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公开(公告)号：US10526457B2
公开(公告)日：2020-01-07
申请号：US15764942
申请日：2016-09-30
发明人： Elazer Edelman , Natalie Artzi , Hyun Seok Song , Yuji Yamamoto , Hiroki Yoshioka , Ken-ichiro Nakamoto
摘要： Provided herein are narrowly distributed multi-armed polyethylene glycol compounds, and hydrogels containing the same. Also provided are methods for treating, adhering, or sealing a biological tissue with hydrogels, and kits for making a hydrogel. Drug releasing compositions also are provided that include a narrowly distributed multi-armed polyethylene glycol compound.
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2.发明申请公开(公告)号：US20180282495A1
公开(公告)日：2018-10-04
申请号：US15764942
申请日：2016-09-30
发明人： Elazer Edelman , Natalie Artzi , Hyun Seok Song , Yuji Yamamoto , Hiroki Yoshioka , Ken-ichiro Nakamoto
CPC分类号： C08J3/246 , A61K9/0024 , A61L27/18 , A61L27/20 , A61L27/38 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2400/06 , C08J2305/02 , C08J2343/02 , C08J2371/02 , C08L71/02
摘要： Provided herein are narrowly distributed multi-armed polyethylene glycol compounds, and hydrogels containing the same. Also provided are methods for treating, adhering, or sealing a biological tissue with hydrogels, and kits for making a hydrogel. Drug releasing compositions also are provided that include a narrowly distributed multi-armed polyethylene glycol compound.
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公开(公告)号：US10736914B2
公开(公告)日：2020-08-11
申请号：US15882613
申请日：2018-01-29
摘要： Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. Drug delivery compositions and kits containing these two components also are provided.
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公开(公告)号：US09707313B2
公开(公告)日：2017-07-18
申请号：US14446805
申请日：2014-07-30
IPC分类号： A61K31/74 , A61M37/00 , A61K31/00 , A61K47/48 , A61L24/04 , A61L24/08 , A61L24/00 , A61M5/19 , A61M5/315
CPC分类号： A61L24/043 , A61L24/0005 , A61L24/0015 , A61L24/08 , A61M5/19 , A61M5/31596 , C08L5/02
摘要： Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.
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公开(公告)号：US20190142953A1
公开(公告)日：2019-05-16
申请号：US16300161
申请日：2017-05-10
发明人： Elazer R. Edelman , Natalie Artzi , Nuria Oliva
摘要： Abstract of the Disclosure Provided herein are compositions that include a dendrimer to which a drug and a binding peptide are conjugated. The binding peptide may be configured to bind to a receptor that is overexpressed by a diseased cell, such as a cancer cell. The compositions may include a hydrogel in which the dendrimer-drug conjugate is dispersed. Methods of drug delivery and kits also are provided.
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公开(公告)号：US09877984B2
公开(公告)日：2018-01-30
申请号：US14581208
申请日：2014-12-23
CPC分类号： A61K31/785 , A61K9/0019 , A61K47/34 , A61L24/001 , A61L24/08 , A61L27/20 , A61L27/50 , C08L5/02
摘要： Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. Drug delivery compositions and kits containing these two components also are provided.
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7.发明申请公开(公告)号：US20160243254A1
公开(公告)日：2016-08-25
申请号：US15047902
申请日：2016-02-19
发明人： Natalie Artzi , João Conde , Nuria Oliva
CPC分类号： A61K49/0032 , A61K31/513 , A61K31/713 , A61K33/24 , A61K47/6923 , A61K49/0054 , A61K49/0065 , A61K49/0093 , A61K2300/00 , A61K31/24
摘要： Theranostic nanoprobes are provided for overcoming cancer multidrug resistance, and methods for treating biological tissue, including cancerous tissue. The theranostic nanoprobes may include gold nanoparticles functionalized with DNA-hairpin. The DNA-hairpin may be configured to hybridize to a complementary target, which may silence or lessen the multidrug resistance of cancer cells. The theranostic nanoprobes may be configured to release a chemotherapeutic agent upon hybridization of the DNA-hairpin to a target molecule.
摘要翻译： 提供了纳曲酮纳米探针以克服癌症多药耐药性，以及用于治疗生物组织（包括癌组织）的方法。 衍生物纳米探针可以包括用DNA-发夹官能化的金纳米颗粒。 DNA发夹可以被配置为与互补靶物杂交，其可以沉默或减轻癌细胞的多药耐药性。 衍生物纳米探针可以被配置为在DNA-发夹与靶分子杂交时释放化学治疗剂。
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公开(公告)号：US20240149033A1
公开(公告)日：2024-05-09
申请号：US18278907
申请日：2022-02-28
发明人： Natalie Artzi , Pere Dosta , Nuria Puigmal
IPC分类号： A61M37/00 , A61K9/00 , A61K31/198 , A61K31/728
CPC分类号： A61M37/0015 , A61K9/0021 , A61K31/198 , A61K31/728 , A61M2037/0023 , A61M2037/0053
摘要： The present disclosure describes microneedle array compositions comprising a plurality of microneedles projecting from a substrate. Each microneedle of the plurality of microneedles comprise a penetrating tip and a base that is integrally connected with the substrate, wherein each microneedle of the plurality of microneedles is a porous microneedle composed of a degradable hyaluronic acid polymer comprising a disulfide bond.
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公开(公告)号：US10780195B2
公开(公告)日：2020-09-22
申请号：US15739217
申请日：2016-06-23
IPC分类号： A61L24/00 , A61L24/04 , A61L26/00 , C08L5/02 , C08L101/00
摘要： Methods, compositions, kits, and drug delivery devices are provided for treating, adhering, or sealing biological tissues. The methods include combining a first solution that includes an oligomer/polymer component and a second solution that includes a dendrimer component, and at least one of the oligomer/polymer component and dendrimer component includes at least one substituent that is capable of photoreversible dimerization. The reversible dimerization of the substituent may allow for the reversible dimerization and/or polymerization of one or more components. The substituent that is capable of photoreversible dimerization may be active by the application of light, such as UV light.
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公开(公告)号：US10342894B2
公开(公告)日：2019-07-09
申请号：US15293522
申请日：2016-10-14
发明人： Natalie Artzi , Elazer Reuven Edelman , Shimon Aryeh Unterman , Lyndon Fitzgerald Charles , Sara Elaine Strecker
摘要： Provided herein are methods for treating, adhering, or sealing biological tissue with a material, such as a hydrogel, that may include phyllosilicate nanoplatelets. The phyllosilicate nanoplatelets can have a high aspect ratio, a low aspect ratio, or be a mixture of high aspect ratio and low aspect ratio nanoplatelets. Drug releasing compositions and kits also are provided herein.
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