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公开(公告)号：US20180179352A1
公开(公告)日：2018-06-28
申请号：US15902501
申请日：2018-02-22
发明人： Shinji Takeoka , Akihiro Saito , Hong Zhang , Natsuki Takamizawa
CPC分类号： C08J5/18 , B01D67/003 , B01D67/009 , B01D69/02 , B01D69/141 , B01D2323/18 , B01D2325/02 , B01D2325/04 , B01D2325/06 , B29C41/12 , B29C67/202 , B82Y40/00 , C08J2201/04 , C08J2201/0542 , C08J2205/044 , C08J2333/12 , C08J2367/04 , C08J2425/06 , Y10T428/21 , Y10T428/249979
摘要： A porous ultra-thin polymer film has a film thickness of 10 nm-1000 nm. A method of producing the porous ultra-thin polymer film includes dissolving two types of mutually-immiscible polymers in a first solvent in an arbitrary proportion to obtain a solution; applying the solution onto a substrate and then removing the first solvent from the solution applied onto the substrate to obtain a phase-separated ultra-thin polymer film that has been phase-separated into a sea-island structure; and immersing the ultra-thin polymer film in a second solvent which is a good solvent for the polymer of the island parts but a poor solvent for a polymer other than the island parts to remove the island parts, thereby obtaining a porous ultra-thin polymer film.
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公开(公告)号：US10858490B2
公开(公告)日：2020-12-08
申请号：US15902501
申请日：2018-02-22
发明人： Shinji Takeoka , Akihiro Saito , Hong Zhang , Natsuki Takamizawa
IPC分类号： C08J9/26 , B01D67/00 , B01D69/12 , C08J5/18 , B01D69/02 , B82Y30/00 , B01D71/48 , B29C41/12 , B82Y40/00
摘要： A porous ultra-thin polymer film has a film thickness of 10 nm-1000 nm. A method of producing the porous ultra-thin polymer film includes dissolving two types of mutually-immiscible polymers in a first solvent in an arbitrary proportion to obtain a solution; applying the solution onto a substrate and then removing the first solvent from the solution applied onto the substrate to obtain a phase-separated ultra-thin polymer film that has been phase-separated into a sea-island structure; and immersing the ultra-thin polymer film in a second solvent which is a good solvent for the polymer of the island parts but a poor solvent for a polymer other than the island parts to remove the island parts, thereby obtaining a porous ultra-thin polymer film.
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公开(公告)号：US09938384B2
公开(公告)日：2018-04-10
申请号：US14383191
申请日：2013-03-12
发明人： Shinji Takeoka , Akihiro Saito , Hong Zhang , Natsuki Takamizawa
CPC分类号： C08J5/18 , B01D67/003 , B01D67/009 , B01D69/02 , B01D69/141 , B01D2323/18 , B01D2325/02 , B01D2325/04 , B01D2325/06 , B29C41/12 , B29C67/202 , B82Y40/00 , C08J2201/04 , C08J2201/0542 , C08J2205/044 , C08J2333/12 , C08J2367/04 , C08J2425/06 , Y10T428/21 , Y10T428/249979
摘要： The objective of the present invention is to provide a porous ultra-thin polymer film, and a method for producing said porous ultra-thin polymer film. The present invention provides a porous ultra-thin polymer film with a film thickness of 10 nm-1000 nm. In addition, the present invention provides a method for producing a porous ultra-thin polymer film, comprising the steps of: dissolving two types of mutually-immiscible polymers in a first solvent in an arbitrary proportion to obtain a solution; applying the solution onto a substrate and then removing the first solvent from the solution applied onto the substrate to obtain a phase-separated ultra-thin polymer film that has been phase-separated into a sea-island structure; and immersing the ultra-thin polymer film in a second solvent which is a good solvent for the polymer of the island parts but a poor solvent for a polymer other than the island parts to remove the island parts, thereby obtaining a porous ultra-thin polymer film.
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公开(公告)号：US20150056399A1
公开(公告)日：2015-02-26
申请号：US14383191
申请日：2013-03-12
发明人： Shinji Takeoka , Akihiro Saito , Hong Zhang , Natsuki Takamizawa
IPC分类号： C08J5/18
CPC分类号： C08J5/18 , B01D67/003 , B01D67/009 , B01D69/02 , B01D69/141 , B01D2323/18 , B01D2325/02 , B01D2325/04 , B01D2325/06 , B29C41/12 , B29C67/202 , B82Y40/00 , C08J2201/04 , C08J2201/0542 , C08J2205/044 , C08J2333/12 , C08J2367/04 , C08J2425/06 , Y10T428/21 , Y10T428/249979
摘要： The objective of the present invention is to provide a porous ultra-thin polymer film, and a method for producing said porous ultra-thin polymer film. The present invention provides a porous ultra-thin polymer film with a film thickness of 10 nm-1000 nm. In addition, the present invention provides a method for producing a porous ultra-thin polymer film, comprising the steps of: dissolving two types of mutually-immiscible polymers in a first solvent in an arbitrary proportion to obtain a solution; applying the solution onto a substrate and then removing the first solvent from the solution applied onto the substrate to obtain a phase-separated ultra-thin polymer film that has been phase-separated into a sea-island structure; and immersing the ultra-thin polymer film in a second solvent which is a good solvent for the polymer of the island parts but a poor solvent for a polymer other than the island parts to remove the island parts, thereby obtaining a porous ultra-thin polymer film.
摘要翻译： 本发明的目的是提供一种多孔超薄聚合物膜，以及一种生产该多孔超薄聚合物膜的方法。 本发明提供一种膜厚度为10nm-1000nm的多孔超薄聚合物膜。 此外，本发明提供一种多孔超薄聚合物膜的制造方法，其特征在于，包括以下任意比例将两种相互不混溶的聚合物溶解在第一溶剂中，得到溶液; 将溶液施加到基材上，然后从施加到基材上的溶液中除去第一溶剂，得到相分离成海岛结构的相分离超薄膜; 并将超薄聚合物膜浸渍在作为岛部分的聚合物的良溶剂的第二溶剂中，但除了岛部分以外的聚合物的不良溶剂以除去岛部分，从而获得多孔超薄聚合物 电影。
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公开(公告)号：US20180338865A1
公开(公告)日：2018-11-29
申请号：US15534026
申请日：2015-12-04
发明人： Motonori Hochi , Yuki Sekido , Akihiro Saito , Shinji Takeoka , Shinya Ohtsubo , Akinari Hinoki , Manabu Kinoshita
CPC分类号： A61F13/02 , A61L15/24 , A61L15/26 , A61L15/28 , A61L31/042 , A61L31/048 , A61L31/06 , B32B27/00 , B32B27/32 , C08B5/00 , C08L5/08 , C08L67/04
摘要： A laminated film includes a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle and, when stuck to an adherend with curved surface, the laminated film has excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. The acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs. The laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.
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公开(公告)号：US20170348465A1
公开(公告)日：2017-12-07
申请号：US15534188
申请日：2016-06-17
发明人： Akihiro Saito , Toru Arakane , Kazuhiro Tanahashi , Koji Okabayashi , Shinji Takeoka , Toshinori Fujie , Shoichiro Suzuki , Atsushi Murata , Shinya Otsubo
CPC分类号： A61L31/041 , A61L15/00 , A61L15/50 , A61L27/00 , A61L31/00 , C08G65/3311 , C08G65/332 , C08G81/00 , C08G81/02 , C08J5/18 , C08L53/005 , C08L2203/02
摘要： A polymer film can be adjusted to movement or a fine uneven surface of a living body and has excellent ability to adhere to a biological tissue. The polymer film includes a block copolymer having a structure in which branched polyalkylene glycol and polyhydroxyalkanoic acid are bound to each other, wherein the polymer film has a film thickness of 10 to 1000 nm. The branched polyalkylene glycol has at least three terminal hydroxyl groups per molecule, the mass percentage of the branched polyalkylene glycol relative to the total mass of the block copolymer is 1% to 30%, and a value obtained by dividing the average molecular weight of polyhydroxyalkanoic acid in the block copolymer by X that is the number of terminal hydroxyl groups present per a single molecule of the branched polyalkylene glycol is 10000 to 30000.
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公开(公告)号：US20190216971A1
公开(公告)日：2019-07-18
申请号：US16335082
申请日：2017-09-29
发明人： Akihiro Saito , Megumi Nakanishi , Kazuhiro Tanahashi , Toru Arakane , Motonori Hochi , Ai Suzuki , Koji Okabayashi , Shinji Takeoka , Toshinori Fujie , Yuya Ishizuka , Shinya Ohtsubo
CPC分类号： A61L15/26 , A61L15/28 , A61L15/64 , A61L31/06 , A61L31/12 , A61L31/125 , A61L31/14 , A61L31/145 , A61L31/148 , A61P41/00 , C08G65/2615 , C08L5/08
摘要： A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-μm-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-μm-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.
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公开(公告)号：US10940229B2
公开(公告)日：2021-03-09
申请号：US16335082
申请日：2017-09-29
发明人： Akihiro Saito , Megumi Nakanishi , Kazuhiro Tanahashi , Toru Arakane , Motonori Hochi , Ai Suzuki , Koji Okabayashi , Shinji Takeoka , Toshinori Fujie , Yuya Ishiduka , Shinya Ohtsubo
IPC分类号： A61L15/26 , A61L31/14 , A61L31/12 , A61L31/06 , A61L15/64 , A61L15/28 , A61P41/00 , C08G65/26 , C08L5/08
摘要： A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-μm-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-μm-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.
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公开(公告)号：US10531988B2
公开(公告)日：2020-01-14
申请号：US15534026
申请日：2015-12-04
发明人： Motonori Hochi , Yuki Sekido , Akihiro Saito , Shinji Takeoka , Shinya Ohtsubo , Akinari Hinoki , Manabu Kinoshita
IPC分类号： A61F13/02 , B32B27/00 , A61L15/28 , A61L15/24 , A61L15/26 , B32B27/32 , A61L31/06 , A61L31/04 , C08B5/00
摘要： A laminated film includes a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle and, when stuck to an adherend with curved surface, the laminated film has excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. The acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs. The laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.
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公开(公告)号：US10213530B2
公开(公告)日：2019-02-26
申请号：US15534188
申请日：2016-06-17
发明人： Akihiro Saito , Toru Arakane , Kazuhiro Tanahashi , Koji Okabayashi , Shinji Takeoka , Toshinori Fujie , Shoichiro Suzuki , Atsushi Murata , Shinya Otsubo
IPC分类号： C08G81/02 , C08G63/06 , C08G63/664 , C08J5/18 , C08L53/00 , A61L31/04 , A61L27/00 , A61L31/00 , A61L15/00 , C08G81/00 , C08G65/332 , A61L15/50 , C08G65/331
摘要： A polymer film can be adjusted to movement or a fine uneven surface of a living body and has excellent ability to adhere to a biological tissue. The polymer film includes a block copolymer having a structure in which branched polyalkylene glycol and polyhydroxyalkanoic acid are bound to each other, wherein the polymer film has a film thickness of 10 to 1000 nm. The branched polyalkylene glycol has at least three terminal hydroxyl groups per molecule, the mass percentage of the branched polyalkylene glycol relative to the total mass of the block copolymer is 1% to 30%, and a value obtained by dividing the average molecular weight of polyhydroxyalkanoic acid in the block copolymer by X that is the number of terminal hydroxyl groups present per a single molecule of the branched polyalkylene glycol is 10000 to 30000.
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