公开(公告)号：US10012646B2

公开(公告)日：2018-07-03

申请号：US14983568

申请日：2015-12-30

Applicant: Industrial Technology Research Institute

Inventor： Ding-Zheng Lin ,  Feng-Sheng Kao ,  Ting-Yu Shih ,  Ping-Chen Chen ,  Jen-You Chu

IPC: G01N21/75 ,  G01N33/543 ,  G01N33/553

CPC classification number: G01N33/54393 ,  G01N33/54353 ,  G01N33/54373 ,  G01N33/553

Abstract: A sensing chip including a substrate, a plurality of metal nanostructures, a first surface modified layer and a second surface modified layer is provided. The metal nanostructures are disposed on the substrate. The first surface modified layer is disposed on a surface of the metal nanostructures, wherein the first surface modified layer includes a plurality of thiol group-containing molecules. The second surface modified layer is disposed on a surface of the substrate, wherein the second surface modified layer includes a plurality of silyl group-containing molecules.

公开(公告)号：US11246822B2

公开(公告)日：2022-02-15

申请号：US16730564

申请日：2019-12-30

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Ting-Yu Shih ,  Lu-Chih Wang ,  Yuan-Kun Yu ,  Yi-Ting Hsieh ,  Yu-Chun Liu ,  Jing-Wen Tang

IPC: A61K8/00 ,  A61K8/73 ,  A61K8/06 ,  A61K8/49 ,  A61Q19/08 ,  A61K8/04 ,  A61K9/107 ,  A61K31/728 ,  A61K9/00 ,  A61K31/4172 ,  A61K31/375 ,  A61K8/67 ,  A61K31/015 ,  A61K8/02 ,  A61K8/96

Abstract: A method for skin care and/or maintenance including applying or administering a preparation to a subject is provided. The preparation includes a biomedical composition, and the biomedical composition includes an effective amount of micelle, wherein the micelle includes a hyaluronic acid and/or a derivative thereof and a modified histidine. The modified histidine is grafted to at least one primary hydroxyl group of the hyaluronic acid and/or the derivative thereof, and a graft ratio of the modified histidine is 1-100%. Moreover, the hyaluronic acid and/or the derivative thereof and the modified histidine form the micelle on a weight percentage of 0.2-300:1.

公开(公告)号：US20160113905A1

公开(公告)日：2016-04-28

申请号：US14757364

申请日：2015-12-22

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Ting-Yu Shih ,  Tse-Min Teng ,  Chia-Chun Wang ,  Yu-Hua Chen ,  Jui-Hsiang Chen ,  Mei-Ju Yang ,  Shu-Fang Chiang ,  Yen-Chun Chen ,  Chia-Ni Chang

IPC: A61K31/4172 ,  A61L31/04 ,  A61K31/728 ,  A61L31/16 ,  A61K31/765 ,  A61K31/717

CPC classification number: A61K31/4172 ,  A61K31/715 ,  A61K31/717 ,  A61K31/728 ,  A61K31/765 ,  A61K47/58 ,  A61K47/61 ,  A61L15/24 ,  A61L15/28 ,  A61L15/44 ,  A61L27/16 ,  A61L27/20 ,  A61L27/54 ,  A61L29/041 ,  A61L29/043 ,  A61L29/16 ,  A61L31/042 ,  A61L31/048 ,  A61L31/16 ,  A61L2300/204 ,  A61L2300/434 ,  C08B11/04 ,  C08B11/08 ,  C08B11/20 ,  C08B15/06 ,  C08B37/0072 ,  C08L1/08 ,  C08L1/26 ,  C08L1/284 ,  C08L5/08

Abstract: A polymer composition including a polymer having a hydroxyl group and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group. A polymer material is also provided, including a polymer composition which includes a polymer having a hydroxyl group, and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group.

Abstract translation: 包括具有羟基的聚合物和接枝到具有羟基的聚合物上的组氨酸或组氨酸衍生物的聚合物组合物。 还提供了聚合物材料，包括包含具有羟基的聚合物的聚合物组合物和接枝到具有羟基的聚合物上的组氨酸或组氨酸衍生物。

公开(公告)号：US09737607B2

公开(公告)日：2017-08-22

申请号：US14757563

申请日：2015-12-24

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Jui-Hsiang Chen ,  Yu-Hua Chen ,  Chia-Chen Tsai ,  Tse-Min Teng ,  Ting-Yu Shih ,  Chia-Chun Wang ,  Chia-wei Hong ,  Jennline Sheu ,  Hui-Ling Cheng ,  Shu-Feng Chen ,  Hung-Jui Huang ,  Shu-Ling Wang

IPC: A61K47/32 ,  C08G81/02 ,  A61K9/107 ,  A61K31/18 ,  A61K31/235 ,  A61K31/437 ,  A61K31/44 ,  A61K31/5377 ,  A61K31/551 ,  A61K38/07 ,  C08G18/62 ,  C08G18/71 ,  C08G18/73 ,  C08G18/75 ,  C08G18/76 ,  C08G18/80 ,  C08G18/28 ,  A61K9/14 ,  A61K9/20

CPC classification number: A61K47/32 ,  A61K9/1075 ,  A61K9/146 ,  A61K9/2027 ,  A61K31/18 ,  A61K31/235 ,  A61K31/437 ,  A61K31/44 ,  A61K31/5377 ,  A61K31/551 ,  A61K38/07 ,  C08G18/283 ,  C08G18/6212 ,  C08G18/711 ,  C08G18/73 ,  C08G18/755 ,  C08G18/7671 ,  C08G18/8064 ,  C08G81/021 ,  C08G81/025 ,  C08G81/027

Abstract: A polymer and a pharmaceutical composition employing the same are disclosed. The polymer includes a first repeating unit, a second repeating unit, and a third repeating unit. In particular, the first repeating unit is the second repeating unit is wherein R1 is C1-6 alkyl group; and the third repeating unit is wherein X is and Y is a hydrophilic polymeric moiety.

公开(公告)号：US20160184437A1

公开(公告)日：2016-06-30

申请号：US14757563

申请日：2015-12-24

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Jui-Hsiang Chen ,  Yu-Hua Chen ,  Chia-Chen Tsai ,  Tse-Min Teng ,  Ting-Yu Shih ,  Chia-Chun Wang ,  Chia-wei Hong ,  Jennline Sheu ,  Hui-Ling Cheng ,  Shu-Feng Chen ,  Hung-Jui Huang ,  Shu-Ling Wang

IPC: A61K47/32 ,  A61K31/235 ,  A61K31/5377 ,  A61K9/107 ,  A61K31/18 ,  A61K31/44 ,  A61K31/437 ,  A61K38/07 ,  C08G81/02 ,  A61K31/551

CPC classification number: A61K47/32 ,  A61K9/1075 ,  A61K9/146 ,  A61K9/2027 ,  A61K31/18 ,  A61K31/235 ,  A61K31/437 ,  A61K31/44 ,  A61K31/5377 ,  A61K31/551 ,  A61K38/07 ,  C08G18/283 ,  C08G18/6212 ,  C08G18/711 ,  C08G18/73 ,  C08G18/755 ,  C08G18/7671 ,  C08G18/8064 ,  C08G81/021 ,  C08G81/025 ,  C08G81/027

Abstract: A polymer and a pharmaceutical composition employing the same are disclosed. The polymer includes a first repeating unit, a second repeating unit, and a third repeating unit. In particular, the first repeating unit is the second repeating unit is wherein R1 is C1-6 alkyl group; and the third repeating unit is wherein X is and Y is a hydrophilic polymeric moiety.

Abstract translation: 公开了一种聚合物和使用其的药物组合物。 聚合物包括第一重复单元，第二重复单元和第三重复单元。 特别地，第一重复单元是第二重复单元，其中R 1是C 1-6烷基; 并且第三重复单元是其中X是和Y是亲水性聚合物部分。

公开(公告)号：US11629213B2

公开(公告)日：2023-04-18

申请号：US17133872

申请日：2020-12-24

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Ting-Yu Shih ,  Chia-Chun Wang ,  Lu-Chih Wang ,  Yuan-Kun Yu ,  Shu-Fang Chiang ,  Yi-Ting Hsieh ,  Yu-Chun Liu ,  Jing-Wen Tang

IPC: C08F285/00 ,  C08F283/06

Abstract: A graft polymer is provided, which includes a polymer backbone with a plurality of hydroxy groups, protection group modified histidine grafted onto the side of the polymer backbone, and hydrophilic polymer having terminal reactive group grafted onto the side of the polymer backbone. The graft polymer coating can be applied to metal material to form a composite material, which can be implanted into an organism to reduce adhesion problems.

公开(公告)号：US20170184584A1

公开(公告)日：2017-06-29

申请号：US14983568

申请日：2015-12-30

Applicant: Industrial Technology Research Institute

Inventor： Ding-Zheng Lin ,  Feng-Sheng Kao ,  Ting-Yu Shih ,  Ping-Chen Chen ,  Jen-You Chu

IPC: G01N33/543

CPC classification number: G01N33/54393 ,  G01N33/54353 ,  G01N33/54373 ,  G01N33/553

Abstract: A sensing chip including a substrate, a plurality of metal nanostructures, a first surface modified layer and a second surface modified layer is provided. The metal nanostructures are disposed on the substrate. The first surface modified layer is disposed on a surface of the metal nanostructures, wherein the first surface modified layer includes a plurality of thiol group-containing molecules. The second surface modified layer is disposed on a surface of the substrate, wherein the second surface modified layer includes a plurality of silyl group-containing molecules.