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    CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS V
    4.
    发明申请
    CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS V 有权
    羧酰胺化合物及其作为钙抑制剂V

    公开(公告)号：US20140005227A1

    公开(公告)日：2014-01-02

    申请号：US13992582

    申请日：2011-12-08

    申请人： Andreas Kling ,  Katja Jantos ,  Helmut Mack ,  Achim Moller ,  Wilfried Hornberger ,  Yanbin Lao ,  Gisela Backfisch ,  Marjoleen Nijsen

    发明人： Andreas Kling ,  Katja Jantos ,  Helmut Mack ,  Achim Moller ,  Wilfried Hornberger ,  Yanbin Lao ,  Gisela Backfisch ,  Marjoleen Nijsen

    IPC分类号： C07D401/04

    CPC分类号： C07D401/04 ,  A61K31/4439 ,  C07D401/14 ,  Y02A50/411

    摘要： The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula (I) in which R1, R2, R3, R4, X, m and n have the meanings mentioned in the claims and the description, the tautomers thereof, the hydrates thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein R1 is optionally substituted benzyl or hetaryl-methyl, X is a single bond or an oxygen atom, R2 is C1-C4-alkyl, C1-C4-haloalkyl, C2-C4-alkenyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C2-alkyl, C3-C6-heterocycloalkyl-C1-C2-alkyl, phenyl, phenyl-C1-C3-alkyl, pyridin-2-yl-C1-C3-alkyl or CH2—C(O)OCH3, R3 and R4 independently of one another are halogen, CN, CF3, CHF2, CH2F, C1-C2-alkyl or C1-C2-alkoxy, and m and n independently of one another are 0 or 1.

    摘要翻译： 本发明涉及新的羧酰胺化合物及其用于制备药物的用途。 羧酰胺化合物是钙蛋白酶（钙依赖性半胱氨酸蛋白酶）的抑制剂。 因此，本发明还涉及这些羧酰胺化合物用于治疗与升高的钙蛋白酶活性相关的病症的用途。 羧酰胺化合物是通式（I）的化合物，其中R 1，R 2，R 3，R 4，X，m和n具有权利要求书和描述中所述的含义，其互变异构体，其水合物和药学上合适的盐 其中。 在这些化合物中，优选其中R 1为任选取代的苄基或杂芳基 - 甲基，X为单键或氧原子，R 2为C 1 -C 4烷基，C 1 -C 4卤代烷基，C 2 -C 4 - 烯基，C 3 -C 6 环烷基，C 3 -C 6环烷基-C 1 -C 2烷基，C 3 -C 6杂环烷基-C 1 -C 2烷基，苯基，苯基-C 1 -C 3 - 烷基，吡啶-2-基-C 1 -C 3 - 烷基或CH 2 -C（O）OCH 3，R 3和R 4彼此独立地是卤素，CN，CF 3，CHF 2，CH 2 F，C 1 -C 2 - 烷基或C 1 -C 2 - 烷氧基，m和n彼此独立地为0或1。

    Method For Producing Metal Nanoparticles In Polyols
    7.
    发明申请
    Method For Producing Metal Nanoparticles In Polyols 审中-公开
    在多元醇中生产金属纳米粒子的方法

    公开(公告)号：US20110132144A1

    公开(公告)日：2011-06-09

    申请号：US13003785

    申请日：2009-07-15

    申请人： Jochen Mezger ,  Laurent Marc ,  Simone Klapdohr ,  Burkhard Walther ,  Zhizhong Cai ,  Tobias Austermann ,  Silke Flakus ,  Helmut Mack

    发明人： Jochen Mezger ,  Laurent Marc ,  Simone Klapdohr ,  Burkhard Walther ,  Zhizhong Cai ,  Tobias Austermann ,  Silke Flakus ,  Helmut Mack

    IPC分类号： B22F9/18 ,  B22F9/00 ,  B82Y40/00

    CPC分类号： B22F9/24

    摘要： The invention relates to a process for the preparation of metal nanoparticles, selected from the group consisting of lead, bismuth, zinc, antimony, indium, gold, nickel, cobalt, palladium, platinum, iridium, osmium, rhodium, ruthenium, rhenium, vanadium, chromium, manganese, niobium, molybdenum, tungsten, tantalum, cadmium, silver and/or copper, on a rotating body, characterized in that a reduction of corresponding metal salts, corresponding metal salt complexes, corresponding metal hydroxides and/or corresponding metal oxides by polyols having a number of hydroxyl groups in the polyol of 1 to 10 and a molecular weight of the polyols of 2000 to 18 000 Da is effected.

    摘要翻译： 本发明涉及一种选自铅，铋，锌，锑，铟，金，镍，钴，钯，铂，铱，锇，铑，钌，铼，钒的金属纳米颗粒的制备方法 ，铬，锰，铌，钼，钨，钽，镉，银和/或铜，其特征在于相应的金属盐，相应的金属盐络合物，相应的金属氢氧化物和/或相应的金属氧化物的还原 通过在多元醇中具有多个羟基的多元醇为1至10，多元醇的分子量为2000至18000Da。

    METHOD AND DEVICE FOR THE TREATMENT OF SURFACES
    8.
    发明申请
    METHOD AND DEVICE FOR THE TREATMENT OF SURFACES 审中-公开
    用于处理表面的方法和装置

    公开(公告)号：US20100275950A1

    公开(公告)日：2010-11-04

    申请号：US12741861

    申请日：2008-12-09

    申请人： Helmut Mack ,  Tobias Austermann ,  Martin Ebner ,  Michael Leck ,  Wolfgang Viöl

    发明人： Helmut Mack ,  Tobias Austermann ,  Martin Ebner ,  Michael Leck ,  Wolfgang Viöl

    IPC分类号： C03C23/00 ,  C23F1/08

    CPC分类号： H05H1/2406 ,  H05H2001/2412 ,  H05H2245/125

    摘要： The invention relates to a device and a method for the treatment of surfaces with a plasma produced under atmospheric pressure. The device according to the invention is formed as a portable handheld unit and comprises a plasma nozzle (16) for producing a plasma jet (18), which comprises a nozzle opening (17) and at least one electrode and counter-electrode pair (27, 28) arranged upstream of the nozzle opening, the effective electrode surfaces of which pair of electrodes each have a dielectric coating (29, 30), the electrode (27) and the counter-electrode (28) defining between them a working space (34) in which a working gas can be at least partially ionized by means of a dielectric barrier gas discharge, a high-voltage generator (19, 20), which is electrically connected to the electrode and counter-electrode pair (27, 28), a feeding means (15), which produces a gas flow of the working gas from a working gas source into the working space (34) and through the nozzle opening (17), the working gas source being ambient air, and a mains-independent energy source (12) for supplying the high-voltage generator (19, 20) and the feeding means (19).

    摘要翻译： 本发明涉及用于在大气压下产生的等离子体处理表面的装置和方法。 根据本发明的装置形成为便携式手持单元，并且包括用于产生等离子体射流（18）的等离子体喷嘴（16），其包括喷嘴开口（17）和至少一个电极和对电极对（27 ，28）布置在所述喷嘴开口的上游，所述有效电极表面的一对电极各自具有电介质涂层（29,30），所述电极（27）和所述对电极（28）在它们之间限定工作空间 34），其中工作气体可以通过介电阻挡气体放电至少部分地离子化，电连接到电极和对电极对（27,28）的高压发生器（19,20） （15），其将工作气体从工作气体源产生气体流入工作空间（34）并通过喷嘴开口（17），工作气体源是环境空气，以及主干 - 用于供应高压发生器（19,20）的独立能量源（12） 和进给装置（19）。

    Additive Comprising Azomethine Compounds
    10.
    发明申请
    Additive Comprising Azomethine Compounds 有权
    包括偶氮甲碱化合物的添加剂

    公开(公告)号：US20090166581A1

    公开(公告)日：2009-07-02

    申请号：US12282508

    申请日：2007-02-15

    申请人： Helmut Mack

    发明人： Helmut Mack

    IPC分类号： C09K3/00

    CPC分类号： C08G77/26 ,  C08K5/29 ,  C08K5/5465 ,  C08L83/08

    摘要： The present invention relates to a mixture of an oligomeric, blocked aminosilane (azomethine structure) and a monomeric, blocked, primary amine (azomethine structure). This mixture is suitable in particular as a curing agent, crosslinker and adhesion promoter.

    摘要翻译： 本发明涉及低聚封闭的氨基硅烷（偶氮甲碱结构）和单体封闭的伯胺（偶氮甲碱结构）的混合物。 该混合物特别适合作为固化剂，交联剂和粘合促进剂。