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    Pimarane diterpenes from Anisochilus verticillatus
    1.
    发明授权
    Pimarane diterpenes from Anisochilus verticillatus 有权
    来自Anisochilus verticillatus的Pimarane二萜类

    公开(公告)号：US09024043B2

    公开(公告)日：2015-05-05

    申请号：US14236995

    申请日：2012-08-06

    Applicant: Swati Pramod Joshi ,  Roshan Rajan Kulkarni

    Inventor： Swati Pramod Joshi ,  Roshan Rajan Kulkarni

    IPC: C07D493/08 ,  C07C35/42 ,  C07C13/60 ,  C07C409/18 ,  C07D319/14

    CPC classification number: C07D493/08 ,  C07C13/60 ,  C07C35/42 ,  C07C409/18 ,  C07C2603/26 ,  C07D319/14

    Abstract: This invention discloses diterpenes class of novel compounds of general formula I from a novel source. More particularly the invention relates to extracts/fractions containing pimarane diterpenes from Anisochillus (Lamiaceae), useful for prevention, treatment, inhibition or controlling growth and proliferation of mycobacterial activity in mammals. The invention further relates to extracts, fractions standardized to diterpenes class of novel compounds useful for the treatment of cancers.

    Abstract translation: 本发明公开了一种新型来源的通式I的新型化合物二萜类。 更具体地，本发明涉及含有来自Anisochillus（Lamiaceae）的异丙苯二萜的提取物/级分，其可用于预防，治疗，抑制或控制哺乳动物中分枝杆菌活性的生长和增殖。 本发明还涉及标准化为二萜类的提取物，用于治疗癌症的新化合物的级分。

    PROCESS FOR THE PREPARATION OF OXOVINYLIONOL AND ITS O-PROTECTED DERIVATIVES
    2.
    发明申请
    PROCESS FOR THE PREPARATION OF OXOVINYLIONOL AND ITS O-PROTECTED DERIVATIVES 有权
    氧化亚油和其保护的衍生物的制备方法

    公开(公告)号：US20130116473A1

    公开(公告)日：2013-05-09

    申请号：US13673278

    申请日：2012-11-09

    Applicant: BASF SE

    Inventor： Hansgeorg Ernst ,  Michael Puhl ,  Stefan Benson ,  Wolfgang Siegel

    IPC: C07C45/28 ,  C07F9/54 ,  C07C409/18

    CPC classification number: C07C45/28 ,  C07C403/08 ,  C07C407/00 ,  C07C409/18 ,  C07C2601/16 ,  C07F9/5442 ,  Y02P20/55 ,  C07C409/14

    Abstract: The present invention relates to the preparation of oxovinylionol and its O-protected derivatives of the formula I in which R is hydrogen or an OH protecting group, for example a group Si(Ra)3, by reacting a compound of the general formula II in which R has the meanings given above for formula I, i.e. β-vinyl ionol (formula II, R=hydrogen) or an O-protected derivative thereof (formula II, R═OH protecting group) with an oxidant in the presence of at least one transition metal, where the oxidant comprises at least one oxygen-containing compound which is selected from among hydrogen peroxide and organic hydroperoxides.

    Abstract translation: 本发明涉及通过使通式II的化合物与式（I）的化合物反应制备式I化合物的氧代乙烯基醇及其O-保护的衍生物，其中R是氢或OH保护基，例如Si（Ra） 其中R具有上述式I的定义，即β-乙烯基离子（式II，R =氢）或其保护有机化合物（式II，R = OH保护基）与氧化剂在至少 一种过渡金属，其中氧化剂包含至少一种选自过氧化氢和有机氢过氧化物的含氧化合物。

    Process for the preparation of terpene peroxides and peroxides thus obtained
    8.
    发明授权
    Process for the preparation of terpene peroxides and peroxides thus obtained 失效
    制备由此获得的萜烯过氧化物和过氧化物的方法

    公开(公告)号：US4933501A

    公开(公告)日：1990-06-12

    申请号：US311047

    申请日：1989-02-16

    Applicant: Claude Mercier

    Inventor： Claude Mercier

    IPC: C07C67/00 ,  C07C407/00 ,  C07C409/16 ,  C07C409/18 ,  C07F7/08

    CPC classification number: C07F7/0894 ,  C07C407/00 ,  C07C409/16 ,  C07C409/18 ,  C07C2101/14

    Abstract: Terpene peroxides of formula: ##STR1## in which R denotes a tertiary alkyl radical substituted, if desired, by one or more phenyl radicals, a cycloalkyl radical or a trialkylsilyl radical, R.sub.1, R.sub.2 and R.sub.3, which are identical or different, each denote hydrogen or an aliphatic radical optionally containing one or more double or triple bonds and optionally substituted, and R.sub.4 denotes an aliphatic radical optionally containing one or more double or triple bonds and optionally substituted or R.sub.3 denotes hydrogen and R.sub.2 and R.sub.4 together form an alkylene radical which may be substituted by one or more methyl radicals, are obtained by reaction of a hydroperoxide of formula R--OOH with a compound of formula: ##STR2## the operation being carried out in a basic aprotic solvent.

    Abstract translation: 式中：IMA GE denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote denote 氢或任选地含有一个或多个双键或三键并任选取代的脂族基团，并且R 4表示任选含有一个或多个双键或三键并且任选取代的脂族基团或R 3表示氢，且R 2和R 4一起形成亚烷基， 可通过一种或多种甲基自由基代替，其通过式R-OOH的氢过氧化物与式（IIIa）或（IIIb）化合物（IIIb）的反应获得：该操作是在碱性非质子 溶剂。

    Compounds by addition of hydroperoxides to .alpha.-.beta.-unsaturated ketones
    10.
    发明授权
    Compounds by addition of hydroperoxides to .alpha.-.beta.-unsaturated ketones 失效
    通过向α-β-不饱和酮中加入氢过氧化物的化合物

    公开(公告)号：US4257985A

    公开(公告)日：1981-03-24

    申请号：US727335

    申请日：1968-05-07

    Applicant: Wilbur H. McKellin

    Inventor： Wilbur H. McKellin

    IPC: C07C409/16 ,  C07C409/18 ,  C08F4/32 ,  C08F4/34 ,  C07C49/213 ,  C07C45/64 ,  C07C49/04

    CPC classification number: C07C409/16 ,  C08F4/32

    Abstract: Compounds containing at least one keto group and at least one peroxy group, each peroxy oxygen being joined to a tertiary carbon atom.Examples: 2-Methyl-2-(t-butylperoxy)-4-pentanone. 2,6-Dimethyl-2,6-bis(t-butylperoxy)-4-heptanone. 3,5,5-Trimethyl-3-(t-butylperoxy)cyclohexanone.The compounds are prepared by the strong acid catalyzed addition of a tertiary hydroperoxide to an .alpha.,.beta.-unsaturated ketone. Illustration: Mesityl oxide and pinanyl hydroperoxide, in slight excess, were reacted at 0.degree. C. in the presence of 77% sulfuric acid; the reaction mix was stirred for 16 hours at 25.degree. C. Product 2-methyl-2-pinanylperoxy-4-pentanone was recovered.

    Abstract translation: 含有至少一个酮基和至少一个过氧基的化合物，每个过氧氧与叔碳原子连接。 实施例：2-甲基-2-（叔丁基过氧）-4-戊酮。 2,6-二 - 2,6-二（叔丁基过氧）-4-庚酮。 3,5,5-三甲基-3-（叔丁基过氧）环己酮。 通过强酸催化将叔氢过氧化物加成到α，β-不饱和酮中制备化合物。 图示：在77％硫酸存在下，在0℃下使略微过量的三甲氧基硅氧烷和蒎烷基氢过氧化物反应; 将反应混合物在25℃下搅拌16小时。回收产物2-甲基-2-蒎烷基过氧-4-戊酮。

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