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公开(公告)号：US11167066B2
公开(公告)日：2021-11-09
申请号：US15055012
申请日：2016-02-26
发明人： Laura Indolfi , Elazer R. Edelman , Robert S. Langer , Jeffrey W. Clark , David T. Ting , Cristina Rosa Annamaria Ferrone , Matteo Ligorio
IPC分类号： A61K9/70 , A61K31/337 , A61K47/34 , A61F2/04 , A61L31/10 , A61K9/00 , A61L31/16 , A61L31/14 , A61F2/915
摘要： Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 μm to about 1000 μm, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.
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公开(公告)号：US11122981B2
公开(公告)日：2021-09-21
申请号：US16415430
申请日：2019-05-17
摘要： A method, including: obtaining, by a processor, imaging data from a vessel; detecting, using the processor, an inner wall of the vessel based on the imaging data; identifying, using the processor, a plurality of visible edge portions of an outer wall of the vessel based on the imaging data; fitting, using the processor, a continuous surface model to the plurality of identified visible edge portions of the outer wall; and detecting, using the processor, the outer wall of the vessel based on fitting the continuous surface model to the plurality of identified visible edge portions of the outer wall such that the imaging data has defined therein a wall area between the inner wall and the outer wall of the vessel.
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公开(公告)号：US20200146561A1
公开(公告)日：2020-05-14
申请号：US16446427
申请日：2019-06-19
发明人： Qing Tan , Ahmad El Katerji , Noam Josephy , Elazer R. Edelman , Brian Yale Chang , Steven Keller , Sonya Sanat Bhavsar
摘要： The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).
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公开(公告)号：US20190175372A1
公开(公告)日：2019-06-13
申请号：US16043122
申请日：2018-07-23
发明人： Edward Stuart Boyden , Giovanni Talei Franzesi , Christian Wentz , Nir Grossman , Elazer R. Edelman , Colin Derdeyn , Eric Leuthardt
摘要： An electronic intravascular device is placed in tight contact with vessel walls and is used for electrical stimulation and/or electrical recording of the vessel wall and surrounding target tissue. The electrodes may operate via connectors interfacing them to external hardware or may incorporate electronics to allow wireless power, information transfer, and control. The device includes an internal skeleton, a flexible substrate attached to the exterior of the skeleton, at least one pair of electrodes located on the substrate, and power and control circuitry connected to the electrodes. The power and control circuitry may include connectors for direct powering of the electrodes or circuit elements for wireless powering of the device by RF-based, optical-based, ultrasound-based, piezoelectric, or vibrational energy harvesting methods. The power and control circuitry may include circuit elements for wireless communication, including between the device and the external environment, and may include on-board processing for control of the electrodes.
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公开(公告)号：US10318707B2
公开(公告)日：2019-06-11
申请号：US14266954
申请日：2014-05-01
摘要： Apparatus, systems, and methods are provided for assessing clot activity in blood under various conditions in vitro. The apparatus includes a plurality of test receptacles that receive the blood, at least one flow generating mechanism in communication with the test receptacles, and a clot detector configured to analyze an amount of clot formation that occurs within the blood in each receptacle. Blood contacting surfaces of a first subset of the test receptacles are coated with a first surface substrate and blood contacting surfaces of a second subset of the test receptacles are coated with a different second surface substrate. The flow generating mechanism is configured to generate a first blood flow rate through a third subset of the test receptacles and to generate a different second blood flow rate through a fourth subset of the test receptacles.
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公开(公告)号：US20180193518A1
公开(公告)日：2018-07-12
申请号：US15739217
申请日：2016-06-23
CPC分类号： A61L24/043 , A61L24/0015 , A61L26/0052 , A61L26/0066 , C08L5/02 , C08L101/005
摘要： Methods, compositions, kits, and drug delivery devices are provided for treating, adhering, or sealing biological tissues. The methods include combining a first solution that includes an oligomer/polymer component and a second solution that includes a dendrimer component, and at least one of the oligomer/polymer component and dendrimer component includes at least one substituent that is capable of photoreversible dimerization. The reversible dimerization of the substituent may allow for the reversible dimerization and/or polymerization of one or more components. The substituent that is capable of photoreversible dimerization may be active by the application of light, such as UV light.
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公开(公告)号：US20150196687A1
公开(公告)日：2015-07-16
申请号：US14592395
申请日：2015-01-08
CPC分类号： A61L27/3808 , A61K9/0024 , A61K35/12 , A61K39/0011 , A61K47/42 , A61K2039/5152 , A61L27/3804 , A61L27/40 , A61L27/50 , A61L2400/18
摘要： The invention relates to composition and a method of using the composition for modulting proliferation, invasiveness, the expression of a biomarker of an abnormal cell, of reducing the risk of patient cell becoming abnormal, or of modulating proliferation of a carcinoma-associated fibroblast or of a tumor-associated macrophage. The invention also relates to a method of culturing the composition to produce molecules that modulate abnormal cell proliferation, invasiveness, or metastasis. The composition comprises a biocompatible matrix and cells engrafted thereon.
摘要翻译： 本发明涉及组合物和使用该组合物来调节增殖，侵袭性，异常细胞生物标志物表达，降低患者细胞变得异常风险或调节癌相关成纤维细胞增殖的方法 肿瘤相关巨噬细胞。 本发明还涉及培养组合物以产生调节异常细胞增殖，侵袭或转移的分子的方法。 组合物包含生物相容性基质和植入其上的细胞。
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公开(公告)号：US20150174156A1
公开(公告)日：2015-06-25
申请号：US14581208
申请日：2014-12-23
IPC分类号： A61K31/785 , A61K47/34
CPC分类号： A61K31/785 , A61K9/0019 , A61K47/34 , A61L24/001 , A61L24/08 , A61L27/20 , A61L27/50 , C08L5/02
摘要： Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. Drug delivery compositions and kits containing these two components also are provided.
摘要翻译： 提供了处理，粘附或密封生物组织的方法。 所述方法包括组合含有能够彼此反应的聚合物组分和树枝状大分子组分的溶液，并且至少一种组分包括能够可逆地二聚的能够进行可光反应的二聚化的取代基。 还提供了含有这两种组分的药物递送组合物和试剂盒。
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公开(公告)号：US20140341838A1
公开(公告)日：2014-11-20
申请号：US14446805
申请日：2014-07-30
CPC分类号： A61L24/043 , A61L24/0005 , A61L24/0015 , A61L24/08 , A61M5/19 , A61M5/31596 , C08L5/02
摘要： Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.
摘要翻译： 提供生物相容的粘合剂材料，例如用于生物组织和/或医疗植入物，以及用于制备和使用生物相容性粘合剂材料的方法和试剂盒。 生物相容性粘合剂材料包括树枝状大分子组分和聚合物组分，并且可以针对特定的组织类型和条件而定制。
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公开(公告)号：US20140308336A1
公开(公告)日：2014-10-16
申请号：US14250025
申请日：2014-04-10
发明人： Laura Indolfi , Elazer R. Edelman , Robert S. Langer , Jeffrey W. Clark , David T. Ting , Cristina Rosa Annamaria Ferrone , Matteo Ligorio
IPC分类号： A61K9/70 , A61F2/04 , A61K31/337
CPC分类号： A61L31/10 , A61F2/915 , A61F2002/041 , A61F2230/0021 , A61K9/0024 , A61K9/0034 , A61K9/7007 , A61K31/337 , A61K47/34 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2300/606 , A61L2420/06 , C08L67/04
摘要： Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 μm to about 1000 μm, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.
摘要翻译： 提供了用于治疗胰腺，胆汁系统，胆囊，肝脏，小肠或结肠肿瘤的药物洗脱装置和方法。 方法包括部署具有膜的药物洗脱装置，该膜包括可降解聚合物和化学治疗药物的混合物，其中所述膜具有约2μm至约1000μm的厚度，进入组织部位并释放治疗有效量的 来自膜的化学治疗药物以治疗肿瘤，其中通过在组织部位的聚合物的体内降解来控制来自膜的治疗有效量的药物的释放。
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