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1.发明申请公开(公告)号：US20050019956A1
公开(公告)日：2005-01-27
申请号：US10616251
申请日：2003-07-08
申请人： Peter Martin , Keiki-Pua Dancil , Arthur Morsell , Hus Tigli
发明人： Peter Martin , Keiki-Pua Dancil , Arthur Morsell , Hus Tigli
IPC分类号： B01L3/00 , G01N21/84 , G01N33/552 , G01N35/00
CPC分类号： B01L3/502753 , B01L3/5023 , B01L3/5025 , B01L3/502715 , B01L3/502746 , B01L2300/0654 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B01L2400/0655 , G01N21/77 , G01N33/552 , G01N2021/752 , G01N2021/755 , G01N2021/757 , G01N2021/758 , G01N2021/7779 , G01N2021/7796 , G01N2035/0097 , Y10S435/808
摘要： Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules diffuse closely enough to the ligands to become bound. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.
摘要翻译： 用于测量分子结合相互作用的方法和装置。 优选的实施方案提供动力学结合和分离的实时测量，包括蛋白质分子与其它蛋白质分子和其它分子的结合和解离。 在优选的实施方案中，将配体固定在硅衬底中产生的多孔硅相互作用区域的孔内，之后悬浮在流体中的分析物流过多孔硅区域。 结合反应发生在分析物分子向配体扩散得足够接近以成为结合物时。 优选地，使用白光源和薄膜干涉技术观察结合和随后的分离反应，其中光谱仪布置成检测发生结合和解离反应的区域中的折射指数的变化。 在优选实施方案中，配体和分析物通过计算机控制的机器人流体控制技术通过微流体流动通道传递到多孔硅相互作用区域。
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2.发明授权公开(公告)号：US07517656B2
公开(公告)日：2009-04-14
申请号：US10616251
申请日：2003-07-08
申请人： Peter Martin , Keiki-Pua Dancil , Arthur Lee Morsell , Hus Tigli
发明人： Peter Martin , Keiki-Pua Dancil , Arthur Lee Morsell , Hus Tigli
IPC分类号： C12M1/34
CPC分类号： B01L3/502753 , B01L3/5023 , B01L3/5025 , B01L3/502715 , B01L3/502746 , B01L2300/0654 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B01L2400/0655 , G01N21/77 , G01N33/552 , G01N2021/752 , G01N2021/755 , G01N2021/757 , G01N2021/758 , G01N2021/7779 , G01N2021/7796 , G01N2035/0097 , Y10S435/808
摘要： Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules diffuse closely enough to the ligands to become bound. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.
摘要翻译： 用于测量分子结合相互作用的方法和装置。 优选的实施方案提供动力学结合和分离的实时测量，包括蛋白质分子与其它蛋白质分子和其它分子的结合和解离。 在优选的实施方案中，将配体固定在硅衬底中产生的多孔硅相互作用区域的孔内，之后悬浮在流体中的分析物流过多孔硅区域。 结合反应发生在分析物分子向配体扩散得足够接近以成为结合物时。 优选地，使用白光源和薄膜干涉技术观察结合和随后的分离反应，其中光谱仪布置成检测发生结合和解离反应的区域中的折射指数的变化。 在优选实施方案中，配体和分析物通过计算机控制的机器人流体控制技术通过微流体流动通道传递到多孔硅相互作用区域。
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3.发明申请公开(公告)号：US20080153105A1
公开(公告)日：2008-06-26
申请号：US10631592
申请日：2003-07-30
申请人： Peter Martin , Keiki-Pau Dancil , Arthur Lee Morsell , Hus Tigli
发明人： Peter Martin , Keiki-Pau Dancil , Arthur Lee Morsell , Hus Tigli
CPC分类号： G01N33/552 , G01N21/84 , G01N33/54373
摘要： Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules diffuse closely enough to the ligands to become bound. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.
摘要翻译： 用于测量分子结合相互作用的方法和装置。 优选的实施方案提供动力学结合和分离的实时测量，包括蛋白质分子与其它蛋白质分子和其它分子的结合和解离。 在优选的实施方案中，将配体固定在硅衬底中产生的多孔硅相互作用区域的孔内，之后悬浮在流体中的分析物流过多孔硅区域。 结合反应发生在分析物分子向配体扩散得足够接近以成为结合物时。 优选地，使用白光源和薄膜干涉技术观察结合和随后的分离反应，其中光谱仪布置成检测发生结合和解离反应的区域中的折射指数的变化。 在优选实施方案中，配体和分析物通过计算机控制的机器人流体控制技术通过微流体流动通道传递到多孔硅相互作用区域。
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公开(公告)号：US20060063178A1
公开(公告)日：2006-03-23
申请号：US11196894
申请日：2005-08-04
申请人： Christine Rauh-Adelmann , Susant Patra , Hus Tigli , Peter Martin
发明人： Christine Rauh-Adelmann , Susant Patra , Hus Tigli , Peter Martin
CPC分类号： G01N33/54373 , B01L3/502715 , B01L3/502738 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2400/0487 , B01L2400/0655 , B01L2400/086 , G01N21/84 , G01N33/552
摘要： Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules diffuse closely enough to the ligands to become bound. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.
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公开(公告)号：US20100266287A1
公开(公告)日：2010-10-21
申请号：US12799023
申请日：2010-04-16
申请人： Prasanna Adhikari , Hus Tigli , Robert A. Fein
发明人： Prasanna Adhikari , Hus Tigli , Robert A. Fein
CPC分类号： H04W88/085 , H04W72/0453
摘要： A bandwidth allocation and management system for cellular communication networks. The system includes at least one master optical switch and processing station, a number of aggregation base stations that are in optical fiber communication with a master optical switching and processing station and a number of auxiliary cellular base stations surrounded by and supported by each aggregation base station. In preferred embodiments a plurality of sets of three neighboring base stations are each adapted to receive and process RF signals transmitted by cellular users within a broadcast and receive range and transmit the RF signals received, by each of the three neighborhood base stations, from each of the cellular users in analog form to the master optical switching and processing station. The master optical switching and processing station processes the three RF signals and combine, for each user within the broadcast and receive range, the three RF signals and to convert the combined RF signals to digital form for transmission to other users in the communication network.
摘要翻译： 蜂窝通信网络的带宽分配和管理系统。 该系统包括至少一个主光开关和处理站，与主光交换和处理站进行光纤通信的多个聚合基站以及由每个聚合基站包围并由其支持的多个辅助蜂窝基站 。 在优选实施例中，多组三个相邻基站各自适于在广播和接收范围内接收和处理蜂窝用户发射的RF信号，并且将由三个邻近基站中的每一个接收的RF信号从 蜂窝用户以模拟形式向主光交换和处理站。 主光切换和处理站处理三个RF信号，并且为广播和接收范围内的每个用户组合三个RF信号，并将组合的RF信号转换成数字形式，以便传输到通信网络中的其他用户。
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公开(公告)号：US07734127B2
公开(公告)日：2010-06-08
申请号：US11728435
申请日：2007-03-26
申请人： Eric Korevaar , Yoshinao Taketomi , Todd Barrott , Hus Tigli , Matthew Last , Larry Dirvscio , Edward Davis
发明人： Eric Korevaar , Yoshinao Taketomi , Todd Barrott , Hus Tigli , Matthew Last , Larry Dirvscio , Edward Davis
CPC分类号： G02B6/359 , G02B6/3512 , G02B6/3542 , G02B6/3556 , G02B6/356 , G02B6/357 , G02B6/3582 , G02B6/3584
摘要： The present invention provides an all optical cross connect switch utilizing two-axis MEMS mirrors for cross connecting optical fibers in a first set of optical fibers to optical fibers in a second set of optical fibers. The optical fibers in the first and second sets of optical fibers are precisely positioned in a first fiber-microlens positioning array to define a first set of parallel collimated cross-connect communication beam paths, with each collimated cross-connect communication beam path connecting an optical fiber in the first set of optical fibers with a MEMS mirror in a first MEMS mirror array. Alignment beams are added to and aligned co-axially with each of the first and second sets of parallel collimated cross-connect communication beams. Two beam direction sensor units are positioned to detect each alignment beam in the first and second sets of alignment beams transmitted through the dichroic mirror and a MEMS control system controls the positions of the MEMS mirrors to connect optical fibers in the first set of optical fibers to any of the optical fibers in the second set of optical fibers.
摘要翻译： 本发明提供了一种全光交叉连接开关，其利用两轴MEMS镜将第一组光纤中的光纤与第二组光纤中的光纤交叉连接。 第一和第二组光纤中的光纤被精确地定位在第一光纤微透镜定位阵列中，以限定第一组平行准直交叉连接通信光束路径，每个准直交叉连接通信光束路径连接光学 第一组光纤中的光纤具有在第一MEMS反射镜阵列中的MEMS反射镜。 对准光束被加入并与第一组和第二组平行准直交叉连接光束中的每一个同轴地对准。 定位两个光束方向传感器单元以检测透过分色镜的第一组和第二组对准光束中的每个对准光束，并且MEMS控制系统控制MEMS反射镜的位置，以将第一组光纤中的光纤连接到 第二组光纤中的任何光纤。
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公开(公告)号：US20080239443A1
公开(公告)日：2008-10-02
申请号：US11728435
申请日：2007-03-26
申请人： Eric Korevaar , Yoshinao Taketomi , Todd Barrott , Hus Tigli , Matthew Last , Larry Dirvscio , Edward Davis
发明人： Eric Korevaar , Yoshinao Taketomi , Todd Barrott , Hus Tigli , Matthew Last , Larry Dirvscio , Edward Davis
IPC分类号： G02B26/08
CPC分类号： G02B6/359 , G02B6/3512 , G02B6/3542 , G02B6/3556 , G02B6/356 , G02B6/357 , G02B6/3582 , G02B6/3584
摘要： The present invention provides an all optical cross connect switch utilizing two-axis MEMS mirrors for cross connecting optical fibers in a first set of optical fibers to optical fibers in a second set of optical fibers. The optical fibers in the first and second sets of optical fibers are precisely positioned in a first fiber-microlens positioning array to define a first set of parallel collimated cross-connect communication beam paths, with each collimated cross-connect communication beam path connecting an optical fiber in the first set of optical fibers with a MEMS mirror in a first MEMS mirror array. Alignment beams are added to and aligned co-axially with each of the first and second sets of parallel collimated cross-connect communication beams. Two beam direction sensor units are positioned to detect each alignment beam in the first and second sets of alignment beams transmitted through the dichroic mirror and a MEMS control system controls the positions of the MEMS mirrors to connect optical fibers in the first set of optical fibers to any of the optical fibers in the second set of optical fibers.
摘要翻译： 本发明提供了一种全光交叉连接开关，其利用两轴MEMS镜将第一组光纤中的光纤与第二组光纤中的光纤交叉连接。 第一和第二组光纤中的光纤被精确地定位在第一光纤微透镜定位阵列中，以限定第一组平行准直交叉连接通信光束路径，每个准直交叉连接通信光束路径连接光学 第一组光纤中的光纤具有在第一MEMS反射镜阵列中的MEMS反射镜。 对准光束被加入并与第一组和第二组平行准直交叉连接光束中的每一个同轴地对准。 定位两个光束方向传感器单元以检测透过分色镜的第一和第二组对准光束中的每个对准光束，并且MEMS控制系统控制MEMS反射镜的位置，以将第一组光纤中的光纤连接到 第二组光纤中的任何光纤。
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公开(公告)号：US07050669B2
公开(公告)日：2006-05-23
申请号：US10838070
申请日：2004-05-03
申请人： Todd Barrett , Chris Sexton , Donald Bruns , Dave Sandler , Hus Tigli
发明人： Todd Barrett , Chris Sexton , Donald Bruns , Dave Sandler , Hus Tigli
IPC分类号： G02B6/26
CPC分类号： G02B6/3588 , G02B6/266 , G02B6/3512 , G02B6/3518 , G02B6/3542 , G02B6/3556 , G02B6/356 , G02B6/357 , G02B6/3584 , G02B6/359 , G02B26/0833 , G02B27/62 , G02B2006/12104 , H04Q11/0062 , H04Q11/0071 , H04Q2011/0073
摘要： An optical cross connect switch. In this switch any optical fiber in an input set of optical fibers, each carrying a communication beam, can be cross connected to any optical fiber in an output set of optical fibers. An alignment beam is added to and aligned co-axially with the communication beam carried by each fiber in the input set of optical fibers to define a communication-alignment beam for each fiber. Each communication-alignment beam is directed within a confined optical pathway to a specific exit aperture in an input array structure. The exit apertures for all of the communication-alignment beams are arranged in a pattern defining an input array so that each communication-alignment beam can be identified by the location of its exit aperture in the input array structure. Each communication-alignment beam is formed into a cross-connection beam by a micro-lens in a first lens micro-lens array. Each cross-connection beam is directed to a lens in a second lens array by two mirrors, a first mirror in a first mirror array and a second mirror in a second mirror array. The lens in the second micro-lens array focuses the communication beams into a specific input aperture of a confined optical pathway, preferably an optical fiber, in an output array structure. Each of the confined optical pathways in the output array structure is optically connected to an optical fiber of an output set of optical fibers. A first detector array located near the second lens array monitors the position of each alignment beam and provides position information to a processor for control of the mirrors in at least one of the mirror arrays.
摘要翻译： 光交叉开关。 在该开关中，输入光纤组中的任何光纤，每个携带通信光束的光纤可以交叉连接到输出光纤组中的任何光纤。 对准光束被添加到光纤的输入组中并与由每个光纤携带的通信光束同轴地对准，以限定每个光纤的通信对准光束。 每个通信对准光束被引导到一个有限的光学路径中，到达输入阵列结构中的一个特定的出射孔。 用于所有通信对准光束的出射孔以限定输入阵列的图案布置，使得每个通信对准光束可以通过其输入阵列结构中其出射孔的位置来识别。 每个通信对准光束通过第一透镜微透镜阵列中的微透镜形成为交叉连接光束。 每个交叉连接梁通过两个反射镜指向第二透镜阵列中的透镜，第一反射镜阵列中的第一反射镜和第二反射镜阵列中的第二反射镜。 第二微透镜阵列中的透镜将通信光束聚焦成输出阵列结构中的限制光学路径（优选光纤）的特定输入孔径。 输出阵列结构中的每个限制光路径光学地连接到输出光纤组的光纤。 位于第二透镜阵列附近的第一检测器阵列监视每个对准光束的位置，并向处理器提供位置信息，以控制至少一个反射镜阵列中的反射镜。
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公开(公告)号：US08422885B2
公开(公告)日：2013-04-16
申请号：US12799023
申请日：2010-04-16
申请人： Prasanna Adhikari , Hus Tigli , Robert A Fein
发明人： Prasanna Adhikari , Hus Tigli , Robert A Fein
CPC分类号： H04W88/085 , H04W72/0453
摘要： A bandwidth allocation and management system for cellular communication networks. The system includes at least one master optical switch and processing station, a number of aggregation base stations that are in optical fiber communication with a master optical switching and processing station and a number of auxiliary cellular base stations surrounded by and supported by each aggregation base station. In preferred embodiments a plurality of sets of three neighboring base stations are each adapted to receive and process RF signals transmitted by cellular users within a broadcast and receive range and transmit the RF signals received, by each of the three neighborhood base stations, from each of the cellular users in analog form to the master optical switching and processing station. The master optical switching and processing station processes the three RF signals and combine, for each user within the broadcast and receive range, the three RF signals and to convert the combined RF signals to digital form for transmission to other users in the communication network.
摘要翻译： 蜂窝通信网络的带宽分配和管理系统。 该系统包括至少一个主光开关和处理站，与主光交换和处理站进行光纤通信的多个聚合基站以及由每个聚合基站包围并由其支持的多个辅助蜂窝基站 。 在优选实施例中，多组三个相邻基站各自适于在广播和接收范围内接收和处理蜂窝用户发射的RF信号，并且将由三个邻近基站中的每一个接收的RF信号从 蜂窝用户以模拟形式向主光交换和处理站。 主光切换和处理站处理三个RF信号，并且为广播和接收范围内的每个用户组合三个RF信号，并将组合的RF信号转换成数字形式，以便传输到通信网络中的其他用户。
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公开(公告)号：US08218918B2
公开(公告)日：2012-07-10
申请号：US12661622
申请日：2010-03-18
申请人： Hus Tigli , Matthew Last , Yoshi Taketomi
发明人： Hus Tigli , Matthew Last , Yoshi Taketomi
IPC分类号： G02B6/26
CPC分类号： G02B6/359 , G02B6/3512 , G02B6/3542 , G02B6/3556 , G02B6/356 , G02B6/357 , G02B6/3582 , G02B6/3584
摘要： A scalable optical switch especially useful for switching multimode beams carried by optical fibers. Light from an input fiber is focused by a lens which is moved in an x-y direction perpendicular to the beam direction in order to switch the beam from one output fiber to a different fiber. In preferred embodiments the beam can be directed to any one of as many as 90 output fibers. Techniques for scaling the switch to produce N×N switches with N being large are described. Embodiments of the present invention can also be utilized to create more elaborate fiber optical switches such as an N×N switch and a N2×N switch.
摘要翻译： 一种可扩展的光开关，特别适用于切换由光纤承载的多模光束。 来自输入光纤的光由通过垂直于光束方向的x-y方向移动的透镜聚焦，以将光束从一个输出光纤切换到不同的光纤。 在优选实施例中，光束可以被引导到多达90个输出光纤中的任何一个。 描述了用于缩放开关以产生N为大的N×N个开关的技术。 本发明的实施例也可用于创建更精细的光纤开关，例如N×N开关和N2×N开关。
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