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    DEVICE AND METHOD FOR FABRICATING THREE-DIMENSIONAL STRUCTURE FROM CELLS
    1.
    发明申请
    DEVICE AND METHOD FOR FABRICATING THREE-DIMENSIONAL STRUCTURE FROM CELLS 审中-公开

    公开(公告)号：US20190136176A1

    公开(公告)日：2019-05-09

    申请号：US16097286

    申请日：2017-03-01

    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

    Inventor： Ryosuke KAWACHI ,  Toshinari SAKURAI

    IPC: C12M1/42 ,  C12N5/00 ,  C12M1/00

    Abstract: There is a need for fabrication of a three-dimensional structure for forming a regenerated tissue/regenerated organ having a desired size, shape, or structure by adjusting culture conditions with high precision and without causing contamination or damage to cells. Provided are: a device for acquiring a fabrication condition of a three-dimensional structure to be fabricated on the basis of externally inputted information relating to the three-dimensional structure, generating a magnetic field in a culture container for cells on the basis of the acquired fabrication condition, supplying magnetized cells to the culture container in which the magnetic field is generated, and culturing the supplied cells; and a method using the device.

    STERILE CONNECTOR AND CELL CULTURE DEVICE PROVIDED THEREWITH
    2.
    发明申请
    STERILE CONNECTOR AND CELL CULTURE DEVICE PROVIDED THEREWITH 审中-公开

    公开(公告)号：US20190153377A1

    公开(公告)日：2019-05-23

    申请号：US15521348

    申请日：2014-11-07

    Applicant: Hitachi High-Technologies Corporation

    Inventor： Akihiro SHIMASE ,  Eiichiro TAKADA ,  Kazumichi IMAI ,  Toshinari SAKURAI

    IPC: C12M1/12 ,  C12M1/00 ,  C12M3/00

    Abstract: A sterile connector has a first connector including a first housing provided with a first flow channel; a first pipeline connected to the first flow channel; first and second openings, the first opening being positioned inward from the second opening; and a first sealing member covering the second opening. Also, a second connector includes a second housing provided with a second flow channel; a third opening; and a second sealing member covering the third opening. The first and second connectors are detachable from each other. The first sealing member seals a space between the inner circumferential surface of the first housing and the outer circumferential surface of the second housing, while the second sealing member seals a space between the inner circumferential surface of the second housing and the outer circumferential surface of the first pipeline so that the first flow channel communicates with the second flow channel.

    ELECTROCHEMICAL MEASUREMENT DEVICE
    4.
    发明申请
    ELECTROCHEMICAL MEASUREMENT DEVICE 有权
    电化学测量装置

    公开(公告)号：US20150355140A1

    公开(公告)日：2015-12-10

    申请号：US14760032

    申请日：2014-01-14

    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

    Inventor： Shinya MATSUOKA ,  So OGUCHI ,  Yukie TOKIWA ,  Toshinari SAKURAI ,  Yasushi NIIYAMA ,  Noriko IIZUMI

    IPC: G01N27/416

    CPC classification number: G01N27/4163

    Abstract: A flow cell for electrochemical measurement which introduces a sample solution, applies a voltage between a working electrode and a counter electrode to analyze the sample solution electrochemically, discharges the sample solution, and performs the electrochemical measurement continuously. The flow cell includes a unit which measures a value of a current flowing between electrodes at the time of applying a voltage, a unit which records the measured current value, a unit which compares the recorded current value with a current value set separately as a determination standard, and a unit which determines whether the current value measured at a cycle of a determination target and the recorded current value is normal by the comparison.

    Abstract translation: 一种用于电化学测量的流动池，其引入样品溶液，在工作电极和对电极之间施加电压，以电化学方式分析样品溶液，排出样品溶液，并连续进行电化学测量。 流通池包括测量施加电压时在电极之间流动的电流的值的单元，记录测量的电流值的单位，将记录的电流值与分别设定的电流值进行比较的单位作为确定 标准，以及通过比较确定在确定目标的周期测量的当前值和记录的当前值是否正常的单元。

    Nucleic Acid Analyzer
    6.
    发明申请
    Nucleic Acid Analyzer 审中-公开

    公开(公告)号：US20180037930A1

    公开(公告)日：2018-02-08

    申请号：US15548574

    申请日：2015-02-23

    Applicant: Hitachi High-Technologies Corporation

    Inventor： Manami NAMMOKU ,  Terumi TAMURA ,  Kohshi MAEDA ,  Daisuke MORISHIMA ,  Toshinari SAKURAI ,  Wataru SATO

    IPC: C12Q1/68 ,  B01L7/00

    Abstract: The purpose of the invention is to provide a nucleic acid analyzer that sets and executes temperature regulation, said temperature regulation matching the characteristics of analyzing items and the configuration of the analyzer, by a simple operation while preventing deterioration in analytical performance caused by partial overheating of a liquid reaction mixture to thereby improve temperature change speed and shorten analysis time. To achieve the above purpose, provided is a method wherein, in the case of performing overshooting: as a first processing, the temperature is continuously elevated until reaching a target overshoot temperature; as a second processing, after reaching the aforesaid temperature, the overshoot target temperature is maintained for a preset period of time; and, as a third processing, the temperature is continuously lowered until reaching a target temperature of the liquid reaction mixture. By executing the first to third processings, regulation is conducted so that temperature measurement values are in a trapezoidal form.

    CYTOMETRIC MECHANISM, CELL CULTURE DEVICE COMPRISING SAME, AND CYTOMETRIC METHOD
    7.
    发明申请
    CYTOMETRIC MECHANISM, CELL CULTURE DEVICE COMPRISING SAME, AND CYTOMETRIC METHOD 审中-公开

    公开(公告)号：US20170306287A1

    公开(公告)日：2017-10-26

    申请号：US15518041

    申请日：2014-10-22

    Applicant: Hitachi High-Technologies Corporation

    Inventor： Masako KAWARAI ,  Toshinari SAKURAI ,  Akihiro SHIMASE ,  Hiroyuki KOSHI

    IPC: C12M1/34 ,  C12M1/00 ,  C12M1/36 ,  G01N21/53 ,  G01N33/483 ,  G01N15/06 ,  G01N15/00

    Abstract: A cytometric mechanism includes: a flow path through which a cell suspension is made to flow; a liquid drive unit for sending the cell suspension which is in the flow path; and a computation unit for irradiating, with irradiation light from a light source, a cell suspension flowing through a flow cell, and for finding a cell survival rate in the cell suspension on the basis of a resulting forward scattered light intensity and transmittance and/or side scattered light intensity. The invention is provided with a calibration curve database for storing, in advance, respective calibration curves indicative of a relationship between viable cell concentration and forward scattered light intensity, a relationship between dead cell concentration and the transmittance, and a relationship between a cell survival rate and the side scattered light intensity.

    CELL CONCENTRATION ADJUSTMENT DEVICE, AND AUTOMATIC SUBCULTURE SYSTEM USING SAME
    8.
    发明申请
    CELL CONCENTRATION ADJUSTMENT DEVICE, AND AUTOMATIC SUBCULTURE SYSTEM USING SAME 审中-公开

    公开(公告)号：US20170159003A1

    公开(公告)日：2017-06-08

    申请号：US15327208

    申请日：2015-07-08

    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

    Inventor： Akihiro SHIMASE ,  Kazumichi IMAI ,  Sadamitsu ASO ,  Eiichiro TAKADA ,  Masako KAWARAI ,  Toshinari SAKURAI

    IPC: C12M1/34 ,  C12M1/02 ,  C12M1/36 ,  C12M1/00

    CPC classification number: C12M41/40 ,  C12M23/58 ,  C12M27/00 ,  C12M29/14 ,  C12M29/18 ,  C12M31/10 ,  C12M41/06 ,  C12M41/36 ,  C12M41/48 ,  C12Q1/06

    Abstract: A device which automatically performs a step in which expanded and cultured cells are diluted to a desired cell concentration and re-inoculated using a cell-concentration adjustment device having an inlet for taking in a cell suspension; an outlet for discharging a diluted cell suspension; and a flow path which is provided between the inlet and the outlet and is capable of holding a cell suspension, the flow path being provided with: a liquid delivery pump for causing a cell suspension inside to flow; a cell-concentration measurement instrument for collecting data related to a cell concentration per unit amount of the cell suspension; and a dilution-liquid container for holding a dilution liquid which is supplied to the flow path to dilute the cell suspension. The device further includes a control unit for controlling at least the liquid delivery pump on the basis of the data obtained by the cell-concentration measurement instrument, wherein the control unit determines, on the basis of the data obtained by the cell-concentration measurement instrument, an amount of the dilution liquid required to bring the cell concentration to the desired concentration, and drives the liquid delivery pump so as to take in the required amount of the dilution liquid into the flow path and mix the cell suspension and the dilution liquid.

    FLOW PASSAGE MODULE AND CELL CULTURE APPARATUS USING SAME
    10.
    发明申请
    FLOW PASSAGE MODULE AND CELL CULTURE APPARATUS USING SAME 审中-公开

    公开(公告)号：US20180258377A1

    公开(公告)日：2018-09-13

    申请号：US15761114

    申请日：2015-09-28

    Applicant: Hitachi High-Technologies Corporation

    Inventor： Akihiro SHIMASE ,  Toshinari SAKURAI

    IPC: C12M1/00 ,  F16K7/06 ,  B81B3/00 ,  B01F3/08 ,  F04B45/06

    CPC classification number: C12M1/007 ,  B01F3/08 ,  B01F5/102 ,  B01F15/0245 ,  B81B3/0097 ,  C12M23/40 ,  F04B45/06 ,  F16K7/06 ,  F16K11/022

    Abstract: Provided are a flow passage module which can achieve complete liquid substitution in a circulating flow passage with a simple structure, and a cell culture apparatus using said flow passage module. A flow passage module comprises: a flexible branching section which is provided with a first branching flow passage connected with an inflow passage for a fluid, a second branching flow passage connected with an outflow passage, a third branching flow passage connected with an entry-side end part of a circulating flow passage, and a fourth branching flow passage connected with an exit-side end part of the circulating flow passage, and which enables the branching flow passages to be communicated with each other; and a communication state switching part which has opening/closing members for closing and opening the desired branching flow passage from among the plurality of branching flow passages.

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