公开(公告)号：US08100007B2

公开(公告)日：2012-01-24

申请号：US12570319

申请日：2009-09-30

申请人： Olivier Elsenhans ,  Ulrich Opara ,  Vuk Siljegovic

发明人： Olivier Elsenhans ,  Ulrich Opara ,  Vuk Siljegovic

IPC分类号： G01F23/296

CPC分类号： G01N35/1011 ,  G01F23/296 ,  G01N2035/1025

摘要： A method and level sensor apparatus for detecting contact of a pipetting needle with at least a liquid contained in a vessel are disclosed. The apparatus provides a pipetting needle made of a material suitable for transmitting ultrasonic waves, a needle holder for holding the needle, a electromechanical transducer for generating ultrasonic pulses to be transmitted towards the needle, for receiving echo pulses reflected at the tip of the needle, and for generating an electrical output signal representative of the echo pulses, and electronic circuit means for generating and applying a driving signal to the transducer, which generates corresponding pulses which are transmitted to the needle towards the tip thereof, and for monitoring and evaluating the output signal to detect the position of the needle at which the tip of the needle contacts the liquid and for providing a resulting signal representative of the result of said evaluation.

摘要翻译： 公开了一种用于检测移液针与至少包含在容器中的液体的接触的方法和液位传感器装置。 该装置提供由适于发送超声波的材料制成的移液针，用于保持针的针保持器，用于产生要向针传递的超声波脉冲的机电换能器，用于接收在针尖反射的回波脉冲， 并且用于产生表示回波脉冲的电输出信号;以及电子电路装置，用于产生并向换能器施加驱动信号，所述驱动信号产生相应的脉冲，其向针朝向其尖端传递针，并用于监视和评估输出 信号以检测针的尖端与针接触液体的位置，并提供表示所述评估结果的结果信号。

公开(公告)号：US20090311796A1

公开(公告)日：2009-12-17

申请号：US12482707

申请日：2009-06-11

申请人： Patrick Griss ,  Rainer Jaeggi ,  Goran Savatic ,  Vuk Siljegovic

发明人： Patrick Griss ,  Rainer Jaeggi ,  Goran Savatic ,  Vuk Siljegovic

IPC分类号： G01N21/75 ,  G01N33/00 ,  G01N9/30

CPC分类号： B01L3/50273 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0803 ,  B01L2300/0887 ,  B01L2300/168 ,  B01L2400/0409 ,  B01L2400/0688 ,  C12Q1/54 ,  G01N21/07 ,  G01N33/491 ,  Y10T436/144444 ,  Y10T436/146666 ,  Y10T436/15 ,  Y10T436/166666 ,  Y10T436/171538 ,  Y10T436/175383 ,  Y10T436/201666 ,  Y10T436/204165

摘要： An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber.

摘要翻译： 公开了用于分析化学或生物样品的分析装置，基于装置的旋转，集成的样品计量和光学检测使用这种装置的方法，以及包括这种装置的系统。 分析装置包括具有液体处理单元的装置主体。 液体处理单元包括用于将样品与试剂混合的混合室，用于将限定体积的样品输送到混合室的样品计量室，以及用于输送要与样品混合的试剂的试剂通道，其中 混合室也用作检测室。

公开(公告)号：US20070036684A1

公开(公告)日：2007-02-15

申请号：US11502564

申请日：2006-08-10

申请人： Claudius Burkhardt ,  Martin Burri ,  Vuk Siljegovic

发明人： Claudius Burkhardt ,  Martin Burri ,  Vuk Siljegovic

IPC分类号： B01L3/02

CPC分类号： G01N1/10 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/0605 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2400/0406 ,  G01N35/1016 ,  G01N2001/149 ,  Y10T436/2575

摘要： The present invention concerns sample pick-up and metering devices, analytical test systems for determining an analyte in a sample liquid and their use for this purpose and methods for determining an analyte in a sample liquid. They comprise or use a sample pick-up and metering device according to the invention which consists of a support and a metering element integrated into the support for taking up a defined volume of sample liquid and a closed liquid compartment located on the support which contains a defined volume of a liquid where the liquid compartment on the support can be opened.

摘要翻译： 本发明涉及取样和计量装置，用于确定样品液体中的分析物的分析测试系统及其用于该目的的方法以及用于确定样品液体中的分析物的方法。 它们包括或使用根据本发明的样品拾取和计量装置，其由集成到支撑体中的支撑件和计量元件组成，用于吸收限定体积的样品液体和位于支撑件上的封闭的液体隔室，其包含 限定体积的液体，其中支撑体上的液体隔间可以打开。

公开(公告)号：US20060093525A1

公开(公告)日：2006-05-04

申请号：US11128542

申请日：2005-05-13

申请人： Markus Brunner ,  Jurg Dual ,  Oliver Elsenhans ,  Frank May ,  Vuk Siljegovic

发明人： Markus Brunner ,  Jurg Dual ,  Oliver Elsenhans ,  Frank May ,  Vuk Siljegovic

IPC分类号： B01L3/02

CPC分类号： G01N35/1011 ,  B01L3/021 ,  G01F23/2965 ,  G01F23/2966 ,  G01N2035/1025

摘要： A level sensor apparatus is disclosed for detecting contact of a pipetting needle with a liquid contained in a vessel. The apparatus includes a sensor head made up of a pipetting needle, a needle holder, and an electromechanical transducer. The sensor head also has an associated mechanical resonance frequency. An electrical signal generator is used to generate a driving signal which when applied to the electromechanical transducer causes vibration of the pipetting needle at the resonance frequency. A measurement device is used to measure a parameter of a vibration signal indicative of the mechanical vibration of the pipetting needle when it is driven by the driving signal. An electronic circuit and associated computer software is provided to evaluate variation of the vibration signal with time and thus detect contact of the pipetting needle with a liquid contained in the vessel.

摘要翻译： 公开了一种液位传感器装置，用于检测移液针与容纳在容器中的液体的接触。 该装置包括由移液针，针保持器和机电换能器构成的传感器头。 传感器头还具有相关的机械共振频率。 电信号发生器用于产生一个驱动信号，当驱动信号被施加到机电换能器时，会使谐振频率下的移液针振动。 测量装置用于测量当由驱动信号驱动时指示移液针的机械振动的振动信号的参数。 提供电子电路和相关联的计算机软件以评估振动信号随时间的变化，从而检测移液针与容纳在容器中的液体的接触。

公开(公告)号：US08303912B2

公开(公告)日：2012-11-06

申请号：US11502564

申请日：2006-08-10

申请人： Claudius Burkhardt ,  Martin Burri ,  Vuk Siljegovic

发明人： Claudius Burkhardt ,  Martin Burri ,  Vuk Siljegovic

IPC分类号： B01L3/00

CPC分类号： G01N1/10 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/0605 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2400/0406 ,  G01N35/1016 ,  G01N2001/149 ,  Y10T436/2575

摘要： The present invention concerns sample pick-up and metering devices, analytical test systems for determining an analyte in a sample liquid and their use for this purpose and methods for determining an analyte in a sample liquid. They comprise or use a sample pick-up and metering device according to the invention which consists of a support and a metering element integrated into the support for taking up a defined volume of sample liquid and a closed liquid compartment located on the support which contains a defined volume of a liquid where the liquid compartment on the support can be opened.

摘要翻译： 本发明涉及取样和计量装置，用于确定样品液体中的分析物的分析测试系统及其用于该目的的方法以及用于确定样品液体中的分析物的方法。 它们包括或使用根据本发明的样品拾取和计量装置，其由集成到支撑体中的支撑件和计量元件组成，用于吸收限定体积的样品液体和位于支撑件上的封闭的液体隔室，其包含 限定体积的液体，其中支撑体上的液体隔间可以打开。

公开(公告)号：US20100077853A1

公开(公告)日：2010-04-01

申请号：US12570319

申请日：2009-09-30

申请人： Olivier Elsenhans ,  Ulrich Opara ,  Vuk Siljegovic

发明人： Olivier Elsenhans ,  Ulrich Opara ,  Vuk Siljegovic

IPC分类号： G01F23/296 ,  B01L3/02

CPC分类号： G01N35/1011 ,  G01F23/296 ,  G01N2035/1025

摘要： A method and level sensor apparatus for detecting contact of a pipetting needle with at least a liquid contained in a vessel are disclosed. The apparatus provides a pipetting needle made of a material suitable for transmitting ultrasonic waves, a needle holder for holding the needle, a electromechanical transducer for generating ultrasonic pulses to be transmitted towards the needle, for receiving echo pulses reflected at the tip of the needle, and for generating an electrical output signal representative of the echo pulses, and electronic circuit means for generating and applying a driving signal to the transducer, which generates corresponding pulses which are transmitted to the needle towards the tip thereof, and for monitoring and evaluating the output signal to detect the position of the needle at which the tip of the needle contacts the liquid and for providing a resulting signal representative of the result of said evaluation.

摘要翻译： 公开了一种用于检测移液针与至少包含在容器中的液体的接触的方法和液位传感器装置。 该装置提供由适于发送超声波的材料制成的移液针，用于保持针的针保持器，用于产生要向针传递的超声波脉冲的机电换能器，用于接收在针尖反射的回波脉冲， 并且用于产生表示回波脉冲的电输出信号;以及电子电路装置，用于产生并向换能器施加驱动信号，所述驱动信号产生相应的脉冲，其向针朝向其尖端传递针，并用于监视和评估输出 信号以检测针的尖端与针接触液体的位置，并提供表示所述评估结果的结果信号。

公开(公告)号：US07416706B2

公开(公告)日：2008-08-26

申请号：US11128542

申请日：2005-05-13

申请人： Markus Brunner ,  Jürg Dual ,  Olivier Elsenhans ,  Frank May ,  Vuk Siljegovic

发明人： Markus Brunner ,  Jürg Dual ,  Olivier Elsenhans ,  Frank May ,  Vuk Siljegovic

IPC分类号： G05D9/12 ,  B01L3/02

CPC分类号： G01N35/1011 ,  B01L3/021 ,  G01F23/2965 ,  G01F23/2966 ,  G01N2035/1025

摘要： A level sensor apparatus is disclosed for detecting contact of a pipetting needle with a liquid contained in a vessel. The apparatus includes a sensor head made up of a pipetting needle, a needle holder, and an electromechanical transducer. The sensor head also has an associated mechanical resonance frequency. An electrical signal generator is used to generate a driving signal which when applied to the electromechanical transducer causes vibration of the pipetting needle at the resonance frequency. A measurement device is used to measure a parameter of a vibration signal indicative of the mechanical vibration of the pipetting needle when it is driven by the driving signal. An electronic circuit and associated computer software is provided to evaluate variation of the vibration signal with time and thus detect contact of the pipetting needle with a liquid contained in the vessel.

摘要翻译： 公开了一种液位传感器装置，用于检测移液针与容纳在容器中的液体的接触。 该装置包括由移液针，针保持器和机电换能器构成的传感器头。 传感器头还具有相关的机械共振频率。 电信号发生器用于产生一个驱动信号，当驱动信号被施加到机电换能器时，会使谐振频率下的移液针振动。 测量装置用于测量当由驱动信号驱动时指示移液针的机械振动的振动信号的参数。 提供电子电路和相关联的计算机软件以评估振动信号随时间的变化，从而检测移液针与容纳在容器中的液体的接触。

公开(公告)号：US20050118070A1

公开(公告)日：2005-06-02

申请号：US10971859

申请日：2004-10-22

申请人： Patrick Griss ,  Vuk Siljegovic ,  Martin Kopp

发明人： Patrick Griss ,  Vuk Siljegovic ,  Martin Kopp

IPC分类号： G01N35/08 ,  B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  F15C5/00 ,  F16K99/00 ,  G01N37/00 ,  B01L3/02 ,  B32B5/02 ,  B32B27/04 ,  B32B27/12 ,  B65D37/00

CPC分类号： F16K99/0017 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0688 ,  F16K99/0001 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0084

摘要： The present invention is related to a microfluidic device capable of conveying a liquid by capillary forces. The microfluidic device comprises a microfluidic channel system comprising i) a liquid supply compartment; ii) a first channel connected to the liquid supply compartment, having at least one non-closing valve located downstream of the liquid supply compartment; and iii) a second channel. The second channel branches-off from the first channel downstream of the liquid supply compartment but upstream of the at least one non-closing valve and which re-unites with the first channel at the location of the non-closing valve to form an outlet channel. The second channel does not contain any non-closing or closing valve thus creating an unobstructed liquid flow path connecting the liquid supply compartment with the outlet channel.

摘要翻译： 本发明涉及能够通过毛细管力输送液体的微流体装置。 微流体装置包括微流体通道系统，其包括i）液体供应室; ii）连接到液体供应室的第一通道，具有位于液体供应室下游的至少一个非闭合阀; 和iii）第二通道。 第二通道从液体供应室的下游的第一通道分支，而在至少一个非关闭阀的上游分支，并且在非关闭阀的位置处与第一通道重新组合以形成出口通道 。 第二通道不包含任何非闭合或关闭阀，从而产生连接液体供应室与出口通道的无障碍液体流路。