专利检索 ap:"Michael L. Curtin" 第 1 页

1.

发明申请
NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS 有权
标题翻译：新型吡咯并[3,4-d]吡嗪化合物

公开(公告)号：US20120015963A1

公开(公告)日：2012-01-19

申请号：US13157777

申请日：2011-06-10

申请人： Kevin R. Woller , Michael L. Curtin , Kristine E. Frank , Nathan S. Josephsohn , Biqin C. Li , Neil Wishart

发明人： Kevin R. Woller , Michael L. Curtin , Kristine E. Frank , Nathan S. Josephsohn , Biqin C. Li , Neil Wishart

IPC分类号： A61K31/519 , A61P35/00 , A61P19/02 , A61P11/06 , A61P1/00 , A61P17/06 , C07D487/04 , A61P29/00

CPC分类号： C07D487/04

摘要： The present disclosure is directed to novel compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Crohn's disease, psoriasis and asthma.

摘要翻译： 本公开涉及新的式（I）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量如本文所定义。式（I）的化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如类风湿性关节炎，系统性红斑狼疮，多发性硬化症，克罗恩病疾病，牛皮癣和哮喘。

2.

发明授权
Thienopyridine and furopyridine kinase inhibitors 有权
标题翻译：噻吩并吡啶和呋喃啶激酶抑制剂

公开(公告)号：US07737160B2

公开(公告)日：2010-06-15

申请号：US11675183

申请日：2007-02-15

申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada

发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada

IPC分类号： A61K31/4745 , A61K31/4743 , A61K31/4741

CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401

摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。

3.

发明申请
ISOINDOLINONE KINASE INHIBITORS 审中-公开
标题翻译： ISOINDOLINONE激酶抑制剂

公开(公告)号：US20100076051A1

公开(公告)日：2010-03-25

申请号：US12625958

申请日：2009-11-25

申请人： Michael L. Curtin , Steven K. Davidsen , Robin R. Frey , Howard R. Heyman , James H. Holms , Michael Michaelides , Douglas H. Steinman

发明人： Michael L. Curtin , Steven K. Davidsen , Robin R. Frey , Howard R. Heyman , James H. Holms , Michael Michaelides , Douglas H. Steinman

IPC分类号： A61K31/403 , A61P35/04

CPC分类号： C07D401/12 , C07D209/46 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12

摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。

4.

发明授权
C-terminal ketone inhibitors of matrix metalloproteinases and TNF.alpha. secretion 失效
标题翻译：基质金属蛋白酶的C末端酮抑制剂和TNFα分泌

公开(公告)号：US5985911A

公开(公告)日：1999-11-16

申请号：US992578

申请日：1997-12-17

申请人： Steven K. Davidsen , Alan S. Florjancic , George S. Sheppard , Jamie R. Giesler , Lianhong Xu , Yan Guo , Michael L. Curtin , Michael R. Michaelides , Carol K. Wada , James H. Holms

发明人： Steven K. Davidsen , Alan S. Florjancic , George S. Sheppard , Jamie R. Giesler , Lianhong Xu , Yan Guo , Michael L. Curtin , Michael R. Michaelides , Carol K. Wada , James H. Holms

IPC分类号： C07C233/32 , C07C259/06 , C07D207/32 , C07D207/335 , C07D209/14 , C07D213/50 , C07D235/14 , C07D263/32 , C07D277/28 , C07D333/22 , C07C259/10 , A61K31/165

CPC分类号： C07D207/335 , C07C233/32 , C07C259/06 , C07D209/14 , C07D213/50 , C07D235/14 , C07D263/32 , C07D277/28 , C07D333/22 , C07B2200/07 , C07C2101/14

摘要： C-terminal compounds of formula ##STR1## are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.

摘要翻译： C末端化合物是基质金属蛋白酶的有效抑制剂，可用于治疗基质金属蛋白酶发挥作用的疾病。还公开了抑制哺乳动物的基质金属蛋白酶抑制组合物和抑制基质金属蛋白酶的方法。

5.

发明授权
Thienopyridine and furopyridine kinase inhibitors 有权
标题翻译：噻吩并吡啶和呋喃啶激酶抑制剂

公开(公告)号：US08273736B2

公开(公告)日：2012-09-25

申请号：US12623026

申请日：2009-11-20

申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada

发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada

IPC分类号： A61K31/4365 , A61K31/55 , A61K31/5377 , A61K31/496 , C07D495/04

CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401

摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。

6.

发明申请
NAMPT INHIBITORS 审中-公开
标题翻译： NAMPT抑制剂

公开(公告)号：US20120122924A1

公开(公告)日：2012-05-17

申请号：US13294318

申请日：2011-11-11

申请人： Michael L. Curtin , Bryan K. Sorensen , Howard R. Heyman , Rick F. Clark , Michael Michaelides , Chris Tse

发明人： Michael L. Curtin , Bryan K. Sorensen , Howard R. Heyman , Rick F. Clark , Michael Michaelides , Chris Tse

IPC分类号： A61K31/4709 , A61K31/47 , C07D487/00 , A61P25/28 , A61P1/00 , A61P3/10 , A61P35/00 , A61P9/10 , A61P37/02 , A61P11/06 , A61P11/00 , C07D217/16 , A61P19/10

CPC分类号： C07D217/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/04

摘要： Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

摘要翻译： 公开了抑制NAMPT活性的化合物，含有该化合物的组合物和治疗其中NAMPT表达的疾病的方法。

7.

发明授权
Thienopyridine and furopyridine kinase inhibitors 有权
标题翻译：噻吩并吡啶和呋喃啶激酶抑制剂

公开(公告)号：US07202363B2

公开(公告)日：2007-04-10

申请号：US10899168

申请日：2004-07-26

申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada

发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada

IPC分类号： C07D491/04 , C07D421/04

CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401

摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

摘要翻译： 具有式的化合物

8.

发明授权
Pyrazolo[3,4-d]pyrimidine compounds 有权
标题翻译：吡唑并[3,4-d]嘧啶化合物

公开(公告)号：US08637529B2

公开(公告)日：2014-01-28

申请号：US13157777

申请日：2011-06-10

申请人： Kevin R. Woller , Michael L. Curtin , Kristine E. Frank , Nathan S. Josephsohn , Biqin C. Li , Neil Wishart

发明人： Kevin R. Woller , Michael L. Curtin , Kristine E. Frank , Nathan S. Josephsohn , Biqin C. Li , Neil Wishart

IPC分类号： A01N43/90 , A61K31/519 , C07D487/00

CPC分类号： C07D487/04

摘要： The present disclosure is directed to novel compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Crohn's disease, psoriasis and asthma.

摘要翻译： 本公开涉及新的式（I）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量如本文所定义。式（I）的化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如类风湿性关节炎，系统性红斑狼疮，多发性硬化症，克罗恩病疾病，牛皮癣和哮喘。