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公开(公告)号：US10281704B2
公开(公告)日：2019-05-07
申请号：US15607666
申请日：2017-05-29
Applicant: OLYMPUS CORPORATION
Inventor： Shintaro Takahashi , Tadashi Hirata , Yasunobu Iga , Shinichi Takimoto , Takashi Miyoshi
Abstract: Provided is an observation apparatus and an observation method with which it is possible to observe imaging subjects, such as cells or the like, without labeling the imaging subjects and without causing an increase in the apparatus size. Provided is an observation apparatus including: a light-source unit that emits illumination light upward from below a sample; and an image-capturing optical system that has an objective lens that collects transmitted light, which is the illumination light emitted from the light-source unit that has passed through the sample by being reflected above the sample and that captures, below the sample, the transmitted light collected by the objective lens.
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公开(公告)号：US11150456B2
公开(公告)日：2021-10-19
申请号：US16284071
申请日：2019-02-25
Applicant: OLYMPUS CORPORATION
Inventor： Tadashi Hirata
Abstract: An observation apparatus includes: a stage on which a container accommodating a specimen is mounted; a light source generating illumination light emitted in an upward direction from below the specimen on a specimen placement surface; a light-collecting lens disposed parallel to the surface and collecting the light; a diffusion plate disposed between the lens and the surface, parallel to the surface, and diffusing the light collected by the lens; an objective optical system disposed below the stage and collecting light passing through the stage from thereabove; and an image-capturing optical system capturing, below the specimen, transmitted light, which is the light emitted from the source, reflected above the specimen, transmitted through the specimen, and collected by the objective optical system, wherein the source is positioned so that an optical axis thereof is shifted from an optical axis of the lens in a direction away from the image-capturing optical system.
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公开(公告)号：US10016119B2
公开(公告)日：2018-07-10
申请号：US15421754
申请日：2017-02-01
Applicant: OLYMPUS CORPORATION
Inventor： Takeshi Watanabe , Tadashi Hirata
CPC classification number: A61B1/00188 , A61B1/00096 , A61B90/20 , G02B9/64 , G02B21/02 , G02B23/2407
Abstract: Provided is an objective optical system composed of, in order from an object side, a first and a second groups, the first group including: a positive and single lens having a flat surface on an object side and a convex surface directed toward an image plane; a positive and single lens having a convex surface directed toward an object; a positive lens in which a convex lens having a flat surface directed toward the object and a negative lens are cemented, and the second group including: a lens in which a negative lens and a double-convex lens are cemented; a lens in which a lens having a concave surface directed toward the object and a lens having a convex surface directed toward the object are cemented; a negative lens in which a negative lens, a positive lens, and a negative lens are cemented; and a positive and compound lens.
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公开(公告)号：US11016279B2
公开(公告)日：2021-05-25
申请号：US16238585
申请日：2019-01-03
Applicant: OLYMPUS CORPORATION
Inventor： Tadashi Hirata , Masaki Higurashi
Abstract: An observation device includes: an illumination optical system that irradiates illumination light onto a sample, an objective optical system that has a phase modulation region and a light blocking region and that acquires an image of the illumination light transmitted through the sample, and an autofocus mechanism. The objective optical system selectively outputs the illumination light from a first output region disposed at a position where the illumination light is to be projected onto the phase modulation region and a second output region disposed at a position where a portion of the illumination light is to be projected onto the light blocking region. The autofocus mechanism causes the objective optical system to acquire an image of the illumination light while causing the illumination light to be output from the second output region, and detects the focus position of the objective optical system based on the contrast of the acquired image.
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Patent Agency Ranking
公开(公告)号：US20180179487A1
公开(公告)日：2018-06-28
申请号：US15848623
申请日：2017-12-20
Applicant: OLYMPUS CORPORATION
Inventor： Akira MATSUSHITA , Shintaro Takahashi , Masaru Mizunaka , Shinichi Takimoto , Tadashi Hirata , Yohei Tanikawa
CPC classification number: C12M41/46 , G01J5/0003 , G01J5/04 , G01J5/061 , G01J5/0896 , G01J5/10 , G01J2005/0077 , G01J2005/068 , H04N5/2252 , H04N5/2256 , H04N5/33
Abstract: Provided is an observation apparatus including: a housing that has, in a top face thereof, a transmission window on which a container accommodating cells can be placed and through which light can pass; a camera portion that is accommodated in the housing and that captures observation light coming from the cells irradiated with illumination light emitted from an illumination portion and entering the housing by passing through a bottom face of the container and the transmission window of the housing; and a housing-interior heating portion that is accommodated in the housing and that heats the cells.
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公开(公告)号：US11163143B2
公开(公告)日：2021-11-02
申请号：US16285424
申请日：2019-02-26
Applicant: OLYMPUS CORPORATION
Inventor： Tadashi Hirata
Abstract: An observation apparatus is provided with: an illumination optical system that emits illumination light upward from below a specimen; and an image-capture optical system that captures, below the specimen, transmitted light which is the illumination light that has been reflected above the specimen and passed through the specimen, wherein the illumination optical system is provided with a diffusion plate, the image-capture optical system is provided with an objective optical system, and, in the case in which an emission region in the illumination optical system is projected to a pupil of the image-capture optical system, predetermined conditions are satisfied so as to partially block the illumination light at an edge portion of the pupil of the objective optical system.
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公开(公告)号：US10914931B2
公开(公告)日：2021-02-09
申请号：US16003402
申请日：2018-06-08
Applicant: OLYMPUS CORPORATION
Inventor： Tadashi Hirata , Shintaro Takahashi
Abstract: An observation device including: a stage having a transparent pedestal surface; an illumination system under the pedestal surface, the illumination system emitting illumination light toward the pedestal surface; and an object system under the pedestal surface for capturing transmission light generated from the illumination light, reflected off a reflection surface and transmitted through a sample. Wherein a first light path in the illumination system is different from a second light path in the object system, in a first pupil surface of the illumination system, the illumination system generates the illumination light by restricting light in a first transparent region, in a second pupil surface of the object system, the object system restricts the transmission light in a second transparent region, and the second transparent region has first and second subregions with different transmittance, the second subregion located between the first subregion and an edge of the second transparent region.
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公开(公告)号：US10670849B2
公开(公告)日：2020-06-02
申请号：US16003421
申请日：2018-06-08
Applicant: OLYMPUS CORPORATION
Inventor： Tadashi Hirata
IPC: G02B21/10 , G02B21/06 , G01B9/02 , G01B11/02 , G02B21/00 , G02B21/18 , G02B26/02 , G02B5/00 , G02B21/26
Abstract: An observation device where a first light path in an illumination optical system is different from a second light path in an object optical system, the illumination optical system includes a light source that emits the illumination light in a first direction, and an illumination deflector that deflects the illumination light from the first direction to a second direction, a pre-reflected illumination angle between a pedestal surface holding the sample and the first direction is smaller than a post-reflected illumination angle between the pedestal surface and the second direction, the object optical system includes a transmission deflector that deflects the transmission light transmitted through the sample from a third direction to a fourth direction, and a post-reflected transmission angle between the pedestal surface and the fourth direction is smaller than a pre-reflected transmission angle between the pedestal surface and the third direction.
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9.发明授权公开(公告)号：US10437050B2
公开(公告)日：2019-10-08
申请号：US15402466
申请日：2017-01-10
Applicant: OLYMPUS CORPORATION
Inventor： Tadashi Hirata
Abstract: A phase-modulation-element adjustment system including: a positional-relationship adjustment unit that is used for a laser-scanning confocal observation apparatus including a plurality of image-forming lenses for forming a final image and at least one intermediate image and a wavefront-disturbing element and a wavefront-restoring element being placed at positions between which any of the intermediate images formed by the image-forming lenses is disposed and having opposite phase characteristics to each other and that is capable of adjusting a relative positional relationship between the wavefront-disturbing element and the wavefront-restoring element; a wavefront-aberration measurement unit for measuring a wavefront aberration of light that has come from an object and that has passed through the wavefront-disturbing element and the wavefront-restoring element; and a processor for controlling the positional-relationship adjustment unit so that the wavefront aberration measured by the wavefront-aberration measurement unit decreases.
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