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    GLP-1 receptor agonist and allosteric modulator monoclonal antibodies and uses thereof
    4.
    发明申请
    GLP-1 receptor agonist and allosteric modulator monoclonal antibodies and uses thereof 审中-公开
    GLP-1受体激动剂和变构调节剂单克隆抗体及其用途

    公开(公告)号：US20060275288A1

    公开(公告)日：2006-12-07

    申请号：US11335387

    申请日：2006-01-19

    Applicant: Nelson Grihalde ,  Christine Collins ,  Andrea Pellacani ,  Tariq Ghayur

    Inventor： Nelson Grihalde ,  Christine Collins ,  Andrea Pellacani ,  Tariq Ghayur

    IPC: A61K39/395 ,  C07K16/28

    CPC classification number: C07K16/26 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/77

    Abstract: The subject invention relates to monoclonal antibodies that have the ability to bolster the function of the GLP-1 receptor and may therefore have utility in the treatment of mammalian metabolic disorders such as, for example, diabetes. In particular, the invention describes the generation of fully human monoclonal antibodies made against extracellular domains of the human GLP-1 receptor which are capable of binding the intact receptor and activating it in a manner similar to the native ligand. Additionally, the invention describes methods used to generate and develop allosteric modulator antibodies of the human GLP-1 receptor with potential therapeutic uses.

    Abstract translation: 本发明涉及具有增强GLP-1受体功能的能力的单克隆抗体，因此可用于治疗哺乳动物代谢紊乱，例如糖尿病。 特别地，本发明描述了产生针对人GLP-1受体细胞外结构域的完全人单克隆抗体，其能够结合完整受体并以类似于天然配体的方式活化它。 此外，本发明描述了用于产生和开发具有潜在治疗用途的人GLP-1受体的变构调节剂抗体的方法。

    Method and system to centrally monitor the quality of images of financial documents
    8.
    发明授权
    Method and system to centrally monitor the quality of images of financial documents 有权
    集中监控财务文件图像质量的方法和系统

    公开(公告)号：US08320635B2

    公开(公告)日：2012-11-27

    申请号：US11164722

    申请日：2005-12-02

    Applicant: Patrick S. McMonagle ,  Christine Collins ,  John Leon

    Inventor： Patrick S. McMonagle ,  Christine Collins ,  John Leon

    IPC: G06K9/00 ,  G06K9/54 ,  G01B5/28 ,  G01B5/30

    CPC classification number: G06K9/036 ,  G06K9/00979 ,  G06Q40/00 ,  G06Q40/02

    Abstract: Method and system to centrally monitor the quality of images of financial documents. Embodiments of the present invention can provide a way to monitor and evaluate the quality of images of financial documents stored for remote access by financial institutions. In some embodiments, a standard quality analysis of at least some of the images is performed, and, based on the quality analysis, suspect images are identified to a responsible entity. For at least some of the images, a decisioning result from the responsible entity is recorded in association with information identifying the images. The quality analysis can be applied based on exclusion criteria such as an amount threshold, certain routing information, etc. The suspect images can be identified by sending a quality results file to the responsible entity, and a decisioning result can be received in a decisioning results file.

    Abstract translation: 集中监控财务文件图像质量的方法和系统。 本发明的实施例可以提供一种监视和评估由金融机构远程访问存储的财务文件的图像质量的方法。 在一些实施例中，执行至少一些图像的标准质量分析，并且基于质量分析，可疑图像被识别为负责实体。 对于至少一些图像，与识别图像的信息相关联地记录来自负责实体的决定结果。 质量分析可以基于排除标准（如数量阈值，某些路由信息等）应用。可以通过向负责实体发送质量结果文件来识别可疑图像，并可以在决策结果中接收决策结果 文件。

    High-friction glove/wrist guards for ice skating
    9.
    发明申请
    High-friction glove/wrist guards for ice skating 审中-公开
    高摩擦手套/护腕用于溜冰

    公开(公告)号：US20070157364A1

    公开(公告)日：2007-07-12

    申请号：US11652874

    申请日：2007-01-11

    Applicant: R. Comstock ,  Christine Collins

    Inventor： R. Comstock ,  Christine Collins

    IPC: A63B71/14

    CPC classification number: A63B71/141

    Abstract: A protective glove/wrist guard device is provided that prevents hands from slipping out from under a falling ice skater when the ice skater extends his or her hands to break a fall. The protective glove/wrist guard device may include a palm surface portion having a high-friction surface portion, to provide both high-friction when contacting ice, and wrist support to help prevent wrist and hand injuries. Alternatively, the protective device may be in the form of a glove with a high friction material disposed on a palm surface portion of the glove.

    Abstract translation: 提供防护手套/手腕防护装置，防止手上的滑冰手伸出手来摔倒，防止手从跌倒的滑冰运动员滑落。 防护手套/护腕装置可以包括具有高摩擦表面部分的手掌表面部分，以在接触冰时提供高摩擦力和手腕支撑件，以帮助防止手腕和手部受伤。 或者，保护装置可以是设置在手套的手掌表面部分上的具有高摩擦材料的手套的形式。

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