公开(公告)号：US20190216971A1

公开(公告)日：2019-07-18

申请号：US16335082

申请日：2017-09-29

Applicant: Toray Industries, Inc. ,  Nanotheta Co., Ltd.

Inventor： Akihiro Saito ,  Megumi Nakanishi ,  Kazuhiro Tanahashi ,  Toru Arakane ,  Motonori Hochi ,  Ai Suzuki ,  Koji Okabayashi ,  Shinji Takeoka ,  Toshinori Fujie ,  Yuya Ishizuka ,  Shinya Ohtsubo

IPC: A61L15/26 ,  A61L31/14 ,  A61L31/12 ,  A61L31/06 ,  A61L15/28 ,  A61L15/64

CPC classification number: A61L15/26 ,  A61L15/28 ,  A61L15/64 ,  A61L31/06 ,  A61L31/12 ,  A61L31/125 ,  A61L31/14 ,  A61L31/145 ,  A61L31/148 ,  A61P41/00 ,  C08G65/2615 ,  C08L5/08

Abstract: A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-μm-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-μm-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.

公开(公告)号：US20180338865A1

公开(公告)日：2018-11-29

申请号：US15534026

申请日：2015-12-04

Applicant: Toray Industries, Inc. ,  NANOTHETA CO, LTD.

Inventor： Motonori Hochi ,  Yuki Sekido ,  Akihiro Saito ,  Shinji Takeoka ,  Shinya Ohtsubo ,  Akinari Hinoki ,  Manabu Kinoshita

IPC: A61F13/02 ,  C08B5/00

CPC classification number: A61F13/02 ,  A61L15/24 ,  A61L15/26 ,  A61L15/28 ,  A61L31/042 ,  A61L31/048 ,  A61L31/06 ,  B32B27/00 ,  B32B27/32 ,  C08B5/00 ,  C08L5/08 ,  C08L67/04

Abstract: A laminated film includes a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle and, when stuck to an adherend with curved surface, the laminated film has excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. The acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs. The laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.

公开(公告)号：US10563025B2

公开(公告)日：2020-02-18

申请号：US15572210

申请日：2016-05-11

Applicant: Toray Industries, Inc. ,  Nanotheta Co., Ltd.

Inventor： Motonori Hochi ,  Yuki Sekido ,  Ichiro Itagaki ,  Toru Arakane ,  Shinya Ohtsubo ,  Shinji Takeoka ,  Atsushi Murata ,  Mao Fujii ,  Yuya Ishizuka ,  Shuichi Shoji ,  Jun Mizuno ,  Takashi Kasahara

IPC: A61K8/04 ,  A61K8/81 ,  A61K8/85 ,  A61K8/86 ,  A61L15/22 ,  C08J5/18 ,  A61L31/00 ,  A61L15/24 ,  A61L15/26 ,  A61L31/04 ,  A61L31/06 ,  A61Q19/00 ,  C08L25/06 ,  C08L33/12 ,  C08L67/04

Abstract: A polymer film has an average film thickness T0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation Δ defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm≤T0≤1000 nm, (b) 0.1 μm≤L≤500 μm, (c) 0.01 GPa≤E≤4.3 GPa, (d) Δ=1−T1/T2, (e) 0.346E×10−9−1.499

公开(公告)号：US10940229B2

公开(公告)日：2021-03-09

申请号：US16335082

申请日：2017-09-29

Applicant: Toray Industries, Inc. ,  Nanotheta Co., Ltd.

Inventor： Akihiro Saito ,  Megumi Nakanishi ,  Kazuhiro Tanahashi ,  Toru Arakane ,  Motonori Hochi ,  Ai Suzuki ,  Koji Okabayashi ,  Shinji Takeoka ,  Toshinori Fujie ,  Yuya Ishiduka ,  Shinya Ohtsubo

IPC: A61L15/26 ,  A61L31/14 ,  A61L31/12 ,  A61L31/06 ,  A61L15/64 ,  A61L15/28 ,  A61P41/00 ,  C08G65/26 ,  C08L5/08

Abstract: A material for adhesion prevention can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-μm-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-μm-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.

公开(公告)号：US10531988B2

公开(公告)日：2020-01-14

申请号：US15534026

申请日：2015-12-04

Applicant: Toray Industries, Inc. ,  NANOTHETA CO, LTD.

Inventor： Motonori Hochi ,  Yuki Sekido ,  Akihiro Saito ,  Shinji Takeoka ,  Shinya Ohtsubo ,  Akinari Hinoki ,  Manabu Kinoshita

IPC: A61F13/02 ,  B32B27/00 ,  A61L15/28 ,  A61L15/24 ,  A61L15/26 ,  B32B27/32 ,  A61L31/06 ,  A61L31/04 ,  C08B5/00

Abstract: A laminated film includes a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle and, when stuck to an adherend with curved surface, the laminated film has excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. The acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs. The laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.

公开(公告)号：US20180118905A1

公开(公告)日：2018-05-03

申请号：US15572210

申请日：2016-05-11

Applicant: Toray Industries, Inc. ,  Nanotheta Co., Ltd.

Inventor： Motonori Hochi ,  Yuki Sekido ,  Ichiro Itagaki ,  Toru Arakane ,  Shinya Ohtsubo ,  Shinji Takeoka ,  Atsushi Murata ,  Mao Fujii ,  Yuya Ishizuka ,  Shuichi Shoji ,  Jun Mizuno ,  Takashi Kasahara

IPC: C08J5/18 ,  A61Q19/00 ,  A61K8/04 ,  A61K8/81 ,  A61K8/85 ,  A61K8/86 ,  C08L25/06 ,  C08L67/04 ,  C08L33/12 ,  A61L15/22 ,  A61L15/26 ,  A61L15/24 ,  A61L31/04 ,  A61L31/06

CPC classification number: C08J5/18 ,  A61K8/04 ,  A61K8/8117 ,  A61K8/8152 ,  A61K8/8176 ,  A61K8/85 ,  A61K8/86 ,  A61L15/22 ,  A61L15/225 ,  A61L15/24 ,  A61L15/26 ,  A61L31/00 ,  A61L31/041 ,  A61L31/048 ,  A61L31/06 ,  A61Q19/00 ,  C08J2325/06 ,  C08J2333/12 ,  C08J2367/04 ,  C08J2467/04 ,  C08L25/06 ,  C08L33/12 ,  C08L67/04

Abstract: A polymer film has an average film thickness T0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation Δ defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm≤T0≤1000 nm, (b) 0.1 μm≤L≤500 μm, (c) 0.01 GPa≤E≤4.3 GPa, (d) Δ=1−T1/T2, (e) 0.346E×10−9−1.499