公开(公告)号：US5874511A

公开(公告)日：1999-02-23

申请号：US671821

申请日：1996-06-24

Applicant: Ezio Rizzardo ,  Gordon Francis Meijs ,  San Hoa Thang

Inventor： Ezio Rizzardo ,  Gordon Francis Meijs ,  San Hoa Thang

IPC: C07C43/176 ,  C07C43/178 ,  C07C43/215 ,  C07C323/25 ,  C07F7/18 ,  C07F9/40 ,  C08F2/38 ,  C08F246/00 ,  C08F10/00

CPC classification number: C07C323/60 ,  C07C255/00 ,  C07C321/00 ,  C07C323/00 ,  C07C323/25 ,  C07C43/176 ,  C07C43/1787 ,  C07C43/215 ,  C07F7/1852 ,  C07F9/4015 ,  C08F246/00

Abstract: A process for the production of polymers by free radical polymerization, characterized in that there is added to the polymerization system one or more compounds of the general formula (A). ##STR1## where R.sup.1 is hydrogen or a group capable of activating the vinylic carbon towards free radical addition;Y is OR.sup.2 or CH.sub.2 X(R.sup.2).sub.nwhere R.sup.2 is an optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, or optionally substituted saturated, unsaturated or aromatic carbocyclic or heterocyclic ring;X is an element other than carbon selected from Groups IV, V, VI or VII of the Periodic Table or a group consisting of an element selected from Groups IV, V, or VI to which is attached one or more oxygen atoms; andn is a number from 0 to 3, such that the valency of the group X is satisfied and, when n is greater than 1, the groups represented by R.sup.2 may be identical or different.

Abstract translation: 通过自由基聚合制备聚合物的方法，其特征在于向聚合体系中加入一种或多种通式（A）的化合物。 （A）其中R1是氢或能够将乙烯基碳活化成自由基添加的基团; Y是OR2或CH2X（R2）n，其中R2是任选取代的烷基，任选取代的烯基，任选取代的炔基或任选取代的饱和，不饱和或芳族碳环或杂环; X是除了选自元素周期表第Ⅳ，Ⅴ，Ⅵ或Ⅶ族的碳以外的元素，或由选自附有一个或多个氧原子的第Ⅳ，Ⅴ或Ⅵ族元素组成的组元素; 并且n为0至3的数，使得满足基团X的化合价，并且当n大于1时，由R 2表示的基团可以相同或不同。

公开(公告)号：US06197905B1

公开(公告)日：2001-03-06

申请号：US08828201

申请日：1997-03-21

Applicant: Ezio Rizzardo ,  Gordon Francis Meijs ,  San Hoa Thang

Inventor： Ezio Rizzardo ,  Gordon Francis Meijs ,  San Hoa Thang

IPC: C08F238

CPC classification number: C08F2/38

Abstract: A process for the production of polymers by free radical polymerization, characterized in that there is added to the polymerization system one or more compounds of general formula (A), where R1 is a group capable of activating the vinylic carbon towards free radical addition; Y is OR2, where R2 is an optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, or optionally substituted saturated or unsaturated carbocyclic or heterocyclic ring; X is an element other than carbon selected from the Groups, IV, V, VI or VII of the Periodic Table or a group consisting of an element selected from the Groups IV, V, or VI to which is attached one or more oxygen atoms; and n is a number from 0 to 3, such that the valency of the group X is satisfied and, when n is greater than 1, the groups represented by R2 are identical or different.

Abstract translation: 通过自由基聚合制备聚合物的方法，其特征在于向聚合体系中加入一种或多种通式（A）的化合物，其中R 1是能够将乙烯基碳活化成自由基加成的基团; Y是OR 2，其中R 2是任选取代的烷基，任选取代的烯基，任选取代的炔基或任选取代的饱和或不饱和碳环或杂环; X是除了选自元素周期表中第Ⅳ，Ⅴ，Ⅵ或Ⅶ族的碳以外的元素，或由选自附有一个或多个氧原子的第Ⅳ，Ⅴ或Ⅵ族元素组成的组元素; 并且n为0至3的数，使得满足基团X的化合价，并且当n大于1时，由R 2表示的基团相同或不同。

公开(公告)号：US5698648A

公开(公告)日：1997-12-16

申请号：US202473

申请日：1994-02-28

Applicant: Ezio Rizzardo ,  Gordon Francis Meijs ,  San Hoa Thang

Inventor： Ezio Rizzardo ,  Gordon Francis Meijs ,  San Hoa Thang

IPC: C07C409/04 ,  C07C409/16 ,  C07C409/18 ,  C07C409/38 ,  C07C409/40 ,  C08F2/38 ,  C08F4/34 ,  C08F124/00

CPC classification number: C07C409/04 ,  C07C409/16 ,  C07C409/18 ,  C07C409/38 ,  C07C409/40 ,  C08F2/38 ,  C08F4/34

Abstract: A process for the production of lower molecular weight polymers by free radical polymerization, characterized in that there is added to the polymerization system a compound of the general formula I ##STR1## wherein R.sup.1 is hydrogen, chlorine, an alkyl group, or a group capable of activating the vinylic carbon towards free radical addition; R.sup.2 is hydrogen or an optionally substituted alkyl, alkenyl, aryl, cycloalkenyl or cycloalkyl group or the group --COZ, where Z is R.sup.3 or OR.sup.3, where R.sup.3 is hydrogen or an optionally substituted alkyl, alkenyl or aryl group. X is a hydrogen atom, an alkyl or aryl group, or a halogen, and the two X groups may be the same or different. The invention also includes polymers or oligomers made by the process and novel compounds of the general formula I as defined above.

Abstract translation: 通过自由基聚合生产低分子量聚合物的方法，其特征在于向聚合体系中加入通式为I n烷基的化合物或能够将乙烯基碳活化成自由基添加的基团; R2是氢或任选取代的烷基，烯基，芳基，环烯基或环烷基或基团-COZ，其中Z是R3或OR3，其中R3是氢或任选取代的烷基，烯基或芳基。 X是氢原子，烷基或芳基或卤素，两个X基可以相同或不同。 本发明还包括通过该方法制备的聚合物或低聚物和如上定义的通式I的新化合物。

公开(公告)号：US6034263A

公开(公告)日：2000-03-07

申请号：US468305

申请日：1995-06-06

Applicant: Ezio Rizzardo ,  Gordon Francis Meijs ,  San Hoa Thang

Inventor： Ezio Rizzardo ,  Gordon Francis Meijs ,  San Hoa Thang

IPC: C07C409/04 ,  C07C409/08 ,  C07C409/00

CPC classification number: C07C409/04 ,  C07C409/08 ,  C07C409/40

Abstract: A process for the production of lower molecular weight polymers by free radical polymerization, characterized in that there is added to the polymerization system a compound of the general formula I ##STR1## wherein R.sup.1 is hydrogen, chlorine, an alkyl group, or a group capable of activating the vinylic carbon towards free radical addition;R.sup.2 is hydrogen or an optionally substituted alkyl, alkenyl, aryl, cycloalkenyl or cycloalkyl group or the group --COZ, where Z is R.sup.3 or OR.sup.3, where R.sup.3 is hydrogen or an optionally substituted alkyl, alkenyl or aryl group.X is a hydrogen atom, an alkyl or aryl group, or a halogen, and the two X groups may be the same or different.The invention also includes polymers or oligomers made by the process and novel compounds of the generated formula I as defined above.

Abstract translation: 一种通过自由基聚合生产低分子量聚合物的方法，其特征在于在聚合体系中加入通式Ⅰ化合物，其中R 1是氢，氯，烷基或能够活化 乙烯基碳向自由基添加; R2是氢或任选取代的烷基，烯基，芳基，环烯基或环烷基或基团-COZ，其中Z是R3或OR3，其中R3是氢或任选取代的烷基，烯基或芳基。 X是氢原子，烷基或芳基或卤素，两个X基可以相同或不同。 本发明还包括通过该方法制备的聚合物或低聚物和如上定义的所产生的式I的新化合物。

公开(公告)号：US5932675A

公开(公告)日：1999-08-03

申请号：US823299

申请日：1997-03-21

Applicant: Ezio Rizzardo ,  Gordon Francis Meijs ,  San Hoa Thang

Inventor： Ezio Rizzardo ,  Gordon Francis Meijs ,  San Hoa Thang

IPC: C08F2/38

CPC classification number: C08F2/38

Abstract: ##STR1## A process for the production of polymers by free radical polymerization, characterized in that there is added to the polymerization system one or more compounds of general formula (A), where R
1 is a group capable of activating the vinylic carbon towards free radical addition; Y is CH
2 X(R
2 )
n , where R
2 is an optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, or optionally substituted saturated or unsaturated carbocyclic or heterocyclic ring; X is an element other than carbon selected from the Groups, IV, V, VI or VII of the Periodic Table or a group consisting of an element selected from the Groups IV, V, or VI to which is attached one or more oxygen atoms; and n is a number from 0 to 3, such that the valency of the group X is satisfied and, when n is greater than 1, the groups represented by R
2 are identical or different.

Abstract translation: 通过自由基聚合制备聚合物的方法，其特征在于向聚合体系中加入一种或多种通式（A）的化合物，其中R 1是能够将乙烯基碳活化成自由基加成的基团; Y是CH2X（R2）n，其中R2是任选取代的烷基，任选取代的烯基，任选取代的炔基或任选取代的饱和或不饱和碳环或杂环; X是除了选自元素周期表中第Ⅳ，Ⅴ，Ⅵ或Ⅶ族的碳以外的元素，或由选自附有一个或多个氧原子的第Ⅳ，Ⅴ或Ⅵ族元素组成的组元素; 并且n为0至3的数，使得满足基团X的化合价，并且当n大于1时，由R 2表示的基团相同或不同。

公开(公告)号：US5739228A

公开(公告)日：1998-04-14

申请号：US493937

申请日：1995-06-23

Applicant: Gordon Francis Meijs ,  Ezio Rizzardo

Inventor： Gordon Francis Meijs ,  Ezio Rizzardo

IPC: C08F2/38 ,  C08F2/02

CPC classification number: C08F2/38

Abstract: A process for the production of low molecular weight polymers by free radical polymerization of one or more monomers in the presence of a chain transfer agent, wherein the chain transfer agent comprises one or more compounds of the general formula I ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl group, or a group capable of activating the carbon-sulfur double bond towards free radical addition; and R.sup.2 represents an optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, or optionally substituted saturated, unsaturated or aromatic carbocyclic or heterocyclic ring.

Abstract translation: 一种在链转移剂存在下通过一种或多种单体的自由基聚合生产低分子量聚合物的方法，其中链转移剂包含一种或多种通式I烷基的化合物或能够 使碳 - 硫双键活化成自由基添加; 并且R 2表示任选取代的烷基，任选取代的烯基，任选取代的炔基或任选取代的饱和，不饱和或芳族碳环或杂环。

公开(公告)号：US20090046242A1

公开(公告)日：2009-02-19

申请号：US12252397

申请日：2008-10-16

Applicant: Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorge Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, JR. ,  Jurgen Vogt ,  Lynn Cook Winterton

Inventor： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorge Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, JR. ,  Jurgen Vogt ,  Lynn Cook Winterton

IPC: G02C7/04

CPC classification number: G02B1/043 ,  A61L27/26 ,  B29C39/42 ,  B29C71/00 ,  B29L2011/0041 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/5015 ,  C08G18/61 ,  C08G18/672 ,  C08G18/8116 ,  C08G18/8175 ,  C08L43/04 ,  C08L75/04 ,  C08L51/085 ,  C08L2666/20 ,  C08L51/08 ,  C08L83/04 ,  C08L33/00 ,  C08G18/63 ,  C08G18/48

Abstract: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.

Abstract translation: 一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。 在一个实施方案中，眼用透镜是至少一种氧精，至少一种离子交换剂和交联剂的共聚产物。 在一个实施方案中，透镜的拉伸模量小于约3.0MPa，而在另一个实施方案中，拉伸模量为约0.5至约1.5MPa。

公开(公告)号：US06774197B1

公开(公告)日：2004-08-10

申请号：US10048312

申请日：2002-05-31

Applicant: Anthony Brian Clayton ,  Timothy Charles Hughes ,  Peter Agapitos Kambouris ,  Gordon Francis Meijs

Inventor： Anthony Brian Clayton ,  Timothy Charles Hughes ,  Peter Agapitos Kambouris ,  Gordon Francis Meijs

IPC: C08F21200

CPC classification number: A61L27/16 ,  A61F2/14 ,  A61F2/16 ,  A61L2430/16 ,  C08F8/00 ,  C08F8/14 ,  C08F220/56 ,  C08L33/14 ,  C08L33/26 ,  C08F220/00

Abstract: A hydrophilic ethylenically unsaturated macromonomer is disclosed that is prepared by the addition polymerization of addition polymerizable monomers that include monomers that have hydroxyl or amino functional groups, some of which may be subsequently reacted to provide (meth)acryl ethylenic unsaturation. The macromonomers may be used to form intraocular lenses in situ by polymerization of the macromonomers.

Abstract translation: 公开了通过加成聚合单体制备的亲水烯属不饱和大单体，其包括具有羟基或氨基官能团的单体，其中一些可随后反应以提供（甲基）丙烯酸烯键式不饱和度。 大分子单体可用于通过大分子单体的聚合原位形成眼内透镜。

公开(公告)号：US6015609A

公开(公告)日：2000-01-18

申请号：US155548

申请日：1999-05-10

Applicant: Hassan Chaouk ,  Gordon Francis Meijs ,  Bronwyn Glenice Laycock

Inventor： Hassan Chaouk ,  Gordon Francis Meijs ,  Bronwyn Glenice Laycock

IPC: B01D67/00 ,  B01D71/32 ,  C08F290/06 ,  C08G65/00 ,  C08J9/28 ,  C08L71/02 ,  G02B1/04 ,  G02C7/04 ,  B32B5/14 ,  C08K5/00

CPC classification number: B01D67/0006 ,  B01D67/003 ,  B01D71/32 ,  C08G65/007 ,  C08J9/286 ,  C08L71/02 ,  G02B1/043 ,  B01D2323/18 ,  B01D2325/02 ,  B01D2325/026 ,  B01D2325/22 ,  B01D2325/28 ,  B01D2325/30 ,  C08J2371/00 ,  Y10T428/24 ,  Y10T428/24504 ,  Y10T428/249921 ,  Y10T428/249953 ,  Y10T428/249958

Abstract: The present invention is directed to a process for the production of a porous polymer comprising the steps of: i) forming a mixture comprising a polymerizable component and an organic solvent wherein the polymerizable component comprises at least one macromonomer having at least one perfluoropolyether unit; ii) polymerizing said mixture wherein immediately after the polymerization of said mixture at least a substantial proportion of said organic solvent is in the form of a discrete phase and wherein said discrete organic solvent phase forms an interpenetrating network throughout the mixture or is dispersed throughout the mixture; and iii) removing the discrete organic solvent phase.

Abstract translation: PCT No.PCT / EP97 / 01408 Sec。 371日期1999年5月10日 102（e）日期1999年5月10日PCT 1997年3月20日PCT公布。 公开号WO97 / 35904 日期1997年10月2日本发明涉及一种生产多孔聚合物的方法，包括以下步骤：i）形成包含可聚合组分和有机溶剂的混合物，其中可聚合组分包含至少一种至少具有至少一个的大分子单体 一个全氟聚醚单元; ii）使所述混合物聚合，其中在所述混合物的聚合之后立即至少相当比例的所述有机溶剂是离散相的形式，并且其中所述离散的有机溶剂相在整个混合物中形成互穿网络，或者分散在整个混合物中 ; 和iii）除去离散的有机溶剂相。

公开(公告)号：US5849811A

公开(公告)日：1998-12-15

申请号：US682452

申请日：1996-07-17

Applicant: Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

Inventor： Paul Clement Nicolson ,  Richard Carlton Baron ,  Peter Chabrecek ,  John Court ,  Angelika Domschke ,  Hans Jorg Griesser ,  Arthur Ho ,  Jens Hopken ,  Bronwyn Glenice Laycock ,  Qin Liu ,  Dieter Lohmann ,  Gordon Francis Meijs ,  Eric Papaspiliotopoulos ,  Judy Smith Riffle ,  Klaus Schindhelm ,  Deborah Sweeney ,  Wilson Leonard Terry, Jr. ,  Jurgen Vogt ,  Lynn Cook Winterton

IPC: G02C7/04 ,  A61F20060101 ,  A61F2/14 ,  A61L27/00 ,  A61L27/26 ,  A61L27/34 ,  B05D7/24 ,  B29C39/42 ,  B29C71/00 ,  B29D11/00 ,  C08F220/22 ,  C08F290/06 ,  C08F290/14 ,  C08F299/08 ,  C08G20060101 ,  C08G18/10 ,  C08G18/48 ,  C08G18/50 ,  C08G18/61 ,  C08G18/67 ,  C08G18/81 ,  C08G18/83 ,  C08G77/00 ,  C08G77/04 ,  C08G77/46 ,  C08J5/00 ,  C08K3/00 ,  C08L20060101 ,  C08L33/08 ,  C08L33/10 ,  C08L83/04 ,  G02B1/04 ,  G02C20060101 ,  C08F230/08

CPC classification number: G02C7/049 ,  A61L27/26 ,  A61L27/34 ,  B05D1/62 ,  B29C39/42 ,  B29D11/00076 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/5015 ,  C08G18/61 ,  C08G18/672 ,  C08G18/8116 ,  C08G18/8175 ,  G02B1/043 ,  A61L2430/16 ,  B29C71/00 ,  B29L2011/0041 ,  Y10S525/903 ,  Y10S525/936 ,  Y10S525/937

Abstract: An ophthalmic lens suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

Abstract translation: 适合在眼睛上延长穿戴至少一天的眼科镜片，而不会有临床显着量的角膜肿胀并且没有实质的佩戴者不适。 透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。 优选的透镜是含氧大分子单体和离子单体单体的共聚产物。 本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。