公开(公告)号：US11970725B2

公开(公告)日：2024-04-30

申请号：US18299479

申请日：2023-04-12

Applicant: SCARAB GENOMICS LLC

Inventor： Frederick R. Blattner ,  Robert E. Novy ,  David A. Frisch ,  Charles Landry ,  Hyunsic Choi ,  Eric A. Steffen ,  John Brandon

IPC: C12N1/21 ,  C07K14/21 ,  C07K14/285 ,  C07K14/34 ,  C12N1/20 ,  C12N9/18 ,  C12P21/06

CPC classification number: C12P21/06 ,  C07K14/21 ,  C07K14/285 ,  C07K14/34 ,  C12N1/20 ,  C12N9/18 ,  C07K2319/02

Abstract: Provided herein are E. coli host strains with improved capacity for producing recombinant proteins.

公开(公告)号：US11667944B2

公开(公告)日：2023-06-06

申请号：US16644444

申请日：2018-09-04

Applicant: SCARAB GENOMICS LLC

Inventor： Frederick R. Blattner ,  Robert E. Novy ,  David A. Frisch ,  Charles Landry ,  Hyunsic Choi ,  Eric A. Steffen ,  John Brandon

IPC: C12P21/02 ,  C12N9/18 ,  C12N1/21 ,  C12N15/70 ,  C12P21/06 ,  C07K14/21 ,  C07K14/285 ,  C07K14/34 ,  C12N1/20

CPC classification number: C12P21/06 ,  C07K14/21 ,  C07K14/285 ,  C07K14/34 ,  C12N1/20 ,  C12N9/18 ,  C07K2319/02

Abstract: Provided herein are methods for the improved production of periplasmic-targeted recombinant proteins in E. coli host strains. Also provided are E. coli host strains with improved capacity for producing recombinant proteins.

公开(公告)号：US10479820B2

公开(公告)日：2019-11-19

申请号：US15122891

申请日：2015-03-02

Applicant: SCARAB GENOMICS, LLC

Inventor： Cristopher R. Blattner ,  David Frisch ,  Robert E. Novy ,  Terrance M. Henker ,  Eric A. Steffen ,  Frederick R. Blattner ,  Hyunsic Choi ,  Gyorgy Posfai ,  Charles F. Landry

IPC: C07K14/34 ,  C12N1/08 ,  C12N1/20 ,  C12N15/70

Abstract: Rediced genome or native K12 strain E. coli bacteria comprising expression vectors encoding a recombinant CRM197 protein and their use in the production of CRM 197 is provided. The CRM 197 protein may be fused to a signal sequence that directs the expressed CRM197 protein to the periplasm of the E. coli host.

公开(公告)号：US09902965B2

公开(公告)日：2018-02-27

申请号：US15036376

申请日：2014-11-13

Applicant: SCARAB GENOMICS, LLC

Inventor： Frederick R. Blattner ,  David A. Frisch ,  Robert E. Novy ,  Terrance M. Henker ,  Eric A. Steffen ,  Jose A. Sanchez ,  Christopher R. Blattner ,  Hyunsic Choi ,  Gyorgy Posfai

IPC: C12N1/20 ,  C12N15/00 ,  C12P21/06 ,  C07H21/04 ,  C12N15/70 ,  C12N9/10 ,  C12R1/19

CPC classification number: C12N15/70 ,  C12N9/1022 ,  C12N9/1048 ,  C12R1/19 ,  C12Y202/01006 ,  C12Y204/00

Abstract: E. coli bacteria comprising genetic modifications to enhance fermentability and production of protein and nucleic acids are provided.