Method for the production of optically active alpha alkyl carbonyl compounds
    4.
    发明授权
    Method for the production of optically active alpha alkyl carbonyl compounds 失效
    光学活性α-烷基羰基化合物的制备方法

    公开(公告)号:US08212065B2

    公开(公告)日:2012-07-03

    申请号:US12679125

    申请日:2008-09-18

    摘要: A method for the production of optically active α-alkylcarbonyl compounds with retention of the stereo information of the starting compound. The starting compound used here is a carbonyl compound which has, in the α-position, a leaving group which is substituted by an alkyl group with inversion of the configuration. The substitution of the leaving group is effected with the use of an alkylmagnesium Grignard and a zinc (II) salt or a zinc organyl. The method permits the production of optically active α-alkylcarbonyl compounds at very mild temperatures (for example 0° C.) with the use of starting compounds which are easy to prepare and economical and nontoxic catalysts, it also being possible to achieve a very high yield.

    摘要翻译: 用于制备光学活性α-烷基羰基化合物的方法,其保留起始化合物的立体信息。 这里使用的起始化合物是在α位具有被烷基取代的离去基团的羰基化合物,其构型倒置。 离去基团的取代是通过使用格氏态烷基镁和锌(II)盐或锌有机基来实现的。 该方法允许使用容易制备的起始化合物和经济无毒的催化剂在非常温和的温度(例如0℃)下生产光学活性的α-烷基羰基化合物,也可以实现非常高的 产量。

    METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE ALPHA ALKYL CARBONYL COMPOUNDS
    6.
    发明申请
    METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE ALPHA ALKYL CARBONYL COMPOUNDS 失效
    用于生产光学活性的ALPHA烷基碳化合物的方法

    公开(公告)号:US20100305352A1

    公开(公告)日:2010-12-02

    申请号:US12679125

    申请日:2008-09-18

    摘要: A method for the production of optically active α-alkylcarbonyl compounds with retention of the stereo information of the starting compound. The starting compound used here is a carbonyl compound which has, in the α-position, a leaving group which is substituted by an alkyl group with inversion of the configuration. The substitution of the leaving group is effected with the use of an alkylmagnesium Grignard and a zinc (II) salt or a zinc organyl. The method permits the production of optically active α-alkylcarbonyl compounds at very mild temperatures (for example 0° C.) with the use of starting compounds which are easy to prepare and economical and nontoxic catalysts, it also being possible to achieve a very high yield.

    摘要翻译: 用于制备光学活性α-烷基羰基化合物的方法,其保留起始化合物的立体信息。 这里使用的起始化合物是在α位具有被烷基取代的离去基团的羰基化合物,其构型倒置。 离去基团的取代是通过使用格氏态烷基镁和锌(II)盐或锌有机基来实现的。 该方法允许使用容易制备的起始化合物和经济无毒的催化剂在非常温和的温度(例如0℃)下生产光学活性的α-烷基羰基化合物,也可以实现非常高的 产量。