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公开(公告)号：US10593533B2
公开(公告)日：2020-03-17
申请号：US15776704
申请日：2016-11-16
摘要： A time-of-flight mass spectrometer is disclosed comprising: an ion deflector (305) configured to deflect ions to different positions in a first array of positions at different times; a position sensitive ion detector (187); and ion optics (180) arranged and configured to guide ions from the first array of positions to the position sensitive detector (187) so as to map ions from the first array of positions to a second array of positions on the position sensitive detector (187); wherein the ion optics includes at least one ion mirror for reflecting the ions.
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公开(公告)号：US20180144921A1
公开(公告)日：2018-05-24
申请号：US15570537
申请日：2016-04-29
摘要： A method of time-of-flight mass spectrometry is disclosed comprising: providing two ion mirrors (42) that are spaced apart in a first dimension (X-dimension) and that are each elongated in a second dimension (Z-dimension) orthogonal to the first dimension; introducing packets of ions (47) into the space between the mirrors using an ion introduction mechanism (43) such that the ions repeatedly oscillate in the first dimension (X-dimension) between the mirrors (42) as they drift through said space in the second dimension (Z-dimension); oscillating the ions in a third dimension (Y-dimension) orthogonal to both the first and second dimensions as the ions drift through said space in the second dimension (Z-dimension); and receiving the ions in or on an ion receiving mechanism (44) after the ions have oscillated multiple times in the first dimension (X-dimension); wherein at least part of the ion introduction mechanism (43) and/or at least part of the ion receiving mechanism (44) is arranged between the mirrors (42).
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公开(公告)号：US20180358219A1
公开(公告)日：2018-12-13
申请号：US15778341
申请日：2016-11-21
CPC分类号： H01J49/406 , H01J49/063 , H01J49/067 , H01J49/068 , H01J49/08
摘要： An ion mirror is disclosed comprising an ion entrance electrode section (62) at the ion entrance to the ion mirror, an energy focussing electrode section (66) for reflecting ions back along a longitudinal axis towards said ion entrance, and a spatial focussing electrode section (64) arranged between the ion entrance electrode section (62) and the energy focussing electrode section (66) for spatially focussing the ions. One or more DC voltage supply is provided to apply a DC potential to the ion entrance electrode section (62) that is intermediate the DC potential applied to the spatial focussing electrode section (64) and the DC potential applied to the energy focussing electrode section (66). The ion mirror further comprises: (i) at least one first transition electrode (68) arranged between said ion entrance electrode section (62) and said spatial focussing electrode section (64), wherein said one or more DC voltage supply is configured to apply a DC potential to said at least one first transition electrode that is intermediate the DC potential applied to the ion entrance electrode section (62) and the DC potential applied to the spatial focussing electrode section (64); and (ii) at least one second transition electrode (69) arranged between said energy focussing electrode section (66) and said spatial focussing electrode section (64), wherein said one or more DC voltage supply is configured to apply a DC potential to said at least one second transition electrode (69) that is intermediate the DC potential applied to the spatial focussing electrode section (64) and the DC potential applied to the ion entrance electrode section (62).
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公开(公告)号：US20180366313A1
公开(公告)日：2018-12-20
申请号：US15776704
申请日：2016-11-16
CPC分类号： H01J49/406 , H01J49/0004 , H01J49/061 , H01J49/062 , H01J49/40 , H01J49/401
摘要： A time-of-flight mass spectrometer is disclosed comprising: an ion deflector (305) configured to deflect ions to different positions in a first array of positions at different times; a position sensitive ion detector (187); and ion optics (180) arranged and configured to guide ions from the first array of positions to the position sensitive detector (187) so as to map ions from the first array of positions to a second array of positions on the position sensitive detector (187); wherein the ion optics includes at least one ion mirror for reflecting the ions.
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公开(公告)号：US10741376B2
公开(公告)日：2020-08-11
申请号：US15570537
申请日：2016-04-29
摘要： A method of time-of-flight mass spectrometry is disclosed comprising: providing two ion mirrors (42) that are spaced apart in a first dimension (X-dimension) and that are each elongated in a second dimension (Z-dimension) orthogonal to the first dimension; introducing packets of ions (47) into the space between the mirrors using an ion introduction mechanism (43) such that the ions repeatedly oscillate in the first dimension (X-dimension) between the mirrors (42) as they drift through said space in the second dimension (Z-dimension); oscillating the ions in a third dimension (Y-dimension) orthogonal to both the first and second dimensions as the ions drift through said space in the second dimension (Z-dimension); and receiving the ions in or on an ion receiving mechanism (44) after the ions have oscillated multiple times in the first dimension (X-dimension); wherein at least part of the ion introduction mechanism (43) and/or at least part of the ion receiving mechanism (44) is arranged between the mirrors (42).
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公开(公告)号：US20180330936A1
公开(公告)日：2018-11-15
申请号：US15776585
申请日：2016-11-16
CPC分类号： H01J49/405 , H01J49/0004 , H01J49/062 , H01J49/067 , H01J49/10 , H01J49/406
摘要： A time-of-flight mass spectrometer is disclosed comprising ion optics that map an array of ions at an ion source array (71) to a corresponding array of positions on a position sensitive ion detector (79). The ion optics include at least one gridless ion mirror (76) for reflecting ions, which may compensate for various aberrations and allows the spectrometer to have relatively high mass and spatial resolutions.
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公开(公告)号：US11710627B2
公开(公告)日：2023-07-25
申请号：US17558925
申请日：2021-12-22
申请人： Micromass UK Limited
IPC分类号： G01N30/72 , H01J49/04 , A61B10/02 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/00 , H01J49/06 , H01J49/16 , G16B20/50 , G01N27/623 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/624 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26 , G16B20/00 , A61B17/32 , G16H10/40 , G16H15/00 , G16H50/20 , A61B1/00 , A61B1/31 , A61B5/145
CPC分类号： H01J49/049 , A61B1/041 , A61B1/2736 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/055 , A61B5/0507 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/623 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/6848 , G01N33/6851 , G01N33/92 , G16B20/50 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/044 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26 , A61B1/00013 , A61B1/31 , A61B5/14542 , A61B17/320068 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , G01N33/48735 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20
摘要： A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.
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公开(公告)号：US11515136B2
公开(公告)日：2022-11-29
申请号：US17012865
申请日：2020-09-04
申请人： Micromass UK Limited
IPC分类号： H01J49/00 , H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/06 , H01J49/16 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , A61B1/00 , A61B1/31 , A61B5/145
摘要： A method of spectrometric analysis comprises obtaining one or more sample spectra for an aerosol, smoke or vapour sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the aerosol, smoke or vapour sample. The results of the analysis are used for various surgical or non-surgical applications.
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公开(公告)号：US20220367166A1
公开(公告)日：2022-11-17
申请号：US17746308
申请日：2022-05-17
申请人： Micromass UK Limited
发明人： Zoltan Takats , Emrys Jones , James Ian Langridge , Michael Raymond Morris , Tamas Karancsi , Steven Derek Pringle , Julia Balog , Daniel Simon , Lajos Godorhazy , Daniel Szalay , Keith Richardson , Phillip Robert Bennett , David Alan Macintyre , Pamela Pruski
IPC分类号： H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/00 , H01J49/06 , H01J49/16 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26
摘要： A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.
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公开(公告)号：US20220115222A1
公开(公告)日：2022-04-14
申请号：US17558925
申请日：2021-12-22
申请人： Micromass UK Limited
IPC分类号： H01J49/04 , A61B10/02 , H01J49/16 , G01N1/22 , G01N3/00 , G01N33/92 , H01J49/10 , H01J49/14 , G16B20/50 , A61B18/00 , A61B18/14 , A61B18/20 , H01J49/02 , H01J49/06 , A61B1/273 , A61B10/00 , C12Q1/04 , H01J49/00 , A61B5/01 , A61B5/055 , A61B17/00 , C12Q1/18 , G01N9/00 , A61B90/13 , A61B18/04 , C12Q1/24 , G01N33/68 , A61B5/00 , A61B6/03 , A61B8/13 , A61F13/38 , G01N30/72 , A61B5/0507 , G01N27/622 , H01J49/24 , H01J49/26 , A61B1/04 , A61B18/18 , G01N27/624 , G01N33/487 , C12Q1/02 , G16H15/00 , A61B1/31 , G16H50/20 , A61B17/32 , A61B1/00 , G16H10/40 , A61B5/145 , G16B20/00
摘要： A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.
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