公开(公告)号：US08785468B2

公开(公告)日：2014-07-22

申请号：US13148296

申请日：2010-02-12

Applicant: Xiaohui Du ,  Zice Fu ,  Jonathan B. Houze ,  XianYun Jiao ,  Yong-Jae Kim ,  Leping Li ,  Jinqian Liu ,  Mike Elias Lizarzaburu ,  Julio C. Medina ,  Wang Shen ,  Simon Turcotte ,  Ming Yu

Inventor： Xiaohui Du ,  Zice Fu ,  Jonathan B. Houze ,  XianYun Jiao ,  Yong-Jae Kim ,  Leping Li ,  Jinqian Liu ,  Mike Elias Lizarzaburu ,  Julio C. Medina ,  Wang Shen ,  Simon Turcotte ,  Ming Yu

IPC: C07D401/04 ,  A61K31/444

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

Abstract: Provided herein are compounds of formula I: wherein A, B, X, R1, R2 and subscript n are as defined in the following disclosure. Compositions comprising the compounds are also provided, as well as methods for their use, for example, in treatment of type 2 diabetes and type 2 diabetes-related conditions.

Abstract translation: 本文提供了式I的化合物：其中A，B，X，R 1，R 2和下标n如以下公开内容所定义。 还提供了包含该化合物的组合物，以及其用于例如治疗2型糖尿病和2型糖尿病相关病症的方法。

公开(公告)号：US07582803B2

公开(公告)日：2009-09-01

申请号：US11517992

申请日：2006-09-08

Applicant: Michelle Akerman ,  Sean Brown ,  Jonathan B. Houze ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Julio C. Medina ,  Wei Qiu ,  Michael J. Schmitt ,  Yingcai Wang ,  Liusheng Zhu ,  Rajiv Sharma

Inventor： Michelle Akerman ,  Sean Brown ,  Jonathan B. Houze ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Julio C. Medina ,  Wei Qiu ,  Michael J. Schmitt ,  Yingcai Wang ,  Liusheng Zhu ,  Rajiv Sharma

IPC: C07C43/18 ,  C07C43/21 ,  A61K31/075 ,  A61K31/085

CPC classification number: C07D333/24 ,  C07C59/72 ,  C07D231/12 ,  C07D233/26 ,  C07D233/64 ,  C07D239/26 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D261/04 ,  C07D261/08 ,  C07D263/32 ,  C07D317/54 ,  C07D333/16

Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, L2, M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Abstract translation: 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量Q，L1，L2，M，X，L3和A的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

公开(公告)号：US06583165B2

公开(公告)日：2003-06-24

申请号：US09792669

申请日：2001-02-21

Applicant: Jonathan B. Houze

Inventor： Jonathan B. Houze

IPC: A61K314196

CPC classification number: C07D231/38 ,  C07C311/21 ,  C07D295/215 ,  C07D307/52

Abstract: The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.

公开(公告)号：US07968567B2

公开(公告)日：2011-06-28

申请号：US12578498

申请日：2009-10-13

Applicant: Lawrence R. McGee ,  Jonathan B. Houze ,  Steven M. Rubenstein

Inventor： Lawrence R. McGee ,  Jonathan B. Houze ,  Steven M. Rubenstein

IPC: C07D215/38 ,  A61K31/04

CPC classification number: C07D213/70 ,  C07C311/08 ,  C07C311/09 ,  C07C311/21 ,  C07C311/29 ,  C07C317/34 ,  C07C323/49 ,  C07D213/65 ,  C07D213/89 ,  C07D215/20 ,  C07D215/36 ,  C07D215/48 ,  C07D235/14 ,  C07D235/28 ,  C07D263/56 ,  C07D263/58 ,  C07D277/64 ,  C07D277/68 ,  C07D277/74 ,  C07D277/82 ,  C07D307/80 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D513/04

Abstract: Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.

Abstract translation: 提供了PPARγ活性的调节剂，其可用于治疗诸如II型糖尿病和肥胖症的药物组合物和方法。

公开(公告)号：US07714008B2

公开(公告)日：2010-05-11

申请号：US11900006

申请日：2007-09-06

Applicant: Hilary Beck ,  Paul Dransfield ,  Zice Fu ,  Jonathan B. Houze ,  XianYun Jiao ,  Todd J. Kohn ,  SuJen Lai ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Julio C. Medina ,  Michael J. Schmitt ,  Rajiv Sharma ,  Wang Shen ,  Marc Vimolratana ,  Yingcai Wang ,  Zhongyu Wang

Inventor： Hilary Beck ,  Paul Dransfield ,  Zice Fu ,  Jonathan B. Houze ,  XianYun Jiao ,  Todd J. Kohn ,  SuJen Lai ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Julio C. Medina ,  Michael J. Schmitt ,  Rajiv Sharma ,  Wang Shen ,  Marc Vimolratana ,  Yingcai Wang ,  Zhongyu Wang

IPC: A61K31/192 ,  A61K31/422 ,  C07C59/11 ,  C07D261/06

CPC classification number: C07D261/08 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Abstract translation: 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

公开(公告)号：US07060718B2

公开(公告)日：2006-06-13

申请号：US10387217

申请日：2003-03-11

Applicant: Jonathan B. Houze

Inventor： Jonathan B. Houze

IPC: A61K31/4196 ,  C07D249/14

CPC classification number: C07D231/38 ,  C07C311/21 ,  C07D295/215 ,  C07D307/52

Abstract: The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.

公开(公告)号：US07041691B1

公开(公告)日：2006-05-09

申请号：US09606433

申请日：2000-06-28

Applicant: Lawrence R. McGee ,  Jonathan B. Houze ,  Steven M. Rubenstein

Inventor： Lawrence R. McGee ,  Jonathan B. Houze ,  Steven M. Rubenstein

IPC: A61K31/425 ,  C07D277/82 ,  C07D277/62 ,  C07D275/04 ,  C07D275/06

CPC classification number: C07D213/70 ,  C07C311/08 ,  C07C311/09 ,  C07C311/21 ,  C07C311/29 ,  C07C317/34 ,  C07C323/49 ,  C07D213/65 ,  C07D213/89 ,  C07D215/20 ,  C07D215/36 ,  C07D215/48 ,  C07D235/14 ,  C07D235/28 ,  C07D263/56 ,  C07D263/58 ,  C07D277/64 ,  C07D277/68 ,  C07D277/74 ,  C07D277/82 ,  C07D307/80 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D513/04

Abstract: Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.

公开(公告)号：US06211167B1

公开(公告)日：2001-04-03

申请号：US09595398

申请日：2000-06-14

Applicant: Jonathan B. Houze

Inventor： Jonathan B. Houze

IPC: A61K31675

CPC classification number: C07F9/65517 ,  C07F9/12 ,  C07F9/65068

Abstract: The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infrections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.

Abstract translation: 本发明提供了与新的芳基磺酰苯胺衍生物有关的化合物，组合物和方法及其作为药理活性剂的用途。 该组合物特别用作治疗疾病状态，特别是癌症，牛皮癣，血管再狭窄，变应性，动脉粥样硬化和高胆固醇血症的药理作用，或作为用于开发此类药物的铅化合物。

公开(公告)号：US07960408B2

公开(公告)日：2011-06-14

申请号：US12372699

申请日：2009-02-17

Applicant: Lawrence R. McGee ,  Jonathan B. Houze ,  Steven M. Rubenstein ,  Atsushi Hagiwara ,  Noboru Furukawa ,  Hisashi Shinkai

Inventor： Lawrence R. McGee ,  Jonathan B. Houze ,  Steven M. Rubenstein ,  Atsushi Hagiwara ,  Noboru Furukawa ,  Hisashi Shinkai

IPC: A61K31/04

CPC classification number: C07D277/68 ,  C07D215/12 ,  C07D215/20 ,  C07D215/36 ,  C07D215/48 ,  C07D277/64 ,  C07D277/82 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

Abstract: Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARγ. In particular, the compounds of the invention modulate the function of PPARγ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.

Abstract translation: 提供了可用于治疗或预防由PPARγ介导的病症或病症的化合物，组合物和方法。 特别是本发明化合物调节PPARγ的功能。 本发明的方法在治疗和/或预防糖尿病，肥胖，高胆固醇血症，类风湿性关节炎和动脉粥样硬化方面特别有用。

公开(公告)号：US20100137323A1

公开(公告)日：2010-06-03

申请号：US12696770

申请日：2010-01-29

Applicant: Sean P. Brown ,  Paul Dransfield ,  Jonathan B. Houze ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Julio C. Medina ,  Vatee Pattaropong ,  Michael J. Schmitt ,  Rajiv Sharma ,  Yingcai Wang

Inventor： Sean P. Brown ,  Paul Dransfield ,  Jonathan B. Houze ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Julio C. Medina ,  Vatee Pattaropong ,  Michael J. Schmitt ,  Rajiv Sharma ,  Yingcai Wang

IPC: A61K31/498 ,  A61K31/505 ,  A61K31/4409 ,  A61K31/433 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4196 ,  A61K31/4164 ,  C07D239/26 ,  C07D213/55 ,  C07D285/12 ,  C07D263/32 ,  C07D249/08 ,  C07D233/64

CPC classification number: C07D233/64 ,  C07C51/09 ,  C07C51/367 ,  C07C51/47 ,  C07C235/34 ,  C07C2602/10 ,  C07D207/327 ,  C07D213/55 ,  C07D231/12 ,  C07D239/26 ,  C07D249/10 ,  C07D257/04 ,  C07D261/08 ,  C07D263/32 ,  C07D277/587 ,  C07D285/12 ,  C07D333/24 ,  C07C59/72

Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, , L2,M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Abstract translation: 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供了变量Q，L1，，L2，M，X，L3和A的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。