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1.发明申请Novel acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 审中-公开新型乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用公开(公告)号：US20060178400A1
公开(公告)日：2006-08-10
申请号：US11268698
申请日：2005-11-07
Applicant: Bruce Beutel , Heidi Camp , Richard Clark , Yu-Gui Gu , Todd Hansen , Robert Keyes , Qun Li , Gang Liu , Hing Sham , Xiaojun Wang , Moshe Weitzberg , Zhili Xin , Xiangdong Xu , Tianyuan Zhang
Inventor： Bruce Beutel , Heidi Camp , Richard Clark , Yu-Gui Gu , Todd Hansen , Robert Keyes , Qun Li , Gang Liu , Hing Sham , Xiaojun Wang , Moshe Weitzberg , Zhili Xin , Xiangdong Xu , Tianyuan Zhang
IPC: C07D211/68 , A61K31/445
CPC classification number: C07D211/68
Abstract: The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
Abstract translation: 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。
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2.发明授权Thienopyridones as AMPK activators for the treatment of diabetes and obesity 有权噻吩并吡啶酮作为治疗糖尿病和肥胖症的AMPK激活剂公开(公告)号：US07119205B2
公开(公告)日：2006-10-10
申请号：US10847144
申请日：2004-05-17
Applicant: Rajesh R. Iyengar , Andrew S. Judd , Gang Zhao , Philip R. Kym , Hing L. Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard F. Clark , Ernst U. Frevert , Barbara L. Cool , Tianyuan Zhang , Robert F. Keyes , Todd M. Hansen , Zhili Xin
Inventor： Rajesh R. Iyengar , Andrew S. Judd , Gang Zhao , Philip R. Kym , Hing L. Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard F. Clark , Ernst U. Frevert , Barbara L. Cool , Tianyuan Zhang , Robert F. Keyes , Todd M. Hansen , Zhili Xin
IPC: C07D471/102 , A61K31/395
CPC classification number: C07D495/04
Abstract: The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
Abstract translation: 本发明涉及活化AMP-活化蛋白激酶（AMPK）的化合物，包括化合物的制备，含有这些化合物的组合物以及该化合物在预防或治疗诸如糖尿病，代谢综合征和肥胖症中的用途 。
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Patent Agency Ranking
3.发明申请Thienopyridones as AMPK activators for the treatment of diabetes and obesity 有权噻吩并吡啶酮作为治疗糖尿病和肥胖症的AMPK激活剂公开(公告)号：US20050038068A1
公开(公告)日：2005-02-17
申请号：US10847144
申请日：2004-05-17
Applicant: Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
Inventor： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
IPC: A61K31/4743 , C07D495/04 , C07D498/02
CPC classification number: C07D495/04
Abstract: The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
Abstract translation: 本发明涉及活化AMP-活化蛋白激酶（AMPK）的化合物，包括化合物的制备，含有这些化合物的组合物以及该化合物在预防或治疗诸如糖尿病，代谢综合征和肥胖症中的用途 。
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4.发明授权Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 失效乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用公开(公告)号：US08748627B2
公开(公告)日：2014-06-10
申请号：US11675410
申请日：2007-02-15
Applicant: Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard F. Clark , Tianyuan Zhang , Qun Li , Todd M. Hansen , Hing Sham , Bruce A. Beutel , Heidi S. Camp , Xiaojun Wang
Inventor： Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard F. Clark , Tianyuan Zhang , Qun Li , Todd M. Hansen , Hing Sham , Bruce A. Beutel , Heidi S. Camp , Xiaojun Wang
IPC: A61K31/427 , A61K31/433 , A61K31/4245 , A61K31/4439 , A61K31/444 , C07D417/12 , C07D417/14 , C07D417/04 , C07D413/12 , C07D413/14
CPC classification number: C07D277/34 , C07D261/08 , C07D277/56 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
Abstract translation: 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。
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公开(公告)号：US08163769B2
公开(公告)日：2012-04-24
申请号：US10387318
申请日：2003-03-12
Applicant: David Anderson , Bruce Beutel , Todd D. Bosse , Richard Clark , Curt Cooper , Peter Dandliker , Caroline David , Yu-Gui Gu , Todd Matthew Hansen , Mira Hinman , Douglas Kalvin , Daniel P. Larson , Linda Lynch , Zhenkun Ma , Christopher Motter , Fabio Palazzo , Teresa Rosenberg , Tamara Rehm , William Sanders , Michael Tufano , Rolf Wagner , Moshe Weitzberg , Hong Yong , Tianyuan Zhang
Inventor： David Anderson , Bruce Beutel , Todd D. Bosse , Richard Clark , Curt Cooper , Peter Dandliker , Caroline David , Yu-Gui Gu , Todd Matthew Hansen , Mira Hinman , Douglas Kalvin , Daniel P. Larson , Linda Lynch , Zhenkun Ma , Christopher Motter , Fabio Palazzo , Teresa Rosenberg , Tamara Rehm , William Sanders , Michael Tufano , Rolf Wagner , Moshe Weitzberg , Hong Yong , Tianyuan Zhang
IPC: A61K31/04 , C07D215/38
CPC classification number: C07D471/04
Abstract: Antibacterials having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.
Abstract translation: 公开了具有式（I）的抗菌剂及其前体药物的盐，前药和盐，用于制备本方法中使用的化合物和中间体的方法，含该化合物的组合物，以及使用该化合物预防和治疗细菌感染的方法。
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6.发明申请NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 失效新型乙酰胆碱酯酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用公开(公告)号：US20070225332A1
公开(公告)日：2007-09-27
申请号：US11675410
申请日：2007-02-15
Applicant: Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard Clark , Tianyuan Zhang , Qun Li , Todd Hansen , Hing Sham , Bruce Beutel , Heidi Camp , Xiaojun Wang
Inventor： Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard Clark , Tianyuan Zhang , Qun Li , Todd Hansen , Hing Sham , Bruce Beutel , Heidi Camp , Xiaojun Wang
IPC: A61K31/444 , A61K31/4439 , A61K31/433 , A61K31/427 , A61K31/42 , C07D417/14 , C07D413/02
CPC classification number: C07D277/34 , C07D261/08 , C07D277/56 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
Abstract translation: 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。
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公开(公告)号：US20060287356A1
公开(公告)日：2006-12-21
申请号：US11509383
申请日：2006-08-24
Applicant: Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
Inventor： Rajesh Iyengar , Andrew Judd , Gang Zhao , Philip Kym , Hing Sham , Yugui Gu , Gang Liu , Mei Liu , Hongyu Zhao , Richard Clark , Ernst Frevert , Barbara Cool , Tianyuan Zhang , Robert Keyes , Todd Hansen , Zhili Xin
IPC: C07D498/02 , A61K31/4743
CPC classification number: C07D495/04
Abstract: The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
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