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1.发明授权Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 失效乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用公开(公告)号：US08748627B2
公开(公告)日：2014-06-10
申请号：US11675410
申请日：2007-02-15
Applicant: Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard F. Clark , Tianyuan Zhang , Qun Li , Todd M. Hansen , Hing Sham , Bruce A. Beutel , Heidi S. Camp , Xiaojun Wang
Inventor： Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard F. Clark , Tianyuan Zhang , Qun Li , Todd M. Hansen , Hing Sham , Bruce A. Beutel , Heidi S. Camp , Xiaojun Wang
IPC: A61K31/427 , A61K31/433 , A61K31/4245 , A61K31/4439 , A61K31/444 , C07D417/12 , C07D417/14 , C07D417/04 , C07D413/12 , C07D413/14
CPC classification number: C07D277/34 , C07D261/08 , C07D277/56 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
Abstract translation: 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。
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公开(公告)号：US08586594B2
公开(公告)日：2013-11-19
申请号：US13484539
申请日：2012-05-31
Applicant: Andrew J. Souers , Ju Gao , Todd M. Hansen , Rajesh R. Iyengar , Philip R. Kym , Bo Liu , Zhonghua Pei , Vince S. Yeh , Gang Zhao , Zhili Xin
Inventor： Andrew J. Souers , Ju Gao , Todd M. Hansen , Rajesh R. Iyengar , Philip R. Kym , Bo Liu , Zhonghua Pei , Vince S. Yeh , Gang Zhao , Zhili Xin
IPC: A61K31/519 , A61P3/04 , A61P3/10 , A61K31/4152 , C07D487/04 , C07D231/20
CPC classification number: C07D487/04 , C07C59/54 , C07C275/42 , C07D211/60 , C07D231/12 , C07D231/20 , C07D249/08 , C07D263/48 , C07D277/40 , C07D401/04 , C07D407/12 , C07D407/14 , C07D413/12 , C07D413/14
Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Pharmaceutical compositions of formula (I) and related methods for treating or preventing metabolic diseases or conditions.
Abstract translation: 式（I）化合物或其药学上可接受的盐，前药，前药的盐或其组合。 式（I）的药物组合物和治疗或预防代谢疾病或病症的相关方法。
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3.发明授权Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases 有权凋亡诱导剂用于治疗癌症和免疫和自身免疫性疾病公开(公告)号：US08546399B2
公开(公告)日：2013-10-01
申请号：US12787682
申请日：2010-05-26
Applicant: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: A61K31/407 , C07D401/12
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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4.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号：US20120190688A1
公开(公告)日：2012-07-26
申请号：US13430610
申请日：2012-03-26
Applicant: Milan Bruncko , Hong Ding , George A. Doherly , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
Inventor： Milan Bruncko , Hong Ding , George A. Doherly , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
IPC: A61K31/496 , A61P37/00 , A61P35/02 , C07D471/04 , A61P35/00
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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5.发明申请APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号：US20100305122A1
公开(公告)日：2010-12-02
申请号：US12787682
申请日：2010-05-26
Applicant: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
IPC: A61K31/5377 , A61P35/00 , A61P35/04 , C07D471/04 , A61K31/496
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20100298321A1
公开(公告)日：2010-11-25
申请号：US12793418
申请日：2010-06-03
Applicant: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC: A61K31/5377 , A61P35/04 , A61K31/497 , A61K31/4439 , A61K31/415 , A61K31/405 , A61K31/18 , C07D413/02 , C07D413/12 , C07D413/14 , C07D401/12 , C07D235/04 , C07D209/04 , C07C311/00 , A61P35/00
CPC classification number: C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US20090263407A1
公开(公告)日：2009-10-22
申请号：US12425254
申请日：2009-04-16
Applicant: Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Carol K. Wada , Lu Tian , Xiaobin Zhao
Inventor： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Carol K. Wada , Lu Tian , Xiaobin Zhao
IPC: A61K47/18 , C07D207/08 , C07D317/26 , C07D317/28 , C07C229/34 , C07C217/48 , C07C217/28 , A61K47/22 , A61K31/7088 , A61K31/7105 , A61K39/00 , A61K38/02
CPC classification number: C07D207/08 , A61K9/1271 , A61K9/1272 , C07C205/43 , C07C217/28 , C07C235/08 , C07C271/16 , C07D211/22 , C07D233/54 , C07D241/12 , C07D243/08 , C07D265/30 , C07D317/28 , C07D403/04
Abstract: Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
Abstract translation: 公开了阳离子脂质，基于阳离子脂质的药物递送系统，其制备方法和使用它们治疗疾病的方法。
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8.发明授权公开(公告)号：US08586754B2
公开(公告)日：2013-11-19
申请号：US12793418
申请日：2010-06-03
Applicant: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC: C07D209/32 , C07D401/10
CPC classification number: C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US08580794B2
公开(公告)日：2013-11-12
申请号：US12951344
申请日：2010-11-22
Applicant: George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Andrew J. Souers , Zhi-Fu Tao , Gary T. Wang , Le Wang , Robert Mantei , Todd M. Hansen
Inventor： George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Andrew J. Souers , Zhi-Fu Tao , Gary T. Wang , Le Wang , Robert Mantei , Todd M. Hansen
IPC: A61K31/407 , C07D401/12
CPC classification number: C07D471/04 , C07D491/052 , C07D519/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US20120122842A1
公开(公告)日：2012-05-17
申请号：US13294303
申请日：2011-11-11
Applicant: Michael L. Curtin , Bryan K. Sorensen , Howard R. Heyman , Richard F. Clark , Kevin R. Woller , Omar J. Shah , Michael Michaelides , Chris Tse , Anil Vasudevan , Helmut Mack , Todd M. Hansen , Ramzi Sweis , Marina A. Pliushchev
Inventor： Michael L. Curtin , Bryan K. Sorensen , Howard R. Heyman , Richard F. Clark , Kevin R. Woller , Omar J. Shah , Michael Michaelides , Chris Tse , Anil Vasudevan , Helmut Mack , Todd M. Hansen , Ramzi Sweis , Marina A. Pliushchev
IPC: A61K31/541 , C07D491/048 , C07D401/14 , C07D401/12 , C07D495/04 , C07D403/14 , C07D405/12 , C07D403/12 , C07D417/12 , A61K31/4035 , A61K31/496 , A61K31/4439 , A61K31/501 , A61K31/4155 , A61P9/12 , A61P9/04 , A61P9/00 , A61P13/12 , A61P9/10 , A61P11/06 , A61P15/10 , A61P15/00 , A61P13/10 , A61P25/00 , A61P29/00 , A61P25/28 , A61P25/16 , A61P19/02 , A61P19/08 , A61P1/00 , A61P17/06 , A61P35/00 , A61P35/04 , A61P31/12 , A61P31/04 , A61P3/10 , A61P25/24 , A61P25/18 , A61P25/08 , A61P35/02 , A61P11/00 , C07D209/44
CPC classification number: C07D209/44 , A61K31/437 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.
Abstract translation: 公开了抑制NAMPT活性的化合物，含有该化合物的组合物和治疗其中NAMPT表达的疾病的方法。 公开了抑制ROCK活性的化合物，含有化合物的组合物和治疗ROCK表达疾病的方法。
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