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11 条记录 (耗时 0.017 秒)

    INFLUENZA SENSOR
    1.
    发明申请
    INFLUENZA SENSOR 失效
    流感传感器

    公开(公告)号：US20060003318A1

    公开(公告)日：2006-01-05

    申请号：US11132130

    申请日：2005-05-17

    申请人： Basil Swanson ,  Xuedong Song ,  Clifford Unkefer ,  Louis Silks ,  Jurgen Schmidt

    发明人： Basil Swanson ,  Xuedong Song ,  Clifford Unkefer ,  Louis Silks ,  Jurgen Schmidt

    IPC分类号： C12Q1/70

    CPC分类号： C12Q1/701 ,  C12Q1/34 ,  G01N33/56983 ,  G01N2333/11 ,  Y10S435/808 ,  Y10S435/817 ,  Y10S436/805 ,  Y10S436/811 ,  Y10S436/815 ,  Y10T436/13 ,  Y10T436/200833

    摘要： A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a trifunctional linker moiety with groups bonded thereto including (a) an alkyl chain adapted for attachment to a substrate, (b) a fluorescent moiety capable of generating a fluorescent signal, and (c) a recognition moiety having a spacer group of a defined length thereon, the recognition moiety capable of binding with tetrameric multivalent neuraminidase.

    摘要翻译： 公开了用于检测样品中四聚体多价神经氨酸酶的传感器，其中阳性检测表明样品中存在目标病毒。 还公开了一种三官能组合物，其包括具有与其键合的基团的三官能连接体部分，其包含（a）适于连接到底物的烷基链，（b）能够产生荧光信号的荧光部分，和（c）识别 具有其上限定长度的间隔基的部分，所述识别部分能够与四聚体多价神经氨酸酶结合。

    Solid phase immobilized trifunctional linker
    2.
    发明申请
    Solid phase immobilized trifunctional linker 审中-公开
    固相固定三官能接头

    公开(公告)号：US20070141724A1

    公开(公告)日：2007-06-21

    申请号：US11590103

    申请日：2006-10-30

    申请人： Jurgen Schmidt ,  Basil Swanson ,  Clifford Unkefer

    发明人： Jurgen Schmidt ,  Basil Swanson ,  Clifford Unkefer

    IPC分类号： C40B40/10 ,  C07K1/02

    CPC分类号： B01J19/0046 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  C07K1/042 ,  G01N33/54353

    摘要： The present invention is directed to a method of forming an immobilized chemical moiety, such as a trifunctional chemical moiety that includes membrane-anchoring functionalities, on a solid support for use in automated chemical synthesis of a recognition molecule. The invention is further directed to a method of easily and efficiently synthesizing chemical moieties such as those used for biosensor applications. The invention is further directed to a composition, i.e., a solid support having a trifunctional chemical moiety linked thereto, that can be readily and easily used to generate biological molecules for applications, such as biosensor applications.

    摘要翻译： 本发明涉及在用于识别分子的自动化学合成中的固体支持物上形成固定的化学部分例如包括膜锚定功能的三官能化学部分的方法。 本发明进一步涉及容易且有效地合成化学部分的方法，例如用于生物传感器应用的那些。 本发明进一步涉及一种组合物，即具有与其连接的三官能化学部分的固体支持物，其可以容易地和容易地用于产生用于应用的生物分子，例如生物传感器应用。

    Solid phase immobilized trifunctional linker
    3.
    发明申请
    Solid phase immobilized trifunctional linker 审中-公开
    固相固定三官能接头

    公开(公告)号：US20050027100A1

    公开(公告)日：2005-02-03

    申请号：US10629984

    申请日：2003-07-29

    申请人： Jurgen Schmidt ,  Basil Swanson ,  Clifford Unkefer

    发明人： Jurgen Schmidt ,  Basil Swanson ,  Clifford Unkefer

    IPC分类号： B01J19/00 ,  C07K1/02 ,  G01N33/53 ,  G01N33/543

    CPC分类号： G01N33/54353 ,  B01J19/0046 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731

    摘要： The present invention is directed to a method of forming an immobilized chemical moiety, such as a trifunctional chemical moiety that includes membrane-anchoring functionalities, on a solid support for use in automated chemical synthesis of a recognition molecule. The invention is further directed to a method of easily and efficiently synthesizing chemical moieties such as those used for biosensor applications. The invention is further directed to a composition, i.e., a solid support having a trifunctional chemical moiety linked thereto, that can be readily and easily used to generate biological molecules for applications, such as biosensor applications.

    摘要翻译： 本发明涉及在用于识别分子的自动化学合成中的固体支持物上形成固定的化学部分例如包括膜锚定功能的三官能化学部分的方法。 本发明进一步涉及容易且有效地合成化学部分的方法，例如用于生物传感器应用的那些。 本发明进一步涉及一种组合物，即具有与其连接的三官能化学部分的固体支持物，其可以容易地和容易地用于产生用于应用的生物分子，例如生物传感器应用。

    Synthesis of [1-13C]pyruvic acid], [2-13C]pyruvic acid], [3-13C]pyruvic acid] and combinations thereof
    6.
    发明申请
    Synthesis of [1-13C]pyruvic acid], [2-13C]pyruvic acid], [3-13C]pyruvic acid] and combinations thereof 失效

    公开(公告)号：US20060178534A1

    公开(公告)日：2006-08-10

    申请号：US11052589

    申请日：2005-02-07

    申请人： Rodolfo Martinez ,  Clifford Unkefer ,  Marc Alvarez

    发明人： Rodolfo Martinez ,  Clifford Unkefer ,  Marc Alvarez

    IPC分类号： C07C321/02 ,  C07C237/40

    CPC分类号： C07C69/716 ,  C07B59/001 ,  C07B2200/05 ,  C07C59/347 ,  C07C235/80 ,  C07C317/24 ,  C07C317/46 ,  Y10T436/200833

    摘要： The present invention is directed to labeled compounds, of the formulae wherein C* is each independently selected from the group consisting of 13C and 12C with the proviso that at least one C* is 13C, each hydrogen of the methylene group can independently be either hydrogen or deuterium, the methyl group includes either zero or three deuterium atoms, Q is from the group of sulfide, sulfinyl, and sulfone, Z is an aryl group from the group of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R1, R2, R3, R4 and R5 are each independently from the group of hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group from the group of NH2, NHR and NRR′ where R and R′ are each independently from the group of a C1-C4 lower alkyl, a phenyl, and an alkoxy group, and the methyl group can include either zero or three deuterium atoms. The present invention is also directed to labeled compounds of the formula where X is from the group of —NR6R7 and —OR8 where R6 and R7 are each independently selected from the group of C1-C4 lower alkyl, alkoxy and aryl and R8 is from the group of C1-C4 lower alkyl, alkoxy and aryl, T is from the group of —CH3, —CD3, —CH2—S—R9, —CH2—S(O)—R9, and —CH2—(O)S(O)—R9, J is from the group of —CH(OH)—CH2—S—R9, —CH(OH)—CH2—S(O)—R9, and —CH(OH)—CH2—(O)S(O)—R9 where R9 is an aryl group from the group of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R1, R2, R3, R4 and R5 are each independently from the group of hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group from the group of NH2, NHR and NRR′ where R and R′ are each independently from the group of a C1-C4 lower alkyl, a phenyl, and an alkoxy group, and C* are each independently selected from the group consisting of 13C and 12C with the proviso that at least one C* is 13C.

    Synthesis of [13C] and [2H] susbstituted methacrylic acid, [13C] and [2H] substituted methyl methacrylate and/or related compounds
    7.
    发明申请
    Synthesis of [13C] and [2H] susbstituted methacrylic acid, [13C] and [2H] substituted methyl methacrylate and/or related compounds 失效

    公开(公告)号：US20070106085A1

    公开(公告)日：2007-05-10

    申请号：US11268227

    申请日：2005-11-04

    申请人： Marc Alvarez ,  Rodolfo Martinez ,  Clifford Unkefer

    发明人： Marc Alvarez ,  Rodolfo Martinez ,  Clifford Unkefer

    IPC分类号： C07C69/52

    CPC分类号： C07C51/377 ,  C07B2200/05 ,  C07C67/317 ,  C07C317/44 ,  C07C323/52 ,  C07C57/04 ,  C07C69/54

    摘要： The present invention is directed to labeled compounds of the formulae wherein Q is selected from the group consisting of —S—, —S(═O)—, and —S(═O)2—, Z is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R1, R2, R3, R4 and R5 are each independently selected from the group consisting of hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group selected from the group consisting of NH2, NHR and NRR′ where R and R′ are each independently selected from the group consisting of a C1-C4 lower alkyl, an aryl, and an alkoxy group, and X is selected from the group consisting of hydrogen, a C1-C4 lower alkyl group, and a fully-deuterated C1-C4 lower alkyl group. The present invention is also directed to a process of preparing labeled compounds, e.g., process of preparing [13C]methacrylic acid by reacting a (CH3CH2O—13C(O)—13CH2)— aryl sulfone precursor with 13CHI to form a (CH3CH2O—13C(O)—13C(13CH3)2)— aryl sulfone intermediate, and, reacting the (CH3CH2O—13C(O)—13C(13CH3)2)— aryl sulfone intermediate with sodium hydroxide, followed by acid to form [13C]methacrylic acid. The present invention is further directed to a process of preparing [2H8]methyl methacrylate by reacting a (HOOC—C(C2H3)2— aryl sulfinyl intermediate with CD3I to form a (2H3COOC—C(C2H3)2)— aryl sulfinyl intermediate, and heating the(2H3COOC—C(C2H3)2)— aryl sulfinyl intermediate at temperatures and for time sufficient to form [2H8]methyl methacrylate.

    Synthesis of isotopically labeled R- or S-[13C, 2H] glycerols
    9.
    发明申请
    Synthesis of isotopically labeled R- or S-[13C, 2H] glycerols 有权
    同位素标记的R-或S- [13C，2H]甘油的合成

    公开(公告)号：US20050027146A1

    公开(公告)日：2005-02-03

    申请号：US10629982

    申请日：2003-07-30

    申请人： Rodolfo Martinez ,  Clifford Unkefer ,  Marc Alvarez

    发明人： Rodolfo Martinez ,  Clifford Unkefer ,  Marc Alvarez

    IPC分类号： C07C31/22 ,  C07C35/22 ,  C07C35/24

    CPC分类号： C07C31/225 ,  C07B2200/05 ,  C07B2200/07

    摘要： The present invention is directed to asymmetric chiral labeled glycerols including at least one chiral atom, from one to two 13C atoms and from zero to four deuterium atoms bonded directly to a carbon atom, e.g., (2S)[1,2-13C2]glycerol and (2R)[1,2-13C2]glycerol, and to the use of such chiral glycerols in the preparation of labeled amino acids.

    摘要翻译： 本发明涉及不对称手性标记的甘油，包括至少一个手性原子，一个至两个13个碳原子和从零到四个直接与碳原子键合的氘原子，例如（2S）[1,2- C2]甘油和（2R）[1,2-13C2]甘油，以及这些手性甘油在制备标记的氨基酸中的用途。

    Synthesis of [13C] and [2H] substituted methacrylic acid, [13c] and [2H] substituted methyl methacrylate and/ or related compounds
    10.
    发明申请
    Synthesis of [13C] and [2H] substituted methacrylic acid, [13c] and [2H] substituted methyl methacrylate and/ or related compounds 失效

    公开(公告)号：US20070191635A1

    公开(公告)日：2007-08-16

    申请号：US11591828

    申请日：2006-11-02

    申请人： Marc Alvarez ,  Rodolfo Martinez ,  Clifford Unkefer

    发明人： Marc Alvarez ,  Rodolfo Martinez ,  Clifford Unkefer

    IPC分类号： C07C53/124

    CPC分类号： C07C51/377 ,  C07B2200/05 ,  C07C67/317 ,  C07C317/44 ,  C07C323/52 ,  C07C57/04 ,  C07C69/54

    摘要： The present invention is directed to labeled compounds of the formulae wherein Q is selected from the group consisting of —S—, —S(═O)—, and —S(═O)2—, Z is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R1, R2, R3, R4 and R5 are each independently selected from the group consisting of hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group selected from the group consisting of NH2, NHR and NRR′ where R and R′ are each independently selected from the group consisting of a C1-C4 lower alkyl, an aryl, and an alkoxy group, and X is selected from the group consisting of hydrogen, a C1-C4 lower alkyl group, and a fully-deuterated C1-C4 lower alkyl group. The present invention is also directed to a process of preparing labeled compounds, e.g., process of preparing [13C]methacrylic acid by reacting a (CH3CH2O—13C(O)—13CH2)—aryl sulfone precursor with 13CHI to form a (CH3CH2O—13C(O)—13C(13CH3)2)—aryl sulfone intermediate, and, reacting the (CH3CH2O—13C(O)—13C(13CH3)2)—aryl sulfone intermediate with sodium hydroxide, followed by acid to form [13C]methacrylic acid. The present invention is further directed to a process of preparing [2H8]methyl methacrylate by reacting a (HOOC—C(C2H3)2—aryl sulfinyl intermediate with CD3I to form a (2H3COOC—C(C2H3)2)—aryl sulfinyl intermediate, and heating the (2H3COOC—C(C2H3)2)—aryl sulfinyl intermediate at temperatures and for time sufficient to form [2H8]methyl methacrylate.