公开(公告)号：US20060287356A1

公开(公告)日：2006-12-21

申请号：US11509383

申请日：2006-08-24

申请人： Rajesh Iyengar ,  Andrew Judd ,  Gang Zhao ,  Philip Kym ,  Hing Sham ,  Yugui Gu ,  Gang Liu ,  Mei Liu ,  Hongyu Zhao ,  Richard Clark ,  Ernst Frevert ,  Barbara Cool ,  Tianyuan Zhang ,  Robert Keyes ,  Todd Hansen ,  Zhili Xin

发明人： Rajesh Iyengar ,  Andrew Judd ,  Gang Zhao ,  Philip Kym ,  Hing Sham ,  Yugui Gu ,  Gang Liu ,  Mei Liu ,  Hongyu Zhao ,  Richard Clark ,  Ernst Frevert ,  Barbara Cool ,  Tianyuan Zhang ,  Robert Keyes ,  Todd Hansen ,  Zhili Xin

IPC分类号： C07D498/02 ,  A61K31/4743

CPC分类号： C07D495/04

摘要： The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.

公开(公告)号：US20050277638A1

公开(公告)日：2005-12-15

申请号：US11022453

申请日：2004-12-22

申请人： Andrew Souers ,  Christine Collins ,  Ju Gao ,  Andrew Judd ,  Philip Kym ,  Mathew Mulhern ,  Hing Sham ,  Dariusz Wodka

发明人： Andrew Souers ,  Christine Collins ,  Ju Gao ,  Andrew Judd ,  Philip Kym ,  Mathew Mulhern ,  Hing Sham ,  Dariusz Wodka

IPC分类号： A61K31/416 ,  A61K31/5377 ,  C07D231/56 ,  C07D401/04 ,  C07D401/06 ,  C07D403/06 ,  C07D403/14 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D413/02 ,  C07D413/04

CPC分类号： C07D403/14 ,  C07D231/56 ,  C07D401/04 ,  C07D401/06 ,  C07D403/06 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04

摘要： The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

公开(公告)号：US20050209274A1

公开(公告)日：2005-09-22

申请号：US11065918

申请日：2005-02-25

申请人： John Lynch ,  Christine Collins ,  Jennifer Freeman ,  Ju Gao ,  Rajesh Iyengar ,  Andrew Judd ,  Philip Kym ,  Mathew Mulhern ,  Hing Sham ,  Andrew Souers ,  Gang Zhao ,  Dariusz Wodka

发明人： John Lynch ,  Christine Collins ,  Jennifer Freeman ,  Ju Gao ,  Rajesh Iyengar ,  Andrew Judd ,  Philip Kym ,  Mathew Mulhern ,  Hing Sham ,  Andrew Souers ,  Gang Zhao ,  Dariusz Wodka

IPC分类号： A61K31/452 ,  A61K31/4709 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D45/02

CPC分类号： C07D417/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

摘要： The present invention is directed to compounds of formula (I), which antagonize of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

公开(公告)号：US20050187387A1

公开(公告)日：2005-08-25

申请号：US10787694

申请日：2004-02-25

申请人： John Lynch ,  Christine Collins ,  Jennifer Freeman ,  Ju Gao ,  Rajesh Iyengar ,  Andrew Judd ,  Philip Kym ,  Mathew Mulhern ,  Hing Sham ,  Andrew Souers ,  Gang Zhao

发明人： John Lynch ,  Christine Collins ,  Jennifer Freeman ,  Ju Gao ,  Rajesh Iyengar ,  Andrew Judd ,  Philip Kym ,  Mathew Mulhern ,  Hing Sham ,  Andrew Souers ,  Gang Zhao

IPC分类号： B32B27/02 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D405/12 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention is directed to compounds of formula (I), which antagonize of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

摘要翻译： 本发明涉及通过黑色素浓缩激素受体拮抗黑色素浓缩激素（MCH）的作用的式（I）化合物，其可用于预防或治疗进食障碍，体重增加，肥胖症，异常 生殖和性行为，甲状腺激素分泌，利尿和水/电解质体内平衡，感觉加工，记忆，睡眠，觉醒，焦虑，抑郁，癫痫发作，神经变性和精神疾病。

公开(公告)号：US20050187279A1

公开(公告)日：2005-08-25

申请号：US11020464

申请日：2004-12-22

申请人： Andrew Souers ,  Christine Collins ,  Ju Gao ,  Andrew Judd ,  Philip Kym ,  Mathew Mulhern ,  Hing Sham ,  Dariusz Wodka

发明人： Andrew Souers ,  Christine Collins ,  Ju Gao ,  Andrew Judd ,  Philip Kym ,  Mathew Mulhern ,  Hing Sham ,  Dariusz Wodka

IPC分类号： C07D231/56 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06 ,  C07D491/10 ,  A61K31/416

CPC分类号： C07D403/06 ,  C07D231/56 ,  C07D401/06 ,  C07D403/04 ,  C07D405/06 ,  C07D491/10

摘要： The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

公开(公告)号：US20050137243A1

公开(公告)日：2005-06-23

申请号：US10744188

申请日：2003-12-23

申请人： Andrew Souers ,  Christine Collins ,  Ju Gao ,  Andrew Judd ,  Philip Kym ,  Mathew Mulhern ,  Hing Sham ,  Anil Vasudevan ,  Dariusz Wodka

发明人： Andrew Souers ,  Christine Collins ,  Ju Gao ,  Andrew Judd ,  Philip Kym ,  Mathew Mulhern ,  Hing Sham ,  Anil Vasudevan ,  Dariusz Wodka

IPC分类号： C07D231/56 ,  C07D401/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  A61K31/416

CPC分类号： C07D413/12 ,  C07D231/56 ,  C07D401/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

公开(公告)号：US20070027117A1

公开(公告)日：2007-02-01

申请号：US11491337

申请日：2006-07-21

申请人： Richard Bishop ,  Russell Cink ,  Bradley Gates ,  Lars Hagberg ,  Peer Jacobsen ,  Philip Kym ,  Chunqiu Lai ,  Marvin Leanna ,  James Link ,  Steven Richards ,  Noah Tu ,  Tom von Geldern

发明人： Richard Bishop ,  Russell Cink ,  Bradley Gates ,  Lars Hagberg ,  Peer Jacobsen ,  Philip Kym ,  Chunqiu Lai ,  Marvin Leanna ,  James Link ,  Steven Richards ,  Noah Tu ,  Tom von Geldern

IPC分类号： A61K31/66 ,  A61K31/56

CPC分类号： C07J1/00 ,  Y10S514/866 ,  Y10S514/909

摘要： This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.

摘要翻译： 本发明涉及作为肝脏选择性糖皮质激素受体拮抗剂的新型化合物，制备这些化合物的方法，以及使用这些化合物来调节代谢的方法，特别是降低血清葡萄糖水平，胰岛素水平或脂质水平，和/或 减轻体重。

公开(公告)号：US20080064717A1

公开(公告)日：2008-03-13

申请号：US11749952

申请日：2007-05-17

申请人： Rajesh Iyengar ,  Gang Zhao ,  Jennifer Freeman ,  Ju Gao ,  Andrew Judd ,  Philip Kym ,  John Lynch ,  Mathew Mulhern ,  Andrew Souers

发明人： Rajesh Iyengar ,  Gang Zhao ,  Jennifer Freeman ,  Ju Gao ,  Andrew Judd ,  Philip Kym ,  John Lynch ,  Mathew Mulhern ,  Andrew Souers

IPC分类号： A61K31/4402 ,  A61K31/17 ,  A61K31/19 ,  A61P3/00 ,  C07C61/06 ,  C07D471/04 ,  C07D213/46 ,  C07C275/28 ,  A61P1/16 ,  A61K31/4375

CPC分类号： C07C335/22 ,  C07C229/46 ,  C07C275/30 ,  C07C275/32 ,  C07C275/38 ,  C07C279/28 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/55 ,  C07D213/75 ,  C07D277/30 ,  C07D333/22 ,  C07D333/36 ,  C07D401/04 ,  C07D401/12 ,  C07D409/12 ,  C07D409/14

摘要： The present invention relates to compounds of formula (I): wherein R1, R3, X, Q, Z, A, 9, m, and n are defined herein Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.

摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 3，X，Q，Z，A，9，m和n如本文所定义 还公开了治疗DGAT-1相关疾病或病症的药物组合物和方法。

公开(公告)号：US20050137187A1

公开(公告)日：2005-06-23

申请号：US10744571

申请日：2003-12-23

申请人： Andrew Souers ,  Christine Collins ,  Ju Gao ,  Andrew Judd ,  Philip Kym ,  Mathew Mulhern ,  Hing Sham ,  Dariusz Wodka

发明人： Andrew Souers ,  Christine Collins ,  Ju Gao ,  Andrew Judd ,  Philip Kym ,  Mathew Mulhern ,  Hing Sham ,  Dariusz Wodka

IPC分类号： A61K31/416 ,  A61K31/454 ,  A61K31/55 ,  C07D231/56 ,  C07D401/06 ,  C07D403/06 ,  C07D405/12 ,  C07D491/10 ,  C07D43/02

CPC分类号： C07D401/06 ,  A61K31/416 ,  A61K31/454 ,  A61K31/55 ,  C07D231/56 ,  C07D403/06 ,  C07D405/12 ,  C07D491/10

摘要： The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

摘要翻译： 本发明涉及黑色素浓缩激素（MCH）通过黑色素浓缩激素受体的作用的拮抗作用，其可用于预防或治疗进食障碍，体重增加，肥胖，生殖和性行为异常，甲状腺激素 分泌，利尿和水/电解质体内平衡，感觉加工，记忆，睡眠，唤醒，焦虑，抑郁，癫痫发作，神经变性和精神疾病。

公开(公告)号：US20080015227A1

公开(公告)日：2008-01-17

申请号：US11749940

申请日：2007-05-17

申请人： Philip Kym ,  Gang Zhao

发明人： Philip Kym ,  Gang Zhao

IPC分类号： C07C275/28 ,  A61K31/17 ,  A61K31/196 ,  A61K31/215 ,  A61K31/235 ,  A61K31/381 ,  A61K31/44 ,  C07D333/06 ,  C07D211/70 ,  A61K31/454 ,  A61P1/16 ,  A61P3/00 ,  A61P3/10 ,  C07C229/40

CPC分类号： C07C275/42 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/75 ,  C07D317/66 ,  C07D333/36

摘要： The present invention relates to compounds of formula (I). wherein R1, R2, R3, R4, R5, R6, m, n, p and q are defined herein Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.

摘要翻译： 本发明涉及式（I）化合物。 其中R 1，R 2，R 3，R 4，R 5， R 6，m，n，p和q如本文所定义。也公开了治疗DGAT-1相关疾病或病症的药物组合物和方法。