专利检索 ap:"Bryan K. Sorensen" 第 1 页

1.

发明授权
Imidazopyridines as a novel scaffold for multi-targeted kinase inhibition 有权
标题翻译：咪唑并吡啶作为多靶向激酶抑制的新型支架

公开(公告)号：US09051315B2

公开(公告)日：2015-06-09

申请号：US12906681

申请日：2010-10-18

申请人： Nwe Y. Ba-maung , Richard F. Clark , Scott A. Erickson , Steve D. Fidanze , Megumi Kawai , Robert A. Mantei , George S. Sheppard , Bryan K. Sorensen , Gary T. Wang

发明人： Nwe Y. Ba-maung , Richard F. Clark , Scott A. Erickson , Steve D. Fidanze , Megumi Kawai , Robert A. Mantei , George S. Sheppard , Bryan K. Sorensen , Gary T. Wang

IPC分类号： A61K31/55 , A61K31/535 , A61K31/497 , C07D223/14 , C07D413/04 , C07D239/02 , C07D471/04

CPC分类号： C07D471/04

摘要： Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

摘要翻译： 公开了抑制蛋白激酶的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。

2.

发明申请
INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME 有权

公开(公告)号：US20150065508A1

公开(公告)日：2015-03-05

申请号：US14226615

申请日：2014-03-26

申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh

发明人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh

IPC分类号： C07C235/14 , C07C235/22 , C07C271/28 , C07D295/088 , C07D207/48 , C07D257/04 , C07D401/04 , C07D261/08 , C07C237/24 , C07C311/46

CPC分类号： C07C235/14 , A61K31/165 , A61K31/19 , A61K31/4439 , C07C235/22 , C07C237/24 , C07C271/28 , C07C311/46 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/48 , C07D257/04 , C07D261/08 , C07D295/088 , C07D401/04

摘要： The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

3.

发明授权
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme 有权
标题翻译： 11-β-羟基类固醇脱氢酶1型酶的抑制剂

公开(公告)号：US08716345B2

公开(公告)日：2014-05-06

申请号：US13530422

申请日：2012-06-22

申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh

发明人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh

IPC分类号： A61K31/16 , C07C239/00

CPC分类号： C07C235/14 , A61K31/165 , A61K31/19 , A61K31/4439 , C07C235/22 , C07C237/24 , C07C271/28 , C07C311/46 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/48 , C07D257/04 , C07D261/08 , C07D295/088 , C07D401/04

摘要： The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

摘要翻译： 本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征，中枢神经系统疾病和疾病中的用途，以及与过量糖皮质激素有关的病症。

4.

发明授权
Pyrimidine inhibitors of kinase activity 失效
标题翻译：嘧啶抑制剂激酶活性

公开(公告)号：US08536180B2

公开(公告)日：2013-09-17

申请号：US12787915

申请日：2010-05-26

申请人： Richard F. Clark , Nwe Y. Ba-maung , Scott A. Erickson , Steve D. Fidanze , Robert A. Mantei , George S. Sheppard , Bryan K. Sorensen , Gary T. Wang , Jieyi Wang , Randy L. Bell

发明人： Richard F. Clark , Nwe Y. Ba-maung , Scott A. Erickson , Steve D. Fidanze , Robert A. Mantei , George S. Sheppard , Bryan K. Sorensen , Gary T. Wang , Jieyi Wang , Randy L. Bell

IPC分类号： A61K31/497 , A61K31/535 , A61K31/505 , C07D413/14 , C07D403/14

CPC分类号： C07D471/04 , C07D403/14 , C07D487/04 , C07D513/04

摘要： Described herein are compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, L1, R2, R3, n, p, Ar1, and Ar2 are defined in the description. Methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-1R are also disclosed.

摘要翻译： 本文描述了式（I）化合物或其药学上可接受的盐或溶剂合物，其中在说明书中定义了G1，L1，R2，R3，n，p，Ar1和Ar2。还公开了制备所述化合物的方法，以及包含所述化合物的组合物，其可用于抑制激酶如IGF-1R。

5.

发明授权
Pyrimidine inhibitors of kinase activity 有权
标题翻译：嘧啶抑制剂激酶活性

公开(公告)号：US08354422B2

公开(公告)日：2013-01-15

申请号：US12788008

申请日：2010-05-26

申请人： Richard F. Clark , Randy L. Bell , Nwe Y. Ba-maung , Scott A. Erickson , Steve D. Fidanze , Robert A. Mantei , George S. Sheppard , Bryan K. Sorensen , Gary T. Wang , Jieyi Wang

发明人： Richard F. Clark , Randy L. Bell , Nwe Y. Ba-maung , Scott A. Erickson , Steve D. Fidanze , Robert A. Mantei , George S. Sheppard , Bryan K. Sorensen , Gary T. Wang , Jieyi Wang

IPC分类号： C07D403/14 , C07D413/14 , A61K31/5377 , A61K31/506

CPC分类号： C07D471/04 , C07D487/04 , C07D513/04

摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar1, and Ar2 are defined in the description. The present invention relates also to methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-1R.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐或溶剂化物，其中在说明书中定义了G1，R2，R3，R4，R5，n，p，q，Ar1和Ar2。本发明还涉及制备所述化合物的方法，以及包含所述化合物的组合物，其可用于抑制诸如IGF-1R的激酶。

6.

发明申请
PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE INHIBITORS OF KINASES 有权
标题翻译：吡咯啉和吡咯啉嘧啶抑制剂

公开(公告)号：US20110281842A1

公开(公告)日：2011-11-17

申请号：US13106076

申请日：2011-05-12

申请人： Michael R. Michaelides , Andrew S. Judd , Shannon R. Fix-Stenzel , Richard F. Clark , Bryan K. Sorensen , Zhiqin Ji

发明人： Michael R. Michaelides , Andrew S. Judd , Shannon R. Fix-Stenzel , Richard F. Clark , Bryan K. Sorensen , Zhiqin Ji

IPC分类号： A61K31/5377 , C07D401/14 , C07D471/04 , A61P35/00 , C07D487/04 , A61K31/496 , A61K31/437 , A61K31/519 , C07D413/14 , C07D243/08

CPC分类号： C07D471/04 , C07D487/04

摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, B, R1, R2, R3, R4a, R5, and Z are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as aurora.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中A，B，R 1，R 2，R 3，R 4a，R 5和Z在说明书中定义。本发明还涉及制备所述化合物的方法和含有所述化合物的组合物，其可用于抑制激酶例如极光。

7.

发明授权
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme 有权
标题翻译： 11-β-羟基类固醇脱氢酶1型酶的抑制剂

公开(公告)号：US07880001B2

公开(公告)日：2011-02-01

申请号：US11119022

申请日：2005-04-29

申请人： James T. Link , Yixian Chen , Hwan-Soo Jae , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Qi Shuai , Bryan K. Sorensen , Martin Winn , Dariusz Wodka , Hong Yong

发明人： James T. Link , Yixian Chen , Hwan-Soo Jae , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Qi Shuai , Bryan K. Sorensen , Martin Winn , Dariusz Wodka , Hong Yong

IPC分类号： A61K31/496 , C07D401/04

CPC分类号： C07D213/75 , C07D205/04 , C07D207/12 , C07D209/44 , C07D211/42 , C07D231/12 , C07D239/42 , C07D277/82 , C07D295/14 , C07D307/68 , C07D403/12 , C07D413/12 , C07D487/18 , C07D491/056

摘要： The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, and other diseases and conditions that are mediated by excessive glucocorticoid action.

摘要翻译： 本发明涉及作为11-β-羟基类固醇脱氢酶1型酶抑制剂的化合物。本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征以及其它疾病和病症的用途由过度的糖皮质激素作用介导。

8.

发明申请
TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：中枢神经系统疾病的治疗

公开(公告)号：US20090054426A1

公开(公告)日：2009-02-26

申请号：US12195937

申请日：2008-08-21

申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Yixian Chen , Jurgen Dinges , Karla Drescher , Peer Jacobson , Hwan-soo Jae , Ravi Kurukulasuriya , James T. Link , David J. Madar , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Lynne E. Rueter , Qi Shuai , Bryan K. Sorensen , Jiahong Wang , Karsten M. Wicke , Martin Winn , Dariusz Wodka , Vince Yeh , Hong Yong

发明人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Yixian Chen , Jurgen Dinges , Karla Drescher , Peer Jacobson , Hwan-soo Jae , Ravi Kurukulasuriya , James T. Link , David J. Madar , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Lynne E. Rueter , Qi Shuai , Bryan K. Sorensen , Jiahong Wang , Karsten M. Wicke , Martin Winn , Dariusz Wodka , Vince Yeh , Hong Yong

IPC分类号： A61K31/496 , A61P25/00 , A61K31/5375 , A61K31/445 , A61K31/16

CPC分类号： C07D403/12 , A61K31/44 , A61K31/495 , C07D207/267 , C07D401/12 , C07D401/14

摘要： A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, depression, and schizophrenia, comprising administering to a patient in need of such treatment an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme activity.

摘要翻译： 一种治疗患有与老化和神经变性相关的糖尿病中枢神经系统紊乱和缺陷的患者的方法，包括注意力缺陷障碍，注意力缺陷多动障碍（ADHD），阿尔茨海默病（AD），轻度认知障碍老年性痴呆，艾滋病痴呆，神经变性，抑郁和精神分裂症，包括向需要这种治疗的患者施用有效量的11-β-羟基类固醇脱氢酶1型酶活性的选择性抑制剂。