公开(公告)号：US20170252481A1

公开(公告)日：2017-09-07

申请号：US15599975

申请日：2017-05-19

Applicant: Tepha, Inc.

Inventor： Matthew Bernasconi ,  Dennis Connelly ,  Said Rizk ,  David P. Martin ,  Simon F. Williams

IPC: A61L27/18 ,  A61L31/12

CPC classification number: A61L27/18 ,  A61L27/48 ,  A61L27/50 ,  A61L27/54 ,  A61L31/06 ,  A61L31/129 ,  A61L31/14 ,  A61L31/16 ,  A61L2430/34 ,  B29C51/002 ,  B29C51/421 ,  B29K2067/04 ,  B29K2995/0056 ,  B29L2031/753 ,  B29L2031/7532 ,  Y10T428/31786 ,  Y10T442/164 ,  C08L67/04

Abstract: Methods to produce thermoforms from P4HB homopolymer and blends thereof have been developed. These thermoforms are produced from films and sheets including P4HB, wherein the intrinsic viscosity of the P4HB is less than 3.5 dl/g, but greater than 0.35 dl/g, and the thermoforms are produced at a temperature equal to or greater than the softening point of P4HB, and more preferably at a temperature higher than the melting point of P4HB. A preferred embodiment includes a P4HB thermoform wherein a film or sheet including a P4HB polymer is thermoformed at a temperature between its melting point and 150° C. In a particularly preferred embodiment the thermoform is a laminate made from a P4HB film and a P4HB mesh.

公开(公告)号：US10179189B2

公开(公告)日：2019-01-15

申请号：US15599975

申请日：2017-05-19

Applicant: Tepha, Inc.

Inventor： Matthew Bernasconi ,  Dennis Connelly ,  Said Rizk ,  David P. Martin ,  Simon F. Williams

IPC: A61L27/00 ,  A61L31/00 ,  A61L27/18 ,  B29C51/00 ,  B29C51/42 ,  A61L31/06 ,  A61L27/48 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  B29K67/00 ,  B29L31/00

Abstract: Methods to produce thermoforms from P4HB homopolymer and blends thereof have been developed. These thermoforms are produced from films and sheets including P4HB, wherein the intrinsic viscosity of the P4HB is less than 3.5 dl/g, but greater than 0.35 dl/g, and the thermoforms are produced at a temperature equal to or greater than the softening point of P4HB, and more preferably at a temperature higher than the melting point of P4HB. A preferred embodiment includes a P4HB thermoform wherein a film or sheet including a P4HB polymer is thermoformed at a temperature between its melting point and 150° C. In a particularly preferred embodiment the thermoform is a laminate made from a P4HB film and a P4HB mesh.

公开(公告)号：US20150057368A1

公开(公告)日：2015-02-26

申请号：US14464099

申请日：2014-08-20

Applicant: TEPHA, INC.

Inventor： Dennis Connelly ,  Fabio Felix ,  David P. Martin ,  Jon Montcrieff ,  Said Rizk ,  Simon F. Williams

IPC: C08J9/12 ,  C08G63/06 ,  A61K47/34 ,  A61K9/12 ,  A61L31/14 ,  A61L15/26 ,  A61L27/18 ,  A61L31/06 ,  A61L15/42 ,  A61L27/56 ,  C08L67/04 ,  A61L26/00

Abstract: Methods to produce substantially closed cell foams with densities less than 0.75 g/cm3, and more preferably less than 0.5 g/cm3, without substantial loss of the polymer's weight average molecular weight, have been developed. The closed cells foams have an open cell content of generally less than 50%, and more preferably an open cell content of less than 20%, and the cells have a maximum diameter of less than 5 mm. The foam may include poly-4-hydroxybutyrate or a copolymer thereof. Preferably, the foam is derived by heating a foam polymer formula to a temperature above the melt temperature of the polymer to form a melt polymer system, adding a blowing agent to produce a foamable melt, extruding the foamable melt through a die to a lower pressure to cause foaming, cooling of the foam, and solidification of the foam. These foam structures can be used for fabrication of medical products.

Abstract translation: 已经开发了生产密度小于0.75g / cm 3，更优选小于0.5g / cm 3的基本上闭合的泡孔的方法，而基本上不损失聚合物的重均分子量。 闭孔泡沫具有通常小于50％的开孔含量，更优选开细胞含量小于20％，细胞的最大直径小于5mm。 泡沫可以包括聚-4-羟基丁酸酯或其共聚物。 优选地，通过将​​泡沫聚合物配方加热到高于聚合物熔体温度的温度得到泡沫，以形成熔体聚合物体系，加入发泡剂以产生可发泡的熔体，将可发泡的熔体通过模头挤出到较低的压力 以引起发泡，泡沫的冷却和泡沫体的固化。 这些泡沫结构可用于制造医疗产品。

公开(公告)号：US09687585B2

公开(公告)日：2017-06-27

申请号：US14464105

申请日：2014-08-20

Applicant: Tepha, Inc.

Inventor： Matthew Bernasconi ,  Dennis Connelly ,  Said Rizk ,  David P. Martin ,  Simon F. Williams

IPC: A61L27/00 ,  A61L31/00 ,  A61L27/18 ,  B29C51/00 ,  B29C51/42 ,  A61L31/06 ,  A61L27/48 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  B29K67/00 ,  B29L31/00

CPC classification number: A61L27/18 ,  A61L27/48 ,  A61L27/50 ,  A61L27/54 ,  A61L31/06 ,  A61L31/129 ,  A61L31/14 ,  A61L31/16 ,  A61L2430/34 ,  B29C51/002 ,  B29C51/421 ,  B29K2067/04 ,  B29K2995/0056 ,  B29L2031/753 ,  B29L2031/7532 ,  Y10T428/31786 ,  Y10T442/164 ,  C08L67/04

Abstract: Methods to produce thermoforms from P4HB homopolymer and blends thereof have been developed. These thermoforms are produced from films and sheets including P4HB, wherein the intrinsic viscosity of the P4HB is less than 3.5 dl/g, but greater than 0.35 dl/g, and the thermoforms are produced at a temperature equal to or greater than the softening point of P4HB, and more preferably at a temperature higher than the melting point of P4HB. A preferred embodiment includes a P4HB thermoform wherein a film or sheet including a P4HB polymer is thermoformed at a temperature between its melting point and 150° C. In a particularly preferred embodiment the thermoform is a laminate made from a P4HB film and a P4HB mesh.

公开(公告)号：US11292885B1

公开(公告)日：2022-04-05

申请号：US16899255

申请日：2020-06-11

Applicant: Tepha, Inc.

Inventor： Dennis Connelly ,  Fabio Felix ,  David P. Martin ,  Jon Montcrieff ,  Said Rizk ,  Simon F. Williams

IPC: C08J9/12 ,  A61K47/34 ,  A61L15/26 ,  A61L15/42 ,  A61L26/00 ,  A61L27/18 ,  A61L27/56 ,  A61L31/06 ,  A61L31/14 ,  C08G63/06 ,  C08L67/04 ,  A61K9/12

Abstract: Methods to produce substantially closed cell foams with densities less than 0.75 g/cm3, and more preferably less than 0.5 g/cm3, without substantial loss of the polymer's weight average molecular weight, have been developed. The closed cells foams have an open cell content of generally less than 50%, and more preferably an open cell content of less than 20%, and the cells have a maximum diameter of less than 5 mm. The foam may include poly-4-hydroxybutyrate or a copolymer thereof. Preferably, the foam is derived by heating a foam polymer formula to a temperature above the melt temperature of the polymer to form a melt polymer system, adding a blowing agent to produce a foamable melt, extruding the foamable melt through a die to a lower pressure to cause foaming, cooling of the foam, and solidification of the foam. These foam structures can be used for fabrication of medical products.

公开(公告)号：US10689498B2

公开(公告)日：2020-06-23

申请号：US14464099

申请日：2014-08-20

Applicant: Tepha, Inc.

Inventor： Dennis Connelly ,  Fabio Felix ,  David P. Martin ,  Jon Montcrieff ,  Said Rizk ,  Simon F. Williams

IPC: C08J9/12 ,  A61K9/12 ,  A61K47/34 ,  A61L15/26 ,  A61L15/42 ,  A61L26/00 ,  A61L27/18 ,  A61L31/06 ,  A61L31/14 ,  C08G63/06 ,  C08L67/04 ,  A61L27/56

Abstract: Methods to produce substantially closed cell foams with densities less than 0.75 g/cm3, and more preferably less than 0.5 g/cm3, without substantial loss of the polymer's weight average molecular weight, have been developed. The closed cells foams have an open cell content of generally less than 50%, and more preferably an open cell content of less than 20%, and the cells have a maximum diameter of less than 5 mm. The foam may include poly-4-hydroxybutyrate or a copolymer thereof. Preferably, the foam is derived by heating a foam polymer formula to a temperature above the melt temperature of the polymer to form a melt polymer system, adding a blowing agent to produce a foamable melt, extruding the foamable melt through a die to a lower pressure to cause foaming, cooling of the foam, and solidification of the foam. These foam structures can be used for fabrication of medical products.

公开(公告)号：US20150056131A1

公开(公告)日：2015-02-26

申请号：US14464105

申请日：2014-08-20

Applicant: Tepha, Inc.

Inventor： Matthew Bernasconi ,  Dennis Connelly ,  Said Rizk ,  David P. Martin ,  Simon F. Williams

IPC: A61L27/18 ,  B29C51/42 ,  A61L31/06 ,  B29C51/00

CPC classification number: A61L27/18 ,  A61L27/48 ,  A61L27/50 ,  A61L27/54 ,  A61L31/06 ,  A61L31/129 ,  A61L31/14 ,  A61L31/16 ,  A61L2430/34 ,  B29C51/002 ,  B29C51/421 ,  B29K2067/04 ,  B29K2995/0056 ,  B29L2031/753 ,  B29L2031/7532 ,  Y10T428/31786 ,  Y10T442/164 ,  C08L67/04

Abstract: Methods to produce thermoforms from P4HB homopolymer and blends thereof have been developed. These thermoforms are produced from films and sheets including P4HB, wherein the intrinsic viscosity of the P4HB is less than 3.5 dl/g, but greater than 0.35 dl/g, and the thermoforms are produced at a temperature equal to or greater than the softening point of P4HB, and more preferably at a temperature higher than the melting point of P4HB. A preferred embodiment includes a P4HB thermoform wherein a film or sheet including a P4HB polymer is thermoformed at a temperature between its melting point and 150° C. In a particularly preferred embodiment the thermoform is a laminate made from a P4HB film and a P4HB mesh.

Abstract translation: 已经开发了从P4HB均聚物及其共混物生产热成型体的方法。 这些热成型体由包括P4HB在内的薄膜和片材生产，其中P4HB的特性粘度小于3.5dl / g，但大于0.35dl / g，并且在等于或大于软化点的温度下生产热成型 的P4HB，更优选在高于P4HB的熔点的温度下进行。 优选的实施方案包括P4HB热成型体，其中包含P4HB聚合物的膜或片材在其熔点和150℃之间的温度下热成型。在特别优选的实施方案中，热成型体是由P4HB膜和P4HB网制成的层压体。