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    REDUCED GENOME E. COLI
    3.
    发明申请
    REDUCED GENOME E. COLI 审中-公开
    减少基因大肠杆菌

    公开(公告)号：US20150344838A1

    公开(公告)日：2015-12-03

    申请号：US14803923

    申请日：2015-07-20

    Applicant: SCARAB GENOMICS, LLC

    Inventor： John W. Campbell ,  Frederick R. Blattner ,  Guy Plunkett ,  Gyorgy Posfai

    IPC: C12N1/20 ,  C12P21/00 ,  C12P19/34 ,  C12R1/19

    CPC classification number: C12N1/20 ,  C12P19/34 ,  C12P21/00 ,  C12R1/19

    Abstract: Reduced genome strains of E. coli MG1 655 are described. In various embodiments, the strains have one or more of equal or improved growth rate, transformation efficiency, protein expression, DNA production, DNA yield and/or DNA quality compared to the parental strain and commercially available strains.

    Abstract translation: 描述了大肠杆菌MG1 655的还原基因组菌株。 在各种实施方案中，与亲本菌株和市售菌株相比，菌株具有相同或改善的生长速率，转化效率，蛋白质表达，DNA产生，DNA产量和/或DNA质量的一种或多种。

    Materials and methods for extended continuous flow fermentation of reduced genome bacteria
    7.
    发明授权
    Materials and methods for extended continuous flow fermentation of reduced genome bacteria 有权

    公开(公告)号：US10604736B2

    公开(公告)日：2020-03-31

    申请号：US15563540

    申请日：2016-04-01

    Applicant: Scarab Genomics, LLC

    Inventor： Frederick R. Blattner

    IPC: C12N1/20 ,  C12M1/00 ,  C07K14/21 ,  C07K14/34 ,  C07K14/47 ,  C12M1/02 ,  C12P21/00

    Abstract: A two-vessel continuous flow system in conjunction with low mutation reduced genome bacterial strains provides a platform for long term extended fermentations. Such systems require modification of standard fermentation devices such as probes, pumps and monitoring systems as well as improved procedures for feed delivery, culture monitoring and product harvesting methods. An optimized two-vessel system for producing large quantities of fermentation products from small volume, long duration continuous fermentations represents a significant improvement over existing fermentation strategies. Methods and compositions for long term continuous flow fermentation using a two vessel continuous culture fermentation apparatus are described.

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