt％的共混物制备，并使用聚合物 成型期间的熔融温度至少为150℃。优选的实施方案包括特性粘度小于3.2dl / g的P4HB模塑，其体内迅速降解。
-
公开(公告)号：US11828006B2
公开(公告)日：2023-11-28
申请号：US16813430
申请日：2020-03-09
申请人： Tepha, Inc.
发明人： Amit Ganatra , Fabio Felix , Bhavin Shah , Matthew Bernasconi , Said Rizk , David P. Martin , Simon F. Williams
IPC分类号： D01F6/62 , A61L17/10 , A61L31/06 , A61L31/14 , B29C55/00 , D01F8/14 , D01D5/08 , D02G3/04 , B29K73/00 , B29L31/00 , B29K673/00
CPC分类号： D01F6/625 , A61L17/105 , A61L31/06 , A61L31/148 , B29C55/005 , D01D5/08 , D01F8/14 , D02G3/04 , B29K2073/00 , B29K2673/00 , B29L2031/731 , D10B2331/04 , D10B2331/041 , D10B2401/063 , D10B2509/04 , D10B2509/08
摘要： Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.
-
10.发明授权公开(公告)号：US10590566B2
公开(公告)日：2020-03-17
申请号：US15924693
申请日：2018-03-19
申请人： Tepha, Inc.
发明人： Amit Ganatra , Fabio Felix , Bhavin Shah , Matthew Bernasconi , Said Rizk , David P. Martin , Simon F. Williams
IPC分类号： A61K9/00 , D01F6/62 , A61L17/10 , A61L31/06 , A61L31/14 , B29C55/00 , D01F8/14 , D01D5/08 , D02G3/04 , B29K73/00 , B29L31/00 , B29K673/00
摘要： Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.
-
-
-
-
-
-
-
-
-
搜索结果
20 条记录 (耗时 0.017 秒)
