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公开(公告)号：US09044387B2
公开(公告)日：2015-06-02
申请号：US12742357
申请日：2008-11-19
Applicant: Xiaobin Zhao , Kevin Alexander Burd
Inventor： Xiaobin Zhao , Kevin Alexander Burd
IPC: A61K31/722 , A61P15/02 , A61K9/00 , A61P15/08 , A61K31/728
CPC classification number: A61K9/0034 , A61K31/722 , A61K31/728
Abstract: A vaginal lubricant comprising high molecular weight hyaluronic acid combined with low molecular weight hyaluronic acid and/or chitosan which has improved stability and which has applications in, for example, maintaining and/or promoting sperm motility.
Abstract translation: 包含高分子量透明质酸与低分子量透明质酸和/或壳聚糖结合的阴道润滑剂，其具有改善的稳定性并且可用于例如维持和/或促进精子活力。
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2.发明授权公开(公告)号：US08080641B2
公开(公告)日：2011-12-20
申请号：US12409361
申请日：2009-03-23
Applicant: Xiaobin Zhao
Inventor： Xiaobin Zhao
CPC classification number: A61L27/34 , A61L27/20 , A61L29/085 , C08B37/0072 , C08L5/08
Abstract: The present invention relates to a process for the production of cross-linked hyaluronic acid (HA) derivatives, in particular multiple, e.g. double cross-linked hyaluronic acid derivatives. The invention also provides novel cross-linked HA derivatives, products containing them and their uses in medical and pharmaceutical and cosmetic applications.
Abstract translation: 本发明涉及制备交联透明质酸（HA）衍生物的方法，特别是多种，例如， 双交联透明质酸衍生物。 本发明还提供新颖的交联HA衍生物，含有它们的产品及其在医药和制药和化妆品应用中的用途。
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公开(公告)号：US20090263407A1
公开(公告)日：2009-10-22
申请号：US12425254
申请日：2009-04-16
Applicant: Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Carol K. Wada , Lu Tian , Xiaobin Zhao
Inventor： Prasad A. Dande , Todd M. Hansen , Robert D. Hubbard , Carol K. Wada , Lu Tian , Xiaobin Zhao
IPC: A61K47/18 , C07D207/08 , C07D317/26 , C07D317/28 , C07C229/34 , C07C217/48 , C07C217/28 , A61K47/22 , A61K31/7088 , A61K31/7105 , A61K39/00 , A61K38/02
CPC classification number: C07D207/08 , A61K9/1271 , A61K9/1272 , C07C205/43 , C07C217/28 , C07C235/08 , C07C271/16 , C07D211/22 , C07D233/54 , C07D241/12 , C07D243/08 , C07D265/30 , C07D317/28 , C07D403/04
Abstract: Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
Abstract translation: 公开了阳离子脂质，基于阳离子脂质的药物递送系统，其制备方法和使用它们治疗疾病的方法。
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4.发明授权公开(公告)号：US07385052B2
公开(公告)日：2008-06-10
申请号：US09920286
申请日：2001-08-02
Applicant: Xiaobin Zhao
Inventor： Xiaobin Zhao
IPC: C07H5/04 , C07H5/06 , C08B37/00 , A01N43/04 , A61K31/715
CPC classification number: A61L27/34 , A61L27/20 , A61L29/085 , C08B37/0072 , C08L5/08
Abstract: The present invention relates to a process for the production of cross-linked hyaluronic acid (HA) derivatives, in particular multiple, e.g. double cross-linked hyaluronic acid derivatives. The invention also provides novel cross-linked HA derivatives, products containing them and their uses in medical and pharmaceutical and cosmetic applications.
Abstract translation: 本发明涉及制备交联透明质酸（HA）衍生物的方法，特别是多种，例如， 双交联透明质酸衍生物。 本发明还提供新颖的交联HA衍生物，含有它们的产品及其在医药和制药和化妆品应用中的用途。
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公开(公告)号：US07226972B2
公开(公告)日：2007-06-05
申请号：US10756351
申请日：2004-01-14
Applicant: Xiaobin Zhao , Catherine Alexander , Jane Fraser
Inventor： Xiaobin Zhao , Catherine Alexander , Jane Fraser
IPC: C08G73/00
CPC classification number: A61Q19/00 , A61K8/735 , A61K2800/594 , A61L15/28 , A61L27/20 , C08B37/0072 , C08L5/08
Abstract: The present invention provides a process for the production of hyaluronic acid (HA) derivatives cross-linked with another polymer, in particular multiple e.g. double cross-linked hyaluronic acid derivatives. The invention also provides novel cross-linked derivatives, products containing them and their uses in cosmetic, medical and pharmaceutical applications.
Abstract translation: 本发明提供了一种制备与另一种聚合物交联的透明质酸（HA）衍生物的方法， 双交联透明质酸衍生物。 本发明还提供新颖的交联衍生物，含有它们的产品及其在化妆品，医药和药物应用中的用途。
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Patent Agency Ranking
公开(公告)号：US20100284937A1
公开(公告)日：2010-11-11
申请号：US12742357
申请日：2008-11-19
Applicant: Xiaobin Zhao , Kevin Alexander Burd
Inventor： Xiaobin Zhao , Kevin Alexander Burd
IPC: G01F11/00 , A61K31/715 , A61K31/7088 , A61K9/12
CPC classification number: A61K9/0034 , A61K31/722 , A61K31/728
Abstract: A vaginal lubricant comprising high molecular weight hyaluronic acid combined with low molecular weight hyaluronic acid and/or chitosan which has improved stability and which has applications in, for example, maintaining and/or promoting sperm motility.
Abstract translation: 包含高分子量透明质酸与低分子量透明质酸和/或壳聚糖结合的阴道润滑剂，其具有改善的稳定性并且可用于例如维持和/或促进精子活力。
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公开(公告)号：US20100143490A1
公开(公告)日：2010-06-10
申请号：US12438385
申请日：2007-08-21
Applicant: Gareth Roberts , Robert Daniels , Xiaobin Zhao , Ian Thompson
Inventor： Gareth Roberts , Robert Daniels , Xiaobin Zhao , Ian Thompson
CPC classification number: A61L26/0004 , A61F2/0077 , A61F2/30767 , A61L15/18 , A61L15/32 , A61L26/0042 , A61L26/0047 , A61L26/0095 , A61L27/10 , A61L27/227 , A61L27/32 , A61L27/34 , A61L27/446 , A61L27/54 , A61L29/085 , A61L31/10 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/802
Abstract: The present invention provides a composite material comprising lactoferrin and a bioactive glass. The invention also relates to pharmaceutical compositions containing the composite material. Further aspects of the invention relate to the use of the composite material of the for treating a wound, treating or preventing bacterial or viral infections in a wound, preventing viral transmission, regenerating bone, treating osteoporosis, preventing or alleviating bleeding in a wound, sterilising a wound and/or controlling haemorrhaging.
Abstract translation: 本发明提供了包含乳铁蛋白和生物活性玻璃的复合材料。 本发明还涉及含有复合材料的药物组合物。 本发明的其它方面涉及用于治疗伤口，治疗或预防伤口中细菌或病毒感染的复合材料的用途，防止病毒传播，再生骨，治疗骨质疏松症，预防或减轻伤口出血，灭菌 伤口和/或控制性出血。
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公开(公告)号：US20100022655A1
公开(公告)日：2010-01-28
申请号：US12302953
申请日：2007-06-01
Applicant: John C. Byrd , Danilo Perrotti , Ching-Shih Chen , James T. Dalton , Frank Frissora , Xiaobin Zhao , Qing Liu , Natarajan Muthusamy
Inventor： John C. Byrd , Danilo Perrotti , Ching-Shih Chen , James T. Dalton , Frank Frissora , Xiaobin Zhao , Qing Liu , Natarajan Muthusamy
IPC: A61K31/137 , A61P35/02
CPC classification number: A61K31/137 , A61K45/06
Abstract: Methods—for treatment and prevention of lymphoid malignancies, including, but not limited to acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), B-cell lymphoma, Acute Myeloid leukemia (AML), and mantle cell lymphoma (MCL). The methods include administration of a therapeutically effective amount of FTY720 (2-Amino-2-[2-(4-octylphenyl)ethyl]propane 1,3-diol hydrochloride) or a derivative, pharmaceutically acceptable salt thereof, or a prodrug thereof to a subject.
Abstract translation: 方法 - 用于治疗和预防淋巴恶性肿瘤，包括但不限于急性淋巴细胞性白血病（ALL），慢性淋巴细胞性白血病（CLL），B细胞淋巴瘤，急性骨髓性白血病（AML）和外套细胞淋巴瘤（MCL）。 所述方法包括将治疗有效量的FTY720（2-氨基-2- [2-（4-辛基苯基）乙基]丙烷-1,3-二醇盐酸盐）或其衍生物，药学上可接受的盐或其前药给予 课程。
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公开(公告)号：US07514541B2
公开(公告)日：2009-04-07
申请号：US11185575
申请日：2005-07-19
Applicant: Xiaobin Zhao
Inventor： Xiaobin Zhao
CPC classification number: A61L27/34 , A61L27/20 , A61L29/085 , C08B37/0072 , C08L5/08
Abstract: The present invention relates to a process for the production of cross-linked hyaluronic acid (HA) derivatives, in particular multiple, e.g. double cross-linked hyaluronic acid derivatives. The invention also provides novel cross-linked HA derivatives, products containing them and their uses in medical and pharmaceutical and cosmetic applications.
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10.发明申请公开(公告)号：US20110262489A1
公开(公告)日：2011-10-27
申请号：US13063280
申请日：2009-09-09
Applicant: Xiaobin Zhao
Inventor： Xiaobin Zhao
IPC: A61K31/738 , A61Q19/08 , A61P17/02 , A61K9/00 , A61K8/73
CPC classification number: A61K9/06 , A61K9/0021 , A61K31/728
Abstract: There is provided a process for preparing a HA cryogel, the process comprising the steps of combining HA, a cross-linking agent and a solvent to form a solution, freezing the solution before the formation of less than 10% of the cross-linking bonds of the cross-linked HA cryogel formed and thawing the solution. An HA cryogel is also provided, in particular an HA cryogel obtained from this process.
Abstract translation: 提供了一种制备HA冷冻凝胶的方法，该方法包括以下步骤：将HA，交联剂和溶剂混合以形成溶液，在形成少于10％的交联键之前冷冻溶液 的交联HA冷冻凝胶形成并解冻溶液。 还提供了HA冷冻凝胶，特别是从该方法获得的HA冷冻凝胶。
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