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Patent Agency Ranking
公开(公告)号：US20170348465A1
公开(公告)日：2017-12-07
申请号：US15534188
申请日：2016-06-17
Applicant: Toray Industries, Inc. , Nanotheta Co., Ltd.
Inventor： Akihiro Saito , Toru Arakane , Kazuhiro Tanahashi , Koji Okabayashi , Shinji Takeoka , Toshinori Fujie , Shoichiro Suzuki , Atsushi Murata , Shinya Otsubo
CPC classification number: A61L31/041 , A61L15/00 , A61L15/50 , A61L27/00 , A61L31/00 , C08G65/3311 , C08G65/332 , C08G81/00 , C08G81/02 , C08J5/18 , C08L53/005 , C08L2203/02
Abstract: A polymer film can be adjusted to movement or a fine uneven surface of a living body and has excellent ability to adhere to a biological tissue. The polymer film includes a block copolymer having a structure in which branched polyalkylene glycol and polyhydroxyalkanoic acid are bound to each other, wherein the polymer film has a film thickness of 10 to 1000 nm. The branched polyalkylene glycol has at least three terminal hydroxyl groups per molecule, the mass percentage of the branched polyalkylene glycol relative to the total mass of the block copolymer is 1% to 30%, and a value obtained by dividing the average molecular weight of polyhydroxyalkanoic acid in the block copolymer by X that is the number of terminal hydroxyl groups present per a single molecule of the branched polyalkylene glycol is 10000 to 30000.
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公开(公告)号：US20190216971A1
公开(公告)日：2019-07-18
申请号：US16335082
申请日：2017-09-29
Applicant: Toray Industries, Inc. , Nanotheta Co., Ltd.
Inventor： Akihiro Saito , Megumi Nakanishi , Kazuhiro Tanahashi , Toru Arakane , Motonori Hochi , Ai Suzuki , Koji Okabayashi , Shinji Takeoka , Toshinori Fujie , Yuya Ishizuka , Shinya Ohtsubo
CPC classification number: A61L15/26 , A61L15/28 , A61L15/64 , A61L31/06 , A61L31/12 , A61L31/125 , A61L31/14 , A61L31/145 , A61L31/148 , A61P41/00 , C08G65/2615 , C08L5/08
Abstract: A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-μm-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-μm-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.
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公开(公告)号：US10940229B2
公开(公告)日：2021-03-09
申请号：US16335082
申请日：2017-09-29
Applicant: Toray Industries, Inc. , Nanotheta Co., Ltd.
Inventor： Akihiro Saito , Megumi Nakanishi , Kazuhiro Tanahashi , Toru Arakane , Motonori Hochi , Ai Suzuki , Koji Okabayashi , Shinji Takeoka , Toshinori Fujie , Yuya Ishiduka , Shinya Ohtsubo
IPC: A61L15/26 , A61L31/14 , A61L31/12 , A61L31/06 , A61L15/64 , A61L15/28 , A61P41/00 , C08G65/26 , C08L5/08
Abstract: A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-μm-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-μm-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.
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公开(公告)号：US10213530B2
公开(公告)日：2019-02-26
申请号：US15534188
申请日：2016-06-17
Applicant: Toray Industries, Inc. , Nanotheta Co, Ltd.
Inventor： Akihiro Saito , Toru Arakane , Kazuhiro Tanahashi , Koji Okabayashi , Shinji Takeoka , Toshinori Fujie , Shoichiro Suzuki , Atsushi Murata , Shinya Otsubo
IPC: C08G81/02 , C08G63/06 , C08G63/664 , C08J5/18 , C08L53/00 , A61L31/04 , A61L27/00 , A61L31/00 , A61L15/00 , C08G81/00 , C08G65/332 , A61L15/50 , C08G65/331
Abstract: A polymer film can be adjusted to movement or a fine uneven surface of a living body and has excellent ability to adhere to a biological tissue. The polymer film includes a block copolymer having a structure in which branched polyalkylene glycol and polyhydroxyalkanoic acid are bound to each other, wherein the polymer film has a film thickness of 10 to 1000 nm. The branched polyalkylene glycol has at least three terminal hydroxyl groups per molecule, the mass percentage of the branched polyalkylene glycol relative to the total mass of the block copolymer is 1% to 30%, and a value obtained by dividing the average molecular weight of polyhydroxyalkanoic acid in the block copolymer by X that is the number of terminal hydroxyl groups present per a single molecule of the branched polyalkylene glycol is 10000 to 30000.
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公开(公告)号：US09956751B2
公开(公告)日：2018-05-01
申请号：US13904882
申请日：2013-05-29
Applicant: NANOTHETA CO, LTD. , TORAY INDUSTRIES, INC. , Shinji Takeoka
Inventor： Shinji Takeoka , Yosuke Okamura , Toshinori Fujie , Saori Utsunomiya , Takahiro Goto
CPC classification number: B32B37/02 , A61K9/0014 , A61K9/70 , A61K9/7007 , B32B38/10 , C08J5/18 , C08J7/12 , C12N5/0068 , C12N2535/10 , Y10T156/10 , Y10T428/31504
Abstract: A thin film polymer structure having a functional substance on the face (A surface) and reverse face (B surface) of the film, obtained by the steps of: (a) causing polyfunctional molecules to adsorb to an area of an arbitrary shape in an interface between a substrate body and a liquid phase; (b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film; (c) bonding a functional substance to the A surface of the formed thin film and then (d) forming a soluble support film thereon; exfoliating the thin film and the soluble support film from the substrate body; (e) bonding to the B surface of the thin film a functional substance identical to or different from the abovementioned functional substance and then dissolving the soluble support film with a solvent.
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