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公开(公告)号：US20230097403A1
公开(公告)日：2023-03-30
申请号：US18049517
申请日：2022-10-25
申请人： Promega Corporation
IPC分类号： C07D307/42 , C07C317/28 , C07D307/80 , C07D311/58 , C12N9/12 , C12P19/34
摘要： The present disclosure includes compositions and methods for improved DNA amplification reactions. In particular, the present disclosure provides compositions and methods for hot-start PCR applications using DNA polymerase inhibitors that minimize non-specific DNA amplification by inactivating DNA polymerase at lower temperatures.
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公开(公告)号：US20170137456A1
公开(公告)日：2017-05-18
申请号：US15322519
申请日：2015-07-02
申请人： PROMEGA CORPORATION
发明人： Thomas Kirkland , Mark McDougall , Poncho Meisenheimer , Min Zhou
摘要： Provided herein are chelator constructs (e.g., nucleic acid, peptide, peptide nucleic acid, etc.) that sequester metal ions (e.g., Mg2+) under a first set of conditions and fail to sequester or release sequestered metal ions under a second set of conditions. In particular, nucleic acid constructs are provided that sequester metal ions (e.g., Mg2+) under conditions that favor secondary and tertiary structure formation and release or fail to sequester metal ions under conditions that disfavor the formation of such structures.
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公开(公告)号：US20220396830A1
公开(公告)日：2022-12-15
申请号：US17744255
申请日：2022-05-13
申请人： Promega Corporation
发明人： Wenhui Zhou , Hui Wang , Min Zhou , Natasha Karassina , James Cali , Jolanta Vidugiriene
IPC分类号： C12Q1/6841 , C12N9/14 , C07H19/06 , C07H19/14
摘要： Provided herein are reagents and methods for incorporating modified nucleotides into DNA and detecting DNA synthesis. In particular, haloalkyl-modified nucleobases are provided for incorporation into nucleic acids for detection by bioluminescent binding agents.
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公开(公告)号：US20240182434A1
公开(公告)日：2024-06-06
申请号：US18440576
申请日：2024-02-13
申请人： Promega Corporation
IPC分类号： C07D307/42 , C07C317/28 , C07D307/80 , C07D311/58 , C12N9/12 , C12P19/34
CPC分类号： C07D307/42 , C07C317/28 , C07D307/80 , C07D311/58 , C12N9/1252 , C12P19/34 , C12Y207/07007
摘要： The present disclosure includes compositions and methods for improved DNA amplification reactions. In particular, the present disclosure provides compositions and methods for hot-start PCR applications using DNA polymerase inhibitors that minimize non-specific DNA amplification by inactivating DNA polymerase at lower temperatures.
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公开(公告)号：US20230366045A1
公开(公告)日：2023-11-16
申请号：US18176918
申请日：2023-03-01
申请人： Promega Corporation
发明人： Subhanjan Mondal , Nathan Feirer , Min Zhou , Michael Scurria , Wenhui Zhou , Said Goueli , James J. Cali
IPC分类号： C12Q1/70 , C12Q1/6851 , C07D221/12 , C07F15/00 , C07D235/20 , C07F9/6558 , C07D417/06 , C07D417/14 , C07D495/04
CPC分类号： C12Q1/701 , C12Q1/6851 , C07D221/12 , C07F15/0093 , C07D235/20 , C07F9/65583 , C07D417/06 , C07D417/14 , C07D495/04 , C12Q1/6806
摘要： Provided herein multifunctional compounds that bind and modify nucleic acids, forming crosslinks between the nucleic acid strands. In particular embodiments, the multifunctional nucleic-acid binding/modifying compounds are selective for nucleic acids of non-viable cells and viruses (i.e., they are excluded from or degraded within viable cells and viruses), and therefore find use in methods for detecting or discriminating viable and non-viable cells/viruses and nucleic acids therefrom.
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公开(公告)号：US20140272990A1
公开(公告)日：2014-09-18
申请号：US14210818
申请日：2014-03-14
申请人： PROMEGA CORPORATION
发明人： Wenhui Zhou , Poncho Meisenheimer , Min Zhou
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C09B11/24 , C09B11/28 , C09B69/008 , G01N21/6456 , G01N33/582
摘要： Si- and Ge-based dyes and methods of using same.
摘要翻译： Si-和Ge-基染料及其使用方法。
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公开(公告)号：US11939311B2
公开(公告)日：2024-03-26
申请号：US16986682
申请日：2020-08-06
申请人： Promega Corporation
发明人： Joel Walker , Sergei Saveliev , Zhiyang Zeng , Robert Kargbo , Hui Wang , Sergiy Levin , Valerie Ressler , Jun Zhang , Ce Shi , Harry Tetsuo Uyeda , Jean Osterman , Min Zhou , Prabin Rai , Wenhui Zhou
IPC分类号： C07D317/24 , C07C309/15 , C12Q1/37 , G01N33/68
CPC分类号： C07D317/24 , C07C309/15 , C12Q1/37 , G01N33/6848
摘要： Provided herein are surfactant compounds that can be used to aid in preparation of protein samples for analysis, for example by mass spectrometry.
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公开(公告)号：US11524946B2
公开(公告)日：2022-12-13
申请号：US16712098
申请日：2019-12-12
申请人： Promega Corporation
IPC分类号： C07D307/42 , C07C317/28 , C07D307/80 , C07D311/58 , C12N9/12 , C12P19/34
摘要： The present disclosure includes compositions and methods for improved DNA amplification reactions. In particular, the present disclosure provides compositions and methods for hot-start PCR applications using DNA polymerase inhibitors that minimize non-specific DNA amplification by inactivating DNA polymerase at lower temperatures.
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公开(公告)号：US20210040058A1
公开(公告)日：2021-02-11
申请号：US16986682
申请日：2020-08-06
申请人： Promega Corporation
发明人： Joel Walker , Sergei Saveliev , Zhiyang Zeng , Robert Kargbo , Hui Wang , Sergiy Levin , Valerie Ressler , Jun Zhang , Ce Shi , Harry Tetsuo Uyeda , Jean Osterman , Min Zhou , Prabin Rai , Wenhui Zhou
IPC分类号： C07D317/24 , C07C309/15 , C07C309/14 , C12Q1/37 , G01N33/68
摘要： Provided herein are surfactant compounds that can be used to aid in preparation of protein samples for analysis, for example by mass spectrometry.
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公开(公告)号：US11939310B2
公开(公告)日：2024-03-26
申请号：US18049517
申请日：2022-10-25
申请人： Promega Corporation
IPC分类号： C07D307/42 , C07C317/28 , C07D307/80 , C07D311/58 , C12N9/12 , C12P19/34
CPC分类号： C07D307/42 , C07C317/28 , C07D307/80 , C07D311/58 , C12N9/1252 , C12P19/34 , C12Y207/07007
摘要： The present disclosure includes compositions and methods for improved DNA amplification reactions. In particular, the present disclosure provides compositions and methods for hot-start PCR applications using DNA polymerase inhibitors that minimize non-specific DNA amplification by inactivating DNA polymerase at lower temperatures.
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