公开(公告)号：US20050118070A1

公开(公告)日：2005-06-02

申请号：US10971859

申请日：2004-10-22

申请人： Patrick Griss ,  Vuk Siljegovic ,  Martin Kopp

发明人： Patrick Griss ,  Vuk Siljegovic ,  Martin Kopp

IPC分类号： G01N35/08 ,  B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  F15C5/00 ,  F16K99/00 ,  G01N37/00 ,  B01L3/02 ,  B32B5/02 ,  B32B27/04 ,  B32B27/12 ,  B65D37/00

CPC分类号： F16K99/0017 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0688 ,  F16K99/0001 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0084

摘要： The present invention is related to a microfluidic device capable of conveying a liquid by capillary forces. The microfluidic device comprises a microfluidic channel system comprising i) a liquid supply compartment; ii) a first channel connected to the liquid supply compartment, having at least one non-closing valve located downstream of the liquid supply compartment; and iii) a second channel. The second channel branches-off from the first channel downstream of the liquid supply compartment but upstream of the at least one non-closing valve and which re-unites with the first channel at the location of the non-closing valve to form an outlet channel. The second channel does not contain any non-closing or closing valve thus creating an unobstructed liquid flow path connecting the liquid supply compartment with the outlet channel.

摘要翻译： 本发明涉及能够通过毛细管力输送液体的微流体装置。 微流体装置包括微流体通道系统，其包括i）液体供应室; ii）连接到液体供应室的第一通道，具有位于液体供应室下游的至少一个非闭合阀; 和iii）第二通道。 第二通道从液体供应室的下游的第一通道分支，而在至少一个非关闭阀的上游分支，并且在非关闭阀的位置处与第一通道重新组合以形成出口通道 。 第二通道不包含任何非闭合或关闭阀，从而产生连接液体供应室与出口通道的无障碍液体流路。

公开(公告)号：US20090311796A1

公开(公告)日：2009-12-17

申请号：US12482707

申请日：2009-06-11

申请人： Patrick Griss ,  Rainer Jaeggi ,  Goran Savatic ,  Vuk Siljegovic

发明人： Patrick Griss ,  Rainer Jaeggi ,  Goran Savatic ,  Vuk Siljegovic

IPC分类号： G01N21/75 ,  G01N33/00 ,  G01N9/30

CPC分类号： B01L3/50273 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0803 ,  B01L2300/0887 ,  B01L2300/168 ,  B01L2400/0409 ,  B01L2400/0688 ,  C12Q1/54 ,  G01N21/07 ,  G01N33/491 ,  Y10T436/144444 ,  Y10T436/146666 ,  Y10T436/15 ,  Y10T436/166666 ,  Y10T436/171538 ,  Y10T436/175383 ,  Y10T436/201666 ,  Y10T436/204165

摘要： An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber.

摘要翻译： 公开了用于分析化学或生物样品的分析装置，基于装置的旋转，集成的样品计量和光学检测使用这种装置的方法，以及包括这种装置的系统。 分析装置包括具有液体处理单元的装置主体。 液体处理单元包括用于将样品与试剂混合的混合室，用于将限定体积的样品输送到混合室的样品计量室，以及用于输送要与样品混合的试剂的试剂通道，其中 混合室也用作检测室。

公开(公告)号：US08814808B2

公开(公告)日：2014-08-26

申请号：US12879500

申请日：2010-09-10

申请人： Irio Guiseppe Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  Dave Hasker ,  Volker Zimmer ,  Wilifried Schmid ,  Otto Fuerst ,  Hans List ,  Hans-Peter Haar ,  Theo Arnitz ,  Steven N. Roe

发明人： Irio Guiseppe Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  Dave Hasker ,  Volker Zimmer ,  Wilifried Schmid ,  Otto Fuerst ,  Hans List ,  Hans-Peter Haar ,  Theo Arnitz ,  Steven N. Roe

IPC分类号： A61B5/151 ,  A61B5/15 ,  A61B5/145

CPC分类号： A61B5/1411 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/150396 ,  A61B5/150419 ,  A61B5/150427 ,  A61B5/15045 ,  A61B5/150503 ,  A61B5/15151 ,  A61B5/15163

摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid. In one embodiment, the collection zone includes a plurality of holes, e.g., 3 or more holes, or 50 to 100 holes. The hole size may be small, e.g., having a diameter of 0.01 to 0.5 mm. The holes may or may not extend through the lancet. In some embodiments, the holes have a depth of 50 to 500 μm. In other embodiments, the collection zone is porous, or is a roughened area. The collection zone can take up a very small volume of body fluid, e.g., 3 to 10 nL, in a very short time period, e.g., less than 0.5 seconds. In other embodiments, the device further comprises a fluid receiving means spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially.

摘要翻译： 体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件。 在一个实施例中，收集区包括多个孔，例如3个或更多个孔，或50至100个孔。 孔尺寸可以较小，例如具有0.01至0.5mm的直径。 这些孔可以延伸穿过刺血针也可能不延伸穿过刺血针。 在一些实施例中，孔的深度为50至500μm。 在其它实施方案中，收集区是多孔的，或者是粗糙区域。 收集区可以在非常短的时间段（例如小于0.5秒）内占据非常小体积的体液，例如3至10nL。 在其他实施例中，该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液最初不会接触流体接收装置。

公开(公告)号：US08162854B2

公开(公告)日：2012-04-24

申请号：US11470021

申请日：2006-09-05

申请人： Irio G. Calasso ,  Patrick Griss ,  Rainer Jaeggi ,  Emad Sarofim

发明人： Irio G. Calasso ,  Patrick Griss ,  Rainer Jaeggi ,  Emad Sarofim

IPC分类号： B65D81/00

CPC分类号： A61B5/14532 ,  A61B5/1411 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150251 ,  A61B5/150297 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15117

摘要： Body fluid sampling device comprising a skin-piercing element (10) having a fluid pathway (11) for receiving body fluid, at least a portion of the fluid pathway is open to the environment and further comprising a fluid receiving element (40) being spaced from the fluid pathway so that fluid in the pathway will not contact the fluid receiving element initially. The fluid receiving element may have a test zone (45) for performing an analytical reaction. Fluid from the channel is contacted with the fluid receiving element either by bringing the fluid receiving element and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving element.

摘要翻译： 体液取样装置包括具有用于接收体液的流体通道（11）的皮肤刺穿元件（10），所述流体通道的至少一部分对环境开放，并且还包括间隔开的流体接收元件（40） 从流体通路使得通道中的流体最初不会接触流体接收元件。 流体接收元件可以具有用于进行分析反应的测试区（45）。 通过将流体接收元件和流体机械接触或将流体从通道电输送到流体接收元件上，来自通道的流体与流体接收元件接触。

公开(公告)号：US08087141B2

公开(公告)日：2012-01-03

申请号：US11763266

申请日：2007-06-14

申请人： Patrick Griss ,  Marzellinus Zipfel ,  Angel Lopez

发明人： Patrick Griss ,  Marzellinus Zipfel ,  Angel Lopez

IPC分类号： B21D53/00

CPC分类号： A61M37/00 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150419 ,  A61B5/15105 ,  A61B5/15142 ,  Y10T29/302 ,  Y10T29/304 ,  Y10T29/49812 ,  Y10T29/49995 ,  Y10T29/53339 ,  Y10T428/12188

摘要： The sheet metal or substrate material 22 is constructed by a photo-chemical machining or milling method. In this exemplary process, an etching mask 24 is applied to both sides of the substrate 22 and covers the structure of the flat-shaped member 12, which is to be uncovered in a subsequent etching step. The mask 24 is formed by coating the substrate 22 with a photoresist and is exposed through a photomask having the desired pattern that is arranged in front of the mask, whereby the photoresist is polymerized or hardened in the covered areas while the other areas are rinsed away after development.

摘要翻译： 金属板或基板材料22通过光化学加工或研磨方法构成。 在该示例性工艺中，将蚀刻掩模24施加到基板22的两侧，并且覆盖在随后的蚀刻步骤中未被覆盖的平坦形构件12的结构。 掩模24通过用光致抗蚀剂涂覆基板22而形成，并且通过布置在掩模前面的具有所需图案的光掩模曝光，由此光致抗蚀剂在覆盖区域聚合或硬化，而其它区域被冲洗掉 后发展。

公开(公告)号：US20070255205A1

公开(公告)日：2007-11-01

申请号：US11661113

申请日：2005-08-30

申请人： Patrick Griss ,  Goran Stemme

发明人： Patrick Griss ,  Goran Stemme

IPC分类号： A61M37/00

CPC分类号： B29C45/2628 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B29C2045/0094 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C99/0085 ,  B81C2201/034

摘要： Method of hollow micro-projections having side walls and at least one opening in a side wall, by a molding technique. The hollow micro-projections are defined by a first, negative mold defining the exterior shape of the micro-projections and a second, positive mold defining the hollow interior shape of the micro-projections. The method includes injecting a moldable material into the space between the two molds, in a state where they have been brought together. The positive and negative molds each have an essentially cylindrical geometry. In the process of bringing the molds together, the mold halves are laterally off-set with respect to each other, such that the distance between an inner wall of the negative mold and the positive mold in the area, ranges from zero to a finite distance. Micro-projections and arrays of micro-projections are also disclosed.

摘要翻译： 通过成型技术的具有侧壁和侧壁中的至少一个开口的中空微型突起的方法。 中空微突起由限定微突起的外部形状的第一负模具和限定微突起的中空内部形状的第二正模定义。 该方法包括将可模塑材料注入到两个模具之间的空间中，并将它们合并在一起。 正负模具各自具有基本上圆柱形的几何形状。 在将模具合在一起的过程中，半模相对于彼此横向偏移，使得阴模的内壁和该区域中的正模之间的距离从零到有限距离 。 还公开了微突起和微突起的阵列。

公开(公告)号：US08420024B2

公开(公告)日：2013-04-16

申请号：US13439036

申请日：2012-04-04

申请人： Stephan Korner ,  Patrick Griss ,  Emad Sarofim ,  Carlo Effenhauser

发明人： Stephan Korner ,  Patrick Griss ,  Emad Sarofim ,  Carlo Effenhauser

IPC分类号： B01L3/00

CPC分类号： G01N1/20 ,  B01L3/0244 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2400/025 ,  B01L2400/0406 ,  Y10T29/49826 ,  Y10T436/110833 ,  Y10T436/2575

摘要： A device for sampling, transporting and/or disposal of fluid media in the nl and μl-range comprises a substrate with an open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open or closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.

公开(公告)号：US08369918B2

公开(公告)日：2013-02-05

申请号：US13167243

申请日：2011-06-23

申请人： Irio G. Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  David Hasker ,  Volker Zimmer

发明人： Irio G. Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  David Hasker ,  Volker Zimmer

IPC分类号： A61B5/04

CPC分类号： A61B5/14532 ,  A61B5/1411 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150251 ,  A61B5/150297 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15117

摘要： Body fluid sampling device comprising a sampling element having a fluid pathway (11) for receiving body fluid, at least a portion of the fluid pathway is open to the environment and further comprising a fluid receiving means (40) being spaced from the fluid pathway so that fluid in the pathway will not contact the fluid receiving means initially. The fluid receiving means has two or more test zones (45) for performing analytical reactions. Fluid from the channel is contacted with the fluid receiving means either by bringing the fluid receiving means and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving means.

摘要翻译： 体液取样装置包括具有用于接收体液的流体通道（11）的采样元件，流体通路的至少一部分对环境开放，并且还包括与流体通道间隔开的流体接收装置（40） 路径中的流体最初不会接触流体接收装置。 流体接收装置具有用于进行分析反应的两个或更多个测试区（45）。 来自通道的流体通过使流体接收装置和流体机械接触或者将流体从流路电输送到流体接收装置上而与流体接收装置接触。

公开(公告)号：US07258805B2

公开(公告)日：2007-08-21

申请号：US10486541

申请日：2002-08-14

申请人： Göran Stemme ,  Patrick Griss

发明人： Göran Stemme ,  Patrick Griss

IPC分类号： A61M5/00

CPC分类号： A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053

摘要： A micro-needle protrudes from a support member. The needle has a needle body portion, a closed pointed tip portion, and an inner lumen extending through the support member and into the protruding needle. The needle body portion has at least one side opening communicating with the inner lumen. The method of making the needle comprises providing a mask on the front side of an etchable wafer such that the vertical projection of the mask at least partially covers the extension of a hole made in the back side. The mask is isotropically underetched to remove wafer material. An anisotropic etch forms a protruding structure. Optionally a second isotropic etch on the protruding structure exposes the blind hole. Optionally a final anisotropic etch extends the needle without forming side openings.

摘要翻译： 微针从支撑构件突出。 针具有针体部分，封闭的尖端部分和延伸穿过支撑部件并进入突出针的内腔。 针体部具有与内腔连通的至少一个侧开口。 制造针的方法包括在可蚀刻晶片的正面上设置掩模，使得掩模的垂直投影至少部分地覆盖在后侧形成的孔的延伸部。 掩模各向同性地去除晶片材料。 各向异性蚀刻形成突出结构。 可选地，突出结构上的第二各向同性蚀刻暴露盲孔。 可选地，最终的各向异性蚀刻使针不会形成侧面开口。

公开(公告)号：US20070038149A1

公开(公告)日：2007-02-15

申请号：US11470021

申请日：2006-09-05

申请人： Irio Calasso ,  Patrick Griss ,  Rainer Jaeggi ,  Emad Sarofim

发明人： Irio Calasso ,  Patrick Griss ,  Rainer Jaeggi ,  Emad Sarofim

IPC分类号： A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/1411 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150251 ,  A61B5/150297 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15117

摘要： Body fluid sampling device comprising a skin-piercing element (10) having a fluid pathway (11) for receiving body fluid, at least a portion of said fluid pathway is open to the environment and further comprising a fluid receiving means (40) being spaced from said fluid pathway so that fluid in said pathway will not contact the fluid receiving means initially. Said fluid receiving means may have a test zone (45) for performing an analytical reaction. Fluid from said channel is contacted with said fluid receiving means either by bringing the fluid receiving means and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving means.

摘要翻译： 体液取样装置包括具有用于接收体液的流体通道（11）的皮肤刺穿元件（10），所述流体通道的至少一部分对环境开放，并且还包括间隔开的流体接收装置（40） 从所述流体通道使得所述通路中的流体最初不会接触流体接收装置。 所述流体接收装置可以具有用于进行分析反应的测试区（45）。 来自所述通道的流体与所述流体接收装置接触，通过使流体接收装置和流体进入机械接触或者将流体从通道电输送到流体接收装置上。